JP2008526815A - 低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用 - Google Patents
低コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしての新規２−アミノベンゾイミダゾール誘導体及びそれらの使用 Download PDFInfo
- Publication number
- JP2008526815A JP2008526815A JP2007549905A JP2007549905A JP2008526815A JP 2008526815 A JP2008526815 A JP 2008526815A JP 2007549905 A JP2007549905 A JP 2007549905A JP 2007549905 A JP2007549905 A JP 2007549905A JP 2008526815 A JP2008526815 A JP 2008526815A
- Authority
- JP
- Japan
- Prior art keywords
- benzimidazol
- dihydrobenzimidazol
- difluorobenzyl
- ylideneamine
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US64253805P | 2005-01-11 | 2005-01-11 | |
| DKPA200500049 | 2005-01-11 | ||
| DKPA200500240 | 2005-02-16 | ||
| US65351305P | 2005-02-17 | 2005-02-17 | |
| PCT/EP2006/050108 WO2006074991A1 (en) | 2005-01-11 | 2006-01-10 | Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
Publications (2)
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| JP2008526815A true JP2008526815A (ja) | 2008-07-24 |
| JP2008526815A5 JP2008526815A5 (https=) | 2009-02-19 |
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| US (3) | US7842817B2 (https=) |
| EP (2) | EP2319512A1 (https=) |
| JP (1) | JP2008526815A (https=) |
| AT (1) | ATE488235T1 (https=) |
| DE (1) | DE602006018255D1 (https=) |
| WO (1) | WO2006074991A1 (https=) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020530479A (ja) * | 2017-08-14 | 2020-10-22 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤としての置換ベンゾイミダゾール |
| JP2020531512A (ja) * | 2017-08-23 | 2020-11-05 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤として有用なベンゾイミダゾール誘導体 |
| JP2023516932A (ja) * | 2020-02-26 | 2023-04-21 | ザ スクリプス リサーチ インスティテュート | 抗炎症活性を有する低分子ｓｃｌ１５ａ４阻害剤 |
| JP2024511101A (ja) * | 2021-03-22 | 2024-03-12 | アセシオン ファーマ エイピーエス | 新規カリウムチャネル阻害剤 |
| JP7853995B2 (ja) | 2021-03-22 | 2026-04-30 | アセシオン ファーマ エイピーエス | 新規カリウムチャネル阻害剤 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007042571A1 (en) * | 2005-10-14 | 2007-04-19 | Neurosearch A/S | Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels |
| US20070232673A1 (en) * | 2006-01-19 | 2007-10-04 | Roth Gregory P | 2-Imino-benzimidazoles |
| WO2008003752A1 (en) * | 2006-07-07 | 2008-01-10 | Neurosearch A/S | 2 -amino benzimidazole derivatives and their use as modulators of small - conductance calcium -act ivated potassium channels |
| US8039632B2 (en) * | 2006-11-13 | 2011-10-18 | Neurosearch A/S | 2-aminio-pyridine derivatives and their use as potassium channel modulators |
| JP2010509249A (ja) * | 2006-11-13 | 2010-03-25 | ノイロサーチ アクティーゼルスカブ | 新規な４−アミノ−ピリジン誘導体及びカリウムチャネルモジュレーターとしてのその使用 |
| AU2009326259A1 (en) | 2008-12-08 | 2011-07-28 | Boehringer Ingelheim International Gmbh | Compounds for treating cancer |
| WO2011157793A1 (en) | 2010-06-17 | 2011-12-22 | Novartis Ag | Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives |
| CN102947274A (zh) * | 2010-06-17 | 2013-02-27 | 诺瓦提斯公司 | 联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物 |
| EP2810773A1 (en) | 2013-06-05 | 2014-12-10 | Basell Poliolefine Italia S.r.l. | Butene-1 copolymer tie layer in multilayer film structures having a low seal temperature and improved hot tack |
| BR112016007065A2 (pt) | 2013-10-10 | 2017-08-01 | Basf Se | composto, composição, utilização de um composto e método para o controle da vegetação |
| WO2016077541A1 (en) * | 2014-11-12 | 2016-05-19 | The Trustees Of The University Of Pennsylvania | Novel anti-infective compounds and methods using same |
| CN104744375B (zh) * | 2015-02-10 | 2017-09-19 | 南开大学 | 一种胍类ntr1小分子拮抗剂 |
| US20200377505A1 (en) * | 2017-08-04 | 2020-12-03 | Goldfinch Bio., Inc. | Benzimidazoles and aza-benzimidazoles, and methods of use thereof |
| CN112165940A (zh) * | 2018-03-27 | 2021-01-01 | 德克萨斯州立大学董事会 | Ox2r化合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3981886A (en) | 1975-01-20 | 1976-09-21 | E. R. Squibb & Sons, Inc. | Amino-benzimidazole derivatives |
| US4004016A (en) * | 1975-08-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Amino-benzimidazole derivatives |
| ATE292120T1 (de) | 1998-07-02 | 2005-04-15 | Neurosearch As | Kaliumkanal-blockierende mittel |
| US6194447B1 (en) * | 1998-07-02 | 2001-02-27 | Neurosearch A/S | Bis (benzimidazole) derivatives serving as potassium blocking agents |
| MA26659A1 (fr) | 1998-08-06 | 2004-12-20 | Pfizer | Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation. |
| EP1178977B1 (en) * | 1999-05-12 | 2005-06-01 | Neurosearch A/S | Ion channel modulating agents |
| EP1309594B1 (fr) | 2000-08-08 | 2004-12-15 | Sanofi-Aventis | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| HUP0400063A2 (hu) * | 2001-02-20 | 2004-04-28 | Bristol-Myers Squibb Company | Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények |
| DE10135050A1 (de) | 2001-07-09 | 2003-02-06 | Schering Ag | 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate |
| JP2005530763A (ja) | 2002-05-13 | 2005-10-13 | アイシーエージェン，インコーポレイティド | カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物 |
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2006
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- 2006-01-10 DE DE602006018255T patent/DE602006018255D1/de not_active Expired - Lifetime
- 2006-01-10 AT AT06701206T patent/ATE488235T1/de not_active IP Right Cessation
- 2006-01-10 WO PCT/EP2006/050108 patent/WO2006074991A1/en not_active Ceased
- 2006-01-10 JP JP2007549905A patent/JP2008526815A/ja not_active Abandoned
- 2006-01-10 EP EP10182012A patent/EP2319512A1/en not_active Withdrawn
- 2006-01-10 EP EP06701206A patent/EP1838306B1/en not_active Expired - Lifetime
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2010
- 2010-07-08 US US12/832,343 patent/US20100280087A1/en not_active Abandoned
- 2010-10-21 US US12/909,362 patent/US20110034527A1/en not_active Abandoned
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020530479A (ja) * | 2017-08-14 | 2020-10-22 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤としての置換ベンゾイミダゾール |
| JP7158464B2 (ja) | 2017-08-14 | 2022-10-21 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤としての置換ベンゾイミダゾール |
| JP2020531512A (ja) * | 2017-08-23 | 2020-11-05 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤として有用なベンゾイミダゾール誘導体 |
| JP7097435B2 (ja) | 2017-08-23 | 2022-07-07 | アセシオン ファーマ エイピーエス | カリウムチャネル阻害剤として有用なベンゾイミダゾール誘導体 |
| JP2023516932A (ja) * | 2020-02-26 | 2023-04-21 | ザ スクリプス リサーチ インスティテュート | 抗炎症活性を有する低分子ｓｃｌ１５ａ４阻害剤 |
| JP7760513B2 (ja) | 2020-02-26 | 2025-10-27 | ザ スクリプス リサーチ インスティテュート | 抗炎症活性を有する低分子ｓｌｃ１５ａ４阻害剤 |
| JP2024511101A (ja) * | 2021-03-22 | 2024-03-12 | アセシオン ファーマ エイピーエス | 新規カリウムチャネル阻害剤 |
| JP7853995B2 (ja) | 2021-03-22 | 2026-04-30 | アセシオン ファーマ エイピーエス | 新規カリウムチャネル阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US7842817B2 (en) | 2010-11-30 |
| US20080200529A1 (en) | 2008-08-21 |
| EP1838306A1 (en) | 2007-10-03 |
| EP2319512A1 (en) | 2011-05-11 |
| US20100280087A1 (en) | 2010-11-04 |
| EP1838306B1 (en) | 2010-11-17 |
| DE602006018255D1 (de) | 2010-12-30 |
| WO2006074991A1 (en) | 2006-07-20 |
| US20110034527A1 (en) | 2011-02-10 |
| ATE488235T1 (de) | 2010-12-15 |
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