JP2008528514A5 - - Google Patents
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- Publication number
- JP2008528514A5 JP2008528514A5 JP2007552380A JP2007552380A JP2008528514A5 JP 2008528514 A5 JP2008528514 A5 JP 2008528514A5 JP 2007552380 A JP2007552380 A JP 2007552380A JP 2007552380 A JP2007552380 A JP 2007552380A JP 2008528514 A5 JP2008528514 A5 JP 2008528514A5
- Authority
- JP
- Japan
- Prior art keywords
- disorder
- pharmaceutical composition
- disease
- related disorder
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 60
- 208000035475 disorder Diseases 0.000 claims 47
- 239000008194 pharmaceutical composition Substances 0.000 claims 31
- 201000010099 disease Diseases 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- 239000012453 solvate Substances 0.000 claims 12
- 230000033115 angiogenesis Effects 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 7
- 201000001320 Atherosclerosis Diseases 0.000 claims 6
- 208000018565 Hemochromatosis Diseases 0.000 claims 6
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 6
- 208000019693 Lung disease Diseases 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 208000002193 Pain Diseases 0.000 claims 6
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 6
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 6
- 208000027418 Wounds and injury Diseases 0.000 claims 6
- 230000002159 abnormal effect Effects 0.000 claims 6
- 239000010425 asbestos Substances 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 208000015114 central nervous system disease Diseases 0.000 claims 6
- 230000006378 damage Effects 0.000 claims 6
- 208000014674 injury Diseases 0.000 claims 6
- 208000002780 macular degeneration Diseases 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 6
- 229940002612 prodrug Drugs 0.000 claims 6
- 229910052895 riebeckite Inorganic materials 0.000 claims 6
- 208000017520 skin disease Diseases 0.000 claims 6
- 208000019116 sleep disease Diseases 0.000 claims 6
- 208000020685 sleep-wake disease Diseases 0.000 claims 6
- 208000011580 syndromic disease Diseases 0.000 claims 6
- -1 3-methyl-2,6-dioxo-piperidin-3-yl Chemical group 0.000 claims 5
- 208000030852 Parasitic disease Diseases 0.000 claims 5
- VZTDWPXKIYLLAT-UHFFFAOYSA-N 4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Chemical compound O=C1C2=CC=CC(N)=C2C(=O)N1C1(C)CCC(=O)NC1=O VZTDWPXKIYLLAT-UHFFFAOYSA-N 0.000 claims 4
- 238000007911 parenteral administration Methods 0.000 claims 4
- VZTDWPXKIYLLAT-CQSZACIVSA-N 4-amino-2-[(3r)-3-methyl-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC(N)=C2C(=O)N1[C@]1(C)CCC(=O)NC1=O VZTDWPXKIYLLAT-CQSZACIVSA-N 0.000 claims 3
- VZTDWPXKIYLLAT-AWEZNQCLSA-N 4-amino-2-[(3s)-3-methyl-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC(N)=C2C(=O)N1[C@@]1(C)CCC(=O)NC1=O VZTDWPXKIYLLAT-AWEZNQCLSA-N 0.000 claims 3
- 239000013543 active substance Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000024241 parasitism Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64650505P | 2005-01-25 | 2005-01-25 | |
| PCT/US2006/002503 WO2006081251A2 (en) | 2005-01-25 | 2006-01-24 | Methods and compositions using 4-amino-2-(3-methyl-2,6-dioxopiperidin-3-yl)-isoindole-1-3-dione |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528514A JP2008528514A (ja) | 2008-07-31 |
| JP2008528514A5 true JP2008528514A5 (https=) | 2009-07-16 |
Family
ID=36609267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007552380A Abandoned JP2008528514A (ja) | 2005-01-25 | 2006-01-24 | ４−アミノ−２−（３−メチル−２，６−ジオキソピペリジン−３−イル）−イソインドール−１，３−ジオンを使用する方法及び組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060205787A1 (https=) |
| EP (1) | EP1848433A2 (https=) |
| JP (1) | JP2008528514A (https=) |
| KR (1) | KR20070099031A (https=) |
| CN (1) | CN101141960A (https=) |
| AR (1) | AR052196A1 (https=) |
| AU (1) | AU2006208201A1 (https=) |
| BR (1) | BRPI0607239A2 (https=) |
| CA (1) | CA2595711A1 (https=) |
| IL (1) | IL184821A0 (https=) |
| MX (1) | MX2007008903A (https=) |
| WO (1) | WO2006081251A2 (https=) |
| ZA (1) | ZA200707010B (https=) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070004689A1 (en) * | 2004-03-12 | 2007-01-04 | Agoston Gregory E | Antiangiogenic agents |
| CA2558014A1 (en) * | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Antiangiogenic agents |
| WO2007059111A2 (en) * | 2005-11-14 | 2007-05-24 | Entremed, Inc. | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| US20070253960A1 (en) * | 2006-04-28 | 2007-11-01 | Josee Roy | Pharmaceutical removal of vascular extensions from a degenerating disc |
| WO2008094665A1 (en) * | 2007-01-31 | 2008-08-07 | Entremed, Inc. | Method of treating amyloidosis mediated diseases |
| US7579464B2 (en) * | 2007-05-25 | 2009-08-25 | Hoffmann-La Roche Inc. | Process for preparation of enantiomerically pure compounds |
| WO2009085234A2 (en) | 2007-12-20 | 2009-07-09 | Signal Pharmaceuticals, Inc. | Use of micro-rna as a biomarker of immunomodulatory drug activity |
| WO2009105256A2 (en) * | 2008-02-20 | 2009-08-27 | Celgene Corporation | Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand |
| EP3085231A1 (en) | 2008-05-27 | 2016-10-26 | Intra-Cellular Therapies, Inc. | Method and compositions for sleep disorders and other disorders |
| EP3489352A1 (en) | 2009-03-25 | 2019-05-29 | Celularity, Inc. | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| EP2436387B1 (en) | 2009-05-25 | 2018-07-25 | Celgene Corporation | Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex |
| WO2011069608A1 (en) * | 2009-12-09 | 2011-06-16 | Ratiopharm Gmbh | S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide |
| MX337566B (es) | 2010-01-05 | 2016-03-10 | Celgene Corp | Combinación de un compuesto inmunomodulador y una artemisinina o un derivado de ésta para tratar cáncer. |
| WO2012145309A1 (en) | 2011-04-18 | 2012-10-26 | Celgene Corporation | Biomarkers for the treatment of multiple myeloma |
| AU2012249491B2 (en) | 2011-04-29 | 2016-12-15 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| ES2872967T3 (es) | 2012-06-29 | 2021-11-03 | Celgene Corp | Métodos para determinar la eficacia de fármacos usando IKZF3 (AIOLOS) |
| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| CA2914178C (en) | 2013-01-07 | 2023-06-13 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| US9708322B2 (en) | 2013-03-15 | 2017-07-18 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity |
| US20150031697A1 (en) * | 2013-07-26 | 2015-01-29 | Wisconsin Alumni Research Foundation | Method for preventing ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas |
| CN104557858B (zh) * | 2013-10-29 | 2018-06-01 | 上海医药工业研究院 | 一种泊利度胺的制备方法 |
| KR102373288B1 (ko) | 2013-12-03 | 2022-03-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| JP6513095B2 (ja) | 2014-01-03 | 2019-05-15 | ユニバーシティ オブ サザン カリフォルニア | ヘテロ原子含有デオキシウリジントリホスファターゼ阻害剤 |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| US10302644B2 (en) | 2014-11-04 | 2019-05-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating multiple myeloma |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| PT3319939T (pt) | 2015-07-08 | 2025-03-05 | Cv6 Therapeutics Ni Ltd | Inibidores de desoxiuridina-trifosfatase contendo hidantoína |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| WO2017006270A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017117118A1 (en) | 2015-12-28 | 2017-07-06 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
| DK3407889T3 (da) | 2016-03-25 | 2021-08-09 | Intra Cellular Therapies Inc | Organiske forbindelser og deres anvendelse til behandling og forebyggelse af lidelser i centralnervesystemet |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| EP3436455A4 (en) | 2016-03-28 | 2019-09-04 | Intra-Cellular Therapies, Inc. | NOVEL SALTS AND CRYSTALS |
| US11014925B2 (en) | 2016-03-28 | 2021-05-25 | Intra-Cellular Therapies, Inc. | Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide |
| EP3525763B1 (en) | 2016-10-12 | 2025-03-05 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| WO2018098204A1 (en) | 2016-11-23 | 2018-05-31 | Cv6 Therapeutics (Ni) Limited | 6-membered uracil isosteres |
| US11014924B2 (en) | 2016-11-23 | 2021-05-25 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US10829457B2 (en) | 2016-11-23 | 2020-11-10 | Cv6 Therapeutics (Ni) Limited | Nitrogen ring linked deoxyuridine triphosphatase inhibitors |
| US10858344B2 (en) | 2016-11-23 | 2020-12-08 | Cv6 Therapeutics (Ni) Limited | Hydantoin containing deoxyuridine triphosphatase inhibitors |
| US11168059B2 (en) | 2016-11-23 | 2021-11-09 | Cv6 Therapeutics (Ni) Limited | Amino sulfonyl compounds |
| WO2018095377A1 (zh) | 2016-11-24 | 2018-05-31 | 天津和美生物技术有限公司 | 哌啶-2,6-二酮衍生物以及溃疡性结肠炎的治疗 |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3562484B1 (en) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders |
| CN106806366B (zh) * | 2016-12-29 | 2020-02-11 | 兰州大学 | 一种异吲哚-1，3-二酮类化合物的新用途 |
| WO2018128720A1 (en) | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
| WO2019023062A1 (en) | 2017-07-26 | 2019-01-31 | Intra-Cellular Therapies, Inc. | ORGANIC COMPOUNDS |
| EP3658144B1 (en) | 2017-07-26 | 2022-01-26 | Intra-Cellular Therapies, Inc. | Pyridopyrroloquinoxaline compounds, their compositions and uses in therapy |
| BR112020017053A2 (pt) | 2018-02-21 | 2020-12-15 | Celgene Corporation | Anticorpos que se ligam ao bcma e usos dos mesmos |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| AU2019280850C1 (en) | 2018-06-06 | 2025-02-13 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| EP3801527B1 (en) | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Fused gamma-carbolines for acute treatment of anxiety or depression |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| WO2020047408A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| WO2021007245A1 (en) | 2019-07-07 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Novel methods |
| US11583536B2 (en) | 2019-10-21 | 2023-02-21 | Celgene Corporation | Substituted 4-aminoisoindoline-1,3-dione compounds and second active agents for combined use |
| AU2020370039B2 (en) | 2019-10-21 | 2026-02-19 | Celgene Corporation | Pharmaceutical compositions comprising (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione and methods of using the same |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) * | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US7091353B2 (en) * | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
-
2006
- 2006-01-24 EP EP06719389A patent/EP1848433A2/en not_active Withdrawn
- 2006-01-24 WO PCT/US2006/002503 patent/WO2006081251A2/en not_active Ceased
- 2006-01-24 CN CNA2006800081712A patent/CN101141960A/zh active Pending
- 2006-01-24 BR BRPI0607239-9A patent/BRPI0607239A2/pt not_active IP Right Cessation
- 2006-01-24 JP JP2007552380A patent/JP2008528514A/ja not_active Abandoned
- 2006-01-24 CA CA002595711A patent/CA2595711A1/en not_active Abandoned
- 2006-01-24 KR KR1020077019386A patent/KR20070099031A/ko not_active Withdrawn
- 2006-01-24 AU AU2006208201A patent/AU2006208201A1/en not_active Abandoned
- 2006-01-24 ZA ZA200707010A patent/ZA200707010B/xx unknown
- 2006-01-24 AR ARP060100261A patent/AR052196A1/es not_active Application Discontinuation
- 2006-01-24 MX MX2007008903A patent/MX2007008903A/es not_active Application Discontinuation
- 2006-01-25 US US11/338,688 patent/US20060205787A1/en not_active Abandoned
-
2007
- 2007-07-24 IL IL184821A patent/IL184821A0/en unknown
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