JP2008528004A5 - - Google Patents
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- Publication number
- JP2008528004A5 JP2008528004A5 JP2007552402A JP2007552402A JP2008528004A5 JP 2008528004 A5 JP2008528004 A5 JP 2008528004A5 JP 2007552402 A JP2007552402 A JP 2007552402A JP 2007552402 A JP2007552402 A JP 2007552402A JP 2008528004 A5 JP2008528004 A5 JP 2008528004A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- crt
- acid molecule
- seq
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 25
- 108020004707 nucleic acids Proteins 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 14
- 229920001184 polypeptide Polymers 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 238000006467 substitution reaction Methods 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 102000004082 Calreticulin Human genes 0.000 claims 5
- 108090000549 Calreticulin Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 231100001223 noncarcinogenic Toxicity 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 231100001222 nononcogenic Toxicity 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 241000701806 Human papillomavirus Species 0.000 claims 1
- 101000954493 Human papillomavirus type 16 Protein E6 Proteins 0.000 claims 1
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000010255 intramuscular injection Methods 0.000 claims 1
- 239000007927 intramuscular injection Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64715005P | 2005-01-26 | 2005-01-26 | |
| US64734105P | 2005-01-26 | 2005-01-26 | |
| PCT/US2006/002707 WO2006081323A2 (en) | 2005-01-26 | 2006-01-26 | Anti-cancer dna vaccine employing plasmids encoding mutant oncoprotein antigen and calreticulin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008528004A JP2008528004A (ja) | 2008-07-31 |
| JP2008528004A5 true JP2008528004A5 (enExample) | 2009-03-19 |
Family
ID=36741036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007552402A Pending JP2008528004A (ja) | 2005-01-26 | 2006-01-26 | 突然変異癌タンパク質抗原およびカルレティキュリンをコードするプラスミドを用いる抗癌dnaワクチン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080102084A1 (enExample) |
| EP (1) | EP1846026A4 (enExample) |
| JP (1) | JP2008528004A (enExample) |
| CA (1) | CA2595726A1 (enExample) |
| WO (1) | WO2006081323A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8128922B2 (en) | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| US7342002B2 (en) | 2000-08-03 | 2008-03-11 | The Johns Hopkins University | Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen |
| EP1363660A4 (en) | 2001-02-01 | 2006-06-21 | Univ Johns Hopkins | HIGHER MOLECULAR VACCINE BASED ON AUTOMPLICATIVE RNA, SUICIDE DNA OR UNDNA DNA VECTOR, WHICH LINKS ANTIGEN WITH A POLYPEPTIDE WHICH PROMOTES THE PRESENTATION OF THE ANTIGEN |
| WO2004098526A2 (en) | 2003-05-05 | 2004-11-18 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
| CA2594040A1 (en) | 2005-01-06 | 2006-07-13 | The Johns Hopkins University | Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines |
| WO2008046251A1 (fr) * | 2006-10-19 | 2008-04-24 | Sunbio Biotech Pharmaceuticals(Tianjin) Co., Ltd. | Protéines hybrides contenant un domaine n de la calréticuline humaine et des protéines e6 ou e7 du papillomavirus humain de type 16, et utilisations associées |
| US9085638B2 (en) | 2007-03-07 | 2015-07-21 | The Johns Hopkins University | DNA vaccine enhancement with MHC class II activators |
| RU2644201C2 (ru) | 2011-12-21 | 2018-02-08 | Вэксибоди Ас | Вакцины против hpv |
| ES2871325T3 (es) * | 2013-09-16 | 2021-10-28 | Cemm Forschungszentrum Fuer Molekulare Medizin Gmbh | Composición de vacuna que comprende calreticulina mutante |
| MX348980B (es) | 2013-09-16 | 2017-07-05 | Cemm-Forschungszentrum Für Molekulare Medizin Gmbh | Calreticulina mutante para la diagnosis de malignidades mieloides. |
| CA3008437A1 (en) | 2016-01-08 | 2017-07-13 | Vaccibody As | Therapeutic anticancer neoepitope vaccine |
| US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
Family Cites Families (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5744133A (en) * | 1986-08-13 | 1998-04-28 | Transgene S.A. | Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventitive or curative treatment of the corresponding tumor |
| US4898730A (en) * | 1987-03-13 | 1990-02-06 | The University Of British Columbia | Method to stimulate the immune response to specific antigens |
| US5582831A (en) * | 1991-11-26 | 1996-12-10 | Yeda Research And Development Co., Ltd. | Anti-tumor vaccines |
| US5217879A (en) * | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
| DE3907721A1 (de) * | 1989-03-10 | 1990-09-20 | Behringwerke Ag | Immunogene regionen auf dem e7-protein des humanen papillomvierus typ 16 |
| US5545727A (en) * | 1989-05-10 | 1996-08-13 | Somatogen, Inc. | DNA encoding fused di-alpha globins and production of pseudotetrameric hemoglobin |
| US5348945A (en) * | 1990-04-06 | 1994-09-20 | Wake Forest University | Method of treatment with hsp70 |
| US5821088A (en) * | 1990-05-11 | 1998-10-13 | Siga Pharmaceuticals, Inc. | Use of gram-positive bacteria to express recombinant proteins |
| AU8762991A (en) * | 1990-09-26 | 1992-04-15 | Bristol-Myers Squibb Company | Human papilloma viral protein expression for use in vaccine compositions |
| US5674486A (en) * | 1991-06-25 | 1997-10-07 | San Diego Regional Cancer Center | Cancer immunotherapy with carrier cells |
| PT523391E (pt) * | 1991-07-13 | 2003-08-29 | Dade Behring Marburg Gmbh | Utilizacao dos peptidos derivados dos genes hpv-16 e6 e e7 para fins de diagnostico |
| GB9207701D0 (en) * | 1992-04-08 | 1992-05-27 | Cancer Res Campaign Tech | Papillomavirus e7 protein |
| US5618536A (en) * | 1992-09-03 | 1997-04-08 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric papillomavirus-like particles |
| US5997869A (en) * | 1993-03-15 | 1999-12-07 | The United States Of America As Represented By The Department Of Health And Human Services | Peptides containing a fusion joint of a chimeric protein encoded by DNA spanning a tumor-associated chromosomal translocation and their use as immunogens |
| GB9306731D0 (en) * | 1993-03-31 | 1993-05-26 | Cancer Res Campaign Tech | Vaccines |
| US5426097A (en) * | 1993-04-06 | 1995-06-20 | The Trustees Of Columbia University In The City Of New York | Calreticulin: a novel antithrombotic agent |
| US5646008A (en) * | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
| US5591716A (en) * | 1993-11-19 | 1997-01-07 | New York University | Beneficial wound healing applications of calreticulin and other hyaluronan-associated proteins |
| US5750119A (en) * | 1994-01-13 | 1998-05-12 | Mount Sinai School Of Medicine Of The City University Of New York | Immunotherapeutic stress protein-peptide complexes against cancer |
| AUPM566794A0 (en) * | 1994-05-17 | 1994-06-09 | University Of Queensland, The | Process and product |
| US5854202A (en) * | 1995-01-24 | 1998-12-29 | Dedhar; Shoukat | Peptide fragments of calreticulin, peptide mimetics thereof, and pharmaceutical compostions comprising same |
| US5792462A (en) * | 1995-05-23 | 1998-08-11 | University Of North Carolina At Chapel Hill | Alphavirus RNA replicon systems |
| US5837251A (en) * | 1995-09-13 | 1998-11-17 | Fordham University | Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases |
| US5935576A (en) * | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| CA2249354A1 (en) * | 1996-03-28 | 1997-10-02 | Genitrix, L.L.C. | Opsonin-enhanced cells, and methods of modulating an immune response to an antigen |
| US5951975A (en) * | 1996-06-28 | 1999-09-14 | University Of Pittsburgh | Induction of CTLs specific for natural antigens by cross priming immunization |
| US6066716A (en) * | 1996-09-20 | 2000-05-23 | University Of New Mexico | Purified heat shock protein complexes |
| US5962318A (en) * | 1996-11-15 | 1999-10-05 | St. Jude Children's Research Hospital | Cytotoxic T lymphocyte-mediated immunotherapy |
| US6046158A (en) * | 1996-12-20 | 2000-04-04 | Board Of Regents The University Of Texas Systems | Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof |
| US6017735A (en) * | 1997-01-23 | 2000-01-25 | Marie Curie Cancer Care | Materials and methods for intracellular transport and their uses |
| US5830464A (en) * | 1997-02-07 | 1998-11-03 | Fordham University | Compositions and methods for the treatment and growth inhibition of cancer using heat shock/stress protein-peptide complexes in combination with adoptive immunotherapy |
| US6017540A (en) * | 1997-02-07 | 2000-01-25 | Fordham University | Prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases with heat shock/stress protein-peptide complexes |
| US6007821A (en) * | 1997-10-16 | 1999-12-28 | Fordham University | Method and compositions for the treatment of autoimmune disease using heat shock proteins |
| US6331388B1 (en) * | 1997-10-17 | 2001-12-18 | Wisconsin Alumni Research Foundation | Immune response enhancer |
| US5948646A (en) * | 1997-12-11 | 1999-09-07 | Fordham University | Methods for preparation of vaccines against cancer comprising heat shock protein-peptide complexes |
| ES2291039T3 (es) * | 1998-09-04 | 2008-02-16 | Sanofi Pasteur Limited | Tratamiento del cancer cervical. |
| US7001995B1 (en) * | 1999-08-25 | 2006-02-21 | Merck & Co., Inc. | Synthetic human papillomavirus genes |
| US6734173B1 (en) * | 1999-10-20 | 2004-05-11 | Johns Hopkins University | HSP DNA vaccines |
| US8128922B2 (en) * | 1999-10-20 | 2012-03-06 | Johns Hopkins University | Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen |
| US20010034042A1 (en) * | 2000-01-20 | 2001-10-25 | Srivastava Pramod K. | Complexes of peptide-binding fragments of heat shock proteins and their use as immunotherapeutic agents |
| US7030219B2 (en) * | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
| US7318928B2 (en) * | 2000-08-01 | 2008-01-15 | The Johns Hopkins University | Molecular vaccine linking intercellular spreading protein to an antigen |
| US7342002B2 (en) * | 2000-08-03 | 2008-03-11 | The Johns Hopkins University | Molecular vaccine linking an endoplasmic chaperone polypeptide to an antigen |
| US20020065771A1 (en) * | 2000-11-30 | 2002-05-30 | International Business Machines Corporation | System and method for merchant provided pre-printed checks |
| RU2322500C2 (ru) * | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| US7892730B2 (en) * | 2000-12-22 | 2011-02-22 | Sagres Discovery, Inc. | Compositions and methods for cancer |
| EP1363660A4 (en) * | 2001-02-01 | 2006-06-21 | Univ Johns Hopkins | HIGHER MOLECULAR VACCINE BASED ON AUTOMPLICATIVE RNA, SUICIDE DNA OR UNDNA DNA VECTOR, WHICH LINKS ANTIGEN WITH A POLYPEPTIDE WHICH PROMOTES THE PRESENTATION OF THE ANTIGEN |
| JP2004535816A (ja) * | 2001-07-20 | 2004-12-02 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | Cinを含むhpv関連の前癌性増殖および癌性増殖に関する方法および組成物 |
| CN1720060B (zh) * | 2002-10-03 | 2011-12-14 | 惠氏控股公司 | 人乳头瘤病毒多肽和免疫原性组合物 |
| US20070026076A1 (en) * | 2003-02-24 | 2007-02-01 | Tzyy-Choou Wu | Molecular vaccines employing nucleic acid encoding anti-apoptotic proteins |
| WO2004098526A2 (en) * | 2003-05-05 | 2004-11-18 | Johns Hopkins University | Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein |
-
2006
- 2006-01-26 CA CA 2595726 patent/CA2595726A1/en not_active Abandoned
- 2006-01-26 WO PCT/US2006/002707 patent/WO2006081323A2/en not_active Ceased
- 2006-01-26 EP EP06733904A patent/EP1846026A4/en not_active Ceased
- 2006-01-26 JP JP2007552402A patent/JP2008528004A/ja active Pending
-
2007
- 2007-07-26 US US11/828,807 patent/US20080102084A1/en not_active Abandoned
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