JP2008519969A - オーム抵抗の最小化を伴うマイクロ流体装置 - Google Patents
オーム抵抗の最小化を伴うマイクロ流体装置 Download PDFInfo
- Publication number
- JP2008519969A JP2008519969A JP2007540593A JP2007540593A JP2008519969A JP 2008519969 A JP2008519969 A JP 2008519969A JP 2007540593 A JP2007540593 A JP 2007540593A JP 2007540593 A JP2007540593 A JP 2007540593A JP 2008519969 A JP2008519969 A JP 2008519969A
- Authority
- JP
- Japan
- Prior art keywords
- microfluidic device
- microstructure
- electrochemical
- electrochemical microfluidic
- electrode
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims abstract description 51
- 238000012545 processing Methods 0.000 claims abstract description 24
- 239000000758 substrate Substances 0.000 claims description 59
- 239000000243 solution Substances 0.000 claims description 44
- 239000010410 layer Substances 0.000 claims description 34
- 239000000126 substance Substances 0.000 claims description 26
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 25
- 229910052737 gold Inorganic materials 0.000 claims description 25
- 239000010931 gold Substances 0.000 claims description 25
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 23
- 238000004458 analytical method Methods 0.000 claims description 23
- 238000005530 etching Methods 0.000 claims description 23
- 239000011247 coating layer Substances 0.000 claims description 21
- 229910052802 copper Inorganic materials 0.000 claims description 20
- 239000010949 copper Substances 0.000 claims description 20
- 229910052751 metal Inorganic materials 0.000 claims description 20
- 239000002184 metal Substances 0.000 claims description 20
- 229920000642 polymer Polymers 0.000 claims description 16
- 238000006243 chemical reaction Methods 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 7
- 108090000790 Enzymes Proteins 0.000 claims description 7
- 108091034117 Oligonucleotide Proteins 0.000 claims description 6
- 238000009713 electroplating Methods 0.000 claims description 6
- 239000011324 bead Substances 0.000 claims description 5
- 238000003486 chemical etching Methods 0.000 claims description 5
- 239000004020 conductor Substances 0.000 claims description 5
- 230000001900 immune effect Effects 0.000 claims description 5
- 239000012528 membrane Substances 0.000 claims description 5
- 229910052697 platinum Inorganic materials 0.000 claims description 5
- 239000012620 biological material Substances 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 238000005266 casting Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 230000005684 electric field Effects 0.000 claims description 3
- 238000004049 embossing Methods 0.000 claims description 3
- 238000001746 injection moulding Methods 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 238000001179 sorption measurement Methods 0.000 claims description 3
- 238000005251 capillar electrophoresis Methods 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000005611 electricity Effects 0.000 claims description 2
- 238000001962 electrophoresis Methods 0.000 claims description 2
- 238000003475 lamination Methods 0.000 claims description 2
- 238000001819 mass spectrum Methods 0.000 claims description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 2
- 238000001020 plasma etching Methods 0.000 claims description 2
- 238000005498 polishing Methods 0.000 claims description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 2
- 150000003573 thiols Chemical class 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims 11
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 238000012512 characterization method Methods 0.000 claims 2
- 238000009585 enzyme analysis Methods 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 239000000976 ink Substances 0.000 claims 1
- 238000001155 isoelectric focusing Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000000465 moulding Methods 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 239000007795 chemical reaction product Substances 0.000 abstract description 3
- 238000002848 electrochemical method Methods 0.000 abstract description 2
- 230000008569 process Effects 0.000 description 24
- 239000000463 material Substances 0.000 description 16
- 238000001514 detection method Methods 0.000 description 15
- 230000002829 reductive effect Effects 0.000 description 12
- 239000004642 Polyimide Substances 0.000 description 11
- -1 polyethylene Polymers 0.000 description 11
- 229920001721 polyimide Polymers 0.000 description 11
- 229910021607 Silver chloride Inorganic materials 0.000 description 10
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 10
- 238000005259 measurement Methods 0.000 description 9
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 8
- 239000012491 analyte Substances 0.000 description 8
- 239000011888 foil Substances 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 239000000523 sample Substances 0.000 description 7
- GPRSOIDYHMXAGW-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopentanecarboxylic acid iron Chemical compound [CH-]1[CH-][CH-][C-]([CH-]1)C(=O)O.[CH-]1C=CC=C1.[Fe] GPRSOIDYHMXAGW-UHFFFAOYSA-N 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 229910052709 silver Inorganic materials 0.000 description 6
- 239000004332 silver Substances 0.000 description 6
- 239000004698 Polyethylene Substances 0.000 description 5
- 229920000573 polyethylene Polymers 0.000 description 5
- 229920000139 polyethylene terephthalate Polymers 0.000 description 5
- 239000005020 polyethylene terephthalate Substances 0.000 description 5
- 239000011241 protective layer Substances 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
- 239000010452 phosphate Substances 0.000 description 4
- 230000002441 reversible effect Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 238000001039 wet etching Methods 0.000 description 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- 238000004026 adhesive bonding Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000002484 cyclic voltammetry Methods 0.000 description 3
- 238000007306 functionalization reaction Methods 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 238000010030 laminating Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 229920002120 photoresistant polymer Polymers 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000008929 regeneration Effects 0.000 description 3
- 238000011069 regeneration method Methods 0.000 description 3
- ZYPZVOKVDNSKLP-UHFFFAOYSA-N tris(4-aminophenyl) phosphate Chemical compound C1=CC(N)=CC=C1OP(=O)(OC=1C=CC(N)=CC=1)OC1=CC=C(N)C=C1 ZYPZVOKVDNSKLP-UHFFFAOYSA-N 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 229920000106 Liquid crystal polymer Polymers 0.000 description 2
- 239000004977 Liquid-crystal polymers (LCPs) Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 2
- 238000002679 ablation Methods 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000005829 chemical entities Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001312 dry etching Methods 0.000 description 2
- 238000000835 electrochemical detection Methods 0.000 description 2
- 238000002847 impedance measurement Methods 0.000 description 2
- 238000007373 indentation Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 239000002861 polymer material Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000005495 thyroid hormone Substances 0.000 description 2
- 229940036555 thyroid hormone Drugs 0.000 description 2
- 238000001075 voltammogram Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- FXZCCINCKDATPA-UHFFFAOYSA-N (4-aminophenyl) dihydrogen phosphate Chemical compound NC1=CC=C(OP(O)(O)=O)C=C1 FXZCCINCKDATPA-UHFFFAOYSA-N 0.000 description 1
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000012863 analytical testing Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 229920001940 conductive polymer Polymers 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 238000000635 electron micrograph Methods 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000003891 environmental analysis Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 238000001952 enzyme assay Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical compound [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000004375 physisorption Methods 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000002468 redox effect Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000006276 transfer reaction Methods 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004457 water analysis Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/53—Means to assemble or disassemble
- Y10T29/5313—Means to assemble electrical device
- Y10T29/532—Conductor
- Y10T29/53204—Electrode
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62705504P | 2004-11-12 | 2004-11-12 | |
| PCT/EP2005/012112 WO2006050972A1 (en) | 2004-11-12 | 2005-11-11 | Microfluidic device with minimised ohmic resistance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008519969A true JP2008519969A (ja) | 2008-06-12 |
| JP2008519969A5 JP2008519969A5 (enExample) | 2008-12-25 |
Family
ID=35503966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540593A Pending JP2008519969A (ja) | 2004-11-12 | 2005-11-11 | オーム抵抗の最小化を伴うマイクロ流体装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20070240986A1 (enExample) |
| EP (1) | EP1817576A1 (enExample) |
| JP (1) | JP2008519969A (enExample) |
| CN (1) | CN101057136A (enExample) |
| WO (1) | WO2006050972A1 (enExample) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| EP1404233B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
| CA2448790C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Electric lancet actuator |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| WO2004107975A2 (en) | 2003-05-30 | 2004-12-16 | Pelikan Technologies, Inc. | Method and apparatus for fluid injection |
| WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
| WO2005037095A1 (en) | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
| WO2005065414A2 (en) | 2003-12-31 | 2005-07-21 | Pelikan Technologies, Inc. | Method and apparatus for improving fluidic flow and sample capture |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| WO2006011062A2 (en) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Printable hydrogel for biosensors |
| WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
| GB0607205D0 (en) * | 2006-04-10 | 2006-05-17 | Diagnoswiss Sa | Miniaturised biosensor with optimized anperimetric detection |
| CN101558295A (zh) * | 2006-12-12 | 2009-10-14 | 皇家飞利浦电子股份有限公司 | 电化学传感器装置及其制造方法 |
| FR2922023A1 (fr) * | 2007-10-05 | 2009-04-10 | Univ Paris 7 Denis Diderot | Methode et installation de detection electrochimique d'un compose biologique |
| US20090242429A1 (en) * | 2008-01-07 | 2009-10-01 | Ravil Sitdikov | Electrochemical Biosensor |
| WO2009137129A2 (en) * | 2008-02-12 | 2009-11-12 | Stc.Unm | Rapid detection of anti-chromatin autoantibodies in human serum using a portable electrochemical biosensor |
| US7956571B2 (en) * | 2008-04-08 | 2011-06-07 | The Gillette Company | Method and apparatus for measuring electrochemical properties |
| WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
| WO2009140509A1 (en) * | 2008-05-14 | 2009-11-19 | The Board Of Trustees Of The University Of Illinois | Microcavity and microchannel plasma device arrays in a single, unitary sheet |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| US9222819B2 (en) * | 2009-02-20 | 2015-12-29 | University Of Southern California | Tracking and controlling fluid delivery from chamber |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US8940141B2 (en) | 2010-05-19 | 2015-01-27 | Lifescan Scotland Limited | Analytical test strip with an electrode having electrochemically active and inert areas of a predetermined size and distribution |
| EP2595753A1 (en) | 2010-07-22 | 2013-05-29 | Stichting voor de Technische Wetenschappen | Lab-on-a-chip device, for instance for use of the analysis of semen |
| CN101949946B (zh) * | 2010-09-03 | 2012-11-07 | 东华大学 | 一种三电极体系光电化学微流控检测芯片的制作方法 |
| CN102095770A (zh) * | 2010-11-22 | 2011-06-15 | 复旦大学 | 一种基于数字微流控技术的电化学传感器芯片 |
| CN103226127B (zh) * | 2013-03-27 | 2015-02-18 | 清华大学 | 一种多通道微流控芯片-质谱联用装置 |
| CN104132988A (zh) * | 2014-07-28 | 2014-11-05 | 南京邮电大学 | 一种柔性有机离子敏场效应晶体管的制备方法 |
| DE102014113482B4 (de) * | 2014-09-18 | 2019-01-03 | Bruker Daltonik Gmbh | Ionisierungskammer mit temperierter Gaszufuhr |
| CA2993401C (en) | 2014-10-28 | 2018-09-18 | The Governing Council Of The University Of Toronto | Electrochemical metabolic activity detecting device |
| CN104605837B (zh) * | 2014-12-23 | 2016-08-24 | 电子科技大学 | 一种基于微流体传感器的脉搏监测系统 |
| US9925319B2 (en) * | 2015-04-02 | 2018-03-27 | Purdue Research Foundation | Methods and apparatuses for impedance-based gas detection for microfluidic systems |
| KR102540664B1 (ko) | 2015-11-03 | 2023-06-08 | 삼성전자주식회사 | 바이오 센서 및 그의 센싱 방법 |
| WO2018010753A1 (en) * | 2016-07-15 | 2018-01-18 | Unisense A/S | Electrochemical sensor with thin film guard electrode |
| CN106861781B (zh) * | 2017-04-10 | 2023-04-11 | 黑龙江科技大学 | 一种基于表面纳米气泡降低流体阻力的微通道制备方法 |
| ES2942457T3 (es) | 2017-10-24 | 2023-06-01 | Hoffmann La Roche | Sensor electroquímico y procedimiento para producir el mismo |
| DE102018112258B4 (de) * | 2018-05-22 | 2023-01-05 | Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. | Akustofluidische bauelemente und verfahren zu ihrer herstellung |
| US20210333711A1 (en) * | 2018-08-14 | 2021-10-28 | The Board Of Trustees Of The University Of Illinois | Photoresist-free photolithography, photoprocessing tools, and methods with vuv or deep-uv lamps |
| CN115135766A (zh) * | 2020-02-21 | 2022-09-30 | 爱普群生生物技术公司 | 用于适体筛选的装置、方法和组合物 |
| CN113740400B (zh) * | 2021-08-18 | 2023-10-24 | 淮阴工学院 | 带有对称参比电极的封闭式双极电极阵列的分析检测装置 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11352093A (ja) * | 1998-06-11 | 1999-12-24 | Matsushita Electric Ind Co Ltd | バイオセンサ |
| JP2000097899A (ja) * | 1998-09-24 | 2000-04-07 | エヌ・ティ・ティ・アドバンステクノロジ株式会社 | 微少量オンラインバイオセンサー及びその製造方法 |
| JP2004219325A (ja) * | 2003-01-16 | 2004-08-05 | Ntt Advanced Technology Corp | 電気化学オンライン型バイオセンサ及びその製造方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09509485A (ja) * | 1994-02-09 | 1997-09-22 | アボツト・ラボラトリーズ | 診断用フローセルデバイス |
| US6338790B1 (en) * | 1998-10-08 | 2002-01-15 | Therasense, Inc. | Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator |
| GB0010957D0 (en) * | 2000-05-05 | 2000-06-28 | Novartis Ag | Compound & method |
| GB0103516D0 (en) * | 2001-02-13 | 2001-03-28 | Cole Polytechnique Federale De | Apparatus for dispensing a sample |
| US7037417B2 (en) * | 2001-03-19 | 2006-05-02 | Ecole Polytechnique Federale De Lausanne | Mechanical control of fluids in micro-analytical devices |
| GB0111438D0 (en) * | 2001-05-10 | 2001-07-04 | Cole Polytechnique Federale De | Polymer bonding by means of plasma activation |
| GB0116384D0 (en) * | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
| GB0121189D0 (en) * | 2001-08-31 | 2001-10-24 | Diagnoswiss Sa | Apparatus and method for separating an analyte |
| DE10234564B4 (de) * | 2002-07-25 | 2005-06-02 | Senslab-Gesellschaft Zur Entwicklung Und Herstellung Bioelektrochemischer Sensoren Mbh | Biosensor |
| GB0226160D0 (en) * | 2002-11-08 | 2002-12-18 | Diagnoswiss Sa | Apparatus for dispensing a sample in electrospray mass spectrometers |
| GB0300820D0 (en) * | 2003-01-14 | 2003-02-12 | Diagnoswiss Sa | Membrane-microchannel strip |
-
2005
- 2005-11-11 US US11/718,774 patent/US20070240986A1/en not_active Abandoned
- 2005-11-11 JP JP2007540593A patent/JP2008519969A/ja active Pending
- 2005-11-11 CN CN200580038765.3A patent/CN101057136A/zh active Pending
- 2005-11-11 EP EP05806366A patent/EP1817576A1/en not_active Withdrawn
- 2005-11-11 WO PCT/EP2005/012112 patent/WO2006050972A1/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11352093A (ja) * | 1998-06-11 | 1999-12-24 | Matsushita Electric Ind Co Ltd | バイオセンサ |
| JP2000097899A (ja) * | 1998-09-24 | 2000-04-07 | エヌ・ティ・ティ・アドバンステクノロジ株式会社 | 微少量オンラインバイオセンサー及びその製造方法 |
| JP2004219325A (ja) * | 2003-01-16 | 2004-08-05 | Ntt Advanced Technology Corp | 電気化学オンライン型バイオセンサ及びその製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20070240986A1 (en) | 2007-10-18 |
| CN101057136A (zh) | 2007-10-17 |
| EP1817576A1 (en) | 2007-08-15 |
| WO2006050972A1 (en) | 2006-05-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008519969A (ja) | オーム抵抗の最小化を伴うマイクロ流体装置 | |
| US20090178935A1 (en) | Miniaturised Biosensor with Optimized Amperometric Detection | |
| US8354012B2 (en) | Electrochemical cell | |
| US6548311B1 (en) | Device and method for detecting analytes | |
| US20060141469A1 (en) | Multi-layered electrochemical microfluidic sensor comprising reagent on porous layer | |
| Suzuki | Advances in the microfabrication of electrochemical sensors and systems | |
| Bratten et al. | Micromachining sensors for electrochemical measurement in subnanoliter volumes | |
| JP4216712B2 (ja) | マイクロ流体式化学検定装置および方法 | |
| JP4777659B2 (ja) | 集積化固相親水性マトリクス回路およびマイクロ・アレイ | |
| Suzuki et al. | An integrated three-electrode system with a micromachined liquid-junction Ag/AgCl reference electrode | |
| US20060207877A1 (en) | Microfluidic device with various surface properties fabricated in multilayer body by plasma etching | |
| KR100563834B1 (ko) | 미세유체 채널이 집적화된 3차원 전극시스템 | |
| US7988839B2 (en) | Capillary electrophoresis systems and methods | |
| CN111051885A (zh) | 检测系统及生产方法 | |
| JP7362197B2 (ja) | プログラム可能な検知キャビティを有するバイオセンサ | |
| Roussel et al. | Amperometric techniques | |
| JP2009092514A (ja) | 試料液分析チップ、および試料液の移送制御方法 | |
| CN117741117A (zh) | 生物感测芯片、生物感测芯片制造方法及微流道系统 | |
| EP3812042A1 (en) | Ewod device with sensing apparatus | |
| Gao | Microfabricated devices for single cell analysis | |
| Li | Thomas J. Roussel 2, 4 Contact Information, Douglas J. Jackson 3 Contact Information, Richard P. Baldwin 4 Contact Information and Robert S. Keynton 2 Contact Information | |
| GB2436145A (en) | A system for monitoring properties of a single cell | |
| HK1073887A1 (zh) | 一种用於样品电化学分析的传感器和制作方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081110 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20081110 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111206 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120508 |