JP2008511837A5 - - Google Patents
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- Publication number
- JP2008511837A5 JP2008511837A5 JP2007530328A JP2007530328A JP2008511837A5 JP 2008511837 A5 JP2008511837 A5 JP 2008511837A5 JP 2007530328 A JP2007530328 A JP 2007530328A JP 2007530328 A JP2007530328 A JP 2007530328A JP 2008511837 A5 JP2008511837 A5 JP 2008511837A5
- Authority
- JP
- Japan
- Prior art keywords
- sensor
- enzymes
- sensor comprises
- immobilized
- ion selective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000790 Enzymes Proteins 0.000 claims 6
- 102000004190 Enzymes Human genes 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 3
- RMIXHJPMNBXMBU-QIIXEHPYSA-N Nonactin Chemical compound C[C@H]([C@H]1CC[C@H](O1)C[C@@H](OC(=O)[C@@H](C)[C@@H]1CC[C@@H](O1)C[C@@H](C)OC(=O)[C@H](C)[C@H]1CC[C@H](O1)C[C@H](C)OC(=O)[C@H]1C)C)C(=O)O[C@H](C)C[C@H]2CC[C@@H]1O2 RMIXHJPMNBXMBU-QIIXEHPYSA-N 0.000 claims 3
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 3
- 239000004202 carbamide Substances 0.000 claims 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- RMIXHJPMNBXMBU-UHFFFAOYSA-N Nonactin Natural products CC1C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC(O2)CCC2C(C)C(=O)OC(C)CC2CCC1O2 RMIXHJPMNBXMBU-UHFFFAOYSA-N 0.000 claims 2
- 108010046334 Urease Proteins 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims 1
- 108090000209 Carbonic anhydrases Proteins 0.000 claims 1
- 102000003846 Carbonic anhydrases Human genes 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- -1 ammonium ions Chemical class 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims 1
- 238000010382 chemical cross-linking Methods 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 229920000915 polyvinyl chloride Polymers 0.000 claims 1
- 239000004800 polyvinyl chloride Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60643604P | 2004-09-02 | 2004-09-02 | |
| PCT/US2005/031048 WO2006028871A2 (en) | 2004-09-02 | 2005-09-01 | Blood urea nitrogen (bun) sensor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008511837A JP2008511837A (ja) | 2008-04-17 |
| JP2008511837A5 true JP2008511837A5 (https=) | 2008-10-09 |
| JP4659041B2 JP4659041B2 (ja) | 2011-03-30 |
Family
ID=36036847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007530328A Expired - Fee Related JP4659041B2 (ja) | 2004-09-02 | 2005-09-01 | 血液尿素窒素（ｂｕｎ）センサ |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7540948B2 (https=) |
| EP (1) | EP1789796B1 (https=) |
| JP (1) | JP4659041B2 (https=) |
| AT (1) | ATE509118T1 (https=) |
| CA (1) | CA2576272C (https=) |
| ES (1) | ES2362790T3 (https=) |
| WO (1) | WO2006028871A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7214300B2 (en) * | 2001-06-04 | 2007-05-08 | Epocal Inc. | Integrated electrokinetic devices and methods of manufacture |
| US6896778B2 (en) * | 2001-06-04 | 2005-05-24 | Epocal Inc. | Electrode module |
| US7842234B2 (en) | 2002-12-02 | 2010-11-30 | Epocal Inc. | Diagnostic devices incorporating fluidics and methods of manufacture |
| US7767068B2 (en) | 2002-12-02 | 2010-08-03 | Epocal Inc. | Heterogeneous membrane electrodes |
| US7722817B2 (en) * | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| EP1991113B1 (en) * | 2006-02-27 | 2014-08-20 | Edwards Lifesciences Corporation | Flux limiting membrane for intravenous amperometric biosensor |
| US8268604B2 (en) * | 2007-12-20 | 2012-09-18 | Abbott Point Of Care Inc. | Compositions for forming immobilized biological layers for sensing |
| US8241697B2 (en) * | 2007-12-20 | 2012-08-14 | Abbott Point Of Care Inc. | Formation of immobilized biological layers for sensing |
| US8945936B2 (en) | 2011-04-06 | 2015-02-03 | Fresenius Medical Care Holdings, Inc. | Measuring chemical properties of a sample fluid in dialysis systems |
| US8357293B1 (en) * | 2011-07-11 | 2013-01-22 | Gerhardt Van Drie | Biological waste digester |
| US9670538B2 (en) | 2011-08-05 | 2017-06-06 | Ibis Biosciences, Inc. | Nucleic acid sequencing by electrochemical detection |
| KR101772588B1 (ko) * | 2011-08-22 | 2017-09-13 | 한국전자통신연구원 | 클리어 컴파운드 에폭시로 몰딩한 ｍｉｔ 소자 및 그것을 포함하는 화재 감지 장치 |
| WO2013102093A1 (en) | 2011-12-28 | 2013-07-04 | Ibis Biosciences, Inc. | Multiple- analyte assay device and system |
| CN105334250A (zh) * | 2015-10-23 | 2016-02-17 | 吴国清 | 一种银/氯化银电极片及其制备工艺 |
| DK4027137T3 (da) * | 2015-12-18 | 2025-03-31 | Radiometer Medical Aps | Blandet ionofor ion-selektiv elektrode til forbedret detektion af urea i blod |
| US10753900B2 (en) | 2016-06-30 | 2020-08-25 | University Of Connecticut | Real-time in situ sensing of water-related parameters using micro-electrode array |
| US10363245B2 (en) | 2017-02-22 | 2019-07-30 | The Board Of Regents Of The University Of Texas System | Methods for treating CNS lesions |
| US11733197B2 (en) | 2017-05-04 | 2023-08-22 | Siemens Healthcare Diagnostics Inc. | Biosensors produced from enzymes with reduced solubility and methods of production and use thereof |
| EP3537153A1 (en) * | 2018-03-05 | 2019-09-11 | Fuhrmann, Gerda Laura | Means for the quantitative determination of an analyte concentration in a patient's urine sample |
| NO344627B1 (en) * | 2018-04-30 | 2020-02-10 | Sintef Tto As | Hybrid polymer membrane |
| CN109946353A (zh) * | 2018-11-08 | 2019-06-28 | 利多(香港)有限公司 | 电势型生物传感器和检测方法 |
| CN109946352A (zh) * | 2018-11-08 | 2019-06-28 | 利多(香港)有限公司 | 用于电势型生物传感器的反应试剂及其应用 |
| JP7352497B2 (ja) * | 2020-03-09 | 2023-09-28 | 日本特殊陶業株式会社 | 水質計測装置用の校正液、水質計測装置用の校正液入り容器、及び水質計測装置用の校正液を用いる校正方法。 |
| CA3249940A1 (en) | 2022-04-28 | 2023-11-02 | Société des Produits Nestlé S.A. | Methods of determining a health status of a cat based on one or more biomarkers, and methods of treating a mortality risk identified by the health status |
| CN121605196A (zh) * | 2023-07-19 | 2026-03-03 | 美国西门子医学诊断股份有限公司 | 血液尿素氮（bun）传感器和感测生物样本中尿素氮的方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3116995A1 (de) * | 1981-04-29 | 1982-11-25 | Röhm GmbH, 6100 Darmstadt | Latex zur immobilisierung von biologisch wirksamen substanzen |
| JPS61210939A (ja) * | 1985-03-14 | 1986-09-19 | Matsushita Electric Works Ltd | 尿酸の測定法 |
| JPS6264940A (ja) * | 1985-09-18 | 1987-03-24 | Fujitsu Ltd | バイオセンサ− |
| JPS62144062A (ja) * | 1985-12-18 | 1987-06-27 | Fuji Electric Co Ltd | 酵素センサ− |
| JPS636451A (ja) * | 1986-06-27 | 1988-01-12 | Terumo Corp | 酵素センサ |
| US4713165A (en) * | 1986-07-02 | 1987-12-15 | Ilex Corporation | Sensor having ion-selective electrodes |
| US4933048A (en) * | 1988-02-16 | 1990-06-12 | I-Stat Corporation | Reference electrode, method of making and method of using same |
| US5096669A (en) * | 1988-09-15 | 1992-03-17 | I-Stat Corporation | Disposable sensing device for real time fluid analysis |
| US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
| US5063081A (en) | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
| US5081063A (en) * | 1989-07-20 | 1992-01-14 | Harris Corporation | Method of making edge-connected integrated circuit structure |
| US5112455A (en) * | 1990-07-20 | 1992-05-12 | I Stat Corporation | Method for analytically utilizing microfabricated sensors during wet-up |
| US5821399A (en) * | 1993-07-16 | 1998-10-13 | I-Stat Corporation | Automatic test parameters compensation of a real time fluid analysis sensing device |
| AT401653B (de) * | 1994-10-05 | 1996-11-25 | Avl Verbrennungskraft Messtech | Verfahren zur immobilisierung biologischer komponenten in einer polymermatrix sowie biosensoren unter verwendung derartiger immobilisate |
| WO1996040414A1 (en) * | 1995-06-07 | 1996-12-19 | Trachtenberg Michael C | Enzyme systems for gas processing |
| US5858186A (en) * | 1996-12-20 | 1999-01-12 | The Regents Of The University Of California | Urea biosensor for hemodialysis monitoring |
| US6030827A (en) * | 1998-01-23 | 2000-02-29 | I-Stat Corporation | Microfabricated aperture-based sensor |
| JP3477511B2 (ja) * | 1998-03-25 | 2003-12-10 | 国立身体障害者リハビリテーションセンター総長 | 金白金電極を用いたバイオセンサ |
| JP3901860B2 (ja) * | 1998-11-02 | 2007-04-04 | 株式会社セロテック | 複数の酵素を反応させる物質の定量方法及び酵素組成物 |
| IT1307750B1 (it) * | 1999-02-04 | 2001-11-19 | Saicom S R L | Biosensore amperometrico reattivo al ph. |
| US6291200B1 (en) * | 1999-11-17 | 2001-09-18 | Agentase, Llc | Enzyme-containing polymeric sensors |
| JP4404433B2 (ja) * | 2000-02-29 | 2010-01-27 | 株式会社テクノメデイカ | 使い捨てｂｕｎセンサー及びその製造法 |
-
2005
- 2005-09-01 JP JP2007530328A patent/JP4659041B2/ja not_active Expired - Fee Related
- 2005-09-01 AT AT05803876T patent/ATE509118T1/de not_active IP Right Cessation
- 2005-09-01 US US11/216,041 patent/US7540948B2/en not_active Expired - Lifetime
- 2005-09-01 CA CA2576272A patent/CA2576272C/en not_active Expired - Fee Related
- 2005-09-01 ES ES05803876T patent/ES2362790T3/es not_active Expired - Lifetime
- 2005-09-01 EP EP05803876A patent/EP1789796B1/en not_active Expired - Lifetime
- 2005-09-01 WO PCT/US2005/031048 patent/WO2006028871A2/en not_active Ceased
-
2009
- 2009-02-25 US US12/392,551 patent/US8236517B2/en active Active
- 2009-02-25 US US12/392,511 patent/US8182663B2/en not_active Expired - Lifetime
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