JP2008519035A5 - - Google Patents

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Publication number
JP2008519035A5
JP2008519035A5 JP2007540055A JP2007540055A JP2008519035A5 JP 2008519035 A5 JP2008519035 A5 JP 2008519035A5 JP 2007540055 A JP2007540055 A JP 2007540055A JP 2007540055 A JP2007540055 A JP 2007540055A JP 2008519035 A5 JP2008519035 A5 JP 2008519035A5
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JP
Japan
Prior art keywords
group
hydrogen atom
hydroxy
carbonyl
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007540055A
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English (en)
Japanese (ja)
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JP2008519035A (ja
JP5198067B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/039911 external-priority patent/WO2006052710A1/en
Publication of JP2008519035A publication Critical patent/JP2008519035A/ja
Publication of JP2008519035A5 publication Critical patent/JP2008519035A5/ja
Application granted granted Critical
Publication of JP5198067B2 publication Critical patent/JP5198067B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007540055A 2004-11-05 2005-11-03 ４−ヒドロキシベンゾモルファン Expired - Lifetime JP5198067B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62534804P 2004-11-05 2004-11-05
US60/625,348 2004-11-05
PCT/US2005/039911 WO2006052710A1 (en) 2004-11-05 2005-11-03 4-hydroxybenzomorphans

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012256445A Division JP6058981B2 (ja) 2004-11-05 2012-11-22 ４−ヒドロキシベンゾモルファン

Publications (3)

Publication Number Publication Date
JP2008519035A JP2008519035A (ja) 2008-06-05
JP2008519035A5 true JP2008519035A5 (https=) 2008-11-13
JP5198067B2 JP5198067B2 (ja) 2013-05-15

Family

ID=36128632

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007540055A Expired - Lifetime JP5198067B2 (ja) 2004-11-05 2005-11-03 ４−ヒドロキシベンゾモルファン
JP2012256445A Expired - Lifetime JP6058981B2 (ja) 2004-11-05 2012-11-22 ４−ヒドロキシベンゾモルファン
JP2015159733A Pending JP2016020364A (ja) 2004-11-05 2015-08-12 ４−ヒドロキシベンゾモルファン

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012256445A Expired - Lifetime JP6058981B2 (ja) 2004-11-05 2012-11-22 ４−ヒドロキシベンゾモルファン
JP2015159733A Pending JP2016020364A (ja) 2004-11-05 2015-08-12 ４−ヒドロキシベンゾモルファン

Country Status (20)

Country Link
US (7) US7262298B2 (https=)
EP (2) EP2251330B1 (https=)
JP (3) JP5198067B2 (https=)
KR (1) KR101115841B1 (https=)
CN (1) CN101090891B (https=)
AT (1) ATE557006T1 (https=)
AU (1) AU2005304950B2 (https=)
BR (1) BRPI0517091B8 (https=)
CA (1) CA2587074C (https=)
CY (1) CY1112946T1 (https=)
DK (1) DK2251330T3 (https=)
ES (1) ES2387737T3 (https=)
IL (1) IL182983A (https=)
MX (1) MX2007005389A (https=)
NO (1) NO340204B1 (https=)
PL (1) PL2251330T3 (https=)
PT (1) PT2251330E (https=)
RU (2) RU2480455C2 (https=)
SI (1) SI2251330T1 (https=)
WO (1) WO2006052710A1 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002227135B2 (en) * 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
ES2387737T3 (es) * 2004-11-05 2012-10-01 Rensselaer Polytechnic Institute 4-Hidroxibenzomorfanos
JP5266051B2 (ja) 2005-07-21 2013-08-21 レンセラール ポリテクニック インスティチュート 大きい置換基を有する非フェノール性オピオイド
CA2637610A1 (en) 2007-05-04 2008-11-04 Mallinckrodt Inc. Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
CA2693436A1 (en) 2007-07-17 2009-01-22 Christopher W. Grote Preparation of n-alkylated opiates by reductive amination
CN101827819B (zh) 2007-08-09 2013-06-12 伦斯勒理工学院 阿片样物质酰胺季铵盐
CN102227434B (zh) 2008-09-30 2015-02-18 马林克罗特有限公司 选择性胺化酮吗啡喃的方法
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP3170395A1 (en) * 2009-03-19 2017-05-24 Alkermes Pharma Ireland Limited Morphinan derivatives with high oral bioavailability
US20100261906A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of 6-Keto, 3-Alkoxy Morphinans
PL2440562T3 (pl) 2009-06-11 2017-07-31 Mallinckrodt Llc Otrzymywanie 6-alfa-amino-N-podstawionych morfinanów w wyniku katalitycznego przeniesienia wodoru
EP2440561B1 (en) 2009-06-11 2014-04-30 Mallinckrodt LLC Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
TR201908514T4 (tr) * 2009-12-04 2019-07-22 Alkermes Pharma Ireland Ltd İlaç doz aşimi tedavi̇si̇ i̇çi̇n morfi̇nan türevleri̇
US8436175B2 (en) 2010-03-22 2013-05-07 Rensselaer Polytechnic Institute Carboxamide bioisosteres of opiates
WO2011137086A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Llc Preparation of saturated ketone morphinan compounds having low metal content
CA2804940C (en) 2010-07-08 2017-03-07 Alkermes Pharma Ireland Limited Process for the synthesis of substituted morphinans
US8778960B2 (en) * 2010-08-23 2014-07-15 Alkermes Pharma Ireland Limited Methods for treating antipsychotic-induced weight gain
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EP2718294B1 (en) 2011-06-09 2018-09-05 SpecGx LLC Reductive amination of 6-keto morphinans by catalytic hydrogen transfer
WO2013003720A1 (en) 2011-06-29 2013-01-03 Alkermes, Inc. Peripherally acting opioid compounds
CN103917543A (zh) 2011-09-08 2014-07-09 马林克罗特有限公司 在不分离中间体的情况下制备生物碱
LT3153171T (lt) 2011-12-15 2018-12-10 Alkermes Pharma Ireland Limited Samidorfanas (alks 33) derinyje su buprenorfinu, skirtas depresinių sutrikimų gydymui
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
ES2770978T3 (es) 2013-05-24 2020-07-06 Alkermes Pharma Ireland Ltd Análogos de morfanos y morfinanos y métodos de uso
CN110352055A (zh) * 2017-03-02 2019-10-18 株式会社三和化学研究所 酒精使用障碍的治疗药物
CN107089948B (zh) * 2017-04-28 2020-07-17 云南大学 吗吩衍生物及其制备方法和应用
CN111978252A (zh) * 2019-05-21 2020-11-24 复旦大学 手性苯并吗吩烷类衍生物及其制备方法和在药学上的应用
TW202140009A (zh) * 2020-02-13 2021-11-01 大陸商上海翰森生物醫藥科技有限公司 ３－甲醯胺基－４－羥基納曲酮氘代衍生物、其製備方法及其在醫藥上的應用
CN111205151B (zh) * 2020-02-29 2021-03-05 深圳市祥根生物科技有限公司 一种布洛芬杂质i的环保制备方法
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet
CN114621238B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种制备纳呋拉啡的方法
KR102663533B1 (ko) * 2021-11-09 2024-05-08 백미선 레이저 치료기기용 온냉각장치

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US3957793A (en) * 1974-09-20 1976-05-18 Sterling Drug Inc. Hydroxyiminobenzazocines
SU635868A3 (ru) * 1974-11-12 1978-11-30 Бристол Мейерз Компани (Фирма) Способ получени морфиновых производных или их солей
US4205171A (en) * 1976-01-12 1980-05-27 Sterling Drug Inc. Aminomethanobenzazocines and nitromethanobenzazocines
US4373139A (en) * 1979-04-30 1983-02-08 Motorola, Inc. Detectors
US4649200A (en) * 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
EP0632041A1 (en) 1993-07-01 1995-01-04 Katholieke Universiteit Nijmegen New morphine derivatives having improved analgesic and narcotic properties
ATE229958T1 (de) 1996-01-10 2003-01-15 Glaxosmithkline Spa Heterocyclische kondensierte morphin-derivate
AU2002227135B2 (en) * 2000-10-31 2008-01-03 Rensselaer Polytechnic Institute 8- substituted-2, 6-methano-3-benzazocines and 3-substituted morphinanes as opioid receptor binding agents
WO2004007449A1 (en) 2002-07-16 2004-01-22 Rensselaer Polytechnic Institute Process for conversion of phenols to carboxamides via the succinimide esters
ES2387737T3 (es) * 2004-11-05 2012-10-01 Rensselaer Polytechnic Institute 4-Hidroxibenzomorfanos

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