JP2008526699A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008526699A5 JP2008526699A5 JP2007548733A JP2007548733A JP2008526699A5 JP 2008526699 A5 JP2008526699 A5 JP 2008526699A5 JP 2007548733 A JP2007548733 A JP 2007548733A JP 2007548733 A JP2007548733 A JP 2007548733A JP 2008526699 A5 JP2008526699 A5 JP 2008526699A5
- Authority
- JP
- Japan
- Prior art keywords
- sup
- peptide
- array
- providing
- loading factor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 239000007787 solid Substances 0.000 claims 4
- OBSIQMZKFXFYLV-QMMMGPOBSA-N L-phenylalanine amide Chemical compound NC(=O)[C@@H](N)CC1=CC=CC=C1 OBSIQMZKFXFYLV-QMMMGPOBSA-N 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 239000012071 phase Substances 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 238000010532 solid phase synthesis reaction Methods 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- -1 chloro-trityl group Chemical group 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64071604P | 2004-12-30 | 2004-12-30 | |
| US60/640,716 | 2004-12-30 | ||
| PCT/EP2005/013854 WO2006069729A1 (en) | 2004-12-30 | 2005-12-22 | Synthesis of peptide t-1249 using peptide intermediate fragments |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008526699A JP2008526699A (ja) | 2008-07-24 |
| JP2008526699A5 true JP2008526699A5 (cg-RX-API-DMAC7.html) | 2009-01-08 |
| JP4886703B2 JP4886703B2 (ja) | 2012-02-29 |
Family
ID=36001047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548733A Expired - Fee Related JP4886703B2 (ja) | 2004-12-30 | 2005-12-22 | ペプチド中間体断片を使用するペプチドｔ−１２４９の合成 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7544665B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1856142B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4886703B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101133076B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE439371T1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2593866C (cg-RX-API-DMAC7.html) |
| DE (1) | DE602005016024D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2329270T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006069729A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007007917A (es) * | 2004-12-30 | 2007-08-14 | Hoffmann La Roche | Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios. |
| CA2703113A1 (en) * | 2007-10-27 | 2009-04-30 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| CA2707132A1 (en) * | 2007-12-11 | 2009-06-18 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| DE102008017645A1 (de) | 2008-04-04 | 2009-10-08 | Carl Zeiss Smt Ag | Vorrichtung zur mikrolithographischen Projektionsbelichtung sowie Vorrichtung zur Inspektion einer Oberfläche eines Substrats |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4010560B2 (ja) | 1992-07-20 | 2007-11-21 | ドューク ユニバーシティー | Ｈｉｖ複製を阻害する化合物 |
| US6281335B1 (en) | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
| US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
| US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| US20040209999A1 (en) * | 2002-08-16 | 2004-10-21 | Bohling James Charles | Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto |
| AU2004200485A1 (en) * | 2003-02-25 | 2004-09-09 | Rohm And Haas Company | Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto |
| MX2007007917A (es) | 2004-12-30 | 2007-08-14 | Hoffmann La Roche | Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios. |
-
2005
- 2005-12-22 CA CA2593866A patent/CA2593866C/en not_active Expired - Fee Related
- 2005-12-22 WO PCT/EP2005/013854 patent/WO2006069729A1/en not_active Ceased
- 2005-12-22 JP JP2007548733A patent/JP4886703B2/ja not_active Expired - Fee Related
- 2005-12-22 DE DE602005016024T patent/DE602005016024D1/de not_active Expired - Lifetime
- 2005-12-22 ES ES05821840T patent/ES2329270T3/es not_active Expired - Lifetime
- 2005-12-22 EP EP05821840A patent/EP1856142B1/en not_active Expired - Lifetime
- 2005-12-22 CN CN2005800488419A patent/CN101133076B/zh not_active Expired - Fee Related
- 2005-12-22 AT AT05821840T patent/ATE439371T1/de not_active IP Right Cessation
- 2005-12-30 US US11/322,394 patent/US7544665B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6683189B1 (en) | Method for the synthesis of pyrrole and imidazole carboxamides on a solid support | |
| JP2009541288A5 (cg-RX-API-DMAC7.html) | ||
| CN111925418B (zh) | 伊特卡肽的液相合成方法 | |
| TW202112725A (zh) | 肽化合物的製造方法、保護基形成用試藥及縮合多環芳香族烴化合物 | |
| JP2007525499A5 (cg-RX-API-DMAC7.html) | ||
| CN104844710B (zh) | 定向固定化pega复合型树酯的制备方法及应用 | |
| JP2008526699A5 (cg-RX-API-DMAC7.html) | ||
| EP3010930B1 (en) | Peptide-resin conjugate and use thereof | |
| CN108779150A (zh) | 地加瑞克的制备方法及其中间体 | |
| CA2484594A1 (en) | Process for the synthesis of peptides | |
| JP2008526698A5 (cg-RX-API-DMAC7.html) | ||
| WO2005087794A1 (en) | Process for octreotide synthesis | |
| US8829157B2 (en) | Process for the synthesis of cyclic heptapeptide | |
| JP5785177B2 (ja) | ポリペプチドのネイティブライゲーション法 | |
| Guthrie et al. | Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides | |
| CN1300168C (zh) | 一种新的用于肽和小分子有机合成的基于连接剂的固体载体 | |
| WO2025026914A1 (en) | A metal complex of fmoc protected lipopeg-peptide with metal halide salts and the preparation thereof | |
| JP2013509396A5 (cg-RX-API-DMAC7.html) | ||
| Pattarawarapan et al. | A Linker Scaffold to Present Dimers of Pharmacophores Prepared by Solid‐Phase Syntheses | |
| JPH04502908A (ja) | アミノ酸のトリアルキルシリルエステルおよびペプチド合成におけるその使用 | |
| KR101890979B1 (ko) | 알카인을 이용한 아마이드 화합물의 제조방법 및 이를 이용한 펩타이드 제조 방법 | |
| CN103232507B (zh) | 修饰核苷单体及其合成方法和应用 | |
| TW202302620A (zh) | 胺基酸或肽之製造方法、保護基形成用試藥及化合物 | |
| Chen et al. | tert-Butyloxycarbonyl-protected amino acid ionic liquids and their application to dipeptide synthesis | |
| JP2006014637A5 (cg-RX-API-DMAC7.html) |