JP2008519035A5 - - Google Patents
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- Publication number
- JP2008519035A5 JP2008519035A5 JP2007540055A JP2007540055A JP2008519035A5 JP 2008519035 A5 JP2008519035 A5 JP 2008519035A5 JP 2007540055 A JP2007540055 A JP 2007540055A JP 2007540055 A JP2007540055 A JP 2007540055A JP 2008519035 A5 JP2008519035 A5 JP 2008519035A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen atom
- hydroxy
- carbonyl
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- KIBALXBELNWKRK-UHFFFAOYSA-N CN(CC1)C(Cc2ccc3C(N)=O)C(CCC(C4)=O)C14c2c3O Chemical compound CN(CC1)C(Cc2ccc3C(N)=O)C(CCC(C4)=O)C14c2c3O KIBALXBELNWKRK-UHFFFAOYSA-N 0.000 description 1
- SIIKUSQIIPEOEA-UHFFFAOYSA-N NC(c1ccc(CC2N(CC3CCC3)CCC3(CC(CC4)=O)C24O)c3c1O)=O Chemical compound NC(c1ccc(CC2N(CC3CCC3)CCC3(CC(CC4)=O)C24O)c3c1O)=O SIIKUSQIIPEOEA-UHFFFAOYSA-N 0.000 description 1
- NWIALXFYKPFWTR-UHFFFAOYSA-N NC(c1ccc(CC2N(CC3CCC3)CCC3(CC(CC4)O)C24O)c3c1O)=O Chemical compound NC(c1ccc(CC2N(CC3CCC3)CCC3(CC(CC4)O)C24O)c3c1O)=O NWIALXFYKPFWTR-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62534804P | 2004-11-05 | 2004-11-05 | |
| US60/625,348 | 2004-11-05 | ||
| PCT/US2005/039911 WO2006052710A1 (en) | 2004-11-05 | 2005-11-03 | 4-hydroxybenzomorphans |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256445A Division JP6058981B2 (ja) | 2004-11-05 | 2012-11-22 | ４−ヒドロキシベンゾモルファン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008519035A JP2008519035A (ja) | 2008-06-05 |
| JP2008519035A5 true JP2008519035A5 (cg-RX-API-DMAC10.html) | 2008-11-13 |
| JP5198067B2 JP5198067B2 (ja) | 2013-05-15 |
Family
ID=36128632
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007540055A Expired - Lifetime JP5198067B2 (ja) | 2004-11-05 | 2005-11-03 | ４−ヒドロキシベンゾモルファン |
| JP2012256445A Expired - Lifetime JP6058981B2 (ja) | 2004-11-05 | 2012-11-22 | ４−ヒドロキシベンゾモルファン |
| JP2015159733A Pending JP2016020364A (ja) | 2004-11-05 | 2015-08-12 | ４−ヒドロキシベンゾモルファン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256445A Expired - Lifetime JP6058981B2 (ja) | 2004-11-05 | 2012-11-22 | ４−ヒドロキシベンゾモルファン |
| JP2015159733A Pending JP2016020364A (ja) | 2004-11-05 | 2015-08-12 | ４−ヒドロキシベンゾモルファン |
Country Status (20)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE292625T1 (de) * | 2000-10-31 | 2005-04-15 | Rensselaer Polytech Inst | 8-substituierte 2,6-methano-3-benzazocine und 3- substituierte morphinane als opioidrezeptorbindende agenzien |
| US7262298B2 (en) * | 2004-11-05 | 2007-08-28 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphans |
| AU2006272773B2 (en) | 2005-07-21 | 2012-03-08 | Rensselaer Polytechnic Institute | 8-carboxamido-substituted-2 , 6-methano-3-benzazocines and 3 - carboxamido- substituted morphanes as opioid receptor binding agents |
| ATE493416T1 (de) | 2007-05-04 | 2011-01-15 | Mallinckrodt Inc | Verbessertes verfahren zur herstellung von 6- alpha-hydroxy-n-alkylierten opiaten |
| JP2010533719A (ja) | 2007-07-17 | 2010-10-28 | マリンクロッド・インコーポレイテッド | 還元的アミノ化によるｎ−アルキル化オピエートの調製 |
| WO2009023567A1 (en) | 2007-08-09 | 2009-02-19 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
| CA2738628C (en) | 2008-09-30 | 2017-07-04 | Mallinckrodt Inc. | Processes for the selective amination of ketomorphinans |
| US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
| WO2010107457A1 (en) * | 2009-03-19 | 2010-09-23 | Alkermes, Inc. | Morphinan derivatives with high oral bioavailability |
| WO2010118274A1 (en) * | 2009-04-09 | 2010-10-14 | Mallinckrodt Inc. | Preparation of 6-keto, 3-alkoxy morphinans |
| US8471023B2 (en) | 2009-06-11 | 2013-06-25 | Mallinckrodt Llc | Reductive amination of 6-keto normorphinans by catalytic hydrogen transfer |
| CA2764915C (en) | 2009-06-11 | 2017-07-11 | Mallinckrodt Llc | Preparation of 6-alpha-amino n-substituted morphinans by catalytic hydrogen transfer |
| HUE043963T2 (hu) * | 2009-12-04 | 2019-09-30 | Alkermes Pharma Ireland Ltd | Morfinán származékok gyógyszer-túladagolás kezelésére |
| WO2011119605A2 (en) | 2010-03-22 | 2011-09-29 | Rensselaer Polytechnic Institute | Carboxamide biosiosteres of opiates |
| WO2011137086A1 (en) * | 2010-04-29 | 2011-11-03 | Mallinckrodt Llc | Preparation of saturated ketone morphinan compounds having low metal content |
| WO2012005795A1 (en) | 2010-07-08 | 2012-01-12 | Alkermes, Inc. | Process for the synthesis of substituted morphinans |
| EP2608670B1 (en) | 2010-08-23 | 2018-10-31 | Alkermes Pharma Ireland Limited | Methods for treating antipsychotic-induced weight gain |
| US9029543B2 (en) | 2011-04-05 | 2015-05-12 | Alkermes, Inc. | Process for the synthesis of quaternary amine compounds |
| ES2698408T3 (es) | 2011-06-09 | 2019-02-04 | SpecGx LLC | Aminación reductora de 6-ceto morfinanos por transferencia de hidrógeno catalítico |
| CA2840643C (en) | 2011-06-29 | 2017-11-21 | Alkermes, Inc. | Peripherally acting opioid compounds |
| KR20140063763A (ko) | 2011-09-08 | 2014-05-27 | 말린크로트 엘엘씨 | 중간체를 단리하지 않는 알칼로이드의 제조 방법 |
| SMT201800664T1 (it) | 2011-12-15 | 2019-01-11 | Alkermes Pharma Ireland Ltd | Samidorphan (alks 33) in combinazione con buprenorfina per il trattamento di disturbi depressivi |
| US9211293B2 (en) | 2011-12-15 | 2015-12-15 | Alkermes Pharma Ireland Limited | Opioid agonist antagonist combinations |
| ES2770978T3 (es) | 2013-05-24 | 2020-07-06 | Alkermes Pharma Ireland Ltd | Análogos de morfanos y morfinanos y métodos de uso |
| US9656961B2 (en) | 2013-05-24 | 2017-05-23 | Alkermes Pharma Ireland Limited | Methods for treating depressive symptoms |
| KR20190120212A (ko) * | 2017-03-02 | 2019-10-23 | 가부시키가이샤산와카가쿠켄큐쇼 | 알코올 사용 장해의 치료약 |
| CN107089948B (zh) * | 2017-04-28 | 2020-07-17 | 云南大学 | 吗吩衍生物及其制备方法和应用 |
| CN111978252A (zh) * | 2019-05-21 | 2020-11-24 | 复旦大学 | 手性苯并吗吩烷类衍生物及其制备方法和在药学上的应用 |
| TW202140009A (zh) * | 2020-02-13 | 2021-11-01 | 大陸商上海翰森生物醫藥科技有限公司 | ３－甲醯胺基－４－羥基納曲酮氘代衍生物、其製備方法及其在醫藥上的應用 |
| CN111205151B (zh) * | 2020-02-29 | 2021-03-05 | 深圳市祥根生物科技有限公司 | 一种布洛芬杂质i的环保制备方法 |
| WO2022101444A1 (en) | 2020-11-12 | 2022-05-19 | Alkermes Pharma Ireland Limited | Immediate release multilayer tablet |
| CN114621238B (zh) * | 2020-12-10 | 2026-02-03 | 鲁南制药集团股份有限公司 | 一种制备纳呋拉啡的方法 |
| KR102663533B1 (ko) * | 2021-11-09 | 2024-05-08 | 백미선 | 레이저 치료기기용 온냉각장치 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957793A (en) * | 1974-09-20 | 1976-05-18 | Sterling Drug Inc. | Hydroxyiminobenzazocines |
| US4032529A (en) * | 1974-09-20 | 1977-06-28 | Sterling Drug Inc. | Aminomethanobenzazocine intermediates |
| SU635868A3 (ru) * | 1974-11-12 | 1978-11-30 | Бристол Мейерз Компани (Фирма) | Способ получени морфиновых производных или их солей |
| US4205171A (en) * | 1976-01-12 | 1980-05-27 | Sterling Drug Inc. | Aminomethanobenzazocines and nitromethanobenzazocines |
| US4373139A (en) * | 1979-04-30 | 1983-02-08 | Motorola, Inc. | Detectors |
| US4649200A (en) * | 1986-05-08 | 1987-03-10 | Regents Of The University Of Minnesota | Substituted pyrroles with opioid receptor activity |
| EP0632041A1 (en) | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| HUP9900974A3 (en) | 1996-01-10 | 2000-09-28 | Smithkline Beecham Spa | Heterocycle-condensed morphinoid derivatives, process for the preparation thereof, their use and pharmaceutical compositions containing them |
| ATE292625T1 (de) * | 2000-10-31 | 2005-04-15 | Rensselaer Polytech Inst | 8-substituierte 2,6-methano-3-benzazocine und 3- substituierte morphinane als opioidrezeptorbindende agenzien |
| WO2004007449A1 (en) * | 2002-07-16 | 2004-01-22 | Rensselaer Polytechnic Institute | Process for conversion of phenols to carboxamides via the succinimide esters |
| US7262298B2 (en) * | 2004-11-05 | 2007-08-28 | Rensselaer Polytechnic Institute | 4-hydroxybenzomorphans |
-
2005
- 2005-11-03 US US11/266,651 patent/US7262298B2/en not_active Expired - Lifetime
- 2005-11-03 JP JP2007540055A patent/JP5198067B2/ja not_active Expired - Lifetime
- 2005-11-03 EP EP10008474A patent/EP2251330B1/en not_active Expired - Lifetime
- 2005-11-03 EP EP05851351A patent/EP1817291A1/en not_active Withdrawn
- 2005-11-03 AU AU2005304950A patent/AU2005304950B2/en not_active Expired
- 2005-11-03 BR BRPI0517091A patent/BRPI0517091B8/pt active IP Right Grant
- 2005-11-03 PT PT10008474T patent/PT2251330E/pt unknown
- 2005-11-03 CA CA2587074A patent/CA2587074C/en not_active Expired - Lifetime
- 2005-11-03 AT AT10008474T patent/ATE557006T1/de active
- 2005-11-03 WO PCT/US2005/039911 patent/WO2006052710A1/en not_active Ceased
- 2005-11-03 CN CN2005800451698A patent/CN101090891B/zh not_active Expired - Lifetime
- 2005-11-03 KR KR1020077012582A patent/KR101115841B1/ko not_active Expired - Lifetime
- 2005-11-03 MX MX2007005389A patent/MX2007005389A/es active IP Right Grant
- 2005-11-03 PL PL10008474T patent/PL2251330T3/pl unknown
- 2005-11-03 DK DK10008474.8T patent/DK2251330T3/da active
- 2005-11-03 RU RU2007120759/04A patent/RU2415131C2/ru active
- 2005-11-03 RU RU2010147915/04A patent/RU2480455C2/ru active
- 2005-11-03 SI SI200531549T patent/SI2251330T1/sl unknown
- 2005-11-03 ES ES10008474T patent/ES2387737T3/es not_active Expired - Lifetime
-
2007
- 2007-05-03 IL IL182983A patent/IL182983A/en active IP Right Grant
- 2007-06-04 NO NO20072839A patent/NO340204B1/no unknown
- 2007-06-08 US US11/760,039 patent/US8680112B2/en active Active
-
2012
- 2012-07-31 CY CY20121100677T patent/CY1112946T1/el unknown
- 2012-11-22 JP JP2012256445A patent/JP6058981B2/ja not_active Expired - Lifetime
-
2013
- 2013-04-15 US US13/862,975 patent/US20130231361A1/en not_active Abandoned
-
2014
- 2014-01-31 US US14/169,305 patent/US8802655B2/en not_active Expired - Lifetime
- 2014-07-02 US US14/321,885 patent/US20150011768A1/en not_active Abandoned
-
2015
- 2015-04-27 US US14/697,013 patent/US20160075658A1/en not_active Abandoned
- 2015-08-12 JP JP2015159733A patent/JP2016020364A/ja active Pending
-
2023
- 2023-04-17 US US18/301,336 patent/US20240092740A1/en not_active Abandoned
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