JP2008523842A5 - - Google Patents
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- JP2008523842A5 JP2008523842A5 JP2007548379A JP2007548379A JP2008523842A5 JP 2008523842 A5 JP2008523842 A5 JP 2008523842A5 JP 2007548379 A JP2007548379 A JP 2007548379A JP 2007548379 A JP2007548379 A JP 2007548379A JP 2008523842 A5 JP2008523842 A5 JP 2008523842A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- amino acid
- seq
- residues
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 45
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 38
- 125000000539 amino acid group Chemical group 0.000 claims 30
- 238000007912 intraperitoneal administration Methods 0.000 claims 19
- 238000002360 preparation method Methods 0.000 claims 18
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 229940079593 drug Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 15
- 238000000034 method Methods 0.000 claims 12
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 12
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- 102000004127 Cytokines Human genes 0.000 claims 9
- 108090000695 Cytokines Proteins 0.000 claims 9
- 241001465754 Metazoa Species 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 9
- -1 narcotic Substances 0.000 claims 9
- 210000000056 organ Anatomy 0.000 claims 9
- 235000018102 proteins Nutrition 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 210000001519 tissue Anatomy 0.000 claims 9
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 6
- 229930182837 (R)-adrenaline Natural products 0.000 claims 6
- 102000003951 Erythropoietin Human genes 0.000 claims 6
- 108090000394 Erythropoietin Proteins 0.000 claims 6
- 108060003951 Immunoglobulin Proteins 0.000 claims 6
- 239000003263 anabolic agent Substances 0.000 claims 6
- 230000000202 analgesic effect Effects 0.000 claims 6
- 230000002682 anti-psoriatic effect Effects 0.000 claims 6
- 239000000935 antidepressant agent Substances 0.000 claims 6
- 229940005513 antidepressants Drugs 0.000 claims 6
- 239000003435 antirheumatic agent Substances 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000003246 corticosteroid Substances 0.000 claims 6
- 229960005139 epinephrine Drugs 0.000 claims 6
- 229940105423 erythropoietin Drugs 0.000 claims 6
- 239000000122 growth hormone Substances 0.000 claims 6
- 229940088597 hormone Drugs 0.000 claims 6
- 239000005556 hormone Substances 0.000 claims 6
- 230000003053 immunization Effects 0.000 claims 6
- 238000002649 immunization Methods 0.000 claims 6
- 102000018358 immunoglobulin Human genes 0.000 claims 6
- 229960003444 immunosuppressant agent Drugs 0.000 claims 6
- 239000003018 immunosuppressive agent Substances 0.000 claims 6
- 238000001361 intraarterial administration Methods 0.000 claims 6
- 238000007918 intramuscular administration Methods 0.000 claims 6
- 238000001990 intravenous administration Methods 0.000 claims 6
- 238000007914 intraventricular administration Methods 0.000 claims 6
- 239000003589 local anesthetic agent Substances 0.000 claims 6
- 239000003158 myorelaxant agent Substances 0.000 claims 6
- 230000003533 narcotic effect Effects 0.000 claims 6
- 239000000842 neuromuscular blocking agent Substances 0.000 claims 6
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 6
- 229940121896 radiopharmaceutical Drugs 0.000 claims 6
- 239000012217 radiopharmaceutical Substances 0.000 claims 6
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 6
- 239000000932 sedative agent Substances 0.000 claims 6
- 150000003431 steroids Chemical class 0.000 claims 6
- 238000007920 subcutaneous administration Methods 0.000 claims 6
- 230000009261 transgenic effect Effects 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 241000124008 Mammalia Species 0.000 claims 4
- 230000027455 binding Effects 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 241001260012 Bursa Species 0.000 claims 3
- 101100007328 Cocos nucifera COS-1 gene Proteins 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 102000018997 Growth Hormone Human genes 0.000 claims 3
- 108010051696 Growth Hormone Proteins 0.000 claims 3
- 206010025323 Lymphomas Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 229940070021 anabolic steroids Drugs 0.000 claims 3
- 230000003444 anaesthetic effect Effects 0.000 claims 3
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- 230000001430 anti-depressive effect Effects 0.000 claims 3
- 230000003302 anti-idiotype Effects 0.000 claims 3
- 230000000561 anti-psychotic effect Effects 0.000 claims 3
- 230000003356 anti-rheumatic effect Effects 0.000 claims 3
- 229940124350 antibacterial drug Drugs 0.000 claims 3
- 239000000164 antipsychotic agent Substances 0.000 claims 3
- 229940005529 antipsychotics Drugs 0.000 claims 3
- 208000006673 asthma Diseases 0.000 claims 3
- 229940127225 asthma medication Drugs 0.000 claims 3
- 239000002876 beta blocker Substances 0.000 claims 3
- 229940097320 beta blocking agent Drugs 0.000 claims 3
- 239000002981 blocking agent Substances 0.000 claims 3
- 210000000845 cartilage Anatomy 0.000 claims 3
- 210000001638 cerebellum Anatomy 0.000 claims 3
- 229960001334 corticosteroids Drugs 0.000 claims 3
- 239000000409 cytokine receptor agonist Substances 0.000 claims 3
- 239000000430 cytokine receptor antagonist Substances 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000003193 general anesthetic agent Substances 0.000 claims 3
- 229940072221 immunoglobulins Drugs 0.000 claims 3
- 230000001861 immunosuppressant effect Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000007919 intrasynovial administration Methods 0.000 claims 3
- 238000007913 intrathecal administration Methods 0.000 claims 3
- 229960005015 local anesthetics Drugs 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 210000000664 rectum Anatomy 0.000 claims 3
- 229940125723 sedative agent Drugs 0.000 claims 3
- 230000001624 sedative effect Effects 0.000 claims 3
- 239000000021 stimulant Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 210000001215 vagina Anatomy 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 229930195712 glutamate Natural products 0.000 claims 2
- FGRBYDKOBBBPOI-UHFFFAOYSA-N 10,10-dioxo-2-[4-(N-phenylanilino)phenyl]thioxanthen-9-one Chemical compound O=C1c2ccccc2S(=O)(=O)c2ccc(cc12)-c1ccc(cc1)N(c1ccccc1)c1ccccc1 FGRBYDKOBBBPOI-UHFFFAOYSA-N 0.000 claims 1
- 102220625422 E3 ubiquitin-protein ligase RNF187_R98K_mutation Human genes 0.000 claims 1
- 102220481770 Kinesin-like protein KIF20A_R59K_mutation Human genes 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 102220094017 rs876659369 Human genes 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63781904P | 2004-12-21 | 2004-12-21 | |
| PCT/US2005/046063 WO2006069036A2 (en) | 2004-12-21 | 2005-12-20 | Anti-il-12 antibodies, epitopes, compositions, methods and uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008523842A JP2008523842A (ja) | 2008-07-10 |
| JP2008523842A5 true JP2008523842A5 (https=) | 2009-02-12 |
Family
ID=36602254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007548379A Pending JP2008523842A (ja) | 2004-12-21 | 2005-12-20 | 抗ｉｌ−１２抗体、エピトープ、組成物、方法および用途 |
Country Status (23)
| Country | Link |
|---|---|
| US (8) | US8080247B2 (https=) |
| EP (1) | EP1836294A4 (https=) |
| JP (1) | JP2008523842A (https=) |
| KR (1) | KR20070094927A (https=) |
| CN (1) | CN101120087A (https=) |
| AR (1) | AR051805A1 (https=) |
| AU (1) | AU2005319278A1 (https=) |
| BR (1) | BRPI0515858A (https=) |
| CA (1) | CA2591813A1 (https=) |
| CR (1) | CR9265A (https=) |
| EA (1) | EA016022B1 (https=) |
| IL (1) | IL183939A0 (https=) |
| MY (1) | MY157915A (https=) |
| NI (1) | NI200700155A (https=) |
| NO (1) | NO20073778L (https=) |
| NZ (2) | NZ555658A (https=) |
| PE (1) | PE20061115A1 (https=) |
| PY (1) | PY0539343A (https=) |
| SG (1) | SG158150A1 (https=) |
| TW (1) | TWI406943B (https=) |
| UY (1) | UY29291A1 (https=) |
| WO (1) | WO2006069036A2 (https=) |
| ZA (1) | ZA200706036B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6830751B1 (en) * | 1994-03-14 | 2004-12-14 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of rheumatoid arthritis |
| US7883704B2 (en) * | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| SI1839120T1 (sl) | 2004-12-21 | 2013-12-31 | Janssen Biotech, Inc. | Vektorji na osnovi protitelesa anti-il-12, gostiteljske celice in postopki proizvodnje ter uporabe |
| CN103145839A (zh) * | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| PL1933869T3 (pl) | 2005-09-01 | 2010-06-30 | Merck Sharp & Dohme | Zastosowanie antagonistów IL-23 i IL-17 do leczenia autoimmunologicznej zapalnej choroby oczu |
| KR101722261B1 (ko) * | 2006-10-02 | 2017-04-03 | 메다렉스, 엘.엘.시. | Ｃｘｃｒ4에 결합하는 인간 항체 및 이의 용도 |
| WO2008057240A2 (en) | 2006-10-27 | 2008-05-15 | Abbott Biotechnology Ltd. | Crystalline anti-htnfalpha antibodies |
| CN104524567A (zh) | 2007-01-16 | 2015-04-22 | 阿布维公司 | 用于治疗银屑病的方法 |
| CA2681752A1 (en) | 2007-03-29 | 2008-10-09 | Abbott Laboratories | Crystalline anti-human 1l-12 antibodies |
| EP2185201A4 (en) | 2007-08-08 | 2011-11-30 | Abbott Lab | COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODIES |
| EP2205276A4 (en) * | 2007-09-28 | 2012-08-15 | Janssen Biotech Inc | ANTI-IL-12 / 23P40 ANTIBODIES, EPITOPES, FORMULATIONS, COMPOSITIONS, METHODS AND USES |
| EP2220120A2 (en) | 2007-11-27 | 2010-08-25 | Ablynx N.V. | Amino acid sequences directed against heterodimeric cytokines and/or their receptors and polypeptides comprising the same |
| EP2274333A4 (en) | 2008-03-18 | 2011-06-15 | Abbott Lab | PROCESS FOR TREATING PSORIASIS |
| MY153074A (en) | 2008-08-14 | 2014-12-31 | Teva Pharmaceuticals Australia Pty Ltd | Anti-il-12/11-23 antibodies |
| KR20120112384A (ko) * | 2009-09-14 | 2012-10-11 | 애보트 게엠베하 운트 콤파니 카게 | 건선을 치료하는 방법 |
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| AR080428A1 (es) * | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
| WO2012094623A2 (en) * | 2011-01-07 | 2012-07-12 | Abbott Laboratories | Anti-il-12/il-23 antibodies and uses thereof |
| CN105572380A (zh) * | 2014-11-06 | 2016-05-11 | 上海市东方医院 | Il-12在诊断和治疗非小细胞肺癌远处转移中的应用 |
| CA2979210A1 (en) * | 2015-03-11 | 2016-09-15 | Rush University Medical Center | Compositions and methods for treating cancer |
| TWI736575B (zh) | 2016-01-22 | 2021-08-21 | 美商默沙東藥廠 | 抗凝固因子ｘｉ抗體 |
| IL263272B2 (en) | 2016-06-14 | 2025-07-01 | Merck Sharp & Dohme | Antibodies to coagulation factor xi |
| AU2017316955B2 (en) * | 2016-08-25 | 2022-03-03 | Jcr Pharmaceuticals Co., Ltd. | Method for producing antibody fusion protein |
| WO2018097308A1 (ja) | 2016-11-28 | 2018-05-31 | 中外製薬株式会社 | リガンド結合活性が調整可能なリガンド結合分子 |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| CN109813897A (zh) * | 2017-11-18 | 2019-05-28 | 镇江亿特生物科技发展有限公司 | 盐酸可乐定快速时间分辨荧光免疫层析定量检测试纸条 |
| CN111630062A (zh) | 2017-11-28 | 2020-09-04 | 中外制药株式会社 | 具有可调节的配体结合活性的配体结合分子 |
| CN111836828B (zh) | 2017-11-28 | 2024-12-20 | 中外制药株式会社 | 包括抗原结合结构域和运送部分的多肽 |
| EP3793521A4 (en) | 2018-05-18 | 2022-02-23 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY |
| US11744866B2 (en) | 2020-03-18 | 2023-09-05 | Sabine Hazan | Methods of preventing and treating COVID-19 infection with probiotics |
| US11253534B2 (en) | 2020-03-23 | 2022-02-22 | Sabine Hazan | Method of preventing COVID-19 infection |
| US11278520B2 (en) | 2020-03-31 | 2022-03-22 | Sabine Hazan | Method of preventing COVID-19 infection |
| CN111549834B (zh) * | 2020-05-17 | 2021-08-10 | 福建金鼎建筑发展有限公司 | 一种基于地表水渗透的基坑开挖模型试验装置及使用方法 |
| AU2021278562A1 (en) | 2020-05-29 | 2022-12-01 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing formulation |
| TW202321282A (zh) | 2021-07-19 | 2023-06-01 | 美商再生元醫藥公司 | Il12受體促效劑及其使用方法 |
| CN114468015B (zh) * | 2022-03-15 | 2023-10-17 | 重庆大学 | 一种高肉粘性的胶原肠衣及其制备方法和用途 |
| EP4649088A1 (en) | 2023-01-13 | 2025-11-19 | Regeneron Pharmaceuticals, Inc. | Il12 receptor agonists and methods of use thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457038A (en) | 1988-11-10 | 1995-10-10 | Genetics Institute, Inc. | Natural killer stimulatory factor |
| CA2441636A1 (en) | 1988-11-10 | 1990-05-10 | The Wistar Institute Of Anatomy And Biology | Natural killer stimulatory factor |
| US5811523A (en) | 1988-11-10 | 1998-09-22 | Trinchieri; Giorgio | Antibodies to natural killer stimulatory factor |
| ATE366311T1 (de) | 1989-12-22 | 2007-07-15 | Hoffmann La Roche | Zytotoxischer lymphozyten-reifefaktor 35kd untereinheit und monoklonale antikörper spezifisch dafür |
| US6683046B1 (en) | 1989-12-22 | 2004-01-27 | Hoffmann-La Roche Inc. | Purification and characterization of cytotoxic lymphocyte maturation factor and monoclonal antibodies thereto |
| DE4315127A1 (de) | 1993-05-07 | 1994-11-10 | Behringwerke Ag | Arzneimittel enthaltend die Untereinheit p40 von Interleukin-12 |
| ZA95960B (en) | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| WO1995029239A2 (en) | 1994-04-22 | 1995-11-02 | Corixa Corporation | Compounds and methods for the stimulation and enhancement of protective immune responses and il-12 production |
| US5891680A (en) | 1995-02-08 | 1999-04-06 | Whitehead Institute For Biomedical Research | Bioactive fusion proteins comprising the p35 and p40 subunits of IL-12 |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5853697A (en) | 1995-10-25 | 1998-12-29 | The United States Of America, As Represented By The Department Of Health & Human Services | Methods of treating established colitis using antibodies against IL-12 |
| AU6150498A (en) | 1997-02-07 | 1998-08-26 | Wistar Institute, The | Methods and compositions for the inhibition of interleukin-12 production |
| US6060284A (en) | 1997-07-25 | 2000-05-09 | Schering Corporation | DNA encoding interleukin-B30 |
| WO1999037682A2 (en) | 1998-01-23 | 1999-07-29 | F.Hoffmann-La Roche Ag | Antibodies against human il-12 |
| SI2168984T1 (sl) | 1999-03-25 | 2012-12-31 | Abbott Gmbh & Co. Kg | Človeška protitelesa za vezavo IL-12 in postopki izdelave |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| AU7127600A (en) | 1999-09-17 | 2001-04-17 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| US6902734B2 (en) * | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| WO2002097048A2 (en) | 2001-05-30 | 2002-12-05 | Centocor, Inc. | ANTI-p40 IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES |
| EP1532175B1 (en) | 2002-03-22 | 2012-10-17 | Aprogen, Inc. | Humanized antibody and process for preparing the same |
-
2005
- 2005-12-20 SG SG200908473-2A patent/SG158150A1/en unknown
- 2005-12-20 NZ NZ555658A patent/NZ555658A/en unknown
- 2005-12-20 EP EP05854726A patent/EP1836294A4/en not_active Withdrawn
- 2005-12-20 KR KR1020077016698A patent/KR20070094927A/ko not_active Ceased
- 2005-12-20 US US11/722,312 patent/US8080247B2/en not_active Expired - Lifetime
- 2005-12-20 MY MYPI20056053A patent/MY157915A/en unknown
- 2005-12-20 EA EA200701363A patent/EA016022B1/ru unknown
- 2005-12-20 CN CNA2005800482713A patent/CN101120087A/zh active Pending
- 2005-12-20 AR ARP050105380A patent/AR051805A1/es unknown
- 2005-12-20 AU AU2005319278A patent/AU2005319278A1/en not_active Abandoned
- 2005-12-20 TW TW094145355A patent/TWI406943B/zh not_active IP Right Cessation
- 2005-12-20 CA CA002591813A patent/CA2591813A1/en not_active Abandoned
- 2005-12-20 JP JP2007548379A patent/JP2008523842A/ja active Pending
- 2005-12-20 BR BRPI0515858-3A patent/BRPI0515858A/pt not_active Application Discontinuation
- 2005-12-20 WO PCT/US2005/046063 patent/WO2006069036A2/en not_active Ceased
- 2005-12-20 NZ NZ583153A patent/NZ583153A/en unknown
- 2005-12-21 UY UY29291A patent/UY29291A1/es not_active Application Discontinuation
- 2005-12-21 PY PY200500539343A patent/PY0539343A/es unknown
-
2006
- 2006-01-03 PE PE2006000036A patent/PE20061115A1/es not_active Application Discontinuation
-
2007
- 2007-06-14 IL IL183939A patent/IL183939A0/en unknown
- 2007-06-15 NI NI200700155A patent/NI200700155A/es unknown
- 2007-07-19 NO NO20073778A patent/NO20073778L/no not_active Application Discontinuation
- 2007-07-20 ZA ZA200706036A patent/ZA200706036B/xx unknown
- 2007-07-20 CR CR9265A patent/CR9265A/es not_active Application Discontinuation
-
2011
- 2011-11-18 US US13/299,831 patent/US8329170B2/en not_active Expired - Lifetime
-
2012
- 2012-11-06 US US13/669,894 patent/US8894990B2/en not_active Expired - Lifetime
-
2014
- 2014-10-13 US US14/512,757 patent/US9428579B2/en not_active Expired - Lifetime
-
2016
- 2016-07-22 US US15/217,099 patent/US9605067B2/en not_active Expired - Lifetime
-
2017
- 2017-02-14 US US15/432,636 patent/US9862766B2/en not_active Expired - Fee Related
- 2017-12-04 US US15/830,586 patent/US20180079809A1/en not_active Abandoned
-
2018
- 2018-12-04 US US16/209,326 patent/US20190085069A1/en not_active Abandoned
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