JP2008527027A5 - - Google Patents
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- Publication number
- JP2008527027A5 JP2008527027A5 JP2007551725A JP2007551725A JP2008527027A5 JP 2008527027 A5 JP2008527027 A5 JP 2008527027A5 JP 2007551725 A JP2007551725 A JP 2007551725A JP 2007551725 A JP2007551725 A JP 2007551725A JP 2008527027 A5 JP2008527027 A5 JP 2008527027A5
- Authority
- JP
- Japan
- Prior art keywords
- synthase
- leukotriene
- mpges
- activating protein
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 102100033076 Prostaglandin E synthase Human genes 0.000 claims description 10
- 101710096361 Prostaglandin E synthase Proteins 0.000 claims description 8
- 102000004023 5-Lipoxygenase-Activating Proteins Human genes 0.000 claims description 3
- 108090000411 5-Lipoxygenase-Activating Proteins Proteins 0.000 claims description 3
- GWNVDXQDILPJIG-NXOLIXFESA-N leukotriene C4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O GWNVDXQDILPJIG-NXOLIXFESA-N 0.000 claims description 3
- 102000042256 MAPEG family Human genes 0.000 claims 2
- 108091077604 MAPEG family Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 101150058514 PTGES gene Proteins 0.000 description 1
- 108090000748 Prostaglandin-E Synthases Proteins 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64455405P | 2005-01-19 | 2005-01-19 | |
| US64455305P | 2005-01-19 | 2005-01-19 | |
| PCT/GB2005/004978 WO2006077364A1 (en) | 2005-01-19 | 2005-12-22 | Indoles useful in the treatment of inflammation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008527027A JP2008527027A (ja) | 2008-07-24 |
| JP2008527027A5 true JP2008527027A5 (enExample) | 2009-02-19 |
Family
ID=36001052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551725A Withdrawn JP2008527027A (ja) | 2005-01-19 | 2005-12-22 | 炎症の治療に有用なインドール類 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080249091A1 (enExample) |
| EP (1) | EP1844013A1 (enExample) |
| JP (1) | JP2008527027A (enExample) |
| AR (1) | AR053993A1 (enExample) |
| CA (1) | CA2594878A1 (enExample) |
| TW (1) | TW200637820A (enExample) |
| WO (1) | WO2006077364A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080188473A1 (en) * | 2004-06-18 | 2008-08-07 | Kristofer Olofsson | Indoles Useful in the Treatment of Inflammation |
| CN101006053A (zh) * | 2004-06-18 | 2007-07-25 | 比奥里波克斯公司 | 用于治疗炎症的吲哚 |
| DE602005014233D1 (de) * | 2004-06-18 | 2009-06-10 | Biolipox Ab | Zur behandlung von entzündungen geeignete indole |
| JP2008527030A (ja) * | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
| ATE501119T1 (de) | 2005-01-19 | 2011-03-15 | Biolipox Ab | Entzündungshemmende indol-derivate |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| WO2008009924A2 (en) * | 2006-07-18 | 2008-01-24 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| CN101157688B (zh) * | 2006-10-16 | 2010-09-08 | 复旦大学 | 6-苄氧基吲哚-2-甲酸糠醇酯衍生物及其制备方法和用途 |
| KR20090125799A (ko) | 2007-03-29 | 2009-12-07 | 아스비오파마 가부시키가이샤 | Ｃｐｌａ2 저해 활성을 가지는 인돌 유도체 및 그 용도 및 제조 방법 |
| TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
| CN102137858B (zh) | 2008-05-23 | 2014-07-23 | 潘米拉制药有限责任公司 | 5-脂氧合酶-活化蛋白抑制剂 |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| WO2010071865A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| US20100160351A1 (en) * | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2010076566A2 (en) | 2008-12-30 | 2010-07-08 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| JP2012530758A (ja) | 2009-06-24 | 2012-12-06 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規化合物、医薬組成物及びそれに関する方法 |
| NZ596445A (en) | 2009-06-24 | 2013-04-26 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
| JP2012211085A (ja) * | 2009-08-12 | 2012-11-01 | Kyowa Hakko Kirin Co Ltd | ヘッジホッグシグナル阻害剤 |
| WO2011032175A1 (en) | 2009-09-14 | 2011-03-17 | Nuon Therapeutics, Inc. | Combination formulations of tranilast and allopurinol and methods related thereto |
| GB201006846D0 (en) | 2010-04-23 | 2010-06-09 | Glaxo Group Ltd | Novel compounds |
| DK2935302T3 (en) | 2012-12-18 | 2018-08-13 | Vertex Pharma | MANNOS DERIVATIVES FOR TREATING BACTERIAL INFECTIONS |
| PL2970353T3 (pl) | 2013-03-12 | 2018-10-31 | Vertex Pharmaceuticals Incorporated | Pochodne mannozy do leczenia infekcji bakteryjnych |
| PL3240785T3 (pl) | 2014-12-29 | 2021-12-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Inhibitory drobnocząsteczkowe dehydrogenazy mleczanowej i sposoby ich wykorzystania |
| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| US10774064B2 (en) | 2016-06-02 | 2020-09-15 | Cadent Therapeutics, Inc. | Potassium channel modulators |
| BR112019014814B1 (pt) | 2017-01-23 | 2024-03-12 | Novartis Ag | Compostos, composições farmacêuticas dos mesmos e seus usos no tratamento de doenças associadas à disfunção de canais iônicos de potássio |
| CN108892604B (zh) * | 2018-08-15 | 2022-05-31 | 江西师范大学 | 一种制备卤代苯并[b]芴酮系列化合物的方法 |
| AU2019366312B2 (en) | 2018-10-22 | 2025-04-24 | Novartis Ag | Crystalline forms of potassium channel modulators |
| CN109665985B (zh) * | 2018-11-30 | 2020-09-29 | 中国科学院广州生物医药与健康研究院 | 多取代吲哚类化合物及其应用 |
| CN113382990B (zh) | 2019-01-11 | 2024-11-19 | 格吕伦塔尔有限公司 | 取代的吡咯烷酰胺iii |
| CN110804059B (zh) * | 2019-09-30 | 2024-03-12 | 郑州泰基鸿诺医药股份有限公司 | 氨基甲酸酯类化合物、药物组合物及其应用 |
| US20230148601A1 (en) | 2020-02-18 | 2023-05-18 | Bayer Aktiengesellschaft | Novel heteroaryl-triazole compounds as pesticides |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5081138A (en) * | 1986-12-17 | 1992-01-14 | Merck Frosst Canada, Inc. | 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith |
| US4960786A (en) * | 1989-04-24 | 1990-10-02 | Merrell Dow Pharmaceuticals Inc. | Excitatory amino acid antagonists |
| US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
| US5374615A (en) * | 1990-10-31 | 1994-12-20 | E. R. Squibb & Sons, Inc. | Indole- and benzimidazole-substituted imidazole and benzimidazole derivatives |
| US5189054A (en) * | 1990-11-02 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | 3-amidoindolyl derivatives and pharmaceutical compositions thereof |
| US5294722A (en) * | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
| US5236916A (en) * | 1992-05-26 | 1993-08-17 | E. R. Squibb & Sons, Inc. | Oxadiazinone substituted indole and benzimidazole derivatives |
| TW229140B (enExample) * | 1992-06-05 | 1994-09-01 | Shell Internat Res Schappej B V | |
| WO1995033748A1 (en) * | 1994-06-09 | 1995-12-14 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
| US6630496B1 (en) * | 1996-08-26 | 2003-10-07 | Genetics Institute Llc | Inhibitors of phospholipase enzymes |
| GB9716656D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| PT1042287E (pt) * | 1997-12-24 | 2005-08-31 | Aventis Pharma Gmbh | Derivados de indole como inibidores do factor xa |
| GB9803228D0 (en) * | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| CA2322163A1 (en) * | 1998-02-25 | 1999-09-02 | John Mckew | Inhibitors of phospholipase a2 |
| US6828344B1 (en) * | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6500853B1 (en) * | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| GB9902453D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902452D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| JP2001069477A (ja) * | 1999-08-31 | 2001-03-16 | Sony Corp | 番組提供システム及び番組提供方法 |
| US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
| JP2004529855A (ja) * | 2000-10-10 | 2004-09-30 | スミスクライン ビーチャム コーポレーション | 置換インドール類、そのような置換インドール類を含む医薬組成物及びＰＰＡＲ−γ結合剤としてのそれらの使用 |
| US20090042949A1 (en) * | 2005-01-19 | 2009-02-12 | Benjamin Pelcman | Indoles Useful in the Treatment of Inflammation |
-
2005
- 2005-12-22 US US11/795,627 patent/US20080249091A1/en not_active Abandoned
- 2005-12-22 EP EP05823716A patent/EP1844013A1/en not_active Withdrawn
- 2005-12-22 WO PCT/GB2005/004978 patent/WO2006077364A1/en not_active Ceased
- 2005-12-22 CA CA002594878A patent/CA2594878A1/en not_active Abandoned
- 2005-12-22 JP JP2007551725A patent/JP2008527027A/ja not_active Withdrawn
- 2005-12-28 AR ARP050105594A patent/AR053993A1/es not_active Application Discontinuation
- 2005-12-28 TW TW094146945A patent/TW200637820A/zh unknown
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