ATE488235T1 - Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit - Google Patents

Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

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Publication number
ATE488235T1
ATE488235T1 AT06701206T AT06701206T ATE488235T1 AT E488235 T1 ATE488235 T1 AT E488235T1 AT 06701206 T AT06701206 T AT 06701206T AT 06701206 T AT06701206 T AT 06701206T AT E488235 T1 ATE488235 T1 AT E488235T1
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Austria
Prior art keywords
modulators
amino
calcium
new
benzimidazole derivatives
Prior art date
Application number
AT06701206T
Other languages
German (de)
English (en)
Inventor
Ulrik Syrensen
Lene Teuber
Dan Peters
Dorte Strybfk
Tina Johansen
Karin Nielsen
Palle Christophersen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Application granted granted Critical
Publication of ATE488235T1 publication Critical patent/ATE488235T1/de

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
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AT06701206T 2005-01-11 2006-01-10 Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit ATE488235T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64253805P 2005-01-11 2005-01-11
DKPA200500049 2005-01-11
DKPA200500240 2005-02-16
US65351305P 2005-02-17 2005-02-17
PCT/EP2006/050108 WO2006074991A1 (en) 2005-01-11 2006-01-10 Novel 2-amino benzimidazole derivatives and their use as modulators of small-conductance calcium-activated potassium channels

Publications (1)

Publication Number Publication Date
ATE488235T1 true ATE488235T1 (de) 2010-12-15

Family

ID=36010294

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06701206T ATE488235T1 (de) 2005-01-11 2006-01-10 Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit

Country Status (6)

Country Link
US (3) US7842817B2 (https=)
EP (2) EP2319512A1 (https=)
JP (1) JP2008526815A (https=)
AT (1) ATE488235T1 (https=)
DE (1) DE602006018255D1 (https=)
WO (1) WO2006074991A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007042571A1 (en) * 2005-10-14 2007-04-19 Neurosearch A/S Novel pyrimidine-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
US20070232673A1 (en) * 2006-01-19 2007-10-04 Roth Gregory P 2-Imino-benzimidazoles
WO2008003752A1 (en) * 2006-07-07 2008-01-10 Neurosearch A/S 2 -amino benzimidazole derivatives and their use as modulators of small - conductance calcium -act ivated potassium channels
US8039632B2 (en) * 2006-11-13 2011-10-18 Neurosearch A/S 2-aminio-pyridine derivatives and their use as potassium channel modulators
JP2010509249A (ja) * 2006-11-13 2010-03-25 ノイロサーチ アクティーゼルスカブ 新規な４−アミノ−ピリジン誘導体及びカリウムチャネルモジュレーターとしてのその使用
AU2009326259A1 (en) 2008-12-08 2011-07-28 Boehringer Ingelheim International Gmbh Compounds for treating cancer
WO2011157793A1 (en) 2010-06-17 2011-12-22 Novartis Ag Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
CN102947274A (zh) * 2010-06-17 2013-02-27 诺瓦提斯公司 联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物
EP2810773A1 (en) 2013-06-05 2014-12-10 Basell Poliolefine Italia S.r.l. Butene-1 copolymer tie layer in multilayer film structures having a low seal temperature and improved hot tack
BR112016007065A2 (pt) 2013-10-10 2017-08-01 Basf Se composto, composição, utilização de um composto e método para o controle da vegetação
WO2016077541A1 (en) * 2014-11-12 2016-05-19 The Trustees Of The University Of Pennsylvania Novel anti-infective compounds and methods using same
CN104744375B (zh) * 2015-02-10 2017-09-19 南开大学 一种胍类ntr1小分子拮抗剂
US20200377505A1 (en) * 2017-08-04 2020-12-03 Goldfinch Bio., Inc. Benzimidazoles and aza-benzimidazoles, and methods of use thereof
EP3668841A1 (en) * 2017-08-14 2020-06-24 Acesion Pharma ApS Substituted benzimidazoles as potassium channel inhibitors
EP3672953B1 (en) * 2017-08-23 2021-07-28 Acesion Pharma ApS Benzimidazole derivatives useful as potassium channel inhibitors
CN112165940A (zh) * 2018-03-27 2021-01-01 德克萨斯州立大学董事会 Ox2r化合物
CN115667224A (zh) * 2020-02-26 2023-01-31 斯克里普斯研究学院 具有抗炎活性的scl15a4小分子的抑制剂

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3981886A (en) 1975-01-20 1976-09-21 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
US4004016A (en) * 1975-08-11 1977-01-18 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
ATE292120T1 (de) 1998-07-02 2005-04-15 Neurosearch As Kaliumkanal-blockierende mittel
US6194447B1 (en) * 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
MA26659A1 (fr) 1998-08-06 2004-12-20 Pfizer Dérivés de benzimidazole nouveaux, compositions pharmaceutiques les contenant et procédé pour leur préparation.
EP1178977B1 (en) * 1999-05-12 2005-06-01 Neurosearch A/S Ion channel modulating agents
EP1309594B1 (fr) 2000-08-08 2004-12-15 Sanofi-Aventis Derives de benzimidazole, leur preparation et leur application en therapeutique
HUP0400063A2 (hu) * 2001-02-20 2004-04-28 Bristol-Myers Squibb Company Fluor-oxo-indolszármazékok mint KCNQ káliumcsatorna modulátorok, alkalmazásuk és ezeket tartalmazó gyógyszerkészítmények
DE10135050A1 (de) 2001-07-09 2003-02-06 Schering Ag 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate
JP2005530763A (ja) 2002-05-13 2005-10-13 アイシーエージェン，インコーポレイティド カリウム・チャネル調節物質としてのビス−ベンズイミダゾール及び関連化合物

Also Published As

Publication number Publication date
US7842817B2 (en) 2010-11-30
JP2008526815A (ja) 2008-07-24
US20080200529A1 (en) 2008-08-21
EP1838306A1 (en) 2007-10-03
EP2319512A1 (en) 2011-05-11
US20100280087A1 (en) 2010-11-04
EP1838306B1 (en) 2010-11-17
DE602006018255D1 (de) 2010-12-30
WO2006074991A1 (en) 2006-07-20
US20110034527A1 (en) 2011-02-10

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