JP2008514721A - 治療方法 - Google Patents
治療方法 Download PDFInfo
- Publication number
- JP2008514721A JP2008514721A JP2007534765A JP2007534765A JP2008514721A JP 2008514721 A JP2008514721 A JP 2008514721A JP 2007534765 A JP2007534765 A JP 2007534765A JP 2007534765 A JP2007534765 A JP 2007534765A JP 2008514721 A JP2008514721 A JP 2008514721A
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- JP
- Japan
- Prior art keywords
- mtor inhibitor
- administered
- aml
- therapy
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 title claims abstract description 22
- 238000011282 treatment Methods 0.000 title abstract description 16
- 229940124302 mTOR inhibitor Drugs 0.000 claims abstract description 27
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims abstract description 27
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims description 24
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims description 22
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims description 15
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- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims description 11
- 229960002930 sirolimus Drugs 0.000 claims description 11
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- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 8
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 claims description 7
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61548504P | 2004-09-30 | 2004-09-30 | |
| PCT/US2005/035047 WO2006039414A2 (en) | 2004-09-30 | 2005-09-30 | Treatment method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514721A true JP2008514721A (ja) | 2008-05-08 |
| JP2008514721A5 JP2008514721A5 (cg-RX-API-DMAC7.html) | 2008-11-13 |
Family
ID=36143059
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007534765A Pending JP2008514721A (ja) | 2004-09-30 | 2005-09-30 | 治療方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080081053A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1809276A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2008514721A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005292033A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2581372A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2007003790A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006039414A2 (cg-RX-API-DMAC7.html) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009515901A (ja) * | 2005-11-14 | 2009-04-16 | アリアド ジーン セラピューティクス インコーポレイテッド | ｍＴＯＲ阻害剤投与によるがん患者の治療 |
| US8496967B2 (en) | 2006-11-14 | 2013-07-30 | Ariad Pharmaceuticals, Inc. | Oral formulations |
| US9024014B2 (en) | 2002-02-01 | 2015-05-05 | Ariad Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
| JP2016509058A (ja) * | 2013-02-20 | 2016-03-24 | ゴールデン バイオテクノロジー コーポレーション | 白血病を治療する方法と組成物 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2004163B1 (en) * | 2006-04-05 | 2014-09-17 | Novartis Pharma AG | Combination of everolimus and vinorelbine |
| US20090311249A1 (en) * | 2006-06-02 | 2009-12-17 | Luca Gianni | Capecitabine Combination Therapy |
| US20100266590A1 (en) * | 2006-08-02 | 2010-10-21 | Demetri George D | Combination therapy |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5118677A (en) * | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US7041654B2 (en) * | 1997-10-03 | 2006-05-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods and compositions for inducing tumor-specific cytotoxicity |
| EP1478648B1 (en) * | 2002-02-01 | 2014-04-30 | ARIAD Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
| US7026330B2 (en) * | 2002-05-30 | 2006-04-11 | The Children's Hospital Of Philadelphia | Methods for treatment of acute lymphocytic leukemia |
| AU2003248813A1 (en) * | 2002-07-05 | 2004-01-23 | Beth Israel Deaconess Medical Center | Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms |
-
2005
- 2005-09-30 CA CA000000004A patent/CA2581372A1/en not_active Abandoned
- 2005-09-30 AU AU2005292033A patent/AU2005292033A1/en not_active Abandoned
- 2005-09-30 EP EP05799834A patent/EP1809276A4/en not_active Withdrawn
- 2005-09-30 MX MX2007003790A patent/MX2007003790A/es unknown
- 2005-09-30 JP JP2007534765A patent/JP2008514721A/ja active Pending
- 2005-09-30 US US11/663,940 patent/US20080081053A1/en not_active Abandoned
- 2005-09-30 WO PCT/US2005/035047 patent/WO2006039414A2/en not_active Ceased
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9024014B2 (en) | 2002-02-01 | 2015-05-05 | Ariad Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
| JP2009515901A (ja) * | 2005-11-14 | 2009-04-16 | アリアド ジーン セラピューティクス インコーポレイテッド | ｍＴＯＲ阻害剤投与によるがん患者の治療 |
| US8496967B2 (en) | 2006-11-14 | 2013-07-30 | Ariad Pharmaceuticals, Inc. | Oral formulations |
| JP2016509058A (ja) * | 2013-02-20 | 2016-03-24 | ゴールデン バイオテクノロジー コーポレーション | 白血病を治療する方法と組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1809276A4 (en) | 2009-06-17 |
| WO2006039414A3 (en) | 2006-07-06 |
| MX2007003790A (es) | 2007-05-24 |
| US20080081053A1 (en) | 2008-04-03 |
| AU2005292033A1 (en) | 2006-04-13 |
| WO2006039414A2 (en) | 2006-04-13 |
| CA2581372A1 (en) | 2006-04-13 |
| EP1809276A2 (en) | 2007-07-25 |
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