JP2008513354A5 - - Google Patents
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- JP2008513354A5 JP2008513354A5 JP2007522632A JP2007522632A JP2008513354A5 JP 2008513354 A5 JP2008513354 A5 JP 2008513354A5 JP 2007522632 A JP2007522632 A JP 2007522632A JP 2007522632 A JP2007522632 A JP 2007522632A JP 2008513354 A5 JP2008513354 A5 JP 2008513354A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- cancer cells
- administered
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/894,672 US9249229B2 (en) | 2000-12-08 | 2004-07-20 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US10/996,316 US7408041B2 (en) | 2000-12-08 | 2004-11-23 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US11/171,567 US20060057651A1 (en) | 2000-12-08 | 2005-06-30 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| PCT/US2005/025488 WO2006020266A2 (en) | 2004-07-20 | 2005-07-19 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012053212A Division JP5727406B2 (ja) | 2004-07-20 | 2012-03-09 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008513354A JP2008513354A (ja) | 2008-05-01 |
| JP2008513354A5 true JP2008513354A5 (enExample) | 2008-08-14 |
Family
ID=35907987
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007522632A Withdrawn JP2008513354A (ja) | 2004-07-20 | 2005-07-19 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
| JP2012053212A Expired - Fee Related JP5727406B2 (ja) | 2004-07-20 | 2012-03-09 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012053212A Expired - Fee Related JP5727406B2 (ja) | 2004-07-20 | 2012-03-09 | 慢性リンパ性白血病細胞に由来するポリペプチドおよび抗体、ならびにそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20060057651A1 (enExample) |
| EP (2) | EP1786464A4 (enExample) |
| JP (2) | JP2008513354A (enExample) |
| AU (1) | AU2005274785B2 (enExample) |
| CA (1) | CA2574488C (enExample) |
| DK (1) | DK2441777T3 (enExample) |
| ES (1) | ES2569240T3 (enExample) |
| WO (1) | WO2006020266A2 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7408041B2 (en) * | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| CA2674578A1 (en) * | 2007-01-11 | 2008-07-24 | Boehringer Ingelheim International Gmbh | Cd200 and its receptor, cd200r, modulate bone mass via the differentiation of osteoclasts |
| ES2721753T3 (es) * | 2007-05-21 | 2019-08-05 | Alderbio Holdings Llc | Anticuerpos contra IL-6 y usos de los mismos |
| WO2009005673A1 (en) * | 2007-06-28 | 2009-01-08 | Schering Corporation | Anti-igf1r |
| AU2016228280B2 (en) * | 2007-07-12 | 2019-02-21 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| EP2014681A1 (en) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| JP2010534243A (ja) * | 2007-07-25 | 2010-11-04 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | Cd200に対する抗体および免疫応答への使用 |
| US8206897B2 (en) * | 2008-04-04 | 2012-06-26 | Trillium Therapeutics Inc. | Assay for soluble CD200 |
| DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| WO2010067308A2 (en) | 2008-12-08 | 2010-06-17 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| WO2010077634A1 (en) | 2008-12-09 | 2010-07-08 | Genentech, Inc. | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| EP2523976B1 (en) * | 2010-01-11 | 2018-04-25 | Alexion Pharmaceuticals, Inc. | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
| MX2012009321A (es) * | 2010-02-11 | 2012-11-21 | Alexion Pharma Inc | Metodos terapeuticos que utilizan anticuerpos anti-cd200. |
| WO2012035518A1 (en) | 2010-09-17 | 2012-03-22 | Compugen Ltd. | Compositions and methods for treatment of drug resistant multiple myeloma |
| JP6150734B2 (ja) | 2011-02-03 | 2017-06-21 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | 同種移植片の生存を長期化するための抗cd200抗体の使用 |
| KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
| EP3150632B1 (en) | 2011-06-10 | 2020-04-08 | Her Majesty The Queen in right of Canada, as represented by the Minister of National Defence | Anti-ricin antibodies and uses thereof |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| US9382534B2 (en) | 2011-10-05 | 2016-07-05 | Ge Healthcare Dharmacon, Inc. | Optimization of vectors for effective delivery and expression of genetic content |
| CN103566377A (zh) * | 2012-07-18 | 2014-02-12 | 上海博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| CA2936377A1 (en) | 2014-01-10 | 2015-07-16 | Shanghai Birdie Biotech, Inc. | Compounds and compositions for treating egfr expressing tumors |
| EP4001311B1 (en) | 2014-07-09 | 2025-11-05 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1/pd-1 combinations for treating tumors |
| CN112546238A (zh) | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| EP3827838B1 (en) * | 2015-12-16 | 2023-06-07 | The Walter and Eliza Hall Institute of Medical Research | Inhibition of cytokine-induced sh2 protein in nk cells |
| CN115252792A (zh) | 2016-01-07 | 2022-11-01 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN115554406A (zh) | 2016-01-07 | 2023-01-03 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| BR112018076260A2 (pt) | 2016-06-20 | 2019-03-26 | Kymab Limited | anticorpo ou fragmento do mesmo que se liga especificamente a hpd-l1, anticorpo biespecífico ou proteína de fusão, uso de um anticorpo ou fragmento, método, composição farmacêutica, método de modulação, método de inibição, método de tratamento, ácido nucleico, vetor, hospedeiro e imunocitocina |
| US20190048055A1 (en) * | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| CN118515666A (zh) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| CA3067268A1 (en) | 2017-06-23 | 2018-12-27 | Birdie Biopharmaceuticals, Inc. | Crystalline resiquimod monosulfate anhydrate and its preparation and uses |
| WO2019067499A1 (en) | 2017-09-27 | 2019-04-04 | Alexion Pharmaceuticals, Inc. | BIOMARKER SIGNATURE FOR PREDICTING A TUMOR RESPONSE TO ANTI-CD200 THERAPY |
| WO2019126133A1 (en) | 2017-12-20 | 2019-06-27 | Alexion Pharmaceuticals, Inc. | Liquid formulations of anti-cd200 antibodies |
| US11802154B2 (en) | 2017-12-20 | 2023-10-31 | Alexion Pharmaceuticals, Inc. | Humanized anti-CD200 antibodies and uses thereof |
| CN109239334A (zh) * | 2018-09-10 | 2019-01-18 | 吉林大学 | 建立时间分辨荧光免疫层析法检测MxA试剂盒 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN109633142B (zh) * | 2018-12-22 | 2021-08-27 | 中国人民解放军第四军医大学 | 一种急性髓细胞性白血病诊断模型的建立方法及其应用 |
Family Cites Families (57)
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| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US4289747A (en) | 1978-12-26 | 1981-09-15 | E-Y Laboratories, Inc. | Immunological determination using lectin |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| DE3307869A1 (de) | 1983-03-05 | 1984-09-06 | Dragoco Gerberding & Co Gmbh, 3450 Holzminden | Methylsubstituierte 1-((3-methylthio)-1-oxo-butyl)-cyclohex-2-ene, verfahren zu deren herstellung und deren verwendung als riech- und aromastoffe |
| WO1985003508A1 (en) | 1984-02-08 | 1985-08-15 | Cetus Corporation | Toxin conjugates |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| ATE114723T1 (de) | 1987-03-02 | 1994-12-15 | Enzon Lab Inc | Organismus als träger für ''single chain antibody domain (scad)''. |
| JPH0246297A (ja) * | 1988-08-08 | 1990-02-15 | Takeda Chem Ind Ltd | モノクローナル抗体、抗体産生ハイブリドーマおよび抗体の製造法 |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5780279A (en) | 1990-12-03 | 1998-07-14 | Genentech, Inc. | Method of selection of proteolytic cleavage sites by directed evolution and phagemid display |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ATE439435T1 (de) | 1991-03-01 | 2009-08-15 | Dyax Corp | Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon |
| DK0606217T4 (da) | 1991-06-27 | 2009-03-30 | Bristol Myers Squibb Co | CTL4-receptor, fusionsproteiner indeholdende den samt anvendelse deraf |
| US5728815A (en) | 1992-03-30 | 1998-03-17 | Board Of Regents, The University Of Texas System | Bone and prostate-derived protein factors affecting prostate cancer growth, differentiation, and metastasis |
| US5508717A (en) | 1992-07-28 | 1996-04-16 | Sony Corporation | Computer pointing device with dynamic sensitivity |
| US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| WO1997016221A2 (en) | 1995-10-31 | 1997-05-09 | The Uab Research Foundation | Genetic induction of receptors for targeted radiotherapy |
| AU1144097A (en) | 1995-12-08 | 1997-07-03 | Brigham And Women's Hospital | Ox-2 costimulatory molecule |
| JP4751493B2 (ja) | 1996-03-20 | 2011-08-17 | ブリストル−マイヤーズ スクイッブ カンパニー | Gp39/cd40およびctla4/cd28/b7経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物 |
| US6011138A (en) | 1997-02-20 | 2000-01-04 | Idec Pharmaceuticals Corporation | Gamma-1 anti-human CD23 monoclonal antibodies |
| DK1032662T3 (da) * | 1997-11-07 | 2006-07-03 | Trillium Therapeutics Inc | Fremgangsmåder og sammensætninger til immunmodulation |
| US7223729B2 (en) | 1997-11-07 | 2007-05-29 | Trillium Therapeutics Inc. | Methods of treating allergy by administering a CD200 protein |
| US6955811B2 (en) * | 1997-11-07 | 2005-10-18 | Trillium Therapeutics Inc. | Methods of inhibiting immune response suppression by administering antibodies to OX-2 |
| DE19829473C2 (de) * | 1998-07-01 | 2000-08-10 | Magnus Von Knebel Doeberitz Ch | Verfahren zur frühen Diagnose von Carcinomen |
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| US20020192215A1 (en) | 1999-04-13 | 2002-12-19 | Schering Corporation, A New Jersey Corporation | Novel uses of mammalian OX2 protein and related reagents |
| EP1263786A2 (en) | 2000-03-17 | 2002-12-11 | Reginald M. Gorczynski | Methods and compositions for immunoregulation |
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| AU2333802A (en) * | 2000-11-22 | 2002-06-03 | Transplantation Technologies I | Truncated cd200 |
| DK1355942T3 (da) | 2000-12-07 | 2008-11-17 | Lilly Co Eli | GLP-1-fusionsproteiner |
| WO2002059280A2 (en) * | 2000-12-08 | 2002-08-01 | Alexion Pharmaceuticals, Inc. | Chronic lymphocytic leukemia cell line and its use for producing an antibody |
| US7408041B2 (en) * | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| AU2004217434B2 (en) * | 2000-12-08 | 2010-08-26 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US20040198661A1 (en) | 2000-12-08 | 2004-10-07 | Bowdish Katherine S. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| WO2002095030A2 (en) * | 2001-05-24 | 2002-11-28 | Trillium Therapeutics Inc. | Modulation of cd200 receptors |
| AU2002341752B2 (en) | 2001-09-19 | 2008-04-03 | Alexion Pharmaceuticals, Inc. | Engineered templates and their use in single primer amplification |
| WO2003074679A2 (en) | 2002-03-01 | 2003-09-12 | Xencor | Antibody optimization |
| WO2004060295A2 (en) | 2002-12-27 | 2004-07-22 | Schering Corporation | Methods of inducing and maintaining immune tolerance |
| CA2517519A1 (en) | 2003-03-04 | 2004-09-16 | Alexion Pharmaceuticals, Inc. | Vectors used to create hybrid constant regions |
| WO2005007809A2 (en) | 2003-05-30 | 2005-01-27 | Alexion Pharmaceuticals, Inc. | Antibodies and fusion proteins that include engineered constant regions |
| US20070148170A1 (en) * | 2005-10-03 | 2007-06-28 | Desjarlais John R | Fc Variants With Optimized Fc Receptor Binding Properties |
| US6953417B2 (en) * | 2003-11-17 | 2005-10-11 | Borgwarner Inc. | Method for controlling a dual clutch transmission |
| US20050169870A1 (en) | 2004-02-02 | 2005-08-04 | Schering Corporation | Methods of modulating CD200 |
| EP1756165A2 (en) | 2004-06-02 | 2007-02-28 | Sidney Kimmel Cancer Center | Tissue-specific imaging and therapeutical agents targeting proteins expressed on lung endothelial cell surface |
| BRPI0517837A (pt) | 2004-11-12 | 2008-10-21 | Xencor Inc | variantes fc com ligação alterada a fcrn |
| JP2009500458A (ja) * | 2005-07-11 | 2009-01-08 | マクロジェニクス,インコーポレーテッド | ヒト化抗cd16a抗体を用いる自己免疫疾患の治療方法 |
| NZ599035A (en) | 2006-01-12 | 2013-12-20 | Alexion Pharma Inc | Antibodies to ox-2/cd200 and uses thereof |
| US20080131428A1 (en) * | 2006-02-24 | 2008-06-05 | Arius Research, Inc. | Cytotoxicity mediation of cells evidencing surface expression of TROP-2 |
-
2005
- 2005-06-30 US US11/171,567 patent/US20060057651A1/en not_active Abandoned
- 2005-07-19 DK DK11009020.6T patent/DK2441777T3/en active
- 2005-07-19 AU AU2005274785A patent/AU2005274785B2/en not_active Ceased
- 2005-07-19 JP JP2007522632A patent/JP2008513354A/ja not_active Withdrawn
- 2005-07-19 CA CA2574488A patent/CA2574488C/en not_active Expired - Fee Related
- 2005-07-19 ES ES11009020.6T patent/ES2569240T3/es not_active Expired - Lifetime
- 2005-07-19 EP EP05774630A patent/EP1786464A4/en not_active Withdrawn
- 2005-07-19 EP EP11009020.6A patent/EP2441777B1/en not_active Expired - Lifetime
- 2005-07-19 WO PCT/US2005/025488 patent/WO2006020266A2/en not_active Ceased
-
2007
- 2007-11-13 US US11/985,322 patent/US7915000B2/en not_active Expired - Fee Related
-
2011
- 2011-03-25 US US13/072,470 patent/US8999328B2/en not_active Expired - Fee Related
-
2012
- 2012-03-09 JP JP2012053212A patent/JP5727406B2/ja not_active Expired - Fee Related
-
2015
- 2015-02-24 US US14/630,262 patent/US20150368341A1/en not_active Abandoned
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