JP2008518053A5 - - Google Patents
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- JP2008518053A5 JP2008518053A5 JP2007538132A JP2007538132A JP2008518053A5 JP 2008518053 A5 JP2008518053 A5 JP 2008518053A5 JP 2007538132 A JP2007538132 A JP 2007538132A JP 2007538132 A JP2007538132 A JP 2007538132A JP 2008518053 A5 JP2008518053 A5 JP 2008518053A5
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- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 26
- -1 N-methylpropiolamido Chemical group 0.000 claims 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 7
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 239000001301 oxygen Chemical group 0.000 claims 7
- 229920006395 saturated elastomer Polymers 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 239000011593 sulfur Substances 0.000 claims 7
- 150000001412 amines Chemical class 0.000 claims 6
- 125000002619 bicyclic group Chemical group 0.000 claims 3
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 150000003573 thiols Chemical class 0.000 claims 3
- LSBDFXRDZJMBSC-UHFFFAOYSA-N 2-phenylacetamide Chemical compound NC(=O)CC1=CC=CC=C1 LSBDFXRDZJMBSC-UHFFFAOYSA-N 0.000 claims 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 2
- WCGGWVOVFQNRRS-UHFFFAOYSA-N dichloroacetamide Chemical compound NC(=O)C(Cl)Cl WCGGWVOVFQNRRS-UHFFFAOYSA-N 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims 2
- UPQQXPKAYZYUKO-UHFFFAOYSA-N 2,2,2-trichloroacetamide Chemical compound OC(=N)C(Cl)(Cl)Cl UPQQXPKAYZYUKO-UHFFFAOYSA-N 0.000 claims 1
- NRKYWOKHZRQRJR-UHFFFAOYSA-N 2,2,2-trifluoroacetamide Chemical compound NC(=O)C(F)(F)F NRKYWOKHZRQRJR-UHFFFAOYSA-N 0.000 claims 1
- 125000006325 2-propenyl amino group Chemical group [H]C([H])=C([H])C([H])([H])N([H])* 0.000 claims 1
- BIVAVBLJBKSUFI-UHFFFAOYSA-N CN(C(C1=C(C=C(C=C1)C#C)NC1=CC=C(C=C1)C#C)=O)C Chemical compound CN(C(C1=C(C=C(C=C1)C#C)NC1=CC=C(C=C1)C#C)=O)C BIVAVBLJBKSUFI-UHFFFAOYSA-N 0.000 claims 1
- BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 150000001345 alkine derivatives Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- FLLOXIIUBPVUJV-UHFFFAOYSA-N azadisilolidine Chemical compound C1C[SiH2][SiH2]N1 FLLOXIIUBPVUJV-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- VXIVSQZSERGHQP-UHFFFAOYSA-N chloroacetamide Chemical compound NC(=O)CCl VXIVSQZSERGHQP-UHFFFAOYSA-N 0.000 claims 1
- 150000003983 crown ethers Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000005948 methanesulfonyloxy group Chemical group 0.000 claims 1
- DYUWTXWIYMHBQS-UHFFFAOYSA-N n-prop-2-enylprop-2-en-1-amine Chemical compound C=CCNCC=C DYUWTXWIYMHBQS-UHFFFAOYSA-N 0.000 claims 1
- 229960002317 succinimide Drugs 0.000 claims 1
- ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 claims 1
- 125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 claims 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62186604P | 2004-10-25 | 2004-10-25 | |
| US60/621,866 | 2004-10-25 | ||
| PCT/US2005/038187 WO2006047419A2 (en) | 2004-10-25 | 2005-10-24 | Heterobifunctional poly(ethylene glycol) and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010260669A Division JP2011038118A (ja) | 2004-10-25 | 2010-11-22 | ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518053A JP2008518053A (ja) | 2008-05-29 |
| JP2008518053A5 true JP2008518053A5 (enExample) | 2010-06-17 |
| JP4920593B2 JP4920593B2 (ja) | 2012-04-18 |
Family
ID=36228333
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538132A Expired - Fee Related JP4920593B2 (ja) | 2004-10-25 | 2005-10-24 | ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用 |
| JP2010260669A Withdrawn JP2011038118A (ja) | 2004-10-25 | 2010-11-22 | ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010260669A Withdrawn JP2011038118A (ja) | 2004-10-25 | 2010-11-22 | ヘテロ二官能性ポリ（エチレングリコール）およびそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7612153B2 (enExample) |
| EP (2) | EP1807436B1 (enExample) |
| JP (2) | JP4920593B2 (enExample) |
| CA (1) | CA2584510C (enExample) |
| WO (1) | WO2006047419A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ES2738700T3 (es) | 2009-02-13 | 2020-01-24 | Immunomedics Inc | Inmunoconjugados con un enlace escindible intracelularmente |
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| US10744129B2 (en) | 2012-12-13 | 2020-08-18 | Immunomedics, Inc. | Therapy of small-cell lung cancer (SCLC) with a topoisomerase-I inhibiting antibody-drug conjugate (ADC) targeting Trop-2 |
| US10413539B2 (en) | 2012-12-13 | 2019-09-17 | Immunomedics, Inc. | Therapy for metastatic urothelial cancer with the antibody-drug conjugate, sacituzumab govitecan (IMMU-132) |
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| US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
| US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
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| JP6463229B2 (ja) * | 2014-12-04 | 2019-01-30 | 信越化学工業株式会社 | 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法、並びにこれに用いる重合開始剤及びその原料となるアルコール化合物 |
| JP6460937B2 (ja) * | 2014-12-04 | 2019-01-30 | 信越化学工業株式会社 | 末端にアミノ基を有するポリアルキレングリコール誘導体の製造方法 |
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| US9708350B2 (en) | 2014-12-04 | 2017-07-18 | Shin-Etsu Chemical Co., Ltd. | Method for producing polyalkylene glycol derivative having amino group at end, polymerization initiator for use in the same, and alcohol compound as raw material for the polymerization initiator |
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| GB2389855B (en) | 2001-02-01 | 2005-09-21 | Fmc Corp | Functionalized initiators for anionic polymerization,protected funtionalized polymers,deprotected analogues thereof,and method of making the same |
| US6797257B2 (en) | 2001-06-26 | 2004-09-28 | The Board Of Trustees Of The University Of Illinois | Paramagnetic polymerized protein microspheres and methods of preparation thereof |
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| JP2005512991A (ja) | 2001-11-09 | 2005-05-12 | エンゾン，インコーポレーテッド | 高分子チオール結合プロドラッグ |
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-
2005
- 2005-10-24 EP EP05818463.1A patent/EP1807436B1/en not_active Expired - Lifetime
- 2005-10-24 US US11/256,735 patent/US7612153B2/en not_active Expired - Fee Related
- 2005-10-24 WO PCT/US2005/038187 patent/WO2006047419A2/en not_active Ceased
- 2005-10-24 JP JP2007538132A patent/JP4920593B2/ja not_active Expired - Fee Related
- 2005-10-24 EP EP12004700A patent/EP2502941A1/en not_active Withdrawn
- 2005-10-24 CA CA2584510A patent/CA2584510C/en not_active Expired - Fee Related
-
2010
- 2010-11-22 JP JP2010260669A patent/JP2011038118A/ja not_active Withdrawn
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