JP2008506358A5 - - Google Patents

Info

Publication number

JP2008506358A5

JP2008506358A5 JP2007505627A JP2007505627A JP2008506358A5 JP 2008506358 A5 JP2008506358 A5 JP 2008506358A5 JP 2007505627 A JP2007505627 A JP 2007505627A JP 2007505627 A JP2007505627 A JP 2007505627A JP 2008506358 A5 JP2008506358 A5 JP 2008506358A5

Authority

JP

Japan

Prior art keywords

domain

seq

specific binding

amino acid

acid sequence

Prior art date

2005-03-29

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 230000009870 specific binding Effects 0.000 claims 53
• 125000003275 alpha amino acid group Chemical group 0.000 claims 27
• 102000004874 Synaptophysin Human genes 0.000 claims 22
• 108090001076 Synaptophysin Proteins 0.000 claims 22
• 108020004707 nucleic acids Proteins 0.000 claims 18
• 150000007523 nucleic acids Chemical class 0.000 claims 18
• 102000039446 nucleic acids Human genes 0.000 claims 18
• 230000027455 binding Effects 0.000 claims 13
• 238000000034 method Methods 0.000 claims 13
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 12
• 238000012986 modification Methods 0.000 claims 12
• 230000004048 modification Effects 0.000 claims 12
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
• 150000001413 amino acids Chemical class 0.000 claims 3
• 238000004519 manufacturing process Methods 0.000 claims 3
• 238000009007 Diagnostic Kit Methods 0.000 claims 2
• 238000007792 addition Methods 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 2
• 208000019425 cirrhosis of liver Diseases 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 210000004024 hepatic stellate cell Anatomy 0.000 claims 2
• 238000003780 insertion Methods 0.000 claims 2
• 230000037431 insertion Effects 0.000 claims 2
• 238000005259 measurement Methods 0.000 claims 2
• 238000006467 substitution reaction Methods 0.000 claims 2
• 239000003053 toxin Substances 0.000 claims 2
• 231100000765 toxin Toxicity 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• FIVPIPIDMRVLAY-UHFFFAOYSA-N aspergillin Natural products C1C2=CC=CC(O)C2N2C1(SS1)C(=O)N(C)C1(CO)C2=O FIVPIPIDMRVLAY-UHFFFAOYSA-N 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 claims 1
• FIVPIPIDMRVLAY-RBJBARPLSA-N gliotoxin Chemical compound C1C2=CC=C[C@H](O)[C@H]2N2[C@]1(SS1)C(=O)N(C)[C@@]1(CO)C2=O FIVPIPIDMRVLAY-RBJBARPLSA-N 0.000 claims 1
• 229940103893 gliotoxin Drugs 0.000 claims 1
• 229930190252 gliotoxin Natural products 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 238000012360 testing method Methods 0.000 claims 1
• PIILXFBHQILWPS-UHFFFAOYSA-N tributyltin Chemical compound CCCC[Sn](CCCC)CCCC PIILXFBHQILWPS-UHFFFAOYSA-N 0.000 claims 1