JP2008507703A5 - - Google Patents

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Publication number
JP2008507703A5
JP2008507703A5 JP2007522825A JP2007522825A JP2008507703A5 JP 2008507703 A5 JP2008507703 A5 JP 2008507703A5 JP 2007522825 A JP2007522825 A JP 2007522825A JP 2007522825 A JP2007522825 A JP 2007522825A JP 2008507703 A5 JP2008507703 A5 JP 2008507703A5
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Japan
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channel
membrane
voltage
tank
detection
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JP2007522825A
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English (en)
Japanese (ja)
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JP4897681B2 (ja
JP2008507703A (ja
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Priority claimed from PCT/US2005/026181 external-priority patent/WO2006012571A1/en
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Publication of JP2008507703A5 publication Critical patent/JP2008507703A5/ja
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Publication of JP4897681B2 publication Critical patent/JP4897681B2/ja
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JP2007522825A 2004-07-23 2005-07-22 イオン・チャネルを通過する時間的に変化する電流を検出するための方法及び装置 Expired - Fee Related JP4897681B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US59035104P 2004-07-23 2004-07-23
US60/590,351 2004-07-23
PCT/US2005/026181 WO2006012571A1 (en) 2004-07-23 2005-07-22 Method and apparatus for sensing a time varying current passing through an ion channel

Publications (3)

Publication Number Publication Date
JP2008507703A JP2008507703A (ja) 2008-03-13
JP2008507703A5 true JP2008507703A5 (https=) 2011-06-02
JP4897681B2 JP4897681B2 (ja) 2012-03-14

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JP2007522825A Expired - Fee Related JP4897681B2 (ja) 2004-07-23 2005-07-22 イオン・チャネルを通過する時間的に変化する電流を検出するための方法及び装置

Country Status (5)

Country Link
US (1) US7622934B2 (https=)
JP (1) JP4897681B2 (https=)
DE (1) DE112005001781B4 (https=)
GB (1) GB2431013B (https=)
WO (1) WO2006012571A1 (https=)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7663211B2 (en) 2006-05-19 2010-02-16 Fairchild Semiconductor Corporation Dual side cooling integrated power device package and module with a clip attached to a leadframe in the package and the module and methods of manufacture
WO2007146158A1 (en) 2006-06-07 2007-12-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by nanopore using modified nucleotides
DE112007001257T5 (de) 2006-06-15 2009-04-09 Electronic Bio Sciences, LLC, San Diego Vorrichtung und Verfahren zum Sensieren eines zeitvarianten Ionenstroms in einem elektrolytischen System
US20110121840A1 (en) 2007-02-20 2011-05-26 Gurdial Singh Sanghera Lipid Bilayer Sensor System
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
EP2174122A2 (en) * 2007-06-08 2010-04-14 Bharath R Takulapalli Nano structured field effect sensor and methods of forming and using same
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
WO2013154750A1 (en) 2012-04-10 2013-10-17 The Trustees Of Columbia Unversity In The City Of New York Systems and methods for biological ion channel interfaces
EP2483680A4 (en) 2009-09-30 2014-01-01 Quantapore Inc ULTRASOUND SEQUENCING OF BIOLOGICAL POLYMERS WITH THE HELP OF A MARKED NANOPORE
WO2011097028A1 (en) * 2010-02-08 2011-08-11 Genia Technologies, Inc. Systems and methods for manipulating a molecule in a nanopore
US9678055B2 (en) 2010-02-08 2017-06-13 Genia Technologies, Inc. Methods for forming a nanopore in a lipid bilayer
US20120052188A1 (en) 2010-02-08 2012-03-01 Genia Technologies, Inc. Systems and methods for assembling a lipid bilayer on a substantially planar solid surface
US9605307B2 (en) 2010-02-08 2017-03-28 Genia Technologies, Inc. Systems and methods for forming a nanopore in a lipid bilayer
US8324914B2 (en) 2010-02-08 2012-12-04 Genia Technologies, Inc. Systems and methods for characterizing a molecule
WO2012083249A2 (en) 2010-12-17 2012-06-21 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using modified nucleotides and nanopore detection
GB2500360B (en) 2010-12-22 2019-10-23 Genia Tech Inc Nanopore-based single DNA molecule characterization, identification and isolation using speed bumps
DE102011008206A1 (de) * 2011-01-10 2012-07-12 Albert-Ludwigs-Universität Freiburg Mikrostrukturvorrichtung zur Messung an molekularen Membranen und ein Verfahren zur Herstellung dieser Mikrostrukturvorrichtung
CN103620403B (zh) 2011-01-11 2016-08-10 纽约市哥伦比亚大学理事会 使用纳米管监测单分子的系统和方法
US8962242B2 (en) 2011-01-24 2015-02-24 Genia Technologies, Inc. System for detecting electrical properties of a molecular complex
US9110478B2 (en) 2011-01-27 2015-08-18 Genia Technologies, Inc. Temperature regulation of measurement arrays
EP2678669A1 (en) 2011-02-23 2014-01-01 The Trustees of Columbia University in the City of New York Systems and methods for single-molecule detection using nanopores
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US8986629B2 (en) 2012-02-27 2015-03-24 Genia Technologies, Inc. Sensor circuit for controlling, detecting, and measuring a molecular complex
WO2014007890A2 (en) * 2012-03-29 2014-01-09 California Institute Of Technology Sensor probe for bio-sensing and chemical-sensing applications
WO2013154999A2 (en) 2012-04-09 2013-10-17 The Trustees Of Columbia University In The City Of New York Method of preparation of nanopore and uses thereof
US9341592B2 (en) 2012-04-09 2016-05-17 Bharath Takulapalli Field effect transistor, device including the transistor, and methods of forming and using same
WO2013158280A1 (en) 2012-04-20 2013-10-24 The Trustees Of Columbia University In The City Of New York Systems and methods for single-molecule nucleic-acid assay platforms
WO2013188841A1 (en) 2012-06-15 2013-12-19 Genia Technologies, Inc. Chip set-up and high-accuracy nucleic acid sequencing
FR2996737B1 (fr) * 2012-10-12 2015-08-07 Commissariat Energie Atomique Recipient pour le stockage d'un fluide destine a interagir avec un utilisateur
WO2014061273A1 (ja) * 2012-10-18 2014-04-24 バイオセンサー株式会社 センサー、センサーモジュールおよび検出方法
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
US9605309B2 (en) 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
US9759711B2 (en) 2013-02-05 2017-09-12 Genia Technologies, Inc. Nanopore arrays
US10732183B2 (en) 2013-03-15 2020-08-04 The Trustees Of Columbia University In The City Of New York Method for detecting multiple predetermined compounds in a sample
CA2910019A1 (en) 2013-05-24 2014-11-27 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed fret detection
US9551697B2 (en) 2013-10-17 2017-01-24 Genia Technologies, Inc. Non-faradaic, capacitively coupled measurement in a nanopore cell array
US9322062B2 (en) 2013-10-23 2016-04-26 Genia Technologies, Inc. Process for biosensor well formation
JP6461943B2 (ja) 2013-10-23 2019-01-30 ジェニア・テクノロジーズ・インコーポレイテッド ナノポアを備えた高速分子検知
MA39774A (fr) 2014-03-24 2021-05-12 Roche Sequencing Solutions Inc Procédés chimiques pour produire des nucléotides étiquetés
ES2789000T3 (es) 2014-10-10 2020-10-23 Quantapore Inc Análisis de polinucleótidos basado en nanoporos con marcadores fluorescentes que se inactivan mutuamente
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
CN107002126B (zh) 2014-10-24 2021-05-25 昆塔波尔公司 使用纳米结构阵列的聚合物的高效光学分析
US10504656B2 (en) * 2015-04-29 2019-12-10 General Electric Company Electrodes for linear switched capacitive devices
WO2017062425A1 (en) * 2015-10-05 2017-04-13 Arizona Board Of Regents On Behalf Of Arizona State University Timing device using electrodeposit growth
WO2017184790A1 (en) 2016-04-19 2017-10-26 Takulapalli Bharath Nanopore sensor, structure and device including the sensor, and methods of forming and using same
JP2019522983A (ja) 2016-07-05 2019-08-22 クアンタポール， インコーポレイテッド 光学ベースのナノポア配列決定
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
GB201619930D0 (en) * 2016-11-24 2017-01-11 Oxford Nanopore Tech Apparatus and methods for controlling insertion of a membrane channel into a membrane
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
JP7492200B2 (ja) 2019-03-12 2024-05-29 オックスフォード ナノポール テクノロジーズ ピーエルシー ナノ細孔センシングデバイスと操作方法およびその成形方法
EP4675256A3 (en) 2020-07-17 2026-01-28 Oxford Nanopore Technologies PLC Nanopore sensing device
KR20250116014A (ko) 2022-10-28 2025-07-31 리엑스유니버시테이트 그로닝겐 나노기공-기반 단백질 분석

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2502621C3 (de) 1975-01-23 1978-09-14 Kernforschungsanlage Juelich Gmbh, 5170 Juelich Messung elastischer und dielektrischer Eigenschaften der Membran lebender Zellen
US5368712A (en) 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
JP3423041B2 (ja) 1993-10-07 2003-07-07 三洋電機株式会社 神経モデル素子
US6362002B1 (en) 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US5795782A (en) 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
EP0842418A4 (en) 1995-08-01 2004-08-18 Ambri Ltd Composite membrane sensor
US20030054333A1 (en) 1996-08-16 2003-03-20 Hickman James J. Biosensor for use in toxicity assessment and pharmacological screening
WO1998035012A2 (en) 1997-02-12 1998-08-13 Chan Eugene Y Methods and products for analyzing polymers
US7462324B2 (en) 1997-08-07 2008-12-09 Panasonic Corporation Measurement device and method for measuring electric signal from biological sample
DE19744649C2 (de) 1997-10-09 2003-03-27 Fraunhofer Ges Forschung Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
US6426231B1 (en) 1998-11-18 2002-07-30 The Texas A&M University System Analyte sensing mediated by adapter/carrier molecules
AU2898500A (en) 1999-03-02 2000-09-21 Helix Biopharma Corporation Biosensor device and method
DE19936302A1 (de) * 1999-08-02 2001-02-15 Niels Fertig Vorrichtungen und Verfahren zur Untersuchung von Ionenkanälen in Membranen
ATE317545T1 (de) * 1999-10-01 2006-02-15 Sophion Bioscience As Anordnung und verfahren zum feststellen und/oder überwachen elektrophysiologischer eigenschaften von ionenkanälen
US6570196B1 (en) 2000-03-22 2003-05-27 Max-Plank-Gesellschaft Zur Forderung Der Wissenschaften Lipid vesicles or lipid bilayers on chips
US6616895B2 (en) * 2000-03-23 2003-09-09 Advanced Research Corporation Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples
MXPA03000160A (es) 2000-07-07 2003-09-22 Bristol Myers Squibb Co Configuracion de electrofisiologia adecuada para separacion por exclusion de alta produccion de compuestos para el descubrimiento de farmacos.
US7399599B2 (en) 2000-07-10 2008-07-15 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
WO2002029402A2 (en) * 2000-10-02 2002-04-11 Sophion Bioscience A/S System for electrophysiological measurements
US6776896B1 (en) 2000-10-11 2004-08-17 Axon Instruments, Inc. Method of positioning cells for electrophysiological testing
US6686800B2 (en) * 2001-02-13 2004-02-03 Quantum Applied Science And Research, Inc. Low noise, electric field sensor
DE10112505C1 (de) * 2001-03-15 2003-01-30 Iongate Biosciences Gmbh Sensoranordnung und Vorrichtung zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung sowie Verfahren zur amperometrischen und/oder potentiometrischen, pharmakologischen Wirkort- und/oder Wirkstofftestung
EP1372828A4 (en) * 2001-03-24 2008-10-29 Aviva Biosciences Corp BIOCHIPS WITH ION TRANSPORTATION STRUCTURES AND USE METHOD
US20040020773A1 (en) 2001-06-20 2004-02-05 Lars Thomsen Apparatus and method for determining and/or monitoring electrophysiological properties of ion channels
EP1397677A1 (en) * 2001-06-20 2004-03-17 Sophion Bioscience A/S An apparatus and method for determining and/or monitoring electrophysiological properties of ion channels
US20030062657A1 (en) 2001-07-31 2003-04-03 Massachusetts Institute Of Technology On-chip membrane maker
WO2003016555A1 (en) * 2001-08-09 2003-02-27 Matsushita Electric Industrial Co., Ltd. Cell diagnosing method, and device and apparatus used for it
US6953958B2 (en) 2002-03-19 2005-10-11 Cornell Research Foundation, Inc. Electronic gain cell based charge sensor
GB2398635A (en) 2003-02-21 2004-08-25 Sophion Bioscience As A substrate providing a cell gigaseal for a patch clamp
EP1504114B1 (en) 2002-05-10 2017-07-12 The Texas A & M University System Stochastic sensing through covalent interactions
US7205099B2 (en) 2002-05-31 2007-04-17 John Cuppoletti Methods for studying ion channels incorporated onto a solid-supported membrane
DE10236528A1 (de) * 2002-08-09 2004-02-19 Bayer Ag Vorrichtung und Methoden zur Durchführung von elektrischen Messungen an Membrankörpern
US7355216B2 (en) 2002-12-09 2008-04-08 The Regents Of The University Of California Fluidic nanotubes and devices
US20040251145A1 (en) 2003-02-21 2004-12-16 Robertson Janet Kay High throughput screening (HTS) method and apparatus for monitoring ion channels
US7112433B2 (en) 2003-04-24 2006-09-26 Hewlett-Packard Development Company, L.P. Electrical analysis of biological membranes
US20050112557A1 (en) 2003-09-25 2005-05-26 Yongcheng Liu Mesoporous-chip based biosensor for rapid biological agent detection
US6846702B1 (en) * 2003-10-24 2005-01-25 Agilent Technologies, Inc. Nanopore chip with N-type semiconductor

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