JP2008509999A5 - - Google Patents
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- Publication number
- JP2008509999A5 JP2008509999A5 JP2007527837A JP2007527837A JP2008509999A5 JP 2008509999 A5 JP2008509999 A5 JP 2008509999A5 JP 2007527837 A JP2007527837 A JP 2007527837A JP 2007527837 A JP2007527837 A JP 2007527837A JP 2008509999 A5 JP2008509999 A5 JP 2008509999A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- group
- hydroxy
- silyloxy
- acyloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229910052739 hydrogen Inorganic materials 0.000 claims 31
- 239000001257 hydrogen Substances 0.000 claims 31
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 17
- 125000004423 acyloxy group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 150000001875 compounds Chemical class 0.000 claims 13
- -1 methoxymethoxy Chemical group 0.000 claims 10
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 9
- 125000002757 morpholinyl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000003386 piperidinyl group Chemical group 0.000 claims 8
- 125000004469 siloxy group Chemical group [SiH3]O* 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 102000015694 estrogen receptors Human genes 0.000 claims 3
- 108010038795 estrogen receptors Proteins 0.000 claims 3
- 206010020718 hyperplasia Diseases 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 201000009273 Endometriosis Diseases 0.000 claims 2
- 208000033830 Hot Flashes Diseases 0.000 claims 2
- 206010060800 Hot flush Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 206010047791 Vulvovaginal dryness Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000000583 progesterone congener Substances 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- BRSSNUNHNSVDIS-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-5-[[3-(2-piperidin-1-ylethoxy)phenyl]methyl]-3,4-dihydro-2h-1,5-benzoxazepin-8-ol Chemical compound C1=CC(O)=CC=C1C1CN(CC=2C=C(OCCN3CCCCC3)C=CC=2)C2=CC=C(O)C=C2OC1 BRSSNUNHNSVDIS-UHFFFAOYSA-N 0.000 claims 1
- 206010065687 Bone loss Diseases 0.000 claims 1
- 208000014644 Brain disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- GHGIGALAGKPBOH-UHFFFAOYSA-N [8-hydroxy-3-(3-hydroxyphenyl)-3,4-dihydro-2h-1,5-benzoxazepin-5-yl]-[3-(2-piperidin-1-ylethoxy)phenyl]methanone Chemical compound OC1=CC=CC(C2CN(C3=CC=C(O)C=C3OC2)C(=O)C=2C=C(OCCN3CCCCC3)C=CC=2)=C1 GHGIGALAGKPBOH-UHFFFAOYSA-N 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 210000000038 chest Anatomy 0.000 claims 1
- 230000003920 cognitive function Effects 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 201000006828 endometrial hyperplasia Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60205404P | 2004-08-17 | 2004-08-17 | |
| PCT/US2005/026944 WO2006023242A1 (en) | 2004-08-17 | 2005-07-28 | Benzoxazepine derivatives as selective estrogen receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008509999A JP2008509999A (ja) | 2008-04-03 |
| JP2008509999A5 true JP2008509999A5 (https=) | 2008-09-04 |
Family
ID=35431802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527837A Withdrawn JP2008509999A (ja) | 2004-08-17 | 2005-07-28 | 選択的なエストロゲン受容体モジュレーターとしてのベンズオキサゼピン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20060040917A1 (https=) |
| EP (1) | EP1778656A1 (https=) |
| JP (1) | JP2008509999A (https=) |
| CN (1) | CN101039925A (https=) |
| CA (1) | CA2576747A1 (https=) |
| WO (1) | WO2006023242A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103080121B (zh) * | 2010-09-20 | 2015-11-25 | 瑞士诺华动物保健有限公司 | 用于制备在二脱氧甲基己糖环的C-4”处被环氧基团修饰的9-脱氧-9a-氮杂-9a-高红霉素A的新方法 |
| KR101363472B1 (ko) | 2011-03-30 | 2014-02-17 | 한국화학연구원 | 신규한 크로멘 유도체, 이의 약학적으로 허용가능한 염 또는 이의 이성질체, 이의 제조방법 및 이를 포함하는 ｐａｒ-1 관련 질환의 예방 또는 치료용 약학적 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5552412A (en) * | 1995-01-09 | 1996-09-03 | Pfizer Inc | 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis |
| DE19833786A1 (de) * | 1998-07-18 | 2000-01-20 | Schering Ag | Benzocycloheptene, Verfahren zu ihrer Herstellung, pharmazeutische Präparate, die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln |
| ATE321754T1 (de) * | 2001-05-22 | 2006-04-15 | Lilly Co Eli | 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren |
-
2005
- 2005-07-28 EP EP05767648A patent/EP1778656A1/en not_active Withdrawn
- 2005-07-28 CA CA002576747A patent/CA2576747A1/en not_active Abandoned
- 2005-07-28 WO PCT/US2005/026944 patent/WO2006023242A1/en not_active Ceased
- 2005-07-28 CN CNA2005800351717A patent/CN101039925A/zh active Pending
- 2005-07-28 US US11/191,499 patent/US20060040917A1/en not_active Abandoned
- 2005-07-28 JP JP2007527837A patent/JP2008509999A/ja not_active Withdrawn
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