JP2008519035A5 - - Google Patents

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Publication number
JP2008519035A5
JP2008519035A5 JP2007540055A JP2007540055A JP2008519035A5 JP 2008519035 A5 JP2008519035 A5 JP 2008519035A5 JP 2007540055 A JP2007540055 A JP 2007540055A JP 2007540055 A JP2007540055 A JP 2007540055A JP 2008519035 A5 JP2008519035 A5 JP 2008519035A5
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JP
Japan
Prior art keywords
group
hydrogen atom
hydroxy
carbonyl
lower alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007540055A
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English (en)
Japanese (ja)
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JP5198067B2 (ja
JP2008519035A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2005/039911 external-priority patent/WO2006052710A1/en
Publication of JP2008519035A publication Critical patent/JP2008519035A/ja
Publication of JP2008519035A5 publication Critical patent/JP2008519035A5/ja
Application granted granted Critical
Publication of JP5198067B2 publication Critical patent/JP5198067B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2007540055A 2004-11-05 2005-11-03 ４−ヒドロキシベンゾモルファン Expired - Lifetime JP5198067B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62534804P 2004-11-05 2004-11-05
US60/625,348 2004-11-05
PCT/US2005/039911 WO2006052710A1 (en) 2004-11-05 2005-11-03 4-hydroxybenzomorphans

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012256445A Division JP6058981B2 (ja) 2004-11-05 2012-11-22 ４−ヒドロキシベンゾモルファン

Publications (3)

Publication Number Publication Date
JP2008519035A JP2008519035A (ja) 2008-06-05
JP2008519035A5 true JP2008519035A5 (https=) 2008-11-13
JP5198067B2 JP5198067B2 (ja) 2013-05-15

Family

ID=36128632

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2007540055A Expired - Lifetime JP5198067B2 (ja) 2004-11-05 2005-11-03 ４−ヒドロキシベンゾモルファン
JP2012256445A Expired - Lifetime JP6058981B2 (ja) 2004-11-05 2012-11-22 ４−ヒドロキシベンゾモルファン
JP2015159733A Pending JP2016020364A (ja) 2004-11-05 2015-08-12 ４−ヒドロキシベンゾモルファン

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2012256445A Expired - Lifetime JP6058981B2 (ja) 2004-11-05 2012-11-22 ４−ヒドロキシベンゾモルファン
JP2015159733A Pending JP2016020364A (ja) 2004-11-05 2015-08-12 ４−ヒドロキシベンゾモルファン

Country Status (20)

Country Link
US (7) US7262298B2 (https=)
EP (2) EP2251330B1 (https=)
JP (3) JP5198067B2 (https=)
KR (1) KR101115841B1 (https=)
CN (1) CN101090891B (https=)
AT (1) ATE557006T1 (https=)
AU (1) AU2005304950B2 (https=)
BR (1) BRPI0517091B8 (https=)
CA (1) CA2587074C (https=)
CY (1) CY1112946T1 (https=)
DK (1) DK2251330T3 (https=)
ES (1) ES2387737T3 (https=)
IL (1) IL182983A (https=)
MX (1) MX2007005389A (https=)
NO (1) NO340204B1 (https=)
PL (1) PL2251330T3 (https=)
PT (1) PT2251330E (https=)
RU (2) RU2480455C2 (https=)
SI (1) SI2251330T1 (https=)
WO (1) WO2006052710A1 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4340437B2 (ja) 2000-10-31 2009-10-07 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
PT2251330E (pt) * 2004-11-05 2012-07-20 Rensselaer Polytech Inst 4-hidroxibenzomorfanos
WO2007014137A2 (en) 2005-07-21 2007-02-01 Rensselaer Polytechnic Institute 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents
ES2407033T3 (es) 2007-05-04 2013-06-11 Mallinckrodt Llc Procedimientos mejorados para la preparación de opiáceos 6-alfa-hidroxi-n-alquilados
JP2010533719A (ja) 2007-07-17 2010-10-28 マリンクロッド・インコーポレイテッド 還元的アミノ化によるｎ−アルキル化オピエートの調製
AU2008286979B2 (en) 2007-08-09 2013-03-28 Rensselaer Polytechnic Institute Quaternary opioid carboxamides
NZ607842A (en) 2008-09-30 2013-12-20 Mallinckrodt Llc Processes for the selective amination of ketomorphinans
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
EP2408303A4 (en) * 2009-03-19 2012-07-25 Alkermes Inc MORPHINANE DERIVATIVES HAVING HIGH ORAL BIOLOGICAL AVAILABILITY
US20100261906A1 (en) * 2009-04-09 2010-10-14 Mallinckrodt Inc. Preparation of 6-Keto, 3-Alkoxy Morphinans
US8519133B2 (en) 2009-06-11 2013-08-27 Mallinckrodt Llc Preparation of 6-alpha-amino N-substituted morphinans by catalytic hydrogen transfer
US8471023B2 (en) 2009-06-11 2013-06-25 Mallinckrodt Llc Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer
US9119848B2 (en) * 2009-12-04 2015-09-01 Alkermes Pharma Ireland Limited Morphinan derivatives for the treatment of drug overdose
AU2011232628B2 (en) 2010-03-22 2015-04-09 Rensselaer Polytechnic Institute Morphinane derivatives containing a carboxamide group as opioid receptor ligands
PL2563793T3 (pl) * 2010-04-29 2015-03-31 SpecGx LLC Wytwarzanie nasyconych związków ketonowych morfinanu o niskiej zawartości metalu
JP5728084B2 (ja) 2010-07-08 2015-06-03 アルカーメス ファーマ アイルランド リミテッド 置換モルフィナンの合成のための方法
HUE065427T2 (hu) * 2010-08-23 2024-05-28 Alkermes Pharma Ireland Ltd Eljárások antipszichotikum által indukált súlygyarapodás kezelésére
US9029543B2 (en) 2011-04-05 2015-05-12 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
KR20140036215A (ko) 2011-06-09 2014-03-25 말린크로트 엘엘씨 촉매 수소 전달에 의한 6-케토 모르피난의 환원 아미노화
SMT201700400T1 (it) 2011-06-29 2017-09-07 Alkermes Inc Composti oppioidi ad azione periferica
MX2014002630A (es) 2011-09-08 2014-04-14 Mallinckrodt Llc Produccion de alcaloides sin el aislamiento de compuestos intermediarios.
MX375348B (es) 2011-12-15 2025-03-06 Alkermes Pharma Ireland Ltd Composiciones de la buprenorfina y antagonistas de los receptores opioide-mu.
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
CA2911231C (en) 2013-05-24 2021-12-07 Alkermes Pharma Ireland Limited Morphan and morphinan analogues, and methods of use
JPWO2018159716A1 (ja) * 2017-03-02 2019-12-26 株式会社三和化学研究所 アルコール使用障害の治療薬
CN107089948B (zh) * 2017-04-28 2020-07-17 云南大学 吗吩衍生物及其制备方法和应用
CN111978252A (zh) * 2019-05-21 2020-11-24 复旦大学 手性苯并吗吩烷类衍生物及其制备方法和在药学上的应用
TW202140009A (zh) * 2020-02-13 2021-11-01 大陸商上海翰森生物醫藥科技有限公司 ３－甲醯胺基－４－羥基納曲酮氘代衍生物、其製備方法及其在醫藥上的應用
CN111205151B (zh) * 2020-02-29 2021-03-05 深圳市祥根生物科技有限公司 一种布洛芬杂质i的环保制备方法
WO2022101444A1 (en) 2020-11-12 2022-05-19 Alkermes Pharma Ireland Limited Immediate release multilayer tablet
CN114621238B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种制备纳呋拉啡的方法
KR102663533B1 (ko) * 2021-11-09 2024-05-08 백미선 레이저 치료기기용 온냉각장치

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US3957793A (en) 1974-09-20 1976-05-18 Sterling Drug Inc. Hydroxyiminobenzazocines
US4032529A (en) 1974-09-20 1977-06-28 Sterling Drug Inc. Aminomethanobenzazocine intermediates
SU635868A3 (ru) * 1974-11-12 1978-11-30 Бристол Мейерз Компани (Фирма) Способ получени морфиновых производных или их солей
US4205171A (en) 1976-01-12 1980-05-27 Sterling Drug Inc. Aminomethanobenzazocines and nitromethanobenzazocines
US4373139A (en) 1979-04-30 1983-02-08 Motorola, Inc. Detectors
US4649200A (en) 1986-05-08 1987-03-10 Regents Of The University Of Minnesota Substituted pyrroles with opioid receptor activity
EP0632041A1 (en) 1993-07-01 1995-01-04 Katholieke Universiteit Nijmegen New morphine derivatives having improved analgesic and narcotic properties
BR9707136A (pt) 1996-01-10 1999-08-31 Smithkline Beecham Spa Derivados morfinóides condesados em heterociclo (ii)
JP4340437B2 (ja) * 2000-10-31 2009-10-07 レンセラール ポリテクニック インスティチュート ８−カルボキサミド−２，６−メタノ−３−ベンズアゾシン
AU2003281060A1 (en) 2002-07-16 2004-02-02 Rensselaer Polytechnic Institute Process for conversion of phenols to carboxamides via the succinimide esters
PT2251330E (pt) * 2004-11-05 2012-07-20 Rensselaer Polytech Inst 4-hidroxibenzomorfanos

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