KR101248350B1 - ｕＰＡＲ 영상화제 - Google Patents

ｕＰＡＲ 영상화제 Download PDF

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Publication number
KR101248350B1
KR101248350B1 KR1020077007004A KR20077007004A KR101248350B1 KR 101248350 B1 KR101248350 B1 KR 101248350B1 KR 1020077007004 A KR1020077007004 A KR 1020077007004A KR 20077007004 A KR20077007004 A KR 20077007004A KR 101248350 B1 KR101248350 B1 KR 101248350B1
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KR
South Korea
Prior art keywords
imaging
imaging agent
ser
formula
agent
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020077007004A
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English (en)
Korean (ko)
Other versions
KR20070083604A (ko
Inventor
알란 쿠쓰버슨
벤트 이. 아르보
Original Assignee
지이 헬스케어 에이에스
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Application filed by 지이 헬스케어 에이에스 filed Critical 지이 헬스케어 에이에스
Publication of KR20070083604A publication Critical patent/KR20070083604A/ko
Application granted granted Critical
Publication of KR101248350B1 publication Critical patent/KR101248350B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020077007004A 2004-09-29 2005-09-28 ｕＰＡＲ 영상화제 Expired - Fee Related KR101248350B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20044139 2004-09-29
NO20044139 2004-09-29
PCT/NO2005/000362 WO2006036071A2 (en) 2004-09-29 2005-09-28 Urokinase plasminogen activator receptor targeted contrast agent

Publications (2)

Publication Number Publication Date
KR20070083604A KR20070083604A (ko) 2007-08-24
KR101248350B1 true KR101248350B1 (ko) 2013-04-01

Family

ID=35930012

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077007004A Expired - Fee Related KR101248350B1 (ko) 2004-09-29 2005-09-28 ｕＰＡＲ 영상화제

Country Status (11)

Country Link
US (1) US8568689B1 (enExample)
EP (1) EP1796733A2 (enExample)
JP (1) JP5122962B2 (enExample)
KR (1) KR101248350B1 (enExample)
CN (1) CN101065152A (enExample)
AU (1) AU2005287934B2 (enExample)
BR (1) BRPI0516168A (enExample)
CA (1) CA2580464A1 (enExample)
MX (1) MX2007003750A (enExample)
RU (1) RU2394837C2 (enExample)
WO (1) WO2006036071A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070190068A1 (en) * 2005-10-10 2007-08-16 Richard Hart uPAR-binding molecule-drug conjugates and uses thereof
US8273325B2 (en) * 2006-12-20 2012-09-25 Ge Healthcare As Contrast agents
GB0718967D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Peptide imaging agents
GB0718957D0 (en) * 2007-09-28 2007-11-07 Ge Healthcare Ltd Optical imaging agents
DK2598175T3 (da) * 2010-07-27 2020-08-03 Serac Healthcare Ltd Radiofarmaceutiske sammensætninger
JP2015532636A (ja) * 2012-05-08 2015-11-12 リグスホスピタレト 部位特異的ｕＰＡＲ標的化のための１７７−Ｌｕ標識ペプチド
US9884131B2 (en) * 2012-12-03 2018-02-06 Curasight Aps Positron emitting radionuclide labeled peptides for human uPAR PET imaging
US20210138090A1 (en) * 2014-09-17 2021-05-13 Fluoguide A/S uPAR targeting peptide for use in peroperative optical imaging of invasive cancer
AU2015317444B2 (en) * 2014-09-17 2020-07-16 Fluoguide A/S uPAR targeting peptide for use in peroperative optical imaging of invasive cancer
RU2720976C2 (ru) * 2015-06-03 2020-05-15 Сюржимаб С.А.С. Флуоресцентные конъюгаты и их применение для диагностики опухоли
US11970554B2 (en) 2018-03-01 2024-04-30 Tonix Pharmaceuticals Holding Corp. Labeled oxytocin and method of manufacture and use
WO2021009219A1 (en) * 2019-07-16 2021-01-21 Fluoguide A/S A receptor-targeting conjugate with an effective pharmacokinetic profile
BR112022000164A2 (pt) * 2019-07-16 2022-04-12 Fluoguide As Conjugado de peptídeo direcionado a receptor de ativador de uroquinase-plasminogênio, composição farmacêutica, métodos para imageamento óptico e para detecção de uma doença, uso do conjugado de peptídeo ou da composição farmacêutica, e, kit de peças para a preparação de uma dosagem unitária
CN117412777A (zh) * 2020-12-01 2024-01-16 库拉赛特股份公司 尿激酶纤溶酶原活化剂受体靶向的放射性标记的肽缀合物
EP4277666A1 (en) * 2021-01-15 2023-11-22 Fluoguide A/S A upar (urokinase plasminogen activator receptor)-targeting conjugate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514710B1 (en) * 1996-11-12 2003-02-04 Angstrom Pharmaceuticals, Inc. Method of using cyclic peptides to inhibit binding to urokinase-type plasminogen activator receptor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6120765A (en) * 1993-04-02 2000-09-19 Shiseido Co. Ltd. Urokinase plasminogen activator fragments
US6277818B1 (en) * 1998-10-29 2001-08-21 Angstrom Pharmaceuticals, Inc. Cyclic peptide ligands that target urokinase plasminogen activator receptor
GB9705521D0 (en) 1997-03-18 1997-05-07 Univ Sheffield The use of mononuclear phagocytes in the vivo imaging of hypoxic/ischaemic tissue
AR020101A1 (es) * 1998-07-01 2002-04-10 Cancerforskingsfonden Af 1989 Un antagonista peptido del receptor de uroquinasa humana, composicion farmaceutica que lo contiene, su uso para la manufactura de un medicamento y metodopara seleccionar un antagonista peptido adecuado.
US6896870B1 (en) * 1999-10-01 2005-05-24 Angstrom Pharmaceuticals, Inc. Diagnostic probes and therapeutics targeting uPA and uPAR
AU780730B2 (en) * 1999-10-01 2005-04-14 Angstrom Pharmaceuticals, Inc. Diagnostic probes and therapeutics targeting uPA and uPAR
RU2165266C1 (ru) * 2000-06-28 2001-04-20 Центральный научно-исследовательский рентгенорадиологический институт Способ получения [2-18f]-2-дезоксиглюкозы
US7763234B2 (en) 2004-03-04 2010-07-27 Ge Healthcare As Pharmaceutical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514710B1 (en) * 1996-11-12 2003-02-04 Angstrom Pharmaceuticals, Inc. Method of using cyclic peptides to inhibit binding to urokinase-type plasminogen activator receptor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Biochemistry, 2001. vol.40, pp.12157-12168. *
Biochemistry, 2001. vol.40, pp.12157-12168.*

Also Published As

Publication number Publication date
KR20070083604A (ko) 2007-08-24
AU2005287934A1 (en) 2006-04-06
JP2008514588A (ja) 2008-05-08
WO2006036071A3 (en) 2007-02-15
MX2007003750A (es) 2007-11-07
JP5122962B2 (ja) 2013-01-16
RU2007111467A (ru) 2008-11-10
EP1796733A2 (en) 2007-06-20
CA2580464A1 (en) 2006-04-06
BRPI0516168A (pt) 2008-08-26
US8568689B1 (en) 2013-10-29
RU2394837C2 (ru) 2010-07-20
CN101065152A (zh) 2007-10-31
WO2006036071A2 (en) 2006-04-06
AU2005287934B2 (en) 2009-03-26

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