JP2008515405A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008515405A5 JP2008515405A5 JP2007534921A JP2007534921A JP2008515405A5 JP 2008515405 A5 JP2008515405 A5 JP 2008515405A5 JP 2007534921 A JP2007534921 A JP 2007534921A JP 2007534921 A JP2007534921 A JP 2007534921A JP 2008515405 A5 JP2008515405 A5 JP 2008515405A5
- Authority
- JP
- Japan
- Prior art keywords
- ligand
- agent
- nucleic acid
- target gene
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003446 ligand Substances 0.000 claims 13
- 239000003795 chemical substances by application Substances 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 5
- 230000001717 pathogenic effect Effects 0.000 claims 5
- 108091023037 Aptamer Proteins 0.000 claims 4
- 230000024245 cell differentiation Effects 0.000 claims 4
- 230000010261 cell growth Effects 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000003833 cell viability Effects 0.000 claims 3
- 230000008859 change Effects 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000030833 cell death Effects 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 206010020718 hyperplasia Diseases 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000010354 integration Effects 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 230000033458 reproduction Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 230000004565 tumor cell growth Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61597704P | 2004-10-05 | 2004-10-05 | |
| US60/615,977 | 2004-10-05 | ||
| US64165805P | 2005-01-06 | 2005-01-06 | |
| US60/641,658 | 2005-01-06 | ||
| PCT/US2005/036161 WO2006042112A2 (en) | 2004-10-05 | 2005-10-05 | Aptamer regulated nucleic acids and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012178625A Division JP5795563B2 (ja) | 2004-10-05 | 2012-08-10 | アプタマー調節される核酸及びその利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008515405A JP2008515405A (ja) | 2008-05-15 |
| JP2008515405A5 true JP2008515405A5 (https=) | 2008-11-27 |
| JP5101288B2 JP5101288B2 (ja) | 2012-12-19 |
Family
ID=36075582
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534921A Expired - Fee Related JP5101288B2 (ja) | 2004-10-05 | 2005-10-05 | アプタマー調節される核酸及びその利用 |
| JP2012178625A Expired - Fee Related JP5795563B2 (ja) | 2004-10-05 | 2012-08-10 | アプタマー調節される核酸及びその利用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012178625A Expired - Fee Related JP5795563B2 (ja) | 2004-10-05 | 2012-08-10 | アプタマー調節される核酸及びその利用 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US9315862B2 (https=) |
| EP (1) | EP1799825B1 (https=) |
| JP (2) | JP5101288B2 (https=) |
| AT (1) | ATE514776T1 (https=) |
| WO (1) | WO2006042112A2 (https=) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050256071A1 (en) * | 2003-07-15 | 2005-11-17 | California Institute Of Technology | Inhibitor nucleic acids |
| JP5101288B2 (ja) * | 2004-10-05 | 2012-12-19 | カリフォルニア インスティテュート オブ テクノロジー | アプタマー調節される核酸及びその利用 |
| US7727721B2 (en) | 2005-03-08 | 2010-06-01 | California Institute Of Technology | Hybridization chain reaction amplification for in situ imaging |
| WO2007044727A2 (en) | 2005-10-07 | 2007-04-19 | California Institute Of Technology | Pkr activation via hybridization chain reaction |
| JP2009524411A (ja) * | 2005-12-21 | 2009-07-02 | イェール ユニバーシティー | リボスイッチの調節に関連した方法および組成物 |
| US20080026947A1 (en) * | 2006-02-08 | 2008-01-31 | Gmeiner William H | Cytotoxic nucleotides for targeted therapeutics |
| WO2007136833A2 (en) * | 2006-05-19 | 2007-11-29 | Codon Devices, Inc. | Methods and compositions for aptamer production and uses thereof |
| US20090023221A1 (en) * | 2006-05-19 | 2009-01-22 | Exigon A/S | Oligonucleotide probes useful for detection and analysis of microrna precursors |
| WO2007147159A2 (en) * | 2006-06-16 | 2007-12-21 | Cornell Research Foundation, Inc. | Functional nucleic acid ligands to fluorescent proteins |
| US20110288826A1 (en) * | 2006-10-19 | 2011-11-24 | Breaker Ronald R | Computational design of ribozymes |
| US8158595B2 (en) * | 2006-11-09 | 2012-04-17 | California Institute Of Technology | Modular aptamer-regulated ribozymes |
| CA2681634A1 (en) * | 2007-03-22 | 2008-09-25 | Yale University | Methods and compositions related to riboswitches that control alternative splicing |
| US9181554B2 (en) * | 2007-04-05 | 2015-11-10 | Australian Centre for Plant Functional Genomics Pty, Ltd | Methods for detecting a target nucleotide sequence in a sample utilising a nuclease-aptamer complex |
| JP5223237B2 (ja) * | 2007-05-14 | 2013-06-26 | ソニー株式会社 | 検出用核酸鎖及び物質間の結合又は相互作用検出方法 |
| WO2008144562A1 (en) * | 2007-05-16 | 2008-11-27 | California Institute Of Technology | A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| US20090082217A1 (en) * | 2007-07-16 | 2009-03-26 | California Institute Of Technology | Selection of nucleic acid-based sensor domains within nucleic acid switch platform |
| ES2651911T3 (es) | 2007-08-14 | 2018-01-30 | Commonwealth Scientific And Industrial Research Organisation | Métodos mejorados de silenciamiento génico |
| US20120165387A1 (en) | 2007-08-28 | 2012-06-28 | Smolke Christina D | General composition framework for ligand-controlled RNA regulatory systems |
| US8367815B2 (en) * | 2007-08-28 | 2013-02-05 | California Institute Of Technology | Modular polynucleotides for ligand-controlled regulatory systems |
| US8865667B2 (en) | 2007-09-12 | 2014-10-21 | California Institute Of Technology | Higher-order cellular information processing devices |
| US9029524B2 (en) * | 2007-12-10 | 2015-05-12 | California Institute Of Technology | Signal activated RNA interference |
| US8329889B2 (en) * | 2008-02-15 | 2012-12-11 | Trustees Of Boston University | In vivo gene sensors |
| JP5463621B2 (ja) * | 2008-02-27 | 2014-04-09 | ソニー株式会社 | 標的物質の定量方法 |
| US8497364B2 (en) * | 2008-02-27 | 2013-07-30 | California Institute Of Technology | Triggered RNAi |
| US20100021904A1 (en) * | 2008-05-21 | 2010-01-28 | Pierce Niles A | Shielded cross-linking probes |
| US8241854B2 (en) * | 2008-05-22 | 2012-08-14 | California Institute Of Technology | Triggered RNAi |
| US20100021901A1 (en) * | 2008-05-22 | 2010-01-28 | Peng Yin | Compositions and methods for detecting analytes |
| WO2010005055A1 (ja) * | 2008-07-09 | 2010-01-14 | 公立大学法人大阪市立大学 | オリゴヌクレオチド構造体および遺伝子発現制御方法 |
| WO2010006238A2 (en) * | 2008-07-11 | 2010-01-14 | The Administrators Of The Tulane Educational Fund | Stimulus-responsive apta-chelamers |
| US8329882B2 (en) | 2009-02-18 | 2012-12-11 | California Institute Of Technology | Genetic control of mammalian cells with synthetic RNA regulatory systems |
| US9145555B2 (en) * | 2009-04-02 | 2015-09-29 | California Institute Of Technology | Integrated—ligand-responsive microRNAs |
| US9284559B2 (en) * | 2009-04-14 | 2016-03-15 | Wake Forest University Health Sciences | Multivalent aptamer complexes |
| EP2491123B1 (en) * | 2009-10-20 | 2018-04-18 | The Regents of The University of California | Single molecule nucleic acid nanoparticles |
| US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
| US8710199B2 (en) | 2010-06-23 | 2014-04-29 | California Institute Of Technology | Signal activated molecular delivery |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| WO2012056441A1 (en) * | 2010-10-28 | 2012-05-03 | Nanodoc Ltd. | Compositions and methods for specific cleavage of exogenous rna in a cell |
| US9115355B2 (en) | 2011-06-23 | 2015-08-25 | California Institute Of Technology | Exonuclease resistant polynucleotide and related duplex polynucleotides, constructs, compositions, methods and systems |
| US9725715B2 (en) | 2011-06-23 | 2017-08-08 | California Institute Of Technology | Signal activatable constructs and related components compositions methods and systems |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| WO2013119888A1 (en) | 2012-02-09 | 2013-08-15 | President And Fellows Of Harvard College | Selective nucleic acid amplification from nucleic acid pools |
| WO2013142735A1 (en) | 2012-03-21 | 2013-09-26 | California Institute Of Technology | Targeting domain and related signal activated molecular delivery |
| JP5731016B2 (ja) * | 2012-04-27 | 2015-06-10 | キリン株式会社 | リガンドを高感度に検出する核酸分子並びに該核酸分子のスクリーニング方法および該核酸分子の感度の最適化方法 |
| US9856472B2 (en) | 2013-07-01 | 2018-01-02 | California Institute Of Technology | Small conditional RNAs |
| CN105492629A (zh) | 2013-07-18 | 2016-04-13 | 哈佛学院院长及董事 | 具有复合选择性的特异性核酸扩增 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9486533B2 (en) | 2013-09-27 | 2016-11-08 | Wake Forest University Health Sciences | Pharmaceutical compositions for high-capacity targeted delivery |
| WO2015045593A1 (ja) * | 2013-09-30 | 2015-04-02 | Necソリューションイノベータ株式会社 | ターゲットの分析方法および分析キット |
| AU2014346559B2 (en) | 2013-11-07 | 2020-07-09 | Editas Medicine,Inc. | CRISPR-related methods and compositions with governing gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| WO2015095633A1 (en) * | 2013-12-20 | 2015-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions related to nucleic acid circuits and signal transducers |
| DK3155101T3 (da) | 2014-06-16 | 2020-05-04 | Univ Johns Hopkins | Sammensætninger og fremgangsmåder til ekspression af CRISPR-leder-RNA´er under anvendelse af H1-promotoren |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN112029826B (zh) | 2014-07-30 | 2025-03-14 | 哈佛学院院长及董事 | 用于测定核酸的系统和方法 |
| KR101719285B1 (ko) | 2014-11-04 | 2017-03-23 | 한국과학기술원 | 표적 물질에 의해 조절되는 핵산 중합효소 활성을 이용한 생체물질의 검출 및 정량 방법 |
| PL3265563T3 (pl) | 2015-02-02 | 2021-09-13 | Meiragtx Uk Ii Limited | Regulacja ekspresji genów poprzez modulację alternatywnego splicingu za pośrednictwem aptamerów |
| US9434996B1 (en) * | 2015-03-13 | 2016-09-06 | Tracy Ann Hayden | All mini-STR multiplex with increased C.E. through-put by STR prolongation template fusion |
| US20180094309A1 (en) * | 2015-04-03 | 2018-04-05 | President And Fellows Of Harvard College | Nucleic acid retro-activated primers |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したCas9蛋白質 |
| IL324487A (en) | 2016-07-05 | 2026-01-01 | California Inst Of Techn | Hybridization chain reaction based on a minimal initiator |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| CA3034617A1 (en) | 2016-08-30 | 2018-03-08 | California Institute Of Technology | Immunohistochemistry via hybridization chain reaction |
| EP3526320A1 (en) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| EP3592137B1 (en) * | 2017-03-10 | 2024-08-07 | The Medical College of Wisconsin, Inc. | Riboswitch modulated gene therapy for retinal diseases |
| CN111108220B (zh) | 2017-03-15 | 2024-11-19 | 博德研究所 | 用于病毒检测的基于crispr效应系统的诊断 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| WO2018218150A1 (en) | 2017-05-26 | 2018-11-29 | President And Fellows Of Harvard College | Systems and methods for high-throughput image-based screening |
| WO2018226666A1 (en) * | 2017-06-05 | 2018-12-13 | Maumita Mandal | Methods, compositions, and devices involving pseudoknot formation |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| EP3797160A1 (en) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| CA3122569A1 (en) | 2018-12-13 | 2020-06-18 | President And Fellows Of Harvard College | Amplification methods and systems for merfish and other applications |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート,インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| AU2021265719A1 (en) * | 2020-03-06 | 2022-11-03 | California Institute Of Technology | Analysis of target molecules within a sample via hybridization chain reaction |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| US20230340581A1 (en) * | 2020-05-27 | 2023-10-26 | William Marsh Rice University | Non-extensible oligonucleotides in dna amplification reactions |
| US11873485B2 (en) | 2021-01-26 | 2024-01-16 | California Institute Of Technology | Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas |
| KR102661292B1 (ko) * | 2021-09-09 | 2024-04-30 | 포항공과대학교 산학협력단 | 금속 이온 반응성 dna 중합 효소 스위치 및 이에 의해 제어되는 등온 증폭 방법 |
| CN118434758A (zh) * | 2021-12-15 | 2024-08-02 | 梅里特斯英国第二有限公司 | 肠肽的多顺反子表达 |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6019A (en) * | 1849-01-09 | Cast-iron car-wheel | ||
| US1000289A (en) | 1910-09-14 | 1911-08-08 | Arthur Low Patterson | Stocking-folder. |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4426330A (en) | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4534899A (en) | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| DE3788914T2 (de) | 1986-09-08 | 1994-08-25 | Ajinomoto Kk | Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere. |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5264423A (en) | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5276019A (en) | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US4904582A (en) | 1987-06-11 | 1990-02-27 | Synthetic Genetics | Novel amphiphilic nucleic acid conjugates |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5354844A (en) | 1989-03-16 | 1994-10-11 | Boehringer Ingelheim International Gmbh | Protein-polycation conjugates |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| ZA902710B (en) | 1989-05-22 | 1991-12-24 | Univ Georgia Res Found | Enzyme luminescence assay |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5227170A (en) | 1989-06-22 | 1993-07-13 | Vestar, Inc. | Encapsulation process |
| US5356633A (en) | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
| US5527528A (en) | 1989-10-20 | 1996-06-18 | Sequus Pharmaceuticals, Inc. | Solid-tumor treatment method |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| US5469854A (en) | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| WO1991017424A1 (en) | 1990-05-03 | 1991-11-14 | Vical, Inc. | Intracellular delivery of biologically active substances by means of self-assembling lipid complexes |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| JPH0813274B2 (ja) | 1990-08-13 | 1996-02-14 | アイシス・ファーマシューティカルス・インコーポレーテッド | 遺伝子発現を検出及び変調する糖修飾されたオリゴヌクレオチド |
| US5500357A (en) | 1990-11-02 | 1996-03-19 | Agency Of Industrial Science & Technology, Ministry Of International Trade & Industry | RNA transcription system using novel ribozyme |
| JP3220180B2 (ja) | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| US5525719A (en) | 1991-08-30 | 1996-06-11 | Chemgenes Corporation | N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and their phosphoramidite derivatives |
| US5214135A (en) | 1991-08-30 | 1993-05-25 | Chemgenes Corporation | N-protected-2'-O-methyl-ribonucleosides and N-protected 2'-O-methyl-3'-cyanoethyl-N-,N-diisopropyl phosphoramidite ribonucleosides |
| US5521291A (en) | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
| NZ244306A (en) | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5756291A (en) | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| US5583020A (en) | 1992-11-24 | 1996-12-10 | Ribozyme Pharmaceuticals, Inc. | Permeability enhancers for negatively charged polynucleotides |
| JP3351476B2 (ja) | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
| US5395619A (en) | 1993-03-03 | 1995-03-07 | Liposome Technology, Inc. | Lipid-polymer conjugates and liposomes |
| US5462854A (en) | 1993-04-19 | 1995-10-31 | Beckman Instruments, Inc. | Inverse linkage oligonucleotides for chemical and enzymatic processes |
| US5534259A (en) | 1993-07-08 | 1996-07-09 | Liposome Technology, Inc. | Polymer compound and coated particle composition |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US5417978A (en) | 1993-07-29 | 1995-05-23 | Board Of Regents, The University Of Texas System | Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5651981A (en) | 1994-03-29 | 1997-07-29 | Northwestern University | Cationic phospholipids for transfection |
| US5543152A (en) | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| US5777153A (en) | 1994-07-08 | 1998-07-07 | Gilead Sciences, Inc. | Cationic lipids |
| US5591721A (en) | 1994-10-25 | 1997-01-07 | Hybridon, Inc. | Method of down-regulating gene expression |
| US5512295A (en) | 1994-11-10 | 1996-04-30 | The Board Of Trustees Of The Leland Stanford Junior University | Synthetic liposomes for enhanced uptake and delivery |
| US5767099A (en) | 1994-12-09 | 1998-06-16 | Genzyme Corporation | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules |
| US5830430A (en) | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
| US5736392A (en) | 1995-06-07 | 1998-04-07 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
| US5851548A (en) | 1995-06-07 | 1998-12-22 | Gen-Probe Incorporated | Liposomes containing cationic lipids and vitamin D |
| WO1997042317A1 (en) | 1996-05-07 | 1997-11-13 | T Cell Sciences, Inc. | APTAMERS FOR COMPLEMENT PROTEIN C3b |
| WO1999004800A1 (en) * | 1997-07-22 | 1999-02-04 | Genitrix, Llc | Nucleic acid compositions and methods of introducing nucleic acids into cells |
| US5849902A (en) | 1996-09-26 | 1998-12-15 | Oligos Etc. Inc. | Three component chimeric antisense oligonucleotides |
| WO1999027133A1 (en) | 1997-11-26 | 1999-06-03 | Medical Research Council | Improved selex procedure and an anti-cd4 aptamer |
| US6180348B1 (en) | 1998-04-20 | 2001-01-30 | Weihua Li | Method of isolating target specific oligonucleotide ligands |
| US6458559B1 (en) * | 1998-04-22 | 2002-10-01 | Cornell Research Foundation, Inc. | Multivalent RNA aptamers and their expression in multicellular organisms |
| EP1073732A2 (en) * | 1998-04-29 | 2001-02-07 | Ribozyme Pharmaceuticals, Inc. | Nucleoside triphosphates and their incorporation into ribozymes |
| US7001733B1 (en) * | 1998-05-12 | 2006-02-21 | Rigel Pharmaceuticals, Inc. | Methods and compositions for screening for modulations of IgE synthesis, secretion and switch rearrangement |
| AU5677699A (en) * | 1998-08-21 | 2000-03-14 | Affymetrix, Inc. | Expression monitoring for human cytomegalovirus (hcmv) infection |
| AU1201600A (en) | 1998-10-08 | 2000-04-26 | University Of Massachusetts | Controlling gene expression in living cells |
| US20060172925A1 (en) * | 1998-10-26 | 2006-08-03 | Board Of Regents, The University Of Texas System | Thio-siRNA aptamers |
| US20060121510A1 (en) | 1998-11-03 | 2006-06-08 | Breaker Ronald R | Multidomain polynucleotide molecular sensors |
| US6958215B1 (en) * | 1999-03-15 | 2005-10-25 | Geron Corporation | Methods and compositions for inhibition of RNA splicing |
| US6951722B2 (en) * | 1999-03-19 | 2005-10-04 | Takara Bio Inc. | Method for amplifying nucleic acid sequence |
| US8137695B2 (en) | 2006-08-18 | 2012-03-20 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| US20040072785A1 (en) | 1999-11-23 | 2004-04-15 | Wolff Jon A. | Intravascular delivery of non-viral nucleic acid |
| US7098030B2 (en) | 1999-12-31 | 2006-08-29 | Mirus Bio Corporation | Polyampholytes for delivering polyions to a cell |
| EP1272630A2 (en) | 2000-03-16 | 2003-01-08 | Genetica, Inc. | Methods and compositions for rna interference |
| US20020106648A1 (en) | 2000-05-05 | 2002-08-08 | Lizardi Paul M. | Highly multiplexed reporter carrier systems |
| AU2001268481A1 (en) | 2000-06-15 | 2001-12-24 | Board Of Regents, The University Of Texas System | Regulatable, catalytically active nucleic acids |
| US6706474B1 (en) | 2000-06-27 | 2004-03-16 | Board Of Trustees Of The University Of Illinois | Nucleic acid enzyme biosensors for ions |
| JP2004505647A (ja) * | 2000-08-18 | 2004-02-26 | ジヤンセル・エス・アー | 条件的阻害によるトランスジーンの発現をインビボで調節する方法 |
| US7115369B2 (en) * | 2001-03-15 | 2006-10-03 | Iowa State University Research Foundation, Inc. | Functional nucleic acid probes and uses thereof |
| US6951720B2 (en) * | 2001-05-10 | 2005-10-04 | San Diego State University Foundation | Use of phosphorothiolate polynucleotides in ligating nucleic acids |
| WO2002097114A2 (en) * | 2001-05-29 | 2002-12-05 | Sirna Therapeutics, Inc. | Nucleic acid treatment of diseases or conditions related to levels of ras, her2 and hiv |
| EP1575976A4 (en) | 2001-11-02 | 2006-08-23 | Insert Therapeutics Inc | METHODS AND COMPOSITIONS FOR THE THERAPEUTIC USE OF RNA INTERFERENCE |
| US20040063654A1 (en) | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
| JP2005514603A (ja) | 2001-11-06 | 2005-05-19 | アジリックス・コーポレイション | 高感度コード化検出システム |
| AU2002343792A1 (en) * | 2001-11-28 | 2003-06-10 | Center For Advanced Science And Technology Incubation, Ltd. | siRNA EXPRESSION SYSTEM AND PROCESS FOR PRODUCING FUNCTIONAL GENE-KNOCKDOWN CELLS AND THE LIKE USING THE SAME |
| WO2004033653A2 (en) * | 2002-10-10 | 2004-04-22 | Oxford Biomedica (Uk) Limited | Gene regulation with aptamer and modulator complexes for gene therapy |
| ES2343318T3 (es) | 2002-11-26 | 2010-07-28 | University Of Massachusetts | Administracion de arnsis. |
| DE10302421A1 (de) | 2003-01-21 | 2004-07-29 | Ribopharma Ag | Doppelsträngige Ribonukleinsäure mit verbesserter Wirksamkeit |
| US20040162235A1 (en) | 2003-02-18 | 2004-08-19 | Trubetskoy Vladimir S. | Delivery of siRNA to cells using polyampholytes |
| EP1604012A2 (en) | 2003-03-05 | 2005-12-14 | The Board of Trustees of The Leland Stanford Junior University | METHODS AND COMPOSITIONS FOR SELECTIVE RNAi MEDIATED INHIBITION OF GENE EXPRESSION IN MAMMAL CELLS |
| WO2005001039A2 (en) * | 2003-05-29 | 2005-01-06 | Creighton University | Ribozyme-regulated small inhibitory rna (sirna) production and methods of use thereof |
| US20060178327A1 (en) | 2003-05-30 | 2006-08-10 | Yeung Wah Hin A | Inhibition of gene expression by delivery of specially selected double stranded or other forms of small interfering RNA precursors enabling the formation and function of small interfering RNA in vivo and in vitro |
| US20050026823A1 (en) | 2003-06-20 | 2005-02-03 | Biomarin Pharmaceutical Inc. | Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues |
| US7672786B2 (en) | 2003-07-02 | 2010-03-02 | Sergey Krylov | Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development |
| US20050256071A1 (en) * | 2003-07-15 | 2005-11-17 | California Institute Of Technology | Inhibitor nucleic acids |
| ES2559828T3 (es) | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| US20050265957A1 (en) | 2004-04-08 | 2005-12-01 | Monahan Sean D | Polymerized formamides for use in delivery of compounds to cells |
| US20060105975A1 (en) * | 2004-04-19 | 2006-05-18 | Shannon Pendergrast | Aptamer-mediated intracellular delivery of therapeutic oligonucleotides |
| US7799565B2 (en) | 2004-06-07 | 2010-09-21 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering RNA |
| JP5101288B2 (ja) | 2004-10-05 | 2012-12-19 | カリフォルニア インスティテュート オブ テクノロジー | アプタマー調節される核酸及びその利用 |
| WO2006086669A2 (en) | 2005-02-09 | 2006-08-17 | California Institute Of Technology | Aptamer regulated nucleic acids and uses thereof |
| US20060200878A1 (en) * | 2004-12-21 | 2006-09-07 | Linda Lutfiyya | Recombinant DNA constructs and methods for controlling gene expression |
| US20070231392A1 (en) | 2006-01-23 | 2007-10-04 | Ernst Wagner | CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY |
| WO2007089607A2 (en) | 2006-01-26 | 2007-08-09 | University Of Massachusetts | Rna silencing agents for use in therapy and nanotransporters for efficient delivery of same |
| US9878043B2 (en) | 2006-06-23 | 2018-01-30 | Engeneic Molecular Delivery Pty Ltd | Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells |
| WO2008036841A2 (en) | 2006-09-22 | 2008-03-27 | Dharmacon, Inc. | Tripartite oligonucleotide complexes and methods for gene silencing by rna interference |
| US8039010B2 (en) | 2006-11-03 | 2011-10-18 | Allergan, Inc. | Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier |
| US8158595B2 (en) | 2006-11-09 | 2012-04-17 | California Institute Of Technology | Modular aptamer-regulated ribozymes |
| US20090082217A1 (en) | 2007-07-16 | 2009-03-26 | California Institute Of Technology | Selection of nucleic acid-based sensor domains within nucleic acid switch platform |
| US20120165387A1 (en) | 2007-08-28 | 2012-06-28 | Smolke Christina D | General composition framework for ligand-controlled RNA regulatory systems |
| US8367815B2 (en) | 2007-08-28 | 2013-02-05 | California Institute Of Technology | Modular polynucleotides for ligand-controlled regulatory systems |
| US8865667B2 (en) | 2007-09-12 | 2014-10-21 | California Institute Of Technology | Higher-order cellular information processing devices |
| US9029524B2 (en) | 2007-12-10 | 2015-05-12 | California Institute Of Technology | Signal activated RNA interference |
| US8329882B2 (en) | 2009-02-18 | 2012-12-11 | California Institute Of Technology | Genetic control of mammalian cells with synthetic RNA regulatory systems |
| US9145555B2 (en) | 2009-04-02 | 2015-09-29 | California Institute Of Technology | Integrated—ligand-responsive microRNAs |
-
2005
- 2005-10-05 JP JP2007534921A patent/JP5101288B2/ja not_active Expired - Fee Related
- 2005-10-05 AT AT05803129T patent/ATE514776T1/de not_active IP Right Cessation
- 2005-10-05 US US11/243,889 patent/US9315862B2/en not_active Expired - Fee Related
- 2005-10-05 EP EP05803129A patent/EP1799825B1/en not_active Expired - Lifetime
- 2005-10-05 WO PCT/US2005/036161 patent/WO2006042112A2/en not_active Ceased
-
2006
- 2006-02-09 US US11/884,110 patent/US8772464B2/en active Active
-
2012
- 2012-08-10 JP JP2012178625A patent/JP5795563B2/ja not_active Expired - Fee Related
-
2014
- 2014-05-27 US US14/287,824 patent/US9309568B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008515405A5 (https=) | ||
| Li et al. | Emancipating target‐functionalized carbon dots from autophagy vesicles for a novel visualized tumor therapy | |
| Chen et al. | Treatment of human glioblastoma with a live attenuated Zika virus vaccine candidate | |
| Xie et al. | A metal chelation therapy to effectively eliminate breast cancer and intratumor bacteria while suppressing tumor metastasis by copper depletion and zinc ions surge | |
| Bayin et al. | Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells | |
| O'Riordan et al. | Photoinactivation of Mycobacteria in vitro and in a new murine model of localized Mycobacterium bovis BCG-induced granulomatous infection | |
| Fujishiro et al. | 5-Aminolevulinic acid-mediated photodynamic therapy can target human glioma stem-like cells refractory to antineoplastic agents | |
| Quan et al. | Response of aerobic granular sludge to the long-term presence to nanosilver in sequencing batch reactors: reactor performance, sludge property, microbial activity and community | |
| Kolb et al. | Initial testing of dasatinib by the pediatric preclinical testing program | |
| Zhang et al. | Targeting role of glioma stem cells for gliobastoma multiforme | |
| Wood et al. | Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunction | |
| Machineni | Effects of biotic and abiotic factors on biofilm growth dynamics and their heterogeneous response to antibiotic challenge: Lakshmi Machineni | |
| Hu et al. | Synergistic effects of matrine and 5‐fluorouracil on tumor growth of the implanted gastric cancer in nude mice | |
| Li et al. | Ureolytic biomineralization reduces Proteus mirabilis biofilm susceptibility to ciprofloxacin | |
| Silva et al. | Fostering innovation in the treatment of chronic polymicrobial cystic fibrosis-associated infections exploring aspartic acid and succinic acid as ciprofloxacin adjuvants | |
| Thompson et al. | An optimal method of iron starvation of the obligate intracellular pathogen, Chlamydia trachomatis | |
| Ojala et al. | Evolutionary rescue of bacteria via horizontal gene transfer under a lethal β-lactam concentration | |
| Behrstock et al. | Combining growth factors, stem cells, and gene therapy for the aging brain | |
| Makhlin et al. | The mTOR pathway affects proliferation and chemosensitivity of urothelial carcinoma cells and is upregulated in a subset of human bladder cancers | |
| Sulaiman et al. | Nanoparticles Loaded with Wnt and YAP/Mevalonate Inhibitors in Combination with Paclitaxel Stop the Growth of TNBC Patient‐Derived Xenografts and Diminish Tumorigenesis | |
| TWI569802B (zh) | 氧化鐵奈米粒子於抑制困難梭狀芽孢桿菌之孢子發芽的用途 | |
| Yan et al. | ssDNA functionalized nanodiamonds for uranium decorporation | |
| Macià et al. | Antibiotic Resistance Development in Bacterial Biofilms | |
| Xu et al. | Effects of VCP979 novel p38 mitogen activated protein kinase inhibitor on progression of pancreatic cancer in mouse model with diabetic conditions | |
| CN101182517A (zh) | 用于疾病治疗的多靶点鸡尾酒双链小干扰rna及其制备方法 |