JP2008514588A5 - - Google Patents
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- Publication number
- JP2008514588A5 JP2008514588A5 JP2007533418A JP2007533418A JP2008514588A5 JP 2008514588 A5 JP2008514588 A5 JP 2008514588A5 JP 2007533418 A JP2007533418 A JP 2007533418A JP 2007533418 A JP2007533418 A JP 2007533418A JP 2008514588 A5 JP2008514588 A5 JP 2008514588A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- contrast agent
- leu
- trp
- phe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002872 contrast media Substances 0.000 claims 5
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- BVAUMRCGVHUWOZ-ZETCQYMHSA-N (2s)-2-(cyclohexylazaniumyl)propanoate Chemical group OC(=O)[C@H](C)NC1CCCCC1 BVAUMRCGVHUWOZ-ZETCQYMHSA-N 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229940000635 beta-alanine Drugs 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000002059 diagnostic imaging Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000012285 ultrasound imaging Methods 0.000 claims 1
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 claims 1
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20044139 | 2004-09-29 | ||
| NO20044139 | 2004-09-29 | ||
| PCT/NO2005/000362 WO2006036071A2 (en) | 2004-09-29 | 2005-09-28 | Urokinase plasminogen activator receptor targeted contrast agent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008514588A JP2008514588A (ja) | 2008-05-08 |
| JP2008514588A5 true JP2008514588A5 (enExample) | 2008-11-06 |
| JP5122962B2 JP5122962B2 (ja) | 2013-01-16 |
Family
ID=35930012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007533418A Expired - Fee Related JP5122962B2 (ja) | 2004-09-29 | 2005-09-28 | ｕＰＡＲターゲティング造影剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8568689B1 (enExample) |
| EP (1) | EP1796733A2 (enExample) |
| JP (1) | JP5122962B2 (enExample) |
| KR (1) | KR101248350B1 (enExample) |
| CN (1) | CN101065152A (enExample) |
| AU (1) | AU2005287934B2 (enExample) |
| BR (1) | BRPI0516168A (enExample) |
| CA (1) | CA2580464A1 (enExample) |
| MX (1) | MX2007003750A (enExample) |
| RU (1) | RU2394837C2 (enExample) |
| WO (1) | WO2006036071A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070190068A1 (en) * | 2005-10-10 | 2007-08-16 | Richard Hart | uPAR-binding molecule-drug conjugates and uses thereof |
| US8273325B2 (en) * | 2006-12-20 | 2012-09-25 | Ge Healthcare As | Contrast agents |
| GB0718967D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Peptide imaging agents |
| GB0718957D0 (en) * | 2007-09-28 | 2007-11-07 | Ge Healthcare Ltd | Optical imaging agents |
| DK2598175T3 (da) * | 2010-07-27 | 2020-08-03 | Serac Healthcare Ltd | Radiofarmaceutiske sammensætninger |
| JP2015532636A (ja) * | 2012-05-08 | 2015-11-12 | リグスホスピタレト | 部位特異的ｕＰＡＲ標的化のための１７７−Ｌｕ標識ペプチド |
| US9884131B2 (en) * | 2012-12-03 | 2018-02-06 | Curasight Aps | Positron emitting radionuclide labeled peptides for human uPAR PET imaging |
| US20210138090A1 (en) * | 2014-09-17 | 2021-05-13 | Fluoguide A/S | uPAR targeting peptide for use in peroperative optical imaging of invasive cancer |
| AU2015317444B2 (en) * | 2014-09-17 | 2020-07-16 | Fluoguide A/S | uPAR targeting peptide for use in peroperative optical imaging of invasive cancer |
| RU2720976C2 (ru) * | 2015-06-03 | 2020-05-15 | Сюржимаб С.А.С. | Флуоресцентные конъюгаты и их применение для диагностики опухоли |
| US11970554B2 (en) | 2018-03-01 | 2024-04-30 | Tonix Pharmaceuticals Holding Corp. | Labeled oxytocin and method of manufacture and use |
| WO2021009219A1 (en) * | 2019-07-16 | 2021-01-21 | Fluoguide A/S | A receptor-targeting conjugate with an effective pharmacokinetic profile |
| BR112022000164A2 (pt) * | 2019-07-16 | 2022-04-12 | Fluoguide As | Conjugado de peptídeo direcionado a receptor de ativador de uroquinase-plasminogênio, composição farmacêutica, métodos para imageamento óptico e para detecção de uma doença, uso do conjugado de peptídeo ou da composição farmacêutica, e, kit de peças para a preparação de uma dosagem unitária |
| CN117412777A (zh) * | 2020-12-01 | 2024-01-16 | 库拉赛特股份公司 | 尿激酶纤溶酶原活化剂受体靶向的放射性标记的肽缀合物 |
| EP4277666A1 (en) * | 2021-01-15 | 2023-11-22 | Fluoguide A/S | A upar (urokinase plasminogen activator receptor)-targeting conjugate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6120765A (en) * | 1993-04-02 | 2000-09-19 | Shiseido Co. Ltd. | Urokinase plasminogen activator fragments |
| US6277818B1 (en) * | 1998-10-29 | 2001-08-21 | Angstrom Pharmaceuticals, Inc. | Cyclic peptide ligands that target urokinase plasminogen activator receptor |
| US5942492A (en) * | 1996-11-12 | 1999-08-24 | Angstrom Pharmaceuticals, Inc. | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
| GB9705521D0 (en) | 1997-03-18 | 1997-05-07 | Univ Sheffield | The use of mononuclear phagocytes in the vivo imaging of hypoxic/ischaemic tissue |
| AR020101A1 (es) * | 1998-07-01 | 2002-04-10 | Cancerforskingsfonden Af 1989 | Un antagonista peptido del receptor de uroquinasa humana, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento y metodopara seleccionar un antagonista peptido adecuado. |
| US6896870B1 (en) * | 1999-10-01 | 2005-05-24 | Angstrom Pharmaceuticals, Inc. | Diagnostic probes and therapeutics targeting uPA and uPAR |
| AU780730B2 (en) * | 1999-10-01 | 2005-04-14 | Angstrom Pharmaceuticals, Inc. | Diagnostic probes and therapeutics targeting uPA and uPAR |
| RU2165266C1 (ru) * | 2000-06-28 | 2001-04-20 | Центральный научно-исследовательский рентгенорадиологический институт | Способ получения [2-18f]-2-дезоксиглюкозы |
| US7763234B2 (en) | 2004-03-04 | 2010-07-27 | Ge Healthcare As | Pharmaceutical compounds |
-
2005
- 2005-09-28 RU RU2007111467/04A patent/RU2394837C2/ru not_active IP Right Cessation
- 2005-09-28 US US11/576,193 patent/US8568689B1/en not_active Expired - Fee Related
- 2005-09-28 MX MX2007003750A patent/MX2007003750A/es active IP Right Grant
- 2005-09-28 AU AU2005287934A patent/AU2005287934B2/en not_active Ceased
- 2005-09-28 CN CNA2005800408838A patent/CN101065152A/zh active Pending
- 2005-09-28 JP JP2007533418A patent/JP5122962B2/ja not_active Expired - Fee Related
- 2005-09-28 EP EP05788552A patent/EP1796733A2/en not_active Withdrawn
- 2005-09-28 WO PCT/NO2005/000362 patent/WO2006036071A2/en not_active Ceased
- 2005-09-28 KR KR1020077007004A patent/KR101248350B1/ko not_active Expired - Fee Related
- 2005-09-28 CA CA002580464A patent/CA2580464A1/en not_active Abandoned
- 2005-09-28 BR BRPI0516168-1A patent/BRPI0516168A/pt not_active IP Right Cessation
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