JP2008508350A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008508350A5 JP2008508350A5 JP2007524765A JP2007524765A JP2008508350A5 JP 2008508350 A5 JP2008508350 A5 JP 2008508350A5 JP 2007524765 A JP2007524765 A JP 2007524765A JP 2007524765 A JP2007524765 A JP 2007524765A JP 2008508350 A5 JP2008508350 A5 JP 2008508350A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- methyl
- compound according
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 239000004480 active ingredient Substances 0.000 claims 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 239000003638 chemical reducing agent Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims 1
- QVVSIGLGKJAPJQ-MUUNZHRXSA-N 4-[(r)-(3-aminophenyl)-[4-[(2-fluorophenyl)methyl]piperazin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@H](C=1C=C(N)C=CC=1)N1CCN(CC=2C(=CC=CC=2)F)CC1 QVVSIGLGKJAPJQ-MUUNZHRXSA-N 0.000 claims 1
- DTRXQTOMBBWIJZ-MUUNZHRXSA-N 4-[(r)-(3-aminophenyl)-[4-[(3-fluorophenyl)methyl]piperazin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@H](C=1C=C(N)C=CC=1)N1CCN(CC=2C=C(F)C=CC=2)CC1 DTRXQTOMBBWIJZ-MUUNZHRXSA-N 0.000 claims 1
- XGFLMBBZEPJGHY-MUUNZHRXSA-N 4-[(r)-(3-aminophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@H](C=1C=C(N)C=CC=1)N1CCN(CC=2C=CC(F)=CC=2)CC1 XGFLMBBZEPJGHY-MUUNZHRXSA-N 0.000 claims 1
- XGFLMBBZEPJGHY-NDEPHWFRSA-N 4-[(s)-(3-aminophenyl)-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-n,n-diethylbenzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1[C@@H](C=1C=C(N)C=CC=1)N1CCN(CC=2C=CC(F)=CC=2)CC1 XGFLMBBZEPJGHY-NDEPHWFRSA-N 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000020401 Depressive disease Diseases 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- DZRSGSMPPCHMHZ-UHFFFAOYSA-N n,n-diethyl-4-[(3-nitrophenyl)-piperazin-1-ylmethyl]benzamide Chemical compound C1=CC(C(=O)N(CC)CC)=CC=C1C(C=1C=C(C=CC=1)[N+]([O-])=O)N1CCNCC1 DZRSGSMPPCHMHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 0 CCN(CC)C(c1ccc(C(c2cccc(N)c2)N2CCN(CC(C=C3)=CC=C*3F)CC2)cc1)=O Chemical compound CCN(CC)C(c1ccc(C(c2cccc(N)c2)N2CCN(CC(C=C3)=CC=C*3F)CC2)cc1)=O 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0401968-3 | 2004-08-02 | ||
| SE0401968A SE0401968D0 (sv) | 2004-08-02 | 2004-08-02 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| US60236304P | 2004-08-18 | 2004-08-18 | |
| US60/602,363 | 2004-08-18 | ||
| PCT/SE2005/001186 WO2006014133A1 (en) | 2004-08-02 | 2005-07-27 | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008508350A JP2008508350A (ja) | 2008-03-21 |
| JP2008508350A5 true JP2008508350A5 (cg-RX-API-DMAC7.html) | 2008-09-11 |
| JP5006785B2 JP5006785B2 (ja) | 2012-08-22 |
Family
ID=32906880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007524765A Expired - Fee Related JP5006785B2 (ja) | 2004-08-02 | 2005-07-27 | ジアリールメチルピペラジン誘導体、その製造法、およびその使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20070249619A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1781631B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5006785B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1993338B (cg-RX-API-DMAC7.html) |
| AR (1) | AR050260A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE542806T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2005267929B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0514014A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2576067C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2379364T3 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ553539A (cg-RX-API-DMAC7.html) |
| PL (1) | PL1781631T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT1781631E (cg-RX-API-DMAC7.html) |
| RS (1) | RS52315B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2404172C2 (cg-RX-API-DMAC7.html) |
| SE (1) | SE0401968D0 (cg-RX-API-DMAC7.html) |
| SG (1) | SG155181A1 (cg-RX-API-DMAC7.html) |
| SI (1) | SI1781631T1 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI370124B (cg-RX-API-DMAC7.html) |
| UA (1) | UA87146C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006014133A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200700680B (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0401086A3 (en) | 2001-05-18 | 2011-07-28 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds |
| SE0203300D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| KR101234421B1 (ko) * | 2004-08-02 | 2013-02-18 | 아스트라제네카 아베 | 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도 |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| JP5253514B2 (ja) | 2007-12-11 | 2013-07-31 | エフ．ホフマン−ラ ロシュ アーゲー | ステアロイル−ＣｏＡデサチュラーゼの阻害剤 |
| JP2011520956A (ja) * | 2008-05-20 | 2011-07-21 | アストラゼネカ・アクチエボラーグ | 不安大うつ病性障害を処置する方法 |
| US8314250B2 (en) | 2009-11-24 | 2012-11-20 | Hoffmann-La Roche Inc. | Sultam derivatives |
| US20110207745A1 (en) * | 2009-11-25 | 2011-08-25 | Astrazeneca Ab | Solid forms of 4--n,n-diethylbenzamide, compositions thereof, and uses therewith |
| US9073881B2 (en) | 2011-09-23 | 2015-07-07 | Hoffmann-La Roche Inc. | Benzoic acid derivatives |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH583713A5 (cg-RX-API-DMAC7.html) * | 1973-06-29 | 1977-01-14 | Cermol Sa | |
| US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
| SE8500573D0 (sv) * | 1985-02-08 | 1985-02-08 | Ferrosan Ab | Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain |
| US5840896A (en) * | 1989-11-22 | 1998-11-24 | Janssen Pharmaceutica, N.V. | Method of preventing or limiting reperfusion damage |
| US5574159A (en) * | 1992-02-03 | 1996-11-12 | Delta Pharmaceuticals, Inc. | Opioid compounds and methods for making therefor |
| US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
| US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| DE69425662T2 (de) * | 1993-07-30 | 2001-04-12 | Delta Pharmaceuticals, Inc. | Als heilmittel nutzbare piperazin verbindungen |
| SE9504661D0 (sv) * | 1995-12-22 | 1995-12-22 | Astra Pharma Inc | New compounds |
| SE9904674D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE9904673D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Pharma Inc | Novel compounds |
| SE0001209D0 (sv) * | 2000-04-04 | 2000-04-04 | Astrazeneca Canada Inc | Novel compounds |
| HUP0401086A3 (en) * | 2001-05-18 | 2011-07-28 | Astrazeneca Ab | 4 (phenyl-piperazinyl-methyl) benzamide derivatives and their use for preparation of pharmaceutical compositions for the treatment of pain, anxiety or gastrointestinal disorders and process for preparation the compounds |
| SE0101766D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| CN1596113B (zh) * | 2001-10-29 | 2010-05-26 | 蒙特库克生物科学公司 | δ受体激动剂化合物在制备治疗抑郁症的药物中的应用 |
| US8476280B2 (en) * | 2002-05-09 | 2013-07-02 | Versi Group, Llc | Compositions and methods for combating lower urinary tract dysfunctions with delta opioid receptor agonists |
| SE0203300D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203303D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0203302D0 (sv) * | 2002-11-07 | 2002-11-07 | Astrazeneca Ab | Novel Compounds |
| SE0400027D0 (sv) * | 2004-01-09 | 2004-01-09 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
| SE0401968D0 (sv) * | 2004-08-02 | 2004-08-02 | Astrazeneca Ab | Diarylmethyl piperazine derivatives, preparations thereof and uses thereof |
-
2004
- 2004-08-02 SE SE0401968A patent/SE0401968D0/xx unknown
-
2005
- 2005-07-20 AR ARP050102998A patent/AR050260A1/es not_active Application Discontinuation
- 2005-07-21 TW TW094124625A patent/TWI370124B/zh not_active IP Right Cessation
- 2005-07-27 EP EP05762524A patent/EP1781631B1/en not_active Expired - Lifetime
- 2005-07-27 US US11/572,948 patent/US20070249619A1/en not_active Abandoned
- 2005-07-27 ES ES05762524T patent/ES2379364T3/es not_active Expired - Lifetime
- 2005-07-27 CN CN2005800262747A patent/CN1993338B/zh not_active Expired - Fee Related
- 2005-07-27 SG SG200905179-8A patent/SG155181A1/en unknown
- 2005-07-27 JP JP2007524765A patent/JP5006785B2/ja not_active Expired - Fee Related
- 2005-07-27 AU AU2005267929A patent/AU2005267929B2/en not_active Ceased
- 2005-07-27 UA UAA200700154A patent/UA87146C2/ru unknown
- 2005-07-27 NZ NZ553539A patent/NZ553539A/en not_active IP Right Cessation
- 2005-07-27 CA CA2576067A patent/CA2576067C/en not_active Expired - Fee Related
- 2005-07-27 RU RU2007101522/04A patent/RU2404172C2/ru not_active IP Right Cessation
- 2005-07-27 SI SI200531515T patent/SI1781631T1/sl unknown
- 2005-07-27 RS RS20120167A patent/RS52315B/sr unknown
- 2005-07-27 PT PT05762524T patent/PT1781631E/pt unknown
- 2005-07-27 AT AT05762524T patent/ATE542806T1/de active
- 2005-07-27 WO PCT/SE2005/001186 patent/WO2006014133A1/en not_active Ceased
- 2005-07-27 PL PL05762524T patent/PL1781631T3/pl unknown
- 2005-07-27 BR BRPI0514014-5A patent/BRPI0514014A/pt not_active IP Right Cessation
- 2005-10-05 US US11/243,623 patent/US20060030569A1/en not_active Abandoned
-
2007
- 2007-01-24 ZA ZA200700680A patent/ZA200700680B/xx unknown