CA2574488C - Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof - Google Patents
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- CA2574488C CA2574488C CA2574488A CA2574488A CA2574488C CA 2574488 C CA2574488 C CA 2574488C CA 2574488 A CA2574488 A CA 2574488A CA 2574488 A CA2574488 A CA 2574488A CA 2574488 C CA2574488 C CA 2574488C
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K—PEPTIDES
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
- Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Priority Applications (1)
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|---|---|---|---|
| CA2777686A CA2777686A1 (en) | 2004-07-20 | 2005-07-19 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
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| US10/894,672 | 2004-07-20 | ||
| US10/894,672 US9249229B2 (en) | 2000-12-08 | 2004-07-20 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US10/996,316 US7408041B2 (en) | 2000-12-08 | 2004-11-23 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| US10/996,316 | 2004-11-23 | ||
| US11/171,567 | 2005-06-30 | ||
| US11/171,567 US20060057651A1 (en) | 2000-12-08 | 2005-06-30 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| PCT/US2005/025488 WO2006020266A2 (en) | 2004-07-20 | 2005-07-19 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
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| CA2777686A Division CA2777686A1 (en) | 2004-07-20 | 2005-07-19 | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
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| US7408041B2 (en) * | 2000-12-08 | 2008-08-05 | Alexion Pharmaceuticals, Inc. | Polypeptides and antibodies derived from chronic lymphocytic leukemia cells and uses thereof |
| CA2674578A1 (en) * | 2007-01-11 | 2008-07-24 | Boehringer Ingelheim International Gmbh | Cd200 and its receptor, cd200r, modulate bone mass via the differentiation of osteoclasts |
| CN105001332B (zh) * | 2007-05-21 | 2018-12-04 | 奥尔德生物控股有限责任公司 | 针对il-6的抗体及其用途 |
| US20110014117A1 (en) * | 2007-06-28 | 2011-01-20 | Schering Corporation | Anti-igf1r |
| AU2016228280B2 (en) * | 2007-07-12 | 2019-02-21 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| EP2014681A1 (en) * | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
| CA2697159C (en) * | 2007-07-25 | 2017-02-14 | Alexion Pharmaceuticals, Inc. | Antibodies to cd200 and uses thereof in inhibiting immune responses |
| CA2720294A1 (en) * | 2008-04-04 | 2009-10-08 | Trillium Therapeutics Inc. | Assay for soluble cd200 |
| DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| CN102300874B (zh) | 2008-12-08 | 2015-08-05 | 卡姆普根有限公司 | Tmem154多肽和多核苷酸及其作为产生药物和生物制品的药物靶标的用途 |
| HRP20170908T1 (hr) | 2008-12-09 | 2017-09-22 | F. Hoffmann - La Roche Ag | Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice |
| CA2786692A1 (en) * | 2010-01-11 | 2011-07-14 | Alexion Pharmaceuticals, Inc. | Biomarkers of immunomodulatory effects in humans treated with anti-cd200 antibodies |
| BR112012020101A2 (pt) * | 2010-02-11 | 2018-09-25 | Alexion Pharma Inc | método diagnósticos e terapêuticos usando anticorpos anti-cd200. |
| EP2616100B1 (en) | 2010-09-17 | 2016-08-31 | Compugen Ltd. | Compositions and methods for treatment of drug resistant multiple myeloma |
| CA2826453A1 (en) | 2011-02-03 | 2012-08-09 | Alexion Pharmaceuticals, Inc. | Use of an anti-cd200 antibody for prolonging the survival of allografts |
| KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
| DK3006464T3 (en) | 2011-06-10 | 2018-09-17 | Canada Minister Nat Defence | ANTIRICIN ANTIBODIES AND APPLICATIONS THEREOF |
| ES2758884T3 (es) | 2011-06-24 | 2020-05-06 | Stephen D Gillies | Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas |
| US9382534B2 (en) | 2011-10-05 | 2016-07-05 | Ge Healthcare Dharmacon, Inc. | Optimization of vectors for effective delivery and expression of genetic content |
| CN112587658A (zh) | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| SG11201605449YA (en) | 2014-01-10 | 2016-08-30 | Birdie Biopharmaceuticals Inc | Compounds and compositions for immunotherapy |
| EP4001311B1 (en) | 2014-07-09 | 2025-11-05 | Birdie Biopharmaceuticals Inc. | Anti-pd-l1/pd-1 combinations for treating tumors |
| CN112546238A (zh) | 2014-09-01 | 2021-03-26 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-pd-l1结合物 |
| EP3389695A4 (en) * | 2015-12-16 | 2019-10-09 | The Walter and Eliza Hall Institute of Medical Research | INHIBITION OF CYTOKININDUCED SH2 PROTEIN IN NK CELLS |
| CN106943597A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-egfr组合 |
| CN115350279A (zh) | 2016-01-07 | 2022-11-18 | 博笛生物科技有限公司 | 用于治疗肿瘤的抗-her2组合 |
| CN106943596A (zh) | 2016-01-07 | 2017-07-14 | 博笛生物科技（北京）有限公司 | 用于治疗肿瘤的抗-cd20组合 |
| CA3026474A1 (en) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anti-pd-l1 and il-2 cytokines |
| US20190048055A1 (en) * | 2017-03-31 | 2019-02-14 | Altor Bioscience Corporation | Alt-803 in combination with anti-cd38 antibody for cancer therapies |
| CN118515666A (zh) | 2017-04-27 | 2024-08-20 | 博笛生物科技有限公司 | 2-氨基-喹啉衍生物 |
| US11517567B2 (en) | 2017-06-23 | 2022-12-06 | Birdie Biopharmaceuticals, Inc. | Pharmaceutical compositions |
| US11761963B2 (en) | 2017-09-27 | 2023-09-19 | Alexion Pharmaceuticals, Inc. | Biomarker signature for predicting tumor response to anti-CD200 therapy |
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| US11802154B2 (en) | 2017-12-20 | 2023-10-31 | Alexion Pharmaceuticals, Inc. | Humanized anti-CD200 antibodies and uses thereof |
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2005
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- 2005-07-19 WO PCT/US2005/025488 patent/WO2006020266A2/en not_active Ceased
- 2005-07-19 AU AU2005274785A patent/AU2005274785B2/en not_active Ceased
- 2005-07-19 CA CA2574488A patent/CA2574488C/en not_active Expired - Fee Related
- 2005-07-19 EP EP05774630A patent/EP1786464A4/en not_active Withdrawn
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- 2005-07-19 JP JP2007522632A patent/JP2008513354A/ja not_active Withdrawn
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2011
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2012
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| US20090074759A1 (en) | 2009-03-19 |
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| US20110236387A1 (en) | 2011-09-29 |
| JP2008513354A (ja) | 2008-05-01 |
| EP2441777A3 (en) | 2012-07-25 |
| WO2006020266A2 (en) | 2006-02-23 |
| ES2569240T3 (es) | 2016-05-09 |
| JP2012111780A (ja) | 2012-06-14 |
| US20150368341A1 (en) | 2015-12-24 |
| EP2441777A2 (en) | 2012-04-18 |
| EP1786464A4 (en) | 2009-09-02 |
| DK2441777T3 (en) | 2016-05-17 |
| JP5727406B2 (ja) | 2015-06-03 |
| AU2005274785B2 (en) | 2012-05-03 |
| CA2574488A1 (en) | 2006-02-23 |
| US8999328B2 (en) | 2015-04-07 |
| WO2006020266A3 (en) | 2009-03-12 |
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