JP2008526876A5 - - Google Patents
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- Publication number
- JP2008526876A5 JP2008526876A5 JP2007550488A JP2007550488A JP2008526876A5 JP 2008526876 A5 JP2008526876 A5 JP 2008526876A5 JP 2007550488 A JP2007550488 A JP 2007550488A JP 2007550488 A JP2007550488 A JP 2007550488A JP 2008526876 A5 JP2008526876 A5 JP 2008526876A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- irna agent
- antisense strand
- nucleotides
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 24
- 239000003795 chemical substances by application Substances 0.000 claims 19
- 125000003729 nucleotide group Chemical group 0.000 claims 16
- 230000000692 anti-sense effect Effects 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 230000000295 complement effect Effects 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 6
- 230000000241 respiratory effect Effects 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 108091081021 Sense strand Proteins 0.000 claims 2
- 108010067390 Viral Proteins Proteins 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000012986 modification Methods 0.000 claims 2
- 101150062031 L gene Proteins 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64236405P | 2005-01-07 | 2005-01-07 | |
| US60/642,364 | 2005-01-07 | ||
| US65982805P | 2005-03-09 | 2005-03-09 | |
| US60/659,828 | 2005-03-09 | ||
| PCT/US2006/000425 WO2006074346A2 (en) | 2005-01-07 | 2006-01-06 | RNAi MODULATION OF RSV AND THERAPEUTIC USES THEREOF |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011220918A Division JP5814728B2 (ja) | 2005-01-07 | 2011-10-05 | ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526876A JP2008526876A (ja) | 2008-07-24 |
| JP2008526876A5 true JP2008526876A5 (https=) | 2009-02-19 |
| JP5081630B2 JP5081630B2 (ja) | 2012-11-28 |
Family
ID=36648197
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007550488A Expired - Fee Related JP5081630B2 (ja) | 2005-01-07 | 2006-01-06 | ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 |
| JP2011220918A Expired - Fee Related JP5814728B2 (ja) | 2005-01-07 | 2011-10-05 | ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 |
| JP2014113800A Pending JP2014156491A (ja) | 2005-01-07 | 2014-06-02 | ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011220918A Expired - Fee Related JP5814728B2 (ja) | 2005-01-07 | 2011-10-05 | ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 |
| JP2014113800A Pending JP2014156491A (ja) | 2005-01-07 | 2014-06-02 | ＲＳＶのＲＮＡｉ調節及びその治療上の使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US7507809B2 (https=) |
| EP (4) | EP2230304B1 (https=) |
| JP (3) | JP5081630B2 (https=) |
| KR (1) | KR101169668B1 (https=) |
| CN (2) | CN102600480B (https=) |
| AT (1) | ATE551421T1 (https=) |
| AU (2) | AU2006203934B2 (https=) |
| CA (1) | CA2594334A1 (https=) |
| DK (1) | DK2230304T3 (https=) |
| EA (3) | EA017847B1 (https=) |
| ES (1) | ES2385811T3 (https=) |
| IL (2) | IL184162A (https=) |
| NZ (1) | NZ556097A (https=) |
| WO (1) | WO2006074346A2 (https=) |
Families Citing this family (38)
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|---|---|---|---|---|
| DE19956568A1 (de) | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| DE10100586C1 (de) * | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| PT1309726E (pt) | 2000-03-30 | 2010-03-08 | Whitehead Biomedical Inst | Mediadores de interferência por rna específicos de sequência de rna |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US7767802B2 (en) * | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US20040175384A1 (en) * | 2003-12-12 | 2004-09-09 | Mohapatra Shyam S. | Protein kinase C as a target for the treatment of respiratory syncytial virus |
| US7592322B2 (en) * | 2004-10-22 | 2009-09-22 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| NZ556097A (en) * | 2005-01-07 | 2009-12-24 | Alnylam Pharmaceuticals Inc | Rnai modulation of RSV and therapeutic uses thereof |
| US20100196509A1 (en) | 2005-02-28 | 2010-08-05 | Jonathan Braun | Methods for Diagnosis and Treatment of Endometrial Cancer |
| WO2006113526A2 (en) | 2005-04-15 | 2006-10-26 | The Regents Of The University Of California | Prevention of chlamydia infection using a protective antibody |
| US8318906B2 (en) | 2005-04-15 | 2012-11-27 | The Regents Of The University Of California | EMP2 antibodies and their therapeutic uses |
| US8648052B2 (en) * | 2005-04-15 | 2014-02-11 | The Regents Of The University Of California | Prevention of chlamydia infection using SIRNA |
| DK2308514T3 (da) | 2007-03-23 | 2013-09-02 | To Bbb Holding B V | Konjugater til målrettet lægemiddeltransport gennem blod-hjerne barrieren |
| US20100215588A1 (en) * | 2007-04-26 | 2010-08-26 | Rami Skaliter | Therapeutic delivery of inhibitory nucleic acid molecules to the respiratory system |
| ES2428009T3 (es) | 2007-07-05 | 2013-11-05 | Novartis Ag | ARNds para tratar infecciones virales |
| CA2702094C (en) | 2007-10-10 | 2018-05-01 | Parion Sciences, Inc. | Delivering osmolytes by nasal cannula |
| WO2009055445A2 (en) * | 2007-10-22 | 2009-04-30 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| AU2008334948B2 (en) * | 2007-12-13 | 2014-11-20 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
| US8188060B2 (en) | 2008-02-11 | 2012-05-29 | Dharmacon, Inc. | Duplex oligonucleotides with enhanced functionality in gene regulation |
| US20100168205A1 (en) * | 2008-10-23 | 2010-07-01 | Alnylam Pharmaceuticals, Inc. | Methods and Compositions for Prevention or Treatment of RSV Infection Using Modified Duplex RNA Molecules |
| ES2804764T3 (es) | 2009-06-01 | 2021-02-09 | Halo Bio Rnai Therapeutics Inc | Polinucleótidos para la interferencia de ARN multivalente, composiciones y métodos de uso de los mismos |
| EP2495323A4 (en) * | 2009-10-30 | 2014-04-30 | Daiichi Sankyo Co Ltd | MODIFIED DOUBLE-STRENGTH POLYNUCLEOTIDE |
| JP5911805B2 (ja) | 2009-11-20 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 上皮膜タンパク質−２（ｅｍｐ２）および増殖性硝子体網膜症（ｐｖｒ） |
| US8349308B2 (en) | 2010-03-26 | 2013-01-08 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| WO2012027206A1 (en) * | 2010-08-24 | 2012-03-01 | Merck Sharp & Dohme Corp. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| EP2717855A4 (en) | 2011-06-07 | 2014-11-12 | Parion Sciences Inc | Methods of Treatment |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| HUE039734T2 (hu) | 2012-05-29 | 2019-01-28 | Parion Sciences Inc | Nátriumcsatorna-blokkoló aktivitású, dendrimerszerû amino-amid-származékok száraz szem és más nyálkahártya-megbetegedések kezelésére |
| CN108658876A (zh) | 2012-12-17 | 2018-10-16 | 帕里昂科学公司 | 3,5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物 |
| ES2674665T3 (es) | 2012-12-17 | 2018-07-03 | Parion Sciences, Inc. | Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida |
| CA2895512C (en) | 2012-12-17 | 2021-10-19 | Parion Sciences, Inc. | Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration |
| KR20150137350A (ko) * | 2014-05-29 | 2015-12-09 | 삼성전자주식회사 | 화상형성장치 및 화상형성장치의 스캔 방법 |
| JP2018525037A (ja) | 2015-08-24 | 2018-09-06 | ハロー−バイオ・アールエヌエーアイ・セラピューティックス、インコーポレイテッド | 遺伝子発現の調節のためのポリヌクレオチドナノ粒子及びその使用 |
| CN105693557A (zh) * | 2016-01-04 | 2016-06-22 | 湖北卓熙氟化股份有限公司 | 一种氟化氢尿素及其制备方法 |
| JP2018012236A (ja) * | 2016-07-20 | 2018-01-25 | 株式会社東芝 | 印刷システム |
| CN108689886B (zh) * | 2018-06-22 | 2021-06-15 | 湖北卓熙氟化股份有限公司 | 一种氟化氢尿素的制备方法 |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
| HU205839B (en) * | 1987-11-18 | 1992-07-28 | Chinoin Gyogyszer Es Vegyeszet | Synergetic artropodicide composition containining pirethroides and phosphate-esters as active components |
| CA2183992A1 (en) * | 1994-02-23 | 1995-08-31 | Dan T. Stinchcomb | Method and reagent for inhibiting the expression of disease related genes |
| US5693532A (en) * | 1994-11-04 | 1997-12-02 | Ribozyme Pharmaceuticals, Inc. | Respiratory syncytial virus ribozymes |
| US20020032160A1 (en) * | 1995-02-24 | 2002-03-14 | Nyce Jonathan W. | Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels |
| AU6848396A (en) * | 1995-10-17 | 1997-05-07 | Hybridon, Inc. | Oligonucleotides with anti-respiratory syncytial virus activity |
| US6214805B1 (en) * | 1996-02-15 | 2001-04-10 | The United States Of America As Represented By The Department Of Health And Human Services | RNase L activators and antisense oligonucleotides effective to treat RSV infections |
| WO1997029757A1 (en) * | 1996-02-15 | 1997-08-21 | National Institutes Of Health | Rnase l activators and antisense oligonucleotides effective to treat rsv infections |
| US5898031A (en) * | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| WO1998012312A1 (en) | 1996-09-18 | 1998-03-26 | Vanderbilt University | Antisense gene therapy for rna viruses |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| FR2798857B1 (fr) * | 1999-09-23 | 2003-06-06 | Pf Medicament | Utilisation d'une proteine de membrane ompa d'enterobacterie associee a un peptide immunogene du vrs pour la preparation de vaccins administrables par voie nasale |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20030170891A1 (en) | 2001-06-06 | 2003-09-11 | Mcswiggen James A. | RNA interference mediated inhibition of epidermal growth factor receptor gene expression using short interfering nucleic acid (siNA) |
| US20060287267A1 (en) * | 2001-05-18 | 2006-12-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
| WO2003008628A2 (en) * | 2001-07-20 | 2003-01-30 | Ribozyme Pharmacuticals, Inc. | Enzymatic nucleic acid peptide conjugates |
| US6881835B2 (en) * | 2002-01-04 | 2005-04-19 | Dr. Chip Biotechnology Inc. | Detection of respiratory viruses |
| WO2003062258A1 (en) * | 2002-01-22 | 2003-07-31 | The Cleveland Clinic Foundation | Rnase l activator-antisense complexes |
| US20030203868A1 (en) * | 2002-02-06 | 2003-10-30 | Bushman Frederic D. | Inhibition of pathogen replication by RNA interference |
| WO2004042002A2 (en) * | 2002-08-05 | 2004-05-21 | University Of Massachusetts | Compounds for modulating rna interference |
| US7956176B2 (en) | 2002-09-05 | 2011-06-07 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
| MXPA05003287A (es) * | 2002-09-28 | 2005-07-05 | Massachusetts Inst Technology | Influenza terapeutica. |
| US20040242518A1 (en) * | 2002-09-28 | 2004-12-02 | Massachusetts Institute Of Technology | Influenza therapeutic |
| EP2305812A3 (en) | 2002-11-14 | 2012-06-06 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| WO2004064737A2 (en) | 2003-01-17 | 2004-08-05 | Alnylam Pharmaceuticals | Therapeutics compositions |
| WO2004080406A2 (en) | 2003-03-07 | 2004-09-23 | Alnylam Pharmaceuticals | Therapeutic compositions |
| AU2004227414A1 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | iRNA conjugates |
| DK1620544T3 (en) | 2003-04-17 | 2019-01-14 | Alnylam Pharmaceuticals Inc | MODIFIED iRNA AGENTS |
| JP4991288B2 (ja) | 2003-04-17 | 2012-08-01 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | 二本鎖ｉＲＮＡ剤、および二本鎖ｉＲＮＡ剤の対合の安定性を調節する方法。 |
| TW572579U (en) * | 2003-05-12 | 2004-01-11 | Enermax Technology Corp | Power supply still capable of dissipating heat after powering off a computer |
| US7173015B2 (en) | 2003-07-03 | 2007-02-06 | The Trustees Of The University Of Pennsylvania | Inhibition of Syk kinase expression |
| EP1713819A4 (en) * | 2004-02-05 | 2007-11-14 | Intradigm Corp | METHOD AND COMPOSITIONS FOR COMBINING RNAI THERAPEUTICS |
| WO2005097817A2 (en) * | 2004-04-05 | 2005-10-20 | Alnylam Pharmaceuticals, Inc. | Process and reagents for oligonucleotide synthesis and purification |
| WO2006085987A2 (en) * | 2004-07-09 | 2006-08-17 | University Of Iowa Research Foundation | Rna interference in respiratory epitheial cells |
| US7592322B2 (en) * | 2004-10-22 | 2009-09-22 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of RSV, PIV and other respiratory viruses and uses thereof |
| CA2586250A1 (en) * | 2004-11-05 | 2006-11-16 | Intradigm Corporation | Compositions for treating respiratory viral infections and their use |
| NZ556097A (en) | 2005-01-07 | 2009-12-24 | Alnylam Pharmaceuticals Inc | Rnai modulation of RSV and therapeutic uses thereof |
| EP1866414B9 (en) | 2005-03-31 | 2012-10-03 | Calando Pharmaceuticals, Inc. | Inhibitors of ribonucleotide reductase subunit 2 and uses thereof |
| US20070213293A1 (en) | 2005-04-08 | 2007-09-13 | Nastech Pharmaceutical Company Inc. | Rnai therapeutic for respiratory virus infection |
| US7718629B2 (en) | 2006-03-31 | 2010-05-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of Eg5 gene |
| US8598333B2 (en) | 2006-05-26 | 2013-12-03 | Alnylam Pharmaceuticals, Inc. | SiRNA silencing of genes expressed in cancer |
| WO2009055445A2 (en) | 2007-10-22 | 2009-04-30 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV) EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| AU2008334948B2 (en) | 2007-12-13 | 2014-11-20 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
| US20100168205A1 (en) | 2008-10-23 | 2010-07-01 | Alnylam Pharmaceuticals, Inc. | Methods and Compositions for Prevention or Treatment of RSV Infection Using Modified Duplex RNA Molecules |
-
2006
- 2006-01-06 NZ NZ556097A patent/NZ556097A/en not_active IP Right Cessation
- 2006-01-06 AT AT10007180T patent/ATE551421T1/de active
- 2006-01-06 EP EP10007180A patent/EP2230304B1/en not_active Expired - Lifetime
- 2006-01-06 KR KR1020077018167A patent/KR101169668B1/ko not_active Expired - Fee Related
- 2006-01-06 DK DK10007180.2T patent/DK2230304T3/da active
- 2006-01-06 ES ES10007180T patent/ES2385811T3/es not_active Expired - Lifetime
- 2006-01-06 CA CA002594334A patent/CA2594334A1/en not_active Abandoned
- 2006-01-06 WO PCT/US2006/000425 patent/WO2006074346A2/en not_active Ceased
- 2006-01-06 EP EP12161280.8A patent/EP2487243A3/en not_active Withdrawn
- 2006-01-06 JP JP2007550488A patent/JP5081630B2/ja not_active Expired - Fee Related
- 2006-01-06 EA EA200900681A patent/EA017847B1/ru not_active IP Right Cessation
- 2006-01-06 EA EA200701450A patent/EA012573B1/ru not_active IP Right Cessation
- 2006-01-06 CN CN201210068795.0A patent/CN102600480B/zh not_active Expired - Fee Related
- 2006-01-06 AU AU2006203934A patent/AU2006203934B2/en not_active Ceased
- 2006-01-06 EP EP13152226.0A patent/EP2628799A3/en not_active Withdrawn
- 2006-01-06 US US11/326,956 patent/US7507809B2/en not_active Expired - Fee Related
- 2006-01-06 EP EP06717600A patent/EP1833490A4/en not_active Withdrawn
- 2006-01-06 CN CN2006800047355A patent/CN101119734B/zh not_active Expired - Fee Related
- 2006-01-06 EA EA201201356A patent/EA201201356A1/ru unknown
- 2006-04-26 US US11/411,291 patent/US7517865B2/en not_active Expired - Fee Related
-
2007
- 2007-06-24 IL IL184162A patent/IL184162A/en not_active IP Right Cessation
-
2008
- 2008-01-28 US US12/021,245 patent/US8158773B2/en not_active Expired - Fee Related
- 2008-12-02 US US12/326,867 patent/US7981869B2/en not_active Expired - Fee Related
-
2010
- 2010-09-28 AU AU2010224450A patent/AU2010224450B2/en not_active Ceased
-
2011
- 2011-06-14 US US13/160,268 patent/US8263572B2/en not_active Expired - Fee Related
- 2011-10-05 JP JP2011220918A patent/JP5814728B2/ja not_active Expired - Fee Related
-
2012
- 2012-01-02 IL IL217332A patent/IL217332A/en not_active IP Right Cessation
- 2012-03-29 US US13/434,820 patent/US8859750B2/en not_active Expired - Fee Related
- 2012-08-07 US US13/568,725 patent/US20130030037A1/en not_active Abandoned
-
2014
- 2014-06-02 JP JP2014113800A patent/JP2014156491A/ja active Pending
- 2014-09-17 US US14/489,070 patent/US20150011612A1/en not_active Abandoned
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