JP2008510770A - Ｐｌｋ阻害剤としての新規プテリジノン - Google Patents
Ｐｌｋ阻害剤としての新規プテリジノン Download PDFInfo
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- JP2008510770A JP2008510770A JP2007528833A JP2007528833A JP2008510770A JP 2008510770 A JP2008510770 A JP 2008510770A JP 2007528833 A JP2007528833 A JP 2007528833A JP 2007528833 A JP2007528833 A JP 2007528833A JP 2008510770 A JP2008510770 A JP 2008510770A
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- Prior art keywords
- halogen
- compound
- sor
- aryl
- heterocyclyl
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- 239000003112 inhibitor Substances 0.000 title description 3
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04020291 | 2004-08-26 | ||
| PCT/EP2005/054096 WO2006021547A1 (de) | 2004-08-26 | 2005-08-19 | Pteridinone als plk (polo like kinase) inhibitoren |
Publications (2)
| Publication Number | Publication Date |
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| JP2008510770A true JP2008510770A (ja) | 2008-04-10 |
| JP2008510770A5 JP2008510770A5 (enExample) | 2008-10-09 |
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|---|---|
| US (1) | US20060047118A1 (enExample) |
| EP (1) | EP1786817A1 (enExample) |
| JP (1) | JP2008510770A (enExample) |
| CA (1) | CA2575804A1 (enExample) |
| WO (1) | WO2006021547A1 (enExample) |
Cited By (4)
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|---|---|---|---|---|
| JP2013514983A (ja) * | 2009-12-18 | 2013-05-02 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 置換ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン及びそれらの治療用の使用 |
| JP2013519704A (ja) * | 2010-02-17 | 2013-05-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法及び使用 |
| JP2018534267A (ja) * | 2015-10-01 | 2018-11-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｒｏｒガンマのモジュレーターとしてのプテリジン誘導体 |
| JP2024508901A (ja) * | 2021-03-08 | 2024-02-28 | 曁南大学 | ピリドピリミジン系化合物及びその使用 |
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| DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
| US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
| US20060035903A1 (en) | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
| US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
| US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
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| EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
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| JP2003509425A (ja) * | 1999-09-15 | 2003-03-11 | ワーナー−ランバート・カンパニー | キナーゼ阻害剤としてのプテリジノン |
| JP2003523358A (ja) * | 2000-01-27 | 2003-08-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 神経変性疾患の治療のためのピリドピリミジノン誘導体 |
| JP2003528101A (ja) * | 2000-03-06 | 2003-09-24 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117923A (en) * | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
-
2005
- 2005-08-19 WO PCT/EP2005/054096 patent/WO2006021547A1/de not_active Ceased
- 2005-08-19 JP JP2007528833A patent/JP2008510770A/ja active Pending
- 2005-08-19 CA CA002575804A patent/CA2575804A1/en not_active Abandoned
- 2005-08-19 EP EP05784644A patent/EP1786817A1/de not_active Withdrawn
- 2005-08-24 US US11/211,048 patent/US20060047118A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003509425A (ja) * | 1999-09-15 | 2003-03-11 | ワーナー−ランバート・カンパニー | キナーゼ阻害剤としてのプテリジノン |
| JP2003523358A (ja) * | 2000-01-27 | 2003-08-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 神経変性疾患の治療のためのピリドピリミジノン誘導体 |
| JP2003528101A (ja) * | 2000-03-06 | 2003-09-24 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | ５−アルキルピリド［２，３−ｄ］ピリミジンチロシンキナーゼ阻害剤 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013514983A (ja) * | 2009-12-18 | 2013-05-02 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 置換ピリド［２，３−ｄ］ピリミジン−７（８Ｈ）−オン及びそれらの治療用の使用 |
| JP2013519704A (ja) * | 2010-02-17 | 2013-05-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ジヒドロプテリジノン、その製造方法及び使用 |
| JP2018534267A (ja) * | 2015-10-01 | 2018-11-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｒｏｒガンマのモジュレーターとしてのプテリジン誘導体 |
| JP2024508901A (ja) * | 2021-03-08 | 2024-02-28 | 曁南大学 | ピリドピリミジン系化合物及びその使用 |
| JP7756374B2 (ja) | 2021-03-08 | 2025-10-20 | 曁南大学 | ピリドピリミジン系化合物及びその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1786817A1 (de) | 2007-05-23 |
| WO2006021547A1 (de) | 2006-03-02 |
| US20060047118A1 (en) | 2006-03-02 |
| CA2575804A1 (en) | 2006-03-02 |
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