JP2008516004A5 - - Google Patents
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- Publication number
- JP2008516004A5 JP2008516004A5 JP2007543041A JP2007543041A JP2008516004A5 JP 2008516004 A5 JP2008516004 A5 JP 2008516004A5 JP 2007543041 A JP2007543041 A JP 2007543041A JP 2007543041 A JP2007543041 A JP 2007543041A JP 2008516004 A5 JP2008516004 A5 JP 2008516004A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- salt
- radioisotope
- granule
- capsule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Description
実施例１８に対し、カルシウムフラックス及び結合アッセイの比較的高い値を、ＩＰアッセイのアッセイ結果につり合う（実施例１１０中で報告どおり）ことに注意する。
Claims (2)
- 式：
の化合物又は医薬的に許容されるその塩及び医薬上許容される賦形剤を含む経口投与に適した医薬組成物であって、前記化合物又はその塩が放射性同位体を含まない前記医薬組成物。 - 錠剤、カプセル又は分散性粉剤若しくは顆粒剤の形態である、請求項１に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61680504P | 2004-10-07 | 2004-10-07 | |
| US60/616,805 | 2004-10-07 | ||
| PCT/US2005/035921 WO2007050050A2 (en) | 2004-10-07 | 2005-10-06 | Thiazolyl mglur5 antagonists and methods for their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014184615A Division JP2015013885A (ja) | 2004-10-07 | 2014-09-10 | チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516004A JP2008516004A (ja) | 2008-05-15 |
| JP2008516004A5 true JP2008516004A5 (ja) | 2014-10-30 |
| JP5635727B2 JP5635727B2 (ja) | 2014-12-03 |
Family
ID=37968242
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007543041A Active JP5635727B2 (ja) | 2004-10-07 | 2005-10-06 | チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法 |
| JP2014184615A Pending JP2015013885A (ja) | 2004-10-07 | 2014-09-10 | チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014184615A Pending JP2015013885A (ja) | 2004-10-07 | 2014-09-10 | チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US7879882B2 (ja) |
| EP (2) | EP2380889B1 (ja) |
| JP (2) | JP5635727B2 (ja) |
| CN (1) | CN101223166B (ja) |
| AT (1) | ATE520692T1 (ja) |
| AU (1) | AU2005336513B2 (ja) |
| CA (1) | CA2583572C (ja) |
| ES (1) | ES2369783T3 (ja) |
| WO (1) | WO2007050050A2 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5635727B2 (ja) * | 2004-10-07 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法 |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| TW201124391A (en) * | 2009-10-20 | 2011-07-16 | Lundbeck & Co As H | 2-substituted-ethynylthiazole derivatives and uses of same |
| JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | ＣＲＦ−１受容体アンタゴニストとしてのピラゾロ［５，１ｂ］オキサゾール誘導体 |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| US8420661B2 (en) | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
| US8772300B2 (en) * | 2011-04-19 | 2014-07-08 | Hoffmann-La Roche Inc. | Phenyl or pyridinyl-ethynyl derivatives |
| UA113625C2 (xx) * | 2011-04-26 | 2017-02-27 | Похідні піразолідин-3-ону | |
| CA2829170C (en) * | 2011-04-26 | 2019-02-26 | F. Hoffmann-La Roche Ag | Ethynyl derivatives as positive allosteric modulators of the mglur5 |
| US9879004B2 (en) | 2013-02-07 | 2018-01-30 | Merck Patent Gmbh | Substituted acetylene derivatives and their use as positive allosteric modulators of mGluR4 |
| UA116023C2 (uk) * | 2013-07-08 | 2018-01-25 | Ф. Хоффманн-Ля Рош Аг | Етинільні похідні як антагоністи метаботропного глутаматного рецептора |
| WO2015188368A1 (en) * | 2014-06-13 | 2015-12-17 | Merck Sharp & Dohme Corp. | Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles |
| PE20180358A1 (es) | 2015-06-03 | 2018-02-21 | Hoffmann La Roche | Derivados de etinilo |
| BR122020005073A2 (pt) | 2017-08-04 | 2020-10-13 | Skyhawk Therapeutics, Inc. | Composto, composição farmacêutica e uso do composto |
| KR20210135241A (ko) | 2019-02-05 | 2021-11-12 | 스카이호크 테라퓨틱스, 인코포레이티드 | 스플라이싱을 조절하는 방법 및 조성물 |
| WO2020163544A1 (en) | 2019-02-06 | 2020-08-13 | Skyhawk Therapeutics, Inc. | Methods and compositions for modulating splicing |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6956049B1 (en) * | 1999-08-31 | 2005-10-18 | Merck & Co., Inc. | Methods of modulating processes mediated by excitatory amino acid receptors |
| US7365074B2 (en) * | 1999-08-31 | 2008-04-29 | Merck & Co., Inc. | Pyridazine, pyrimidine and pyrazine ethyne compounds |
| EP1214303A1 (en) * | 1999-08-31 | 2002-06-19 | Merck & Co., Inc. | Heterocyclic compounds and methods of use thereof |
| US6774138B2 (en) | 1999-08-31 | 2004-08-10 | Merck & Co., Inc. | Thiazolyl(pyridyl)ethyne compounds |
| US7462619B2 (en) * | 1999-08-31 | 2008-12-09 | Merck & Co., Inc. | Pyridazine, pyrimidine and pyrazine ethyne compounds |
| US6551270B1 (en) | 2000-08-30 | 2003-04-22 | Snowden Pencer, Inc. | Dual lumen access port |
| US6903005B1 (en) * | 2000-08-30 | 2005-06-07 | Micron Technology, Inc. | Method for the formation of RuSixOy-containing barrier layers for high-k dielectrics |
| AU2003285957A1 (en) * | 2002-10-24 | 2004-05-13 | Merck & Co., Inc. | Alkyne derivatives as tracers for metabotropic glutamate receptor binding |
| JP5635727B2 (ja) | 2004-10-07 | 2014-12-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | チアゾリルｍｇｌｕｒ５アンタゴニスト及びそれらの使用のための方法 |
-
2005
- 2005-10-06 JP JP2007543041A patent/JP5635727B2/ja active Active
- 2005-10-06 CA CA2583572A patent/CA2583572C/en active Active
- 2005-10-06 EP EP11167527.8A patent/EP2380889B1/en active Active
- 2005-10-06 US US11/664,902 patent/US7879882B2/en active Active
- 2005-10-06 AU AU2005336513A patent/AU2005336513B2/en not_active Ceased
- 2005-10-06 ES ES05858618T patent/ES2369783T3/es active Active
- 2005-10-06 AT AT05858618T patent/ATE520692T1/de not_active IP Right Cessation
- 2005-10-06 WO PCT/US2005/035921 patent/WO2007050050A2/en active Application Filing
- 2005-10-06 CN CN2005800415189A patent/CN101223166B/zh active Active
- 2005-10-06 EP EP05858618A patent/EP1893608B1/en active Active
-
2011
- 2011-01-28 US US13/016,304 patent/US8242143B2/en active Active
-
2012
- 2012-07-26 US US13/558,537 patent/US8609852B2/en active Active
-
2014
- 2014-09-10 JP JP2014184615A patent/JP2015013885A/ja active Pending
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