JP2008522981A5 - - Google Patents
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- Publication number
- JP2008522981A5 JP2008522981A5 JP2007544636A JP2007544636A JP2008522981A5 JP 2008522981 A5 JP2008522981 A5 JP 2008522981A5 JP 2007544636 A JP2007544636 A JP 2007544636A JP 2007544636 A JP2007544636 A JP 2007544636A JP 2008522981 A5 JP2008522981 A5 JP 2008522981A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- hydrogen
- aryl
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63436604P | 2004-12-07 | 2004-12-07 | |
| US60/634,366 | 2004-12-07 | ||
| US65593005P | 2005-02-23 | 2005-02-23 | |
| US60/655,930 | 2005-02-23 | ||
| PCT/US2005/044451 WO2006063154A1 (en) | 2004-12-07 | 2005-12-07 | Composition for proteasome inhibition |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008522981A JP2008522981A (ja) | 2008-07-03 |
| JP2008522981A5 true JP2008522981A5 (OSRAM) | 2008-10-02 |
| JP4990155B2 JP4990155B2 (ja) | 2012-08-01 |
Family
ID=36143200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544636A Expired - Lifetime JP4990155B2 (ja) | 2004-12-07 | 2005-12-07 | プロテアソームを阻害するための組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7737112B2 (OSRAM) |
| EP (3) | EP2261236B1 (OSRAM) |
| JP (1) | JP4990155B2 (OSRAM) |
| KR (1) | KR101299821B1 (OSRAM) |
| CN (2) | CN102847136A (OSRAM) |
| AT (1) | ATE499109T1 (OSRAM) |
| AU (1) | AU2005313975B2 (OSRAM) |
| CA (1) | CA2589921C (OSRAM) |
| CY (1) | CY1111489T1 (OSRAM) |
| DE (1) | DE602005026556D1 (OSRAM) |
| DK (1) | DK1819353T3 (OSRAM) |
| ES (2) | ES2549763T3 (OSRAM) |
| HU (1) | HUE027850T2 (OSRAM) |
| IL (1) | IL183607A (OSRAM) |
| PL (3) | PL2260835T3 (OSRAM) |
| PT (3) | PT2261236E (OSRAM) |
| WO (1) | WO2006063154A1 (OSRAM) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8129346B2 (en) | 2004-04-15 | 2012-03-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
| PT2030981E (pt) * | 2004-05-10 | 2014-10-14 | Onyx Therapeutics Inc | Compostos para inibição da enzima proteassoma |
| US9034846B2 (en) * | 2004-10-10 | 2015-05-19 | Universite De Liege | Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases |
| KR101434522B1 (ko) | 2005-11-09 | 2014-08-26 | 오닉스 세라퓨틱스, 인크. | 효소 저해를 위한 화합물 |
| RU2450016C2 (ru) * | 2006-06-19 | 2012-05-10 | Протеоликс, Инк. | Пептидные эпоксикетоны для ингибирования протеасомы |
| SI2207791T2 (sl) * | 2007-10-04 | 2019-09-30 | Onyx Therapeutics, Inc. | Kristalinični peptidepoksiketonski proteazni inhibitorji in sinteza aminokislinskih ketoepoksidov |
| US7635773B2 (en) | 2008-04-28 | 2009-12-22 | Cydex Pharmaceuticals, Inc. | Sulfoalkyl ether cyclodextrin compositions |
| WO2010039762A2 (en) * | 2008-10-01 | 2010-04-08 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions comprising boronic acid compounds |
| EP2796134B1 (en) * | 2008-10-21 | 2016-12-07 | Onyx Therapeutics, Inc. | Combination of the peptide epoxyketone proteasome inhibitor carfilzomib with melphalan for use in the treatment of multiple myeloma |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| EP2238973A1 (en) * | 2009-04-07 | 2010-10-13 | Cephalon France | Lyophilized preparations of proteasome inhibitors |
| ES2767880T3 (es) | 2009-05-29 | 2020-06-18 | Cydex Pharmaceuticals Inc | Composiciones inyectables de melfalán que comprenden un derivado de ciclodextrina y métodos de preparación y uso de las mismas |
| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| EP2498793B1 (en) * | 2009-11-13 | 2019-07-10 | Onyx Therapeutics, Inc. | Oprozomib for use in metastasis suppression |
| AU2011223795B2 (en) | 2010-03-01 | 2015-11-05 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
| KR20130094185A (ko) | 2010-04-07 | 2013-08-23 | 오닉스 세라퓨틱스, 인크. | 결정성 펩티드 에폭시케톤 면역프로테아좀 저해제 |
| WO2013112605A2 (en) | 2012-01-23 | 2013-08-01 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
| ES2774901T3 (es) | 2012-02-15 | 2020-07-23 | Cydex Pharmaceuticals Inc | Proceso para la fabricación de derivados de ciclodextrina |
| RU2615385C2 (ru) | 2012-02-28 | 2017-04-04 | Сидекс Фармасьютикалс, Инк. | Композиции алкилированного циклодекстрина и способы их получения и применения |
| WO2013142376A1 (en) * | 2012-03-19 | 2013-09-26 | Aposignal Bioscience Llc | Composition and methods for cell modulation |
| EA033614B1 (ru) * | 2012-05-08 | 2019-11-11 | Onyx Therapeutics Inc | Способы комплексообразования с циклодекстринами для введения пептидных протеасомных ингибиторов в фармацевтические составы |
| MX2012010891A (es) * | 2012-05-08 | 2014-03-05 | Onyx Therapeutics Inc | Procedimientos para la formacion de complejos de ciclodextrina para formular inhibidores del proteasoma peptidico. |
| US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
| US10022326B2 (en) * | 2012-07-18 | 2018-07-17 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
| CN103570806B (zh) * | 2012-07-26 | 2020-04-07 | 圣特莱国际公司 | 多肽环氧酮化合物 |
| WO2014018807A1 (en) * | 2012-07-26 | 2014-01-30 | Centrax International, Inc. | Peptide epoxyketone compounds |
| CN104797591A (zh) * | 2012-08-14 | 2015-07-22 | 弗洛伊诺制药公司 | 氟化环氧酮系化合物及其作为蛋白酶体抑制剂的用途 |
| US9636376B2 (en) | 2012-09-11 | 2017-05-02 | Innopharma, Inc. | Stable compositions of peptide epoxy ketones |
| AU2013334921B2 (en) | 2012-10-22 | 2018-03-29 | Cydex Pharmaceuticals, Inc. | Alkylated cyclodextrin compositions and processes for preparing and using the same |
| IN2015DN04094A (OSRAM) * | 2012-11-30 | 2015-10-09 | Glaxosmithkline Llc | |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| ES2808565T3 (es) | 2013-03-13 | 2021-03-01 | Sanofi Sa | Composiciones que comprenden anticuerpos anti-CD38 y carfilzomib |
| AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
| EP2970225B1 (en) | 2013-03-14 | 2018-08-15 | Onyx Therapeutics, Inc. | Dipeptide and tripeptide epoxy ketone protease inhibitors |
| AU2014290012B2 (en) | 2013-07-19 | 2020-01-16 | Onyx Therapeutics, Inc. | Peptide epoxyketone proteasome inhibitors in combination with PIM kinase inhibitors for treatment of cancers |
| CN105960399B (zh) * | 2014-07-14 | 2018-09-25 | 宁波圣健生物医药科技有限公司 | 酶抑制剂环氧酮化合物 |
| US10851184B2 (en) | 2014-08-22 | 2020-12-01 | Cydex Pharmaceuticals, Inc. | Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same |
| WO2016170489A1 (en) | 2015-04-24 | 2016-10-27 | Fresenius Kabi Oncology Ltd. | Pharmaceutical compositions of proteasome inhibitor |
| WO2017087695A1 (en) * | 2015-11-17 | 2017-05-26 | Taipei Medical University | Aminonaphthoquinone compounds for treatment and/or prevention of fibrosis diseases |
| TWI759301B (zh) * | 2016-05-24 | 2022-04-01 | 美商安美基公司 | 聚乙二醇化卡非佐米化合物 |
| SG10201912268UA (en) | 2016-08-05 | 2020-02-27 | Amgen Inc | Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof |
| WO2018038687A1 (en) | 2016-08-22 | 2018-03-01 | Mustafa Nevzat Ilaç Sanayii A.Ş. | Pharmaceutical formulations comprising a bortezomib-cyclodextrin complex |
| US10098890B2 (en) | 2016-10-29 | 2018-10-16 | Cipla Limited | Stable carfilzomib formulations |
| US11224631B2 (en) | 2017-01-24 | 2022-01-18 | Orbicular Pharmaceutical Technologies Pvt. Ltd. | Ready-to-use Carfilzomib compositions |
| US11401334B2 (en) | 2017-09-14 | 2022-08-02 | Glaxosmithkline Intellectual Property Development Limited | Combination treatment for cancer with anti-BCMA binding protein and proteosome inhibitor |
| CN120884714A (zh) | 2017-11-16 | 2025-11-04 | 美国安进公司 | 聚乙二醇化卡非佐米化合物的稳定的组合物 |
| US10537585B2 (en) | 2017-12-18 | 2020-01-21 | Dexcel Pharma Technologies Ltd. | Compositions comprising dexamethasone |
| WO2023220641A2 (en) | 2022-05-11 | 2023-11-16 | Juno Therapeutics, Inc. | Methods and uses related to t cell therapy and production of same |
| US20250302954A1 (en) | 2022-05-11 | 2025-10-02 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| EP4611798A1 (en) | 2022-11-02 | 2025-09-10 | Celgene Corporation | Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy |
| WO2025035020A2 (en) | 2023-08-09 | 2025-02-13 | Amgen Inc. | Methods of using carfilzomib |
| WO2025092827A1 (zh) * | 2023-10-30 | 2025-05-08 | 上海汇伦医药股份有限公司 | 一种环氧类化合物及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5135919A (en) * | 1988-01-19 | 1992-08-04 | Children's Medical Center Corporation | Method and a pharmaceutical composition for the inhibition of angiogenesis |
| US5441944A (en) * | 1989-04-23 | 1995-08-15 | The Trustees Of The University Of Pennsylvania | Substituted cyclodextrin sulfates and their uses as growth modulating agents |
| KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
| US5376645A (en) * | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| US5340736A (en) | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
| AU4499697A (en) | 1996-09-13 | 1998-04-02 | New York University | Method for treating parasitic diseases with proteasome inhibitors |
| US6046177A (en) * | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| US5874418A (en) * | 1997-05-05 | 1999-02-23 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use |
| US6133248A (en) * | 1997-06-13 | 2000-10-17 | Cydex, Inc. | Polar drug of prodrug compositions with extended shelf-life storage and a method of making thereof |
| US6831099B1 (en) | 1999-05-12 | 2004-12-14 | Yale University | Enzyme inhibition |
| CA2385958A1 (en) * | 1999-10-20 | 2001-04-26 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone and hair growth |
| EP1463719A2 (en) * | 2002-01-08 | 2004-10-06 | Eisai Co., Ltd | Eponemycin and epoxomicin analogs and uses thereof |
| EP1496916A2 (en) * | 2002-04-09 | 2005-01-19 | Greenville Hospital System | Metastasis modulating activity of highly sulfated oligosaccharides |
| US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
| US8129346B2 (en) * | 2004-04-15 | 2012-03-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| PT2030981E (pt) | 2004-05-10 | 2014-10-14 | Onyx Therapeutics Inc | Compostos para inibição da enzima proteassoma |
-
2005
- 2005-12-07 CN CN2012103747120A patent/CN102847136A/zh active Pending
- 2005-12-07 ES ES10179422.0T patent/ES2549763T3/es not_active Expired - Lifetime
- 2005-12-07 DE DE602005026556T patent/DE602005026556D1/de not_active Expired - Lifetime
- 2005-12-07 ES ES10178998T patent/ES2408216T3/es not_active Expired - Lifetime
- 2005-12-07 AT AT05853385T patent/ATE499109T1/de active
- 2005-12-07 JP JP2007544636A patent/JP4990155B2/ja not_active Expired - Lifetime
- 2005-12-07 WO PCT/US2005/044451 patent/WO2006063154A1/en not_active Ceased
- 2005-12-07 PL PL10178998T patent/PL2260835T3/pl unknown
- 2005-12-07 HU HUE10179422A patent/HUE027850T2/en unknown
- 2005-12-07 EP EP10179422.0A patent/EP2261236B1/en not_active Expired - Lifetime
- 2005-12-07 PT PT101794220T patent/PT2261236E/pt unknown
- 2005-12-07 EP EP05853385A patent/EP1819353B1/en not_active Expired - Lifetime
- 2005-12-07 CA CA2589921A patent/CA2589921C/en not_active Expired - Lifetime
- 2005-12-07 CN CNA2005800478775A patent/CN101180071A/zh active Pending
- 2005-12-07 PL PL10179422T patent/PL2261236T3/pl unknown
- 2005-12-07 KR KR1020077015316A patent/KR101299821B1/ko not_active Expired - Lifetime
- 2005-12-07 AU AU2005313975A patent/AU2005313975B2/en active Active
- 2005-12-07 DK DK05853385.2T patent/DK1819353T3/da active
- 2005-12-07 PL PL05853385T patent/PL1819353T3/pl unknown
- 2005-12-07 PT PT101789980T patent/PT2260835E/pt unknown
- 2005-12-07 US US11/299,265 patent/US7737112B2/en active Active
- 2005-12-07 PT PT05853385T patent/PT1819353E/pt unknown
- 2005-12-07 EP EP10178998A patent/EP2260835B1/en not_active Expired - Lifetime
-
2007
- 2007-05-31 IL IL183607A patent/IL183607A/en active IP Right Grant
-
2011
- 2011-04-21 CY CY20111100410T patent/CY1111489T1/el unknown
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