CN101141960A - 使用4-氨基-2-(3-甲基-2,6-二氧代哌啶-3-基)-异吲哚-1,3-二酮的方法和组合物 - Google Patents
使用4-氨基-2-(3-甲基-2,6-二氧代哌啶-3-基)-异吲哚-1,3-二酮的方法和组合物 Download PDFInfo
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- CN101141960A CN101141960A CNA2006800081712A CN200680008171A CN101141960A CN 101141960 A CN101141960 A CN 101141960A CN A2006800081712 A CNA2006800081712 A CN A2006800081712A CN 200680008171 A CN200680008171 A CN 200680008171A CN 101141960 A CN101141960 A CN 101141960A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64650505P | 2005-01-25 | 2005-01-25 | |
| US60/646,505 | 2005-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101141960A true CN101141960A (zh) | 2008-03-12 |
Family
ID=36609267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2006800081712A Pending CN101141960A (zh) | 2005-01-25 | 2006-01-24 | 使用4-氨基-2-(3-甲基-2,6-二氧代哌啶-3-基)-异吲哚-1,3-二酮的方法和组合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20060205787A1 (https=) |
| EP (1) | EP1848433A2 (https=) |
| JP (1) | JP2008528514A (https=) |
| KR (1) | KR20070099031A (https=) |
| CN (1) | CN101141960A (https=) |
| AR (1) | AR052196A1 (https=) |
| AU (1) | AU2006208201A1 (https=) |
| BR (1) | BRPI0607239A2 (https=) |
| CA (1) | CA2595711A1 (https=) |
| IL (1) | IL184821A0 (https=) |
| MX (1) | MX2007008903A (https=) |
| WO (1) | WO2006081251A2 (https=) |
| ZA (1) | ZA200707010B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104557858A (zh) * | 2013-10-29 | 2015-04-29 | 上海医药工业研究院 | 一种泊利度胺的制备方法 |
| CN106806366A (zh) * | 2016-12-29 | 2017-06-09 | 兰州大学 | 一种异吲哚‑1,3‑二酮类化合物的新用途 |
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| WO2007059111A2 (en) * | 2005-11-14 | 2007-05-24 | Entremed, Inc. | Anti-angiogenic activity of 2-methoxyestradiol in combination with anti-cancer agents |
| US20070253960A1 (en) * | 2006-04-28 | 2007-11-01 | Josee Roy | Pharmaceutical removal of vascular extensions from a degenerating disc |
| WO2008094665A1 (en) * | 2007-01-31 | 2008-08-07 | Entremed, Inc. | Method of treating amyloidosis mediated diseases |
| US7579464B2 (en) * | 2007-05-25 | 2009-08-25 | Hoffmann-La Roche Inc. | Process for preparation of enantiomerically pure compounds |
| WO2009085234A2 (en) | 2007-12-20 | 2009-07-09 | Signal Pharmaceuticals, Inc. | Use of micro-rna as a biomarker of immunomodulatory drug activity |
| WO2009105256A2 (en) * | 2008-02-20 | 2009-08-27 | Celgene Corporation | Method of treating cancer by administering an immunomodulatory compound in combination with a cd40 antibody or cd40 ligand |
| EP3085231A1 (en) | 2008-05-27 | 2016-10-26 | Intra-Cellular Therapies, Inc. | Method and compositions for sleep disorders and other disorders |
| EP3489352A1 (en) | 2009-03-25 | 2019-05-29 | Celularity, Inc. | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
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| WO2011069608A1 (en) * | 2009-12-09 | 2011-06-16 | Ratiopharm Gmbh | S-lenalidomide, polymorphic forms thereof and blend comprising s- und r-lenalidomide |
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| CA2914178C (en) | 2013-01-07 | 2023-06-13 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
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| US20150031697A1 (en) * | 2013-07-26 | 2015-01-29 | Wisconsin Alumni Research Foundation | Method for preventing ultraviolet radiation-induced cutaneous damage and development of squamous cell carcinomas |
| KR102373288B1 (ko) | 2013-12-03 | 2022-03-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| JP6513095B2 (ja) | 2014-01-03 | 2019-05-15 | ユニバーシティ オブ サザン カリフォルニア | ヘテロ原子含有デオキシウリジントリホスファターゼ阻害剤 |
| US10077267B2 (en) | 2014-04-04 | 2018-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| US10302644B2 (en) | 2014-11-04 | 2019-05-28 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating multiple myeloma |
| WO2017006271A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors containing amino sulfonyl linkage |
| PT3319939T (pt) | 2015-07-08 | 2025-03-05 | Cv6 Therapeutics Ni Ltd | Inibidores de desoxiuridina-trifosfatase contendo hidantoína |
| US10544105B2 (en) | 2015-07-08 | 2020-01-28 | Cv6 Therapeutics (Ni) Limited | Deoxyuridine triphosphatase inhibitors containing cyclopropano linkage |
| WO2017006270A1 (en) | 2015-07-08 | 2017-01-12 | University Of Southern California | Deoxyuridine triphosphatase inhibitors |
| WO2017117118A1 (en) | 2015-12-28 | 2017-07-06 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| PL3838274T3 (pl) | 2016-01-26 | 2024-04-02 | Intra-Cellular Therapies, Inc. | Pochodna pirydo[3',4':4,5]pirolo[1,2,3-DE]chinoksaliny do zastosowania w leczeniu zaburzeń OUN |
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| WO2018128720A1 (en) | 2017-01-05 | 2018-07-12 | Cv6 Therapeutics (Ni) Limited | Uracil containing compounds |
| RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
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| BR112020017053A2 (pt) | 2018-02-21 | 2020-12-15 | Celgene Corporation | Anticorpos que se ligam ao bcma e usos dos mesmos |
| CN112040940A (zh) | 2018-03-23 | 2020-12-04 | 细胞内治疗公司 | 有机化合物 |
| AU2019280850C1 (en) | 2018-06-06 | 2025-02-13 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| EP3801527B1 (en) | 2018-06-08 | 2025-02-19 | Intra-Cellular Therapies, Inc. | Fused gamma-carbolines for acute treatment of anxiety or depression |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| WO2020047408A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| BR112021003655A2 (pt) | 2018-08-31 | 2021-05-18 | Intra-Cellular Therapies, Inc. | métodos novos |
| WO2021007245A1 (en) | 2019-07-07 | 2021-01-14 | Intra-Cellular Therapies, Inc. | Novel methods |
| US11583536B2 (en) | 2019-10-21 | 2023-02-21 | Celgene Corporation | Substituted 4-aminoisoindoline-1,3-dione compounds and second active agents for combined use |
| AU2020370039B2 (en) | 2019-10-21 | 2026-02-19 | Celgene Corporation | Pharmaceutical compositions comprising (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione and methods of using the same |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| US6281230B1 (en) * | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US7091353B2 (en) * | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
-
2006
- 2006-01-24 EP EP06719389A patent/EP1848433A2/en not_active Withdrawn
- 2006-01-24 WO PCT/US2006/002503 patent/WO2006081251A2/en not_active Ceased
- 2006-01-24 CN CNA2006800081712A patent/CN101141960A/zh active Pending
- 2006-01-24 BR BRPI0607239-9A patent/BRPI0607239A2/pt not_active IP Right Cessation
- 2006-01-24 JP JP2007552380A patent/JP2008528514A/ja not_active Abandoned
- 2006-01-24 CA CA002595711A patent/CA2595711A1/en not_active Abandoned
- 2006-01-24 KR KR1020077019386A patent/KR20070099031A/ko not_active Withdrawn
- 2006-01-24 AU AU2006208201A patent/AU2006208201A1/en not_active Abandoned
- 2006-01-24 ZA ZA200707010A patent/ZA200707010B/xx unknown
- 2006-01-24 AR ARP060100261A patent/AR052196A1/es not_active Application Discontinuation
- 2006-01-24 MX MX2007008903A patent/MX2007008903A/es not_active Application Discontinuation
- 2006-01-25 US US11/338,688 patent/US20060205787A1/en not_active Abandoned
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2007
- 2007-07-24 IL IL184821A patent/IL184821A0/en unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104557858A (zh) * | 2013-10-29 | 2015-04-29 | 上海医药工业研究院 | 一种泊利度胺的制备方法 |
| CN106806366A (zh) * | 2016-12-29 | 2017-06-09 | 兰州大学 | 一种异吲哚‑1,3‑二酮类化合物的新用途 |
| CN106806366B (zh) * | 2016-12-29 | 2020-02-11 | 兰州大学 | 一种异吲哚-1,3-二酮类化合物的新用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006081251A2 (en) | 2006-08-03 |
| AR052196A1 (es) | 2007-03-07 |
| WO2006081251A3 (en) | 2006-12-28 |
| ZA200707010B (en) | 2009-01-28 |
| MX2007008903A (es) | 2007-09-07 |
| US20060205787A1 (en) | 2006-09-14 |
| KR20070099031A (ko) | 2007-10-08 |
| BRPI0607239A2 (pt) | 2009-08-25 |
| CA2595711A1 (en) | 2006-08-03 |
| IL184821A0 (en) | 2007-12-03 |
| JP2008528514A (ja) | 2008-07-31 |
| AU2006208201A1 (en) | 2006-08-03 |
| EP1848433A2 (en) | 2007-10-31 |
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