JP2008507255A5 - - Google Patents

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Publication number
JP2008507255A5
JP2008507255A5 JP2007503099A JP2007503099A JP2008507255A5 JP 2008507255 A5 JP2008507255 A5 JP 2008507255A5 JP 2007503099 A JP2007503099 A JP 2007503099A JP 2007503099 A JP2007503099 A JP 2007503099A JP 2008507255 A5 JP2008507255 A5 JP 2008507255A5
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Japan
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antibody
fragment
domain
amino acid
acid sequence
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JP2007503099A
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Japanese (ja)
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JP2008507255A (ja
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Priority claimed from PCT/US2005/008377 external-priority patent/WO2005105841A2/en
Publication of JP2008507255A publication Critical patent/JP2008507255A/ja
Publication of JP2008507255A5 publication Critical patent/JP2008507255A5/ja
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JP2007503099A 2004-03-12 2005-03-11 ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０ Withdrawn JP2008507255A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55218404P 2004-03-12 2004-03-12
PCT/US2005/008377 WO2005105841A2 (en) 2004-03-12 2005-03-11 Human g-protein chemokine receptor (ccr5) hdgnr10

Related Child Applications (1)

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JP2008085005A Division JP2008259504A (ja) 2004-03-12 2008-03-27 ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０

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JP2008507255A JP2008507255A (ja) 2008-03-13
JP2008507255A5 true JP2008507255A5 (enExample) 2008-05-01

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JP2007503099A Withdrawn JP2008507255A (ja) 2004-03-12 2005-03-11 ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０
JP2008085005A Withdrawn JP2008259504A (ja) 2004-03-12 2008-03-27 ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０

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JP2008085005A Withdrawn JP2008259504A (ja) 2004-03-12 2008-03-27 ヒトｇタンパク質ケモカインレセプター（ｃｃｒ５）ｈｄｇｎｒ１０

Country Status (5)

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US (1) US7501123B2 (enExample)
EP (1) EP1723178A4 (enExample)
JP (2) JP2008507255A (enExample)
CA (1) CA2559809A1 (enExample)
WO (1) WO2005105841A2 (enExample)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040151719A1 (en) * 1995-06-06 2004-08-05 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
DE69637890D1 (de) * 1995-06-07 2009-05-14 Progenics Pharm Inc Monoklonaler antikörper für die inhibierung von hiv-1-hüllgykoprotein-vermittelte membranfusion
US7118859B2 (en) * 1996-01-17 2006-10-10 Progenics Pharmaceuticals, Inc. Methods for inhibiting HIV-1 infection
US6344545B1 (en) * 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US7858298B1 (en) * 1996-04-01 2010-12-28 Progenics Pharmaceuticals Inc. Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists
US20080015348A1 (en) * 1998-12-16 2008-01-17 Progenics Pharmaceuticals, Inc. Nucleic acids encoding polypeptides of anti-CCR5 antibodies
US20040228869A1 (en) * 1998-12-16 2004-11-18 Progenics Pharmaceuticals, Inc. Synergistic inhibition of HIV-1 fusion and attachment, compositions and antibodies thereto
US7138119B2 (en) * 2000-09-15 2006-11-21 Progenics Pharmaceuticals, Inc. Compositions and methods for inhibition of HIV-1 infection
US7175988B2 (en) * 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US7122185B2 (en) * 2002-02-22 2006-10-17 Progenics Pharmaceuticals, Inc. Anti-CCR5 antibody
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
ES2438019T3 (es) * 2005-07-22 2014-01-15 Cytodyn, Inc. Procedimientos para reducir la carga viral en pacientes infectados por el VIH-1
SG10201706600VA (en) 2005-11-30 2017-09-28 Abbvie Inc Monoclonal antibodies and uses thereof
KR20080090408A (ko) 2005-11-30 2008-10-08 아보트 러보러터리즈 항-Ａβ 글로불로머 항체, 이의 항원-결합 잔기, 상응하는하이브리도마, 핵산, 벡터, 숙주 세포, 당해 항체의 제조방법, 당해 항체를 포함하는 조성물, 당해 항체의 용도 및당해 항체의 사용 방법
EP2004231A4 (en) 2006-04-07 2013-07-10 Nektar Therapeutics CONJUGATES OF ANTI-TNF-ALPHA ANTIBODY
US20080015465A1 (en) * 2006-06-15 2008-01-17 Scuderi Gaetano J Methods for diagnosing and treating pain in the spinal cord
KR20090052358A (ko) 2006-09-29 2009-05-25 에프. 호프만-라 로슈 아게 Ｃｃｒ5 에 대한 항체 및 이의 용도
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
WO2008104386A2 (en) 2007-02-27 2008-09-04 Abbott Gmbh & Co. Kg Method for the treatment of amyloidoses
US20080283557A1 (en) * 2007-05-17 2008-11-20 Julianne Desautels Spout for food stuff container
AU2008260077B2 (en) * 2007-06-01 2014-07-03 Cytonics Corporation Methods and kits for diagnosing and treating acute joint injury
US7709215B2 (en) 2007-06-01 2010-05-04 Cytonics Corporation Method for diagnosing and treating acute joint injury
WO2009042773A1 (en) * 2007-09-25 2009-04-02 University Of Miami Adoptively transferred tumor-specific t cells stimulated ex vivo using herpes simplex virus amplicons
WO2009064425A1 (en) * 2007-11-13 2009-05-22 Rational Affinity Devices, L.L.C. Multistate affinity ligands for the separation and purification of antibodies, antibody fragments and conjugates of antibodies and antibody fragments
WO2009102473A2 (en) * 2008-02-14 2009-08-20 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
CN101952670B (zh) 2008-04-18 2013-04-17 株式会社电装 喷射器式制冷循环装置
WO2010028795A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Multivalent antibodies
WO2010028797A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Multivalent antibodies
WO2010028798A1 (en) * 2008-09-10 2010-03-18 F. Hoffmann-La Roche Ag Multivalent antibodies
KR20110084254A (ko) 2008-10-16 2011-07-21 사이토닉스 코포레이션 척추 및 관절 통증을 탐지하고 치료하는 생체표식 및 방법
EP2425001A4 (en) 2009-04-30 2012-11-14 Univ California ANTI-HIV COMBINATION VECTORS, TARGETING VECTORS AND METHOD OF USE
ES2621874T3 (es) 2010-03-26 2017-07-05 Memorial Sloan-Kettering Cancer Center Anticuerpos para MUC16 y métodos de uso de los mismos
EP2558494B1 (en) 2010-04-15 2018-05-23 AbbVie Inc. Amyloid-beta binding proteins
CN101914135B (zh) * 2010-07-23 2013-06-12 暨南大学 一种广谱趋化因子受体拮抗性多肽及其应用
US9062101B2 (en) 2010-08-14 2015-06-23 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
WO2012075173A2 (en) 2010-12-01 2012-06-07 Board Of Regents The University Of Texas System Compositions and method for deimmunization of proteins
EP2882460B1 (en) 2012-08-09 2019-04-24 The Regents of The University of California Cd25 pre-selective combination anti-hiv vectors, targeting vectors, and methods of use
EP2893343B1 (en) 2012-09-07 2019-11-20 The Governors of the University of Alberta Methods for diagnosis of inflammatory liver disease
US20140087463A1 (en) * 2012-09-25 2014-03-27 The Washington University Optical control of cell signaling
EP3082870B1 (en) * 2013-12-20 2019-10-23 The University of Bristol Conjugates for treating inflammatory disease and identification of patients likely to benefit from such treatment
MX391249B (es) 2015-03-17 2025-03-21 Memorial Sloan Kettering Cancer Center Anticuerpos anti-muc16 y sus usos.
BR112018010156A8 (pt) * 2015-11-20 2019-02-26 Treat4Life Ab método para análise de adesão de fármaco em uma amostra de tecido
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
US11045546B1 (en) 2020-03-30 2021-06-29 Cytodyn Inc. Methods of treating coronavirus infection
CN114075286A (zh) * 2020-08-21 2022-02-22 张家港博泽利斯生物技术有限公司 一种抗人cxcr1蛋白单克隆抗体的制备方法

Family Cites Families (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US5440021A (en) 1991-03-29 1995-08-08 Chuntharapai; Anan Antibodies to human IL-8 type B receptor
US5314992A (en) 1991-11-25 1994-05-24 Trustees Of Dartmouth College Lipocortin-1 receptor protein and its uses
US5817310A (en) 1991-12-02 1998-10-06 Cor Therapeutics, Inc. Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
JP3664176B2 (ja) 1992-11-10 2005-06-22 ジェネンテック・インコーポレーテッド Ｃ−ｃ ｃｋｒ−１，ｃ−ｃケモカインレセプター
DE69317883T2 (de) 1992-11-17 1998-11-12 Icos Corp., Bothell, Wash. Neue Sieben-Transmembran-Rezeptor V28
US5652133A (en) 1993-01-28 1997-07-29 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Cloning and expression of the human macrophage inflammatory protein-1.alpha.α) /rantes receptor
EP0612723B1 (de) 1993-02-20 1997-08-27 Hoechst Aktiengesellschaft Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, als Inhibitoren des zellulären Na+/H+-Austauschs oder als Diagnostikum sowie sie enthaltendes Medikament
US5739103A (en) 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
AU1679395A (en) 1994-01-13 1995-08-01 Regents Of The University Of California, The Mammalian monocyte chemoattractant protein receptors
DE4408212A1 (de) 1994-03-11 1995-09-14 Bayer Ag 5-Vinyl- und 5-Ethinyl-chinolon- und -naphthyridon-carbonsäuren
US6806061B1 (en) 1995-01-19 2004-10-19 Children's Medical Center Corporation G protein-coupled receptor gene and methods of use therefor
US6537764B1 (en) 1995-01-19 2003-03-25 Children's Medical Center Corporation Method of identifying inhibitors of C—C chemokine receptor 3
GB9501683D0 (en) 1995-01-27 1995-03-15 Glaxo Group Ltd Substances and their uses
AU2766395A (en) 1995-06-05 1996-12-24 Human Genome Sciences, Inc. Human g-protein receptor hgber32
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
JPH10510719A (ja) 1995-06-06 1998-10-20 ヒューマン ジノーム サイエンシーズ，インコーポレイテッド ヒトｇタンパク質ケモカインレセプターｈｄｇｎｒ１０
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US7265201B1 (en) 1995-06-23 2007-09-04 Millennium Pharmaceuticals, Inc. Human chemotactic cytokine
GB9601081D0 (en) 1995-10-06 1996-03-20 Cambridge Antibody Tech Specific binding members for human transforming growth factor beta;materials and methods
WO1997019696A1 (en) 1995-11-30 1997-06-05 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, National Institutes Of Health, Office Of Technology Transfer C-c chemokines that inhibit retrovirus infection
US6512103B1 (en) 1995-12-08 2003-01-28 Schering Corporation Mammalian chemokine reagents
US6265184B1 (en) 1995-12-20 2001-07-24 Icos Corporation Polynucleotides encoding chemokine receptor 88C
EP0886643A4 (en) 1996-01-11 2000-04-19 Human Genome Sciences Inc HUMAN G-PROTEIN CHEMOKIN RECEPTOR HSATU68
AU1834197A (en) 1996-01-30 1997-08-22 National Institutes Of Health, The Cells expressing both human cd4 and cxcr4
WO1997032019A2 (en) 1996-03-01 1997-09-04 Euroscreen S.A. C-c ckr-5, cc-chemikines receptor, derivatives thereof and their uses
AU2020497A (en) 1996-03-27 1997-10-17 Susan R. George Receptor and transporter antagonists
US6107019A (en) 1996-06-14 2000-08-22 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
US6344545B1 (en) 1996-06-14 2002-02-05 Progenics Pharmaceuticals, Inc. Method for preventing HIV-1 infection of CD4+ cells
JP2000507596A (ja) 1996-04-02 2000-06-20 プロジェニクス・ファーマスーティカルス・インコーポレーテッド Ｃｄ４▲上＋▼細胞のｈｉｖ―１感染を防ぐ方法
WO1997041225A2 (en) 1996-04-26 1997-11-06 Incyte Pharmaceuticals, Inc. Mammalian mixed lymphocyte receptors, chemokine receptors [mmlr-ccr]
AU2775397A (en) 1996-04-30 1997-11-19 Wolf-Georg Forssmann Cc-type chemokines
US6258527B1 (en) 1996-05-20 2001-07-10 The Aaron Diamond Aids Research Center Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US5939320A (en) 1996-05-20 1999-08-17 New York University G-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
WO1997045543A2 (en) 1996-05-28 1997-12-04 The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health Cc chemokine receptor 5, antibodies thereto, transgenic animals
ES2270461T3 (es) 1996-06-03 2007-04-01 United Biomedical, Inc. Anticuerpos contra un complejo de cd4 y un dominio receptor de quemoquina, y sus usos contra las infecciones de vih.
US5961976A (en) 1996-06-03 1999-10-05 United Biomedical, Inc. Antibodies against a host cell antigen complex for pre- and post-exposure protection from infection by HIV
WO1997047318A1 (en) 1996-06-14 1997-12-18 Progenics Pharmaceuticals, Inc. Uses of a chemokine receptor for inhibiting hiv-1 infection
US5994515A (en) 1996-06-25 1999-11-30 Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
WO1997049424A1 (en) 1996-06-25 1997-12-31 The Trustees Of The University Of Pennsylvania Antibodies directed against cellular coreceptors for human immunodeficiency virus and methods of using the same
WO1998000535A2 (en) 1996-06-28 1998-01-08 Dana-Farber Cancer Institute Method for inhibiting hiv-1 infection, drug screens, and methods of diagnosis and prognosis of susceptibility to hiv infection
US5928881A (en) 1996-07-11 1999-07-27 Smithkline Beecham Corporation Method of identifying agonists and antagonist for CC-CKR5 receptor
EP0920306A2 (en) 1996-07-12 1999-06-09 Leukosite, Inc. Chemokine receptor antagonists and methods of use therefor
US6057102A (en) 1996-08-08 2000-05-02 The Aaron Diamond Aids Research Center HIV coreceptor mutants
WO1998005798A1 (en) 1996-08-08 1998-02-12 The Aaron Diamond Aids Research Center Hiv coreceptor mutants
AU734090B2 (en) 1996-09-10 2001-06-07 Millennium Pharmaceuticals, Inc. CXCR3 chemokine receptor, antibodies, nucleic acids, and methods of use
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
EP0956290A1 (en) 1996-10-09 1999-11-17 Dana-Farber Cancer Institute Gp120 polypeptides having conformational discontinuous chemokine receptor binding sites and methods of inhibiting hiv infection
US5939538A (en) 1996-10-25 1999-08-17 Immusol Incorporated Methods and compositions for inhibiting HIV infection of cells by cleaving HIV co-receptor RNA
US6528625B1 (en) 1996-10-28 2003-03-04 Millennium Pharmaceuticals, Inc. Anti-CCR5 antibodies and kits comprising same
CA2270132A1 (en) 1996-11-06 1998-05-14 Sequenom, Inc. Dna diagnostics based on mass spectrometry
WO1998025617A1 (en) 1996-12-13 1998-06-18 Merck & Co., Inc. Substituted aryl piperazines as modulators of chemokine receptor activity
AU5604998A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
AU5803398A (en) 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US5962462A (en) 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
WO1998027815A1 (en) 1996-12-20 1998-07-02 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
US5919776A (en) 1996-12-20 1999-07-06 Merck & Co., Inc. Substituted aminoquinolines as modulators of chemokine receptor activity
AR011057A1 (es) 1997-01-08 2000-08-02 Smithkline Beecham Corp Uso de bis-acridinas sustituidas y compuestos afines para la preparacion de medicamentos y dichos compuestos
US5798206A (en) 1997-01-10 1998-08-25 New York Blood Center Methods for screening of test compounds for inhibiting binding of a CD4-HIV 1 complex to a chemokine receptor
AU6133098A (en) 1997-01-21 1998-08-07 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
RU2126048C1 (ru) 1997-01-28 1999-02-10 Институт молекулярной генетики РАН Способ определения генетической устойчивости обследуемых к инфицированию вирусом иммунодефицита человека первого типа (вич-1)
AU6271598A (en) 1997-02-06 1998-08-26 Epoch Pharmaceuticals, Inc. Targeted modification of the ccr-5 gene
US6100387A (en) 1997-02-28 2000-08-08 Genetics Institute, Inc. Chimeric polypeptides containing chemokine domains
US6214540B1 (en) 1997-03-26 2001-04-10 University Of Maryland Biotechnology Institute Chemokines that inhibit immunodeficiency virus infection and methods based thereon
WO1998044158A1 (en) 1997-03-28 1998-10-08 Epitope, Inc. Simultaneous collection of dna and non-nucleic analytes from oral fluids
IT1291353B1 (it) 1997-05-12 1999-01-07 San Raffaele Centro Fond Peptidi con attivita' antivirale
US6153431A (en) 1997-05-30 2000-11-28 Fond Mondiale Rech & Prev Sida Human immunodeficiency virus co-receptor variants associated with resistance to virus infection
FR2764387B1 (fr) 1997-06-05 1999-07-23 Centre Nat Rech Scient Utilisation d'une proteine fluorescente pour la detection d'interactions entre une proteine cible et son ligand
CA2295059A1 (en) 1997-06-23 1998-12-30 Israel F. Charo Transgenic rabbits expressing cd4 and chemokine receptor
AU3044697A (en) 1997-06-24 1999-01-04 Norman Godin A composition for specific immunoprotection and method for obtaining said comp osition
ZA985542B (en) 1997-07-03 1999-04-07 Smithkline Beecham Corp Substituted benzanilides as CCR5 receptor ligands antiinflammatory agents and antiviral agents
CA2296314A1 (en) 1997-07-25 1999-02-04 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
AU8669598A (en) 1997-07-29 1999-02-22 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Chemokine receptor ccr8 dna and uses thereof
US6019979A (en) 1997-08-15 2000-02-01 The Picower Institute For Medical Research Anti-viral treatment with pertussis toxin B oligomer
EP1009405A4 (en) 1997-08-28 2001-05-09 Merck & Co Inc PAYRROLIDINE AND PIPERIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
WO1999012416A1 (en) 1997-09-09 1999-03-18 The Trustees Of Columbia University In The City Of New York T-independent conjugate-vaccines
US6204024B1 (en) 1997-09-12 2001-03-20 Akzo Nobel N.V. CCR5 RNA transcription based amplification assay
AU9495098A (en) 1997-09-19 1999-04-05 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods for use of interleukin 4 (il-4) to treat human immunodeficiency virus infection
AR013669A1 (es) 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
WO1999023253A1 (en) 1997-10-30 1999-05-14 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Stromal cell derived factor-1 (sdf-1) and method of use for diagnostic and prognostic indicator of aids pathogenesis
AU1449499A (en) 1997-10-31 1999-05-24 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
AU1454599A (en) 1997-11-10 1999-05-31 Dana-Farber Cancer Institute Compounds inhibiting cd4-gp120 interaction and uses thereof
WO1999024553A2 (en) 1997-11-10 1999-05-20 The Trustees Of Columbia University In The City Of New York X-ray crystal comprising hiv-1 gp120
FR2771423A1 (fr) 1997-11-21 1999-05-28 Transgene Sa Vecteurs permettant d'inhiber ou retarder la liaison d'un virus d'immunodeficience et/ou sa penetration dans une cellule cible
AU1616499A (en) 1997-12-01 1999-06-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Chemokine variants and methods of use
WO1999027939A1 (en) 1997-12-04 1999-06-10 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation
US6013644A (en) 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
CA2313805A1 (en) 1997-12-19 1999-07-01 Immunex Corporation Method for reducing susceptibility to hiv infection
CN1282243A (zh) 1997-12-19 2001-01-31 武田药品工业株式会社 用于拮抗ccr5的含n－酰苯胺衍生物的药物组合物
WO1999033989A2 (en) 1997-12-23 1999-07-08 Fondazione Centro San Raffaele Del Monte Tabor Rantes mutants and therapeutic applications thereof
DE69921609T2 (de) 1998-01-15 2005-10-27 King's College London Ribozymale nukleinsäure die ccr5 oder cxcr4 schneiden
WO1999038514A1 (en) 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
WO1999043711A1 (en) 1998-02-27 1999-09-02 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services G protein-coupled receptor antagonists
JPH11243960A (ja) 1998-03-06 1999-09-14 Shionogi & Co Ltd ヒトｃｃ型ケモカインエオタキシン３
US6100087A (en) 1998-03-11 2000-08-08 City Of Hope Ribozymes targeted to human CCR5 mRNA
US6287805B1 (en) 1998-03-20 2001-09-11 Millennium Pharmaceuticals, Inc. Nucleic acid molecules of the protein-coupled heptahelical receptor superfamily and uses therefor
JPH11292795A (ja) 1998-04-02 1999-10-26 Yamanouchi Pharmaceut Co Ltd Ｈｉｖコファクター抑制剤
US6383777B1 (en) 1998-04-16 2002-05-07 Va{Umlaut Over (N)}Derbilt University Methods and compositions for high yield production of eukaryotic proteins
AU4325499A (en) 1998-06-01 1999-12-20 University Of Maryland Biotechnology Institute Receptor ligand antagonist complexes and their use in treating or preventing receptor mediated diseases
US6362371B1 (en) 1998-06-08 2002-03-26 Advanced Medicine, Inc. β2- adrenergic receptor agonists
CA2331760A1 (en) 1998-06-23 1999-12-29 John C. Kappes Cell-based assay for immunodeficiency virus infectivity and sensitivity
EP1145002B2 (en) 1998-07-06 2008-12-10 PerkinElmer Cellular Sciences Belgium BVBA Bioluminescent assay for agonists or antagonists of a calcium-coupled receptor
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
CA2338804A1 (en) 1998-07-28 2000-02-10 Smithkline Beecham Corporation Propenamides as ccr5 modulators
BR9912406A (pt) 1998-07-28 2001-04-24 Smithkline Beecham Corp Compostos de anilida substituida e métodos
WO2000006085A2 (en) 1998-07-28 2000-02-10 Smithkline Beecham Corporation Compounds and methods
EP0979655A1 (de) 1998-08-01 2000-02-16 Boehringer Mannheim Gmbh Mittel zur Behandlung von durch RNA-Viren, wie beispielsweise HIV verursachten Infenktionen
EP1102788A4 (en) 1998-08-03 2002-08-28 Univ Montana PREVENTION AND TREATMENT OF VIRAL PATHOLOGY
CN1317009A (zh) 1998-08-03 2001-10-10 东卡罗来纳大学 低腺苷反义寡核苷酸制剂、组合物、试剂盒及处理
AU5301599A (en) 1998-08-20 2000-03-14 Takeda Chemical Industries Ltd. Quaternary ammonium salts and their use
US6475718B2 (en) 1998-09-08 2002-11-05 Schering Aktiengesellschaft Methods and compositions for modulating the interaction between the APJ receptor and the HIV virus
ATE317436T1 (de) 1998-09-10 2006-02-15 Siffert Winfried Genveränderung im gen für die g$g(b)3- untereinheit des humanen g-proteins
GB9820014D0 (en) 1998-09-14 1998-11-04 Cancer Res Campaign Tech Receptor antagonists and uses thereof
AU2001243145A1 (en) * 2000-02-09 2001-08-20 Human Genome Sciences, Inc. Human g-protein chemokine receptor (ccr5) hdgnr10
JP4715074B2 (ja) 2000-02-29 2011-07-06 ダイキン工業株式会社 テトラフルオロエチレンの製造方法
WO2001096388A2 (en) 2000-06-09 2001-12-20 Corixa Corporation Compositions and methods for the therapy and diagnosis of colon cancer
US7005503B2 (en) * 2002-02-08 2006-02-28 Genetastix Corporation Human monoclonal antibody against coreceptors for human immunodeficiency virus
US7175988B2 (en) 2001-02-09 2007-02-13 Human Genome Sciences, Inc. Human G-protein Chemokine Receptor (CCR5) HDGNR10
US20020146415A1 (en) * 2001-04-06 2002-10-10 Olson William C. Methods for inhibiting HIV-1 infection
US7393934B2 (en) 2001-12-21 2008-07-01 Human Genome Sciences, Inc. Human G-protein chemokine receptor (CCR5) HDGNR10
JP2005519946A (ja) 2002-03-12 2005-07-07 マキシジェン エーピーエス 発作の処置のためのインターフェロンβ様分子
AU2003254641A1 (en) 2002-08-28 2004-03-19 Maxygen Aps Interferon beta-like molecules for treatment of cancer

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