JP2008504272A5 - - Google Patents
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- Publication number
- JP2008504272A5 JP2008504272A5 JP2007518238A JP2007518238A JP2008504272A5 JP 2008504272 A5 JP2008504272 A5 JP 2008504272A5 JP 2007518238 A JP2007518238 A JP 2007518238A JP 2007518238 A JP2007518238 A JP 2007518238A JP 2008504272 A5 JP2008504272 A5 JP 2008504272A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- weight
- composition according
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 75
- 239000008194 pharmaceutical composition Substances 0.000 claims description 53
- 229940074076 glycerol formal Drugs 0.000 claims description 34
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 29
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 25
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 25
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 25
- 150000003839 salts Chemical class 0.000 claims description 23
- 229960002537 betamethasone Drugs 0.000 claims description 22
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims description 22
- 150000002148 esters Chemical class 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 17
- 229960002722 terbinafine Drugs 0.000 claims description 16
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims description 14
- 239000003960 organic solvent Substances 0.000 claims description 14
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical group C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 claims description 14
- 229960000707 tobramycin Drugs 0.000 claims description 14
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims description 14
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims description 10
- 229930182566 Gentamicin Natural products 0.000 claims description 10
- 229960004022 clotrimazole Drugs 0.000 claims description 10
- 229960002518 gentamicin Drugs 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 229920001223 polyethylene glycol Polymers 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 claims description 8
- 229940116333 ethyl lactate Drugs 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 229940121375 antifungal agent Drugs 0.000 claims 8
- 150000003431 steroids Chemical class 0.000 claims 8
- 239000003242 anti bacterial agent Substances 0.000 claims 5
- 239000003429 antifungal agent Substances 0.000 claims 5
- 230000000844 anti-bacterial effect Effects 0.000 claims 3
- AYIRNRDRBQJXIF-NXEZZACHSA-N (-)-Florfenicol Chemical compound CS(=O)(=O)C1=CC=C([C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl)C=C1 AYIRNRDRBQJXIF-NXEZZACHSA-N 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 2
- 229960003760 florfenicol Drugs 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- -1 glycerol formal Chemical compound 0.000 description 28
- 235000014113 dietary fatty acids Nutrition 0.000 description 24
- 239000000194 fatty acid Substances 0.000 description 24
- 229930195729 fatty acid Natural products 0.000 description 24
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 22
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 12
- 229960001950 benzethonium chloride Drugs 0.000 description 12
- DIOQZVSQGTUSAI-UHFFFAOYSA-N decane Chemical compound CCCCCCCCCC DIOQZVSQGTUSAI-UHFFFAOYSA-N 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- 239000002253 acid Substances 0.000 description 4
- 229960004648 betamethasone acetate Drugs 0.000 description 4
- AKUJBENLRBOFTD-QZIXMDIESA-N betamethasone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O AKUJBENLRBOFTD-QZIXMDIESA-N 0.000 description 4
- 229960005150 glycerol Drugs 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229940049964 oleate Drugs 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/874,552 | 2004-06-24 | ||
| US10/874,552 US7618651B2 (en) | 2004-06-24 | 2004-06-24 | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
| US11/019,243 | 2004-12-23 | ||
| US11/019,243 US7622138B2 (en) | 2004-06-24 | 2004-12-23 | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
| PCT/US2005/022073 WO2006012146A2 (en) | 2004-06-24 | 2005-06-23 | Pharmaceutical compositions for drug delivery and methods of treating or preventing conditions using same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008504272A JP2008504272A (ja) | 2008-02-14 |
| JP2008504272A5 true JP2008504272A5 (enExample) | 2012-12-13 |
| JP5324091B2 JP5324091B2 (ja) | 2013-10-23 |
Family
ID=35786640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007518238A Expired - Lifetime JP5324091B2 (ja) | 2004-06-24 | 2005-06-23 | 薬物送達のための医薬組成物及びそれを使用する症状の治療又は予防法 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1765293B1 (enExample) |
| JP (1) | JP5324091B2 (enExample) |
| AU (1) | AU2005267396B2 (enExample) |
| CA (1) | CA2570599C (enExample) |
| WO (1) | WO2006012146A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006103638A2 (en) * | 2005-03-31 | 2006-10-05 | Ranbaxy Laboratories Limited | Topical pharmaceutical compositions of terbinafine and processes for their preparation |
| HUP0700828A2 (en) * | 2007-12-20 | 2010-01-28 | Richter Gedeon Nyrt | Transdermal pharmaceutical compositions containing tolperisone alone and in combination |
| EP2143421A1 (en) * | 2008-07-07 | 2010-01-13 | Almirall Hermal GmbH | Topical composition for the treatment of actinic keratosis |
| SE536091C2 (sv) * | 2011-04-14 | 2013-04-30 | Pep Tonic Medical Ab | Farmaceutisk komposition innehållande oxytocin eller fragment eller varianter därav och åtminstone en icke-jonisk cellulosaeter |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6087215A (ja) * | 1983-10-19 | 1985-05-16 | Mitsui Toatsu Chem Inc | 外用薬用基材 |
| US4678516A (en) * | 1984-10-09 | 1987-07-07 | The Dow Chemical Company | Sustained release dosage form based on highly plasticized cellulose ether gels |
| US4843096A (en) * | 1985-06-26 | 1989-06-27 | Stiefel Laboratories, Inc. | Treatment of acne |
| US5110809A (en) * | 1988-03-21 | 1992-05-05 | Bristol-Myers Squibb Company | Antifungal gel formulations |
| EP0865292A4 (en) * | 1995-11-22 | 2002-01-02 | Intrabiotics Pharmaceuticals | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF INFLAMMATION OF THE ORAL MUCOSA |
| US6630168B1 (en) * | 1997-02-20 | 2003-10-07 | Biomedicines, Inc. | Gel delivery vehicles for anticellular proliferative agents |
| GB9718791D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Medicaments |
| US6238683B1 (en) * | 1998-12-04 | 2001-05-29 | Johnson & Johnson Consumer Companies, Inc. | Anhydrous topical skin preparations |
| IT1308187B1 (it) * | 1999-02-16 | 2001-12-07 | Formenti Farmaceutici Spa | Composizioni farmaceutiche topiche a base di antiinfiammatori nonsteroidei. |
| JP4195178B2 (ja) * | 1999-11-10 | 2008-12-10 | 東興薬品工業株式会社 | 消炎鎮痛外用剤 |
| FR2802810A1 (fr) * | 1999-12-23 | 2001-06-29 | Grinda Jean Robert | Nouveaux produits cosmetiques et therapeutiques a base de composes lipidiques et leur procede de preparation |
| JP2001245913A (ja) * | 1999-12-28 | 2001-09-11 | Lion Corp | 非水系温熱ゲル組成物 |
| TWI232758B (en) * | 2000-03-21 | 2005-05-21 | Jiun-Ren Chen | High concentration vitamin C composition and method for preparing the same |
| WO2003094917A1 (en) * | 2002-05-13 | 2003-11-20 | Takata Seiyaku Co., Ltd. | Vintoperol-containing medicinal composition for transdermal administration |
-
2005
- 2005-06-23 JP JP2007518238A patent/JP5324091B2/ja not_active Expired - Lifetime
- 2005-06-23 AU AU2005267396A patent/AU2005267396B2/en not_active Expired
- 2005-06-23 WO PCT/US2005/022073 patent/WO2006012146A2/en not_active Ceased
- 2005-06-23 EP EP05762750.7A patent/EP1765293B1/en not_active Expired - Lifetime
- 2005-06-23 CA CA2570599A patent/CA2570599C/en not_active Expired - Lifetime
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