JP2008526805A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008526805A5 JP2008526805A5 JP2007549866A JP2007549866A JP2008526805A5 JP 2008526805 A5 JP2008526805 A5 JP 2008526805A5 JP 2007549866 A JP2007549866 A JP 2007549866A JP 2007549866 A JP2007549866 A JP 2007549866A JP 2008526805 A5 JP2008526805 A5 JP 2008526805A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- phenyl
- quinolin
- phenylamino
- ethylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- WBYWAXJHAXSJNI-VOTSOKGWSA-M trans-cinnamate Chemical compound [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims 7
- 229940114081 cinnamate Drugs 0.000 claims 5
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 claims 4
- RURHILYUWQEGOS-UHFFFAOYSA-N 3-(4-methylphenyl)prop-2-enoic acid Chemical compound CC1=CC=C(C=CC(O)=O)C=C1 RURHILYUWQEGOS-UHFFFAOYSA-N 0.000 claims 3
- DMJDEZUEYXVYNO-UHFFFAOYSA-N 3-(4-phenylphenyl)prop-2-enoic acid Chemical class C1=CC(C=CC(=O)O)=CC=C1C1=CC=CC=C1 DMJDEZUEYXVYNO-UHFFFAOYSA-N 0.000 claims 3
- JRRKWFRTDFOWAB-SANMLTNESA-N 5-[(1r)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one Chemical compound C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 JRRKWFRTDFOWAB-SANMLTNESA-N 0.000 claims 3
- YUGFVTIFFGNEOT-SNYZSRNZSA-N 5-[(1r)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one;3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(C=CC(O)=O)C=C1.C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 YUGFVTIFFGNEOT-SNYZSRNZSA-N 0.000 claims 2
- UCJOIXDFPVSTTG-SNYZSRNZSA-N 5-[(1r)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one;3-(4-methylphenyl)prop-2-enoic acid Chemical compound CC1=CC=C(C=CC(O)=O)C=C1.C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 UCJOIXDFPVSTTG-SNYZSRNZSA-N 0.000 claims 2
- CIKAGNFCKFROKQ-ROPHLPQBSA-N 5-[(1r)-2-[2-[4-[4-(2-amino-2-methylpropoxy)anilino]phenyl]ethylamino]-1-hydroxyethyl]-8-hydroxy-1h-quinolin-2-one;3-(4-phenylphenyl)prop-2-enoic acid Chemical compound C1=CC(C=CC(=O)O)=CC=C1C1=CC=CC=C1.C1=CC(C=CC(=O)O)=CC=C1C1=CC=CC=C1.C1=CC(OCC(C)(N)C)=CC=C1NC(C=C1)=CC=C1CCNC[C@H](O)C1=CC=C(O)C2=C1C=CC(=O)N2 CIKAGNFCKFROKQ-ROPHLPQBSA-N 0.000 claims 2
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims 2
- 229930016911 cinnamic acid Natural products 0.000 claims 2
- 235000013985 cinnamic acid Nutrition 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- RURHILYUWQEGOS-VOTSOKGWSA-N 4-Methylcinnamic acid Chemical compound CC1=CC=C(\C=C\C(O)=O)C=C1 RURHILYUWQEGOS-VOTSOKGWSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000048 adrenergic agonist Substances 0.000 claims 1
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- AFDXODALSZRGIH-UHFFFAOYSA-N p-coumaric acid methyl ether Natural products COC1=CC=C(C=CC(O)=O)C=C1 AFDXODALSZRGIH-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64284405P | 2005-01-11 | 2005-01-11 | |
| GB0500513A GB0500513D0 (en) | 2005-01-11 | 2005-01-11 | Novel compounds |
| GB0514199A GB0514199D0 (en) | 2005-07-11 | 2005-07-11 | Novel compounds |
| GB0514200A GB0514200D0 (en) | 2005-07-11 | 2005-07-11 | Novel compounds |
| PCT/EP2006/000141 WO2006074897A1 (en) | 2005-01-11 | 2006-01-09 | Cinnamate salts of a beta-2 adrenergic agonist |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008526805A JP2008526805A (ja) | 2008-07-24 |
| JP2008526805A5 true JP2008526805A5 (OSRAM) | 2009-02-05 |
Family
ID=36046933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007549866A Pending JP2008526805A (ja) | 2005-01-11 | 2006-01-09 | ベータ−２アドレナリン作動薬のケイヒ酸塩 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US7772250B2 (OSRAM) |
| EP (1) | EP1846374A1 (OSRAM) |
| JP (1) | JP2008526805A (OSRAM) |
| KR (1) | KR20070097106A (OSRAM) |
| CN (1) | CN101137625A (OSRAM) |
| AU (1) | AU2006205933A1 (OSRAM) |
| BR (1) | BRPI0606712A2 (OSRAM) |
| CA (1) | CA2594484A1 (OSRAM) |
| EA (1) | EA200701260A1 (OSRAM) |
| IL (1) | IL184246A0 (OSRAM) |
| MA (1) | MA29167B1 (OSRAM) |
| MX (1) | MX2007008459A (OSRAM) |
| NO (1) | NO20073282L (OSRAM) |
| NZ (1) | NZ556335A (OSRAM) |
| WO (1) | WO2006074897A1 (OSRAM) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006074897A1 (en) * | 2005-01-11 | 2006-07-20 | Glaxo Group Limited | Cinnamate salts of a beta-2 adrenergic agonist |
| TW200738658A (en) | 2005-08-09 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
| TW200745067A (en) | 2006-03-14 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| EP2064174B1 (en) | 2006-08-10 | 2016-10-26 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Preparation of (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
| TW200833670A (en) | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| GB0702458D0 (en) | 2007-02-08 | 2007-03-21 | Astrazeneca Ab | Salts 668 |
| EP2231642B1 (en) | 2008-01-11 | 2013-10-23 | Novartis AG | Pyrimidines as kinase inhibitors |
| WO2009154557A1 (en) | 2008-06-18 | 2009-12-23 | Astrazeneca Ab | Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders |
| JP5837890B2 (ja) | 2010-03-10 | 2015-12-24 | アメリカ合衆国 | 神経膠芽腫および星状細胞腫の治療におけるフェノテロールおよびフェノテロール類似体の使用 |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
| AU2012220572A1 (en) | 2011-02-25 | 2013-08-29 | Irm Llc | Compounds and compositions as trk inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US694568A (en) * | 1901-01-03 | 1902-03-04 | James W Mccarthy | Yarn or thread guide for spinning-machines. |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| EP0211595B1 (en) * | 1985-07-30 | 1991-11-13 | Glaxo Group Limited | Devices for administering medicaments to patients |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| HU225869B1 (en) * | 1992-04-02 | 2007-11-28 | Smithkline Beecham Corp | Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them |
| US5998428A (en) * | 1995-05-31 | 1999-12-07 | Smithkline Beecham Corporation | Compounds and methods for treating PDE IV-related diseases |
| GB9700226D0 (en) * | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| US6653323B2 (en) | 2001-11-13 | 2003-11-25 | Theravance, Inc. | Aryl aniline β2 adrenergic receptor agonists |
| TWI249515B (en) * | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
| US20030229058A1 (en) | 2001-11-13 | 2003-12-11 | Moran Edmund J. | Aryl aniline beta2 adrenergic receptor agonists |
| EP1622875B1 (en) | 2003-05-08 | 2009-12-02 | Theravance, Inc. | Crystalline forms of an arylaniline beta-2 adrenergic receptor agonist |
| TW200526547A (en) | 2003-09-22 | 2005-08-16 | Theravance Inc | Amino-substituted ethylamino β2 adrenergic receptor agonists |
| TW200531692A (en) * | 2004-01-12 | 2005-10-01 | Theravance Inc | Aryl aniline derivatives as β2 adrenergic receptor agonists |
| US7317023B2 (en) * | 2004-07-21 | 2008-01-08 | Theravance, Inc. | Diaryl ether β2 adrenergic receptor agonists |
| WO2006074897A1 (en) * | 2005-01-11 | 2006-07-20 | Glaxo Group Limited | Cinnamate salts of a beta-2 adrenergic agonist |
-
2006
- 2006-01-09 WO PCT/EP2006/000141 patent/WO2006074897A1/en not_active Ceased
- 2006-01-09 EP EP06700503A patent/EP1846374A1/en not_active Withdrawn
- 2006-01-09 US US11/327,886 patent/US7772250B2/en not_active Expired - Fee Related
- 2006-01-09 US US11/722,801 patent/US20080125462A1/en not_active Abandoned
- 2006-01-09 JP JP2007549866A patent/JP2008526805A/ja active Pending
- 2006-01-09 EA EA200701260A patent/EA200701260A1/ru unknown
- 2006-01-09 CA CA002594484A patent/CA2594484A1/en not_active Abandoned
- 2006-01-09 CN CNA2006800073097A patent/CN101137625A/zh active Pending
- 2006-01-09 KR KR1020077018424A patent/KR20070097106A/ko not_active Withdrawn
- 2006-01-09 MX MX2007008459A patent/MX2007008459A/es not_active Application Discontinuation
- 2006-01-09 AU AU2006205933A patent/AU2006205933A1/en not_active Abandoned
- 2006-01-09 NZ NZ556335A patent/NZ556335A/en not_active IP Right Cessation
- 2006-01-09 BR BRPI0606712-3A patent/BRPI0606712A2/pt not_active IP Right Cessation
-
2007
- 2007-06-26 IL IL184246A patent/IL184246A0/en unknown
- 2007-06-27 NO NO20073282A patent/NO20073282L/no not_active Application Discontinuation
- 2007-07-26 MA MA30100A patent/MA29167B1/fr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2007109598A (ru) | Кристаллическая форма бифенильного соединения | |
| CN1124844C (zh) | 稳定的冻干药物制剂 | |
| JP2017510624A5 (OSRAM) | ||
| CN105919998B (zh) | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 | |
| JP6374962B2 (ja) | ムスカリン受容体アンタゴニスト活性およびβ２アドレナリン受容体アゴニスト活性の両方を有する、２−アミノ−１−ヒドロキシエチル−８−ヒドロキシキノリン−２（１Ｈ）−オン誘導体の塩 | |
| RU2017127135A (ru) | Терапевтическое средство против рака желчных протоков | |
| JP2013513613A5 (OSRAM) | ||
| JP2009542699A5 (OSRAM) | ||
| JP2017528503A5 (OSRAM) | ||
| WO2009075841A3 (en) | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders | |
| JP2011524896A5 (OSRAM) | ||
| JP2010535252A5 (OSRAM) | ||
| JP2009536191A5 (OSRAM) | ||
| JP2008195730A5 (OSRAM) | ||
| JP2009502743A5 (OSRAM) | ||
| JP2014520886A5 (OSRAM) | ||
| JP2014502641A5 (OSRAM) | ||
| BRPI0707559B8 (pt) | polimorfo de forma i do sal de ácido succínico de 1- [2- (2- cloro- 4- {[(r)- 2- hidróxi- 2- (8- hidróxi- 2- oxo- 1,2- diidroquinolin- 5- il) etilamino] meti1]}- 5- metoxifenilcarbamoil) etil] piperidin- 4- il éster de ácido bifenil- 2- il- carbâmico, seu processo de preparo e usos | |
| JP2011502982A5 (OSRAM) | ||
| JP2010540424A5 (OSRAM) | ||
| EA022018B1 (ru) | Кристаллические оксалатные соли диамидного соединения | |
| PL365224A1 (en) | Nicotinic receptor agonists for the treatment of inflammatory diseases | |
| JP2011520853A5 (OSRAM) | ||
| JP2010500284A5 (OSRAM) | ||
| JP2007515467A5 (OSRAM) |