JP2008514647A5 - - Google Patents
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- Publication number
- JP2008514647A5 JP2008514647A5 JP2007533789A JP2007533789A JP2008514647A5 JP 2008514647 A5 JP2008514647 A5 JP 2008514647A5 JP 2007533789 A JP2007533789 A JP 2007533789A JP 2007533789 A JP2007533789 A JP 2007533789A JP 2008514647 A5 JP2008514647 A5 JP 2008514647A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- dsrna molecule
- dsrna
- cationic lipid
- antisense strand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61341604P | 2004-09-27 | 2004-09-27 | |
| US65657205P | 2005-02-25 | 2005-02-25 | |
| US66783305P | 2005-04-01 | 2005-04-01 | |
| US11/121,566 US20060040882A1 (en) | 2004-05-04 | 2005-05-04 | Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| PCT/US2005/035259 WO2006037126A2 (en) | 2004-09-27 | 2005-09-27 | Method of treating an inflammatory disease by double stranded ribonucleic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008514647A JP2008514647A (ja) | 2008-05-08 |
| JP2008514647A5 true JP2008514647A5 (https=) | 2008-11-27 |
Family
ID=36119611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533789A Pending JP2008514647A (ja) | 2004-09-27 | 2005-09-27 | 二本鎖リボ核酸によって炎症性疾患を治療する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20060040882A1 (https=) |
| EP (1) | EP1793864A4 (https=) |
| JP (1) | JP2008514647A (https=) |
| KR (1) | KR20070059187A (https=) |
| AU (1) | AU2005290336A1 (https=) |
| CA (1) | CA2580996A1 (https=) |
| NO (1) | NO20072148L (https=) |
| NZ (1) | NZ553828A (https=) |
| WO (1) | WO2006037126A2 (https=) |
Families Citing this family (43)
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| US8008355B2 (en) * | 2002-03-11 | 2011-08-30 | Roche Madison Inc. | Endosomolytic poly(vinyl ether) polymers |
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| CA2529752A1 (en) * | 2003-06-20 | 2005-09-15 | The Regents Of The University Of California | Polypeptide transduction and fusogenic peptides |
| US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| CN1946431B (zh) | 2004-03-03 | 2011-12-07 | 雷文斯治疗公司 | 用于肉毒毒素的局部施用和透皮递送的组合物和方法 |
| CA2558676C (en) | 2004-03-03 | 2019-04-16 | Essentia Biosystems, Inc. | Compositions and methods for topical diagnostic and therapeutic transport |
| WO2006029078A2 (en) * | 2004-09-07 | 2006-03-16 | The Regents Of The University Of California | Targeting transducible molecules to specific cell types |
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| CN101160318A (zh) | 2005-03-03 | 2008-04-09 | 雷文斯治疗公司 | 用于局部施用和经皮肤递送寡肽的组合物和方法 |
| SG160357A1 (en) | 2005-03-03 | 2010-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
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| NZ568216A (en) * | 2005-11-17 | 2012-09-28 | Revance Therapeutics Inc | Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins |
| JP2009532017A (ja) * | 2006-02-10 | 2009-09-10 | ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア | PTD/CPPSへのdsRNA結合ドメイン融合体によるsiRNAの導入可能な送達 |
| US20070293657A1 (en) * | 2006-02-17 | 2007-12-20 | Nastech Pharmaceutical Company Inc. | Complexes and methods of forming complexes of ribonucleic acids and peptides |
| CA2659103C (en) * | 2006-07-12 | 2019-05-21 | The Regents Of The University Of California | Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups |
| US9127293B2 (en) * | 2006-07-26 | 2015-09-08 | The University Of Chicago | Receptor-mediated delivery: compositions and methods |
| AU2007286059A1 (en) * | 2006-08-18 | 2008-02-21 | Mdrna, Inc. | Dicer substrate RNA peptide conjugates and methods for RNA therapeutics |
| US20100021502A1 (en) * | 2006-12-28 | 2010-01-28 | Waugh Jacob M | Compositions and Methods of Topical Application and Transdermal Delivery of Botulinum Toxins Stabililzed with Polypeptide Fragments Derived from HIV-TAT |
| JP2010514781A (ja) * | 2006-12-29 | 2010-05-06 | ルバンス セラピュティックス インク. | Hiv−tatに由来するポリペプチド断片を用いて安定化されるボツリヌス毒素を局所適用及び経皮送達する組成物及び方法 |
| NZ598159A (en) * | 2006-12-29 | 2013-08-30 | Revance Therapeutics Inc | Transport molecules using reverse sequence hiv-tat polypeptides |
| WO2008109369A2 (en) * | 2007-03-02 | 2008-09-12 | Mdrna, Inc. | Nucleic acid compounds for inhibiting tnf gene expression and uses thereof |
| US7973019B1 (en) * | 2007-10-03 | 2011-07-05 | Alcon Research, Ltd. | Transferrin/transferrin receptor-mediated siRNA delivery |
| CN102231979B (zh) * | 2008-10-16 | 2014-10-29 | 玛瑞纳生物技术有限公司 | 基因沉默治疗剂的脂质体有效递送方法和组合物 |
| WO2011034811A1 (en) * | 2009-09-17 | 2011-03-24 | Sigma-Aldrich Co. | Short rna mimetics |
| DK2539451T3 (da) * | 2010-02-24 | 2016-04-04 | Arrowhead Res Corp | Sammensætninger til målrettet tilførsel af siRNA |
| WO2011120023A1 (en) | 2010-03-26 | 2011-09-29 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting survivin gene expression uses thereof |
| TW201141513A (en) | 2010-04-14 | 2011-12-01 | Sanofi Aventis | Insulin-siRNA conjugates |
| WO2011133584A2 (en) | 2010-04-19 | 2011-10-27 | Marina Biotech, Inc. | Nucleic acid compounds for inhibiting hras gene expression and uses thereof |
| WO2011139843A2 (en) | 2010-04-28 | 2011-11-10 | Marina Biotech, Inc. | Multi-sirna compositions for reducing gene expression |
| EP2595602B1 (en) | 2010-07-21 | 2018-05-23 | Allergan, Inc. | SUSTAINED RELEASE siRNA FOR OCULAR DRUG DELIVERY |
| WO2012027206A1 (en) | 2010-08-24 | 2012-03-01 | Merck Sharp & Dohme Corp. | SINGLE-STRANDED RNAi AGENTS CONTAINING AN INTERNAL, NON-NUCLEIC ACID SPACER |
| US20150080320A1 (en) * | 2012-05-16 | 2015-03-19 | Aadigen, Llc | Multi-target modulation for treating fibrosis and inflammatory conditions |
| US9950001B2 (en) | 2012-08-20 | 2018-04-24 | The Regents Of The University Of California | Polynucleotides having bioreversible groups |
| SG11201507141SA (en) | 2013-03-15 | 2015-10-29 | Techulon Inc | Antisense molecules for treatment of staphylococcus aureus infection |
| US9777274B2 (en) | 2013-03-15 | 2017-10-03 | Techulon Inc. | Antisense molecules for treatment of staphylococcus aureus infection |
| JP2019532027A (ja) | 2016-08-17 | 2019-11-07 | ソルスティス バイオロジクス,リミティッド | ポリヌクレオチド構築物 |
| WO2019006455A1 (en) | 2017-06-30 | 2019-01-03 | Solstice Biologics, Ltd. | AUXILIARIES OF CHIRAL PHOSPHORAMIDITIS AND METHODS OF USE THEREOF |
| US20240041050A1 (en) * | 2020-12-16 | 2024-02-08 | Pioneer Hi-Bred International, Inc. | Cell penetrating peptide mediated rna transduction within insect cells |
Family Cites Families (58)
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|---|---|---|---|---|
| KR970005898B1 (ko) | 1987-09-21 | 1997-04-21 | 젠- 프로우브 인코퍼레이티드 | 뉴클레오티드 프로브에 대한 비-뉴클레오티드 연결시약 |
| JPH089583B2 (ja) | 1987-11-05 | 1996-01-31 | 小野薬品工業株式会社 | 新規なアミド化合物 |
| US5962219A (en) * | 1990-06-11 | 1999-10-05 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-selex |
| JP3257675B2 (ja) | 1990-10-12 | 2002-02-18 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー.ファウ. | 修飾リボザイム |
| DE4216134A1 (de) * | 1991-06-20 | 1992-12-24 | Europ Lab Molekularbiolog | Synthetische katalytische oligonukleotidstrukturen |
| US5652094A (en) | 1992-01-31 | 1997-07-29 | University Of Montreal | Nucleozymes |
| WO1994002595A1 (en) | 1992-07-17 | 1994-02-03 | Ribozyme Pharmaceuticals, Inc. | Method and reagent for treatment of animal diseases |
| GB9218164D0 (en) | 1992-08-26 | 1992-10-14 | Applied Research Systems | Virus and substances related thereto |
| WO1995006731A2 (en) | 1993-09-02 | 1995-03-09 | Ribozyme Pharmaceuticals, Inc. | Non-nucleotide containing enzymatic nucleic acid |
| EP0725788B1 (en) | 1993-10-27 | 1998-12-16 | Ribozyme Pharmaceuticals, Inc. | 2'-amido and 2'-peptido modified oligonucleotides |
| US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| JP3581877B2 (ja) * | 1995-05-12 | 2004-10-27 | 独立行政法人産業技術総合研究所 | 機能性分子輸送体 |
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| US5744335A (en) * | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| US20030092180A1 (en) * | 2001-08-27 | 2003-05-15 | David Lewis | Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo |
| US5679559A (en) * | 1996-07-03 | 1997-10-21 | University Of Utah Research Foundation | Cationic polymer and lipoprotein-containing system for gene delivery |
| US6001311A (en) * | 1997-02-05 | 1999-12-14 | Protogene Laboratories, Inc. | Apparatus for diverse chemical synthesis using two-dimensional array |
| JPH1121255A (ja) * | 1997-07-02 | 1999-01-26 | Hisamitsu Pharmaceut Co Inc | 機能性分子輸送体及びその製造方法 |
| JP2003528024A (ja) | 1997-12-16 | 2003-09-24 | バレンティス・インコーポレーテッド | 製剤化された核酸分子の無針注入 |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| AU3751299A (en) | 1998-04-20 | 1999-11-08 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid molecules with novel chemical compositions capable of modulating gene expression |
| US6080580A (en) * | 1998-10-05 | 2000-06-27 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of tumor necrosis factor-α (TNF-α) expression |
| US6228642B1 (en) * | 1998-10-05 | 2001-05-08 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of tumor necrosis factor-(α) (TNF-α) expression |
| DE60040274D1 (de) | 1999-03-10 | 2008-10-30 | Phogen Ltd | Verabreichung von nukleinsäuren und proteinen an zellen |
| US7833992B2 (en) * | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
| US20040110928A1 (en) * | 2000-04-12 | 2004-06-10 | Andrea Crisanti | Peptide conjugates for drug delivery |
| EP1287015A1 (en) * | 2000-04-18 | 2003-03-05 | Human Genome Sciences, Inc. | Extracellular matrix polynucleotides, polypeptides, and antibodies |
| EP1280822A2 (en) * | 2000-04-24 | 2003-02-05 | Novartis AG | Histone h2a-derived peptides useful in gene delivery |
| EP1305333A4 (en) * | 2000-07-31 | 2006-04-12 | Active Motif | PEPTIDE-MEDIATED DELIVERY OF MOLECULES IN CELLS |
| US20040259247A1 (en) * | 2000-12-01 | 2004-12-23 | Thomas Tuschl | Rna interference mediating small rna molecules |
| US20020130430A1 (en) * | 2000-12-29 | 2002-09-19 | Castor Trevor Percival | Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products |
| US20050153913A1 (en) * | 2001-04-10 | 2005-07-14 | Kosak Kenneth M. | Nucleic acid carrier compositions and methods for their synthesis |
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| US7101995B2 (en) * | 2001-08-27 | 2006-09-05 | Mirus Bio Corporation | Compositions and processes using siRNA, amphipathic compounds and polycations |
| US7060498B1 (en) | 2001-11-28 | 2006-06-13 | Genta Salus Llc | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
| US7141540B2 (en) | 2001-11-30 | 2006-11-28 | Genta Salus Llc | Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof |
| EP1478730A4 (en) * | 2002-02-20 | 2006-01-25 | Sirna Therapeutics Inc | INTERFERENCE RNA-INDUCED INHIBITION OF THE GENE EXPRESSION OF SUPERFAMILY TFN AND TFN RECEPTOR SUPERFAMILY USING SHORT INTERFERENCE NUCLEIC ACID (SINA) |
| US20040019008A1 (en) * | 2002-05-28 | 2004-01-29 | Lewis David L. | Compositions and processes using siRNA, amphipathic compounds and polycations |
| SE0201863D0 (en) | 2002-06-18 | 2002-06-18 | Cepep Ab | Cell penetrating peptides |
| AU2003281078A1 (en) | 2002-07-17 | 2004-02-02 | University Of Otago | Conjugate for double-stranded rna sequence releasing and methods thereof |
| US7977471B2 (en) * | 2002-11-14 | 2011-07-12 | Dharmacon, Inc. | siRNA targeting TNFα |
| ES2343318T3 (es) * | 2002-11-26 | 2010-07-28 | University Of Massachusetts | Administracion de arnsis. |
| AU2003299971A1 (en) * | 2002-12-30 | 2004-07-29 | Amgen Inc. | Combination therapy with co-stimulatory factors |
| US20040147027A1 (en) * | 2003-01-28 | 2004-07-29 | Troy Carol M. | Complex for facilitating delivery of dsRNA into a cell and uses thereof |
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| CA2520864A1 (en) * | 2003-03-31 | 2004-10-21 | Alza Corporation | Lipid particles having asymmetric lipid coating and method of preparing same |
| US8324365B2 (en) | 2003-04-03 | 2012-12-04 | Korea Advanced Institute Of Science And Technology | Conjugate for gene transfer comprising oligonucleotide and hydrophilic polymer, polyelectrolyte complex micelles formed from the conjugate, and methods for preparation thereof |
| ITMI20030860A1 (it) * | 2003-04-29 | 2004-10-30 | Univ Bologna | Metodo per l'inibizione selettiva del gene n-myc |
| ES2559828T3 (es) * | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| US20050136437A1 (en) | 2003-08-25 | 2005-06-23 | Nastech Pharmaceutical Company Inc. | Nanoparticles for delivery of nucleic acids and stable double-stranded RNA |
| US20050112199A1 (en) * | 2003-09-24 | 2005-05-26 | Mahesh Padval | Therapeutic regimens for administering drug combinations |
| EP1687017B1 (en) * | 2003-10-24 | 2013-03-06 | Gencia Corporation | Methods and compositions for delivering polynucleotides |
| US20060014289A1 (en) * | 2004-04-20 | 2006-01-19 | Nastech Pharmaceutical Company Inc. | Methods and compositions for enhancing delivery of double-stranded RNA or a double-stranded hybrid nucleic acid to regulate gene expression in mammalian cells |
| US20060035815A1 (en) * | 2004-05-04 | 2006-02-16 | Nastech Pharmaceutical Company Inc. | Pharmaceutical compositions for delivery of ribonucleic acid to a cell |
| CA2565685A1 (en) * | 2004-05-04 | 2005-12-15 | Nastech Pharmaceutical Company Inc. | Compositions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells |
| WO2007030619A2 (en) * | 2005-09-08 | 2007-03-15 | Nastech Pharmaceutical Company Inc. | Pharmaceutical compositions for delivery of ribonucleic acid to a cell |
-
2005
- 2005-05-04 US US11/121,566 patent/US20060040882A1/en not_active Abandoned
- 2005-09-27 US US11/576,139 patent/US20100113332A1/en not_active Abandoned
- 2005-09-27 WO PCT/US2005/035259 patent/WO2006037126A2/en not_active Ceased
- 2005-09-27 JP JP2007533789A patent/JP2008514647A/ja active Pending
- 2005-09-27 AU AU2005290336A patent/AU2005290336A1/en not_active Abandoned
- 2005-09-27 NZ NZ553828A patent/NZ553828A/xx not_active IP Right Cessation
- 2005-09-27 KR KR1020077009492A patent/KR20070059187A/ko not_active Withdrawn
- 2005-09-27 EP EP05801811A patent/EP1793864A4/en not_active Withdrawn
- 2005-09-27 CA CA002580996A patent/CA2580996A1/en not_active Abandoned
-
2007
- 2007-04-25 NO NO20072148A patent/NO20072148L/no not_active Application Discontinuation
-
2008
- 2008-09-08 US US12/206,165 patent/US8299236B2/en not_active Expired - Fee Related
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