JP2008532559A5 - - Google Patents

Info

Publication number

JP2008532559A5

JP2008532559A5 JP2008502456A JP2008502456A JP2008532559A5 JP 2008532559 A5 JP2008532559 A5 JP 2008532559A5 JP 2008502456 A JP2008502456 A JP 2008502456A JP 2008502456 A JP2008502456 A JP 2008502456A JP 2008532559 A5 JP2008532559 A5 JP 2008532559A5

Authority

JP

Japan

Prior art keywords

seq

immunoglobulin

immunoglobulin molecule

sequence

hcv

Prior art date

2006-03-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108060003951 Immunoglobulin Proteins 0.000 claims 28
• 102000018358 immunoglobulin Human genes 0.000 claims 28
• 241000711549 Hepacivirus C Species 0.000 claims 14
• 108090000765 processed proteins & peptides Proteins 0.000 claims 13
• 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 8
• 150000001413 amino acids Chemical class 0.000 claims 5
• 102000004196 processed proteins & peptides Human genes 0.000 claims 5
• 125000000539 amino acid group Chemical group 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 102000003886 Glycoproteins Human genes 0.000 claims 2
• 108090000288 Glycoproteins Proteins 0.000 claims 2
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• SHFKGANKURXVMY-LCWPZEQJSA-N hcv e2 protein Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)CC1=CC=CC=C1 SHFKGANKURXVMY-LCWPZEQJSA-N 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 229910052698 phosphorus Inorganic materials 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
• 101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 claims 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
• 108010076039 Polyproteins Proteins 0.000 claims 1
• 108010003723 Single-Domain Antibodies Proteins 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 102000054751 human RUNX1T1 Human genes 0.000 claims 1
• 230000005847 immunogenicity Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 102000040430 polynucleotide Human genes 0.000 claims 1
• 108091033319 polynucleotide Proteins 0.000 claims 1
• 239000002157 polynucleotide Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1