CN101133076B - 使用肽中间片段合成肽t-1249 - Google Patents

使用肽中间片段合成肽t-1249 Download PDF

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Publication number
CN101133076B
CN101133076B CN2005800488419A CN200580048841A CN101133076B CN 101133076 B CN101133076 B CN 101133076B CN 2005800488419 A CN2005800488419 A CN 2005800488419A CN 200580048841 A CN200580048841 A CN 200580048841A CN 101133076 B CN101133076 B CN 101133076B
Authority
CN
China
Prior art keywords
peptide
nmp
reactor
filled
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800488419A
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English (en)
Chinese (zh)
Other versions
CN101133076A (zh
Inventor
Y-K·汉
L·M·霍奇斯
D·A·约翰斯顿
H·N·翰特里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101133076A publication Critical patent/CN101133076A/zh
Application granted granted Critical
Publication of CN101133076B publication Critical patent/CN101133076B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2005800488419A 2004-12-30 2005-12-22 使用肽中间片段合成肽t-1249 Expired - Fee Related CN101133076B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64071604P 2004-12-30 2004-12-30
US60/640,716 2004-12-30
PCT/EP2005/013854 WO2006069729A1 (en) 2004-12-30 2005-12-22 Synthesis of peptide t-1249 using peptide intermediate fragments

Publications (2)

Publication Number Publication Date
CN101133076A CN101133076A (zh) 2008-02-27
CN101133076B true CN101133076B (zh) 2011-07-13

Family

ID=36001047

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800488419A Expired - Fee Related CN101133076B (zh) 2004-12-30 2005-12-22 使用肽中间片段合成肽t-1249

Country Status (9)

Country Link
US (1) US7544665B2 (cg-RX-API-DMAC7.html)
EP (1) EP1856142B1 (cg-RX-API-DMAC7.html)
JP (1) JP4886703B2 (cg-RX-API-DMAC7.html)
CN (1) CN101133076B (cg-RX-API-DMAC7.html)
AT (1) ATE439371T1 (cg-RX-API-DMAC7.html)
CA (1) CA2593866C (cg-RX-API-DMAC7.html)
DE (1) DE602005016024D1 (cg-RX-API-DMAC7.html)
ES (1) ES2329270T3 (cg-RX-API-DMAC7.html)
WO (1) WO2006069729A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007007917A (es) * 2004-12-30 2007-08-14 Hoffmann La Roche Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios.
CA2703113A1 (en) * 2007-10-27 2009-04-30 F. Hoffmann-La Roche Ag Insulinotropic peptide synthesis using solid and solution phase combination techniques
CA2707132A1 (en) * 2007-12-11 2009-06-18 F. Hoffmann-La Roche Ag Insulinotropic peptide synthesis using solid and solution phase combination techniques
DE102008017645A1 (de) 2008-04-04 2009-10-08 Carl Zeiss Smt Ag Vorrichtung zur mikrolithographischen Projektionsbelichtung sowie Vorrichtung zur Inspektion einer Oberfläche eines Substrats

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
EP1452538A1 (en) * 2003-02-25 2004-09-01 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4010560B2 (ja) 1992-07-20 2007-11-21 ドューク ユニバーシティー Ｈｉｖ複製を阻害する化合物
US6281335B1 (en) 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
US6479055B1 (en) 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5464933A (en) 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US20040209999A1 (en) * 2002-08-16 2004-10-21 Bohling James Charles Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto
MX2007007917A (es) 2004-12-30 2007-08-14 Hoffmann La Roche Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
EP1452538A1 (en) * 2003-02-25 2004-09-01 Rohm And Haas Company Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto

Also Published As

Publication number Publication date
US7544665B2 (en) 2009-06-09
JP2008526699A (ja) 2008-07-24
CA2593866C (en) 2013-08-06
CN101133076A (zh) 2008-02-27
ES2329270T3 (es) 2009-11-24
CA2593866A1 (en) 2006-07-06
US20060173163A1 (en) 2006-08-03
DE602005016024D1 (de) 2009-09-24
ATE439371T1 (de) 2009-08-15
EP1856142A1 (en) 2007-11-21
WO2006069729A1 (en) 2006-07-06
JP4886703B2 (ja) 2012-02-29
EP1856142B1 (en) 2009-08-12

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110713

Termination date: 20161222

CF01 Termination of patent right due to non-payment of annual fee