JP2008503230A5 - - Google Patents

Download PDF

Info

Publication number
JP2008503230A5
JP2008503230A5 JP2007517365A JP2007517365A JP2008503230A5 JP 2008503230 A5 JP2008503230 A5 JP 2008503230A5 JP 2007517365 A JP2007517365 A JP 2007517365A JP 2007517365 A JP2007517365 A JP 2007517365A JP 2008503230 A5 JP2008503230 A5 JP 2008503230A5
Authority
JP
Japan
Prior art keywords
vih
amino acid
point mutation
acid mutations
catalytic site
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007517365A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008503230A (ja
JP4861314B2 (ja
Filing date
Publication date
Priority claimed from FR0407017A external-priority patent/FR2872170B1/fr
Application filed filed Critical
Publication of JP2008503230A publication Critical patent/JP2008503230A/ja
Publication of JP2008503230A5 publication Critical patent/JP2008503230A5/ja
Application granted granted Critical
Publication of JP4861314B2 publication Critical patent/JP4861314B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2007517365A 2004-06-25 2005-06-24 非組み込み型且つ非複製型組換えレンチウイルス、その調製および使用 Expired - Fee Related JP4861314B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0407017A FR2872170B1 (fr) 2004-06-25 2004-06-25 Lentivirus non interactif et non replicatif, preparation et utilisations
FR0407017 2004-06-25
PCT/FR2005/001604 WO2006010834A1 (fr) 2004-06-25 2005-06-24 Lentivirus non integratif et non replicatif, preparation et utilisations

Publications (3)

Publication Number Publication Date
JP2008503230A JP2008503230A (ja) 2008-02-07
JP2008503230A5 true JP2008503230A5 (OSRAM) 2008-08-07
JP4861314B2 JP4861314B2 (ja) 2012-01-25

Family

ID=34948183

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007517365A Expired - Fee Related JP4861314B2 (ja) 2004-06-25 2005-06-24 非組み込み型且つ非複製型組換えレンチウイルス、その調製および使用

Country Status (10)

Country Link
US (1) US8119119B2 (OSRAM)
EP (1) EP1761635B1 (OSRAM)
JP (1) JP4861314B2 (OSRAM)
CN (1) CN101023177A (OSRAM)
AT (1) ATE524554T1 (OSRAM)
AU (1) AU2005266221B2 (OSRAM)
CA (1) CA2579753C (OSRAM)
FR (1) FR2872170B1 (OSRAM)
IL (1) IL179740A0 (OSRAM)
WO (1) WO2006010834A1 (OSRAM)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0526211D0 (en) * 2005-12-22 2006-02-01 Oxford Biomedica Ltd Viral vectors
WO2007091066A1 (en) * 2006-02-07 2007-08-16 Ucl Business Plc Applications of non-integrating lentiviral vectors
EP2020444B1 (en) * 2007-08-03 2017-05-31 Institut Pasteur Defective non-integrative lentiviral transfer vectors for vaccines
AU2013203404B2 (en) * 2007-08-03 2016-10-13 Centre National De La Recherche Scientifique (Cnrs) Lentiviral gene transfer vectors and their medicinal applications
AU2008285224B2 (en) 2007-08-03 2015-01-22 Centre National De La Recherche Scientifique (Cnrs) Lentiviral gene transfer vectors and their medicinal applications
WO2009054985A1 (en) 2007-10-25 2009-04-30 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
CA2719938A1 (en) * 2008-03-28 2009-10-01 Virxsys Corporation Lentivirus-based immunogenic vectors
WO2009131706A1 (en) * 2008-04-26 2009-10-29 Yung-Nien Chang Site-specific-integration lentiviral vectors
CA2754603A1 (en) * 2009-03-13 2010-09-16 Lentigen Corporation Non-integrating retroviral vector vaccines
JP6215533B2 (ja) 2009-04-09 2017-10-18 サンガモ セラピューティクス, インコーポレイテッド 幹細胞への標的組込み
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
EP2660318A1 (en) 2010-02-09 2013-11-06 Sangamo BioSciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
EP2385107B1 (en) 2010-05-03 2016-08-24 Institut Pasteur Lentiviral vector based immunological compounds against malaria
WO2012152912A1 (en) 2011-05-12 2012-11-15 Newvectys Genetically modified pig as a cancer prone model
EP2592091B1 (en) 2011-11-08 2017-09-20 Institut Pasteur High MAST2-affinity polypeptides and uses thereof
GB201202516D0 (en) 2012-02-13 2012-03-28 Ucl Business Plc Materials and methods relating to packaging cell lines
ES2707288T3 (es) 2012-03-30 2019-04-03 Immune Design Corp Partículas de vectores lentivíricos que tienen eficiencia de transducción mejorada para células que expresan DC-SIGN
US9713635B2 (en) 2012-03-30 2017-07-25 Immune Design Corp. Materials and methods for producing improved lentiviral vector particles
WO2014093701A1 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
EP4299741A3 (en) 2012-12-12 2024-02-28 The Broad Institute, Inc. Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
ES2701749T3 (es) 2012-12-12 2019-02-25 Broad Inst Inc Métodos, modelos, sistemas y aparatos para identificar secuencias diana para enzimas Cas o sistemas CRISPR-Cas para secuencias diana y transmitir resultados de los mismos
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
HK1220205A1 (zh) 2013-03-15 2017-04-28 Celgene Corporation 修饰的t淋巴细胞
ES2767318T3 (es) * 2013-06-17 2020-06-17 Broad Inst Inc Suministro, modificación y optimización de sistemas, métodos y composiciones para generar modelos y actuar sobre enfermedades y trastornos de células posmitóticas
BR122021009076B1 (pt) 2013-06-17 2024-02-15 The Broad Institute Inc. Vetor viral contendo molécula(s) de ácido nucleico heterólogo, composição, uso e métodos do mesmo
BR112015031608A2 (pt) 2013-06-17 2017-08-22 Massachusetts Inst Technology Aplicação e uso dos sistemas crispr-cas, vetores e composições para direcionamento e terapia hepáticos
AU2014281026B2 (en) 2013-06-17 2020-05-28 Massachusetts Institute Of Technology Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation
CN105492611A (zh) 2013-06-17 2016-04-13 布罗德研究所有限公司 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物
EP3011033B1 (en) 2013-06-17 2020-02-19 The Broad Institute, Inc. Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
EP3046930A1 (en) * 2013-09-17 2016-07-27 INSERM - Institut National de la Santé et de la Recherche Médicale Lentiviral vectors having a mutated integrase protein and uses thereof
EP2878667A1 (en) 2013-11-29 2015-06-03 Institut Pasteur TAL effector means useful for partial or full deletion of DNA tandem repeats
WO2015089364A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Crystal structure of a crispr-cas system, and uses thereof
WO2015089462A1 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing
SG10201804975PA (en) 2013-12-12 2018-07-30 Broad Inst Inc Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders
EP3653703A1 (en) 2013-12-12 2020-05-20 The Broad Institute, Inc. Compositions and methods of use of crispr-cas systems in nucleotide repeat disorders
EP3080259B1 (en) 2013-12-12 2023-02-01 The Broad Institute, Inc. Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
WO2015089486A2 (en) 2013-12-12 2015-06-18 The Broad Institute Inc. Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
GB201322798D0 (en) 2013-12-20 2014-02-05 Oxford Biomedica Ltd Production system
KR102161927B1 (ko) 2014-04-25 2020-10-06 블루버드 바이오, 인코포레이티드. 양자 세포 치료제를 제조하는 개선된 방법
MX382565B (es) 2014-04-25 2025-03-13 2Seventy Bio Inc Receptores de antigenos quimericos del promotor mnd.
ES2846811T3 (es) 2014-06-06 2021-07-29 Bluebird Bio Inc Composiciones de células T mejoradas
SG10201900455YA (en) 2014-07-24 2019-02-27 Bluebird Bio Inc Bcma chimeric antigen receptors
EP3031923A1 (en) 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
EP3985115A1 (en) 2014-12-12 2022-04-20 The Broad Institute, Inc. Protected guide rnas (pgrnas)
WO2016094304A2 (en) 2014-12-12 2016-06-16 Bluebird Bio, Inc. Bcma chimeric antigen receptors
CA2970370A1 (en) 2014-12-24 2016-06-30 Massachusetts Institute Of Technology Crispr having or associated with destabilization domains
JP7107683B2 (ja) 2015-06-18 2022-07-27 ザ・ブロード・インスティテュート・インコーポレイテッド オフターゲット効果を低下させるcrispr酵素突然変異
WO2016205759A1 (en) 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
WO2017053707A1 (en) 2015-09-23 2017-03-30 Sensoriant, Inc. Method and system for using device states and user preferences to create user-friendly environments
WO2017060662A1 (en) * 2015-10-07 2017-04-13 The Secretary Of State For Health Method for providing a control for use in a screen for pathogenic virus
US11479755B2 (en) 2015-12-07 2022-10-25 2Seventy Bio, Inc. T cell compositions
CN109311963A (zh) 2016-04-14 2019-02-05 蓝鸟生物公司 救助嵌合抗原受体系统
WO2017214938A1 (zh) * 2016-06-16 2017-12-21 毛侃琅 特异促进 bace1 基因高表达的慢病毒表达载体及应用
US20190309274A1 (en) 2016-08-16 2019-10-10 Bluebird Bio, Inc. Il-10 receptor alpha homing endonuclease variants, compositions, and methods of use
US20190262398A1 (en) 2016-08-23 2019-08-29 Bluebird Bio, Inc. Tim3 homing endonuclease variants, compositions, and methods of use
IL265045B2 (en) 2016-09-08 2023-09-01 Bluebird Bio Inc Variants of endonuclease pd-1, compositions and methods of use
AU2017346683B2 (en) 2016-10-17 2024-04-18 Regeneron Pharmaceuticals, Inc. TGFβR2 endonuclease variants, compositions, and methods of use
CN110022906A (zh) 2016-11-04 2019-07-16 蓝鸟生物公司 抗bcma car t细胞组合物
IL309526B2 (en) 2016-11-17 2025-02-01 2Seventy Bio Inc TGFBeta signal converter
EP3562937A4 (en) * 2016-12-06 2020-09-16 Bluebird Bio, Inc. GENE THERAPY TO TREAT MUCOPOLYSACCHARIDOSIS TYPE II
CA3046079A1 (en) * 2016-12-06 2018-06-14 Bluebird Bio, Inc. Gene therapy for mucopolysaccharidosis, type i
EP3357504A1 (en) 2017-02-02 2018-08-08 Institut Pasteur Functional screening of antigenic polypeptides - use for the identification of antigens eliciting a protective immune response and for the selection of antigens with optimal protective activity
EP3357506A1 (en) 2017-02-02 2018-08-08 Institut Pasteur Multiple malaria pre-erythrocytic antigens and their use in the elicitation of a protective immune response in a host
ES2969213T3 (es) 2017-02-15 2024-05-17 2Seventy Bio Inc Plantillas de reparación de donantes para edición multiplex del genoma
AU2018273979B2 (en) 2017-05-25 2024-10-17 Regeneron Pharmaceuticals, Inc. CBLB endonuclease variants, compositions, and methods of use
US11779654B2 (en) 2017-10-04 2023-10-10 2Seventy Bio, Inc. PCSK9 endonuclease variants, compositions, and methods of use
EP3502260A1 (en) 2017-12-22 2019-06-26 Oxford BioMedica (UK) Limited Retroviral vector
DE102018100967B4 (de) 2018-01-17 2019-08-14 Immatics US, Inc. Verfahren zur feststellung der wirksamkeit von viralen vektoren
DE102018010282A1 (de) 2018-01-17 2019-07-18 Immatics US, Inc. Verfahren zur Feststellung der Wirksamkeit von viralen Vektoren
EP4365194A3 (en) 2018-06-14 2024-07-24 Regeneron Pharmaceuticals, Inc. Cd79a chimeric antigen receptors
US20210330788A1 (en) 2018-07-11 2021-10-28 Celgene Corporation Uses of anti-bcma chimeric antigen receptors
CA3111076A1 (en) 2018-08-30 2020-03-05 Tenaya Therapeutics, Inc. Cardiac cell reprogramming with myocardin and ascl1
WO2020072059A1 (en) 2018-10-04 2020-04-09 Bluebird Bio, Inc. Cblb endonuclease variants, compositions, and methods of use
CA3122278A1 (en) 2018-12-10 2020-06-18 Bluebird Bio, Inc. Homing endonuclease variants
US20220031750A1 (en) 2018-12-14 2022-02-03 Bluebird Bio, Inc. Dimerizing agent regulated immunoreceptor complexes
US20220154217A1 (en) 2019-04-01 2022-05-19 Tenaya Therapeutics, Inc. Adeno-associated virus with engineered capsid
US20230137971A1 (en) 2019-07-11 2023-05-04 Tenaya Therapeutics Inc. Cardiac cell reprogramming with micrornas and other factors
EP3770264A1 (en) 2019-07-22 2021-01-27 Genethon Precise integration using nuclease targeted idlv
WO2021051390A1 (zh) 2019-09-20 2021-03-25 上海吉倍生物技术有限公司 靶向bcma的抗体及嵌合抗原受体
MX2022005152A (es) 2019-11-05 2022-06-29 Celgene Corp Uso de receptores de antigenos quimericos anti-bcma.
KR20220097492A (ko) 2019-11-12 2022-07-07 옥스포드 바이오메디카(유케이) 리미티드 생산 시스템
KR20220139911A (ko) 2020-02-13 2022-10-17 옥스포드 바이오메디카(유케이) 리미티드 렌티바이러스 벡터의 생산
EP4118217A1 (en) 2020-03-13 2023-01-18 Oxford BioMedica (UK) Limited Lentiviral vectors
WO2021212279A1 (zh) * 2020-04-20 2021-10-28 广东东阳光药业有限公司 慢病毒的滴度提高型转移质粒
CN114807228B (zh) * 2020-04-27 2023-12-15 北京化工大学 一种t7rna聚合酶和t7启动子的表达系统及使用其在真核生物中表达蛋白质的方法
GB202007199D0 (en) 2020-05-15 2020-07-01 Oxford Biomedica Ltd Viral vector production
US11781156B2 (en) 2020-10-09 2023-10-10 Tenaya Therapeutics, Inc. Plakophillin-2 gene therapy methods and compositions
EP3984548A1 (en) 2020-10-16 2022-04-20 Institut Pasteur Generation of lentiviral vectors enabling routing antigens to mhc-ii pathway and inducing cd4+ and cd8+ t-cell responses immune response in a host
WO2022098685A2 (en) 2020-11-04 2022-05-12 Celgene Corporation Car t cell therapy in patients who have had prior anti-cancer alkylator therapy
GB202017725D0 (en) 2020-11-10 2020-12-23 Oxford Biomedica Ltd Method
KR20230117383A (ko) 2020-12-04 2023-08-08 셀진 코포레이션 염증-관련 가용성 인자의 억제제와 조합된 키메라 항원수용체 (car) t-세포 요법의 용도
KR20230156394A (ko) 2021-03-12 2023-11-14 앵스티띠 파스퇴르 Mhc-ii 경로에 대한 항원을 표적화하고 숙주에서 보호 cd8+ 및 cd4+ t 세포 면역성을 유도하는 렌티바이러스 벡터
IL307598A (en) 2021-04-16 2023-12-01 Juno Therapeutics Inc T-cell therapy in patients who have had a previous stem cell transplant
WO2023288267A1 (en) 2021-07-14 2023-01-19 2Seventy Bio, Inc. Engineered t cell receptors fused to binding domains from antibodies
GB202114532D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral Vectors
GB202114534D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Novel viral regulatory elements
GB202114528D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral vectors
GB202114530D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Retroviral vectors
GB202114529D0 (en) 2021-10-12 2021-11-24 Oxford Biomedica Ltd Lentiviral vectors
CN114181972A (zh) * 2021-11-23 2022-03-15 上海本导基因技术有限公司 适用于难治性血管新生性眼疾病基因治疗的慢病毒载体
GB202117844D0 (en) 2021-12-09 2022-01-26 Oxford Biomedica Ltd Purification method
IL316032A (en) 2022-04-08 2024-11-01 Regeneron Pharma Multicomponent receptor and signaling complexes
WO2023198828A1 (en) 2022-04-13 2023-10-19 Universitat Autònoma De Barcelona Treatment of neuromuscular diseases via gene therapy that expresses klotho protein
WO2023220641A2 (en) 2022-05-11 2023-11-16 Juno Therapeutics, Inc. Methods and uses related to t cell therapy and production of same
CN119585438A (zh) 2022-05-26 2025-03-07 再生元制药公司 用于维持慢病毒载体的组合物及其用途
GB202211935D0 (en) 2022-08-16 2022-09-28 Oxford Biomedica Ltd envelope proteins
EP4604993A2 (en) 2022-10-21 2025-08-27 Institut Pasteur Polynucleotides and lentiviral vectors expressing non-structural antigens of a flavivirus selected from the group of denv, zikv and yfv, inducing protective cd8+ t-cell immunity in a host
WO2024102954A1 (en) 2022-11-10 2024-05-16 Massachusetts Institute Of Technology Activation induced clipping system (aics)
WO2024200573A1 (en) 2023-03-27 2024-10-03 LAVA Therapeutics N.V. Nectin-4 binding agents and methods of use
WO2025012118A2 (en) 2023-07-07 2025-01-16 LAVA Therapeutics N.V. 5t4 binding agents and methods of use
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells
WO2025153530A1 (en) 2024-01-16 2025-07-24 Novo Nordisk A/S Albumin-targeted endonucleases, compositions, and methods of use
WO2025235862A1 (en) 2024-05-10 2025-11-13 Inndura Therapeutics Inc. A modified immune cell receptor comprising a target-binding domain and the extracellular domain of cd16a

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3140757B2 (ja) 1989-02-06 2001-03-05 デイナ・フアーバー・キヤンサー・インステイテユート パッケージング欠陥hivプロウイルス、細胞系及びその使用
US5665577A (en) 1989-02-06 1997-09-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US5981276A (en) 1990-06-20 1999-11-09 Dana-Farber Cancer Institute Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
AU726623B2 (en) * 1996-02-21 2000-11-16 Julianna Lisziewicz Methods and compositions for protective and therapeutic genetic immunization
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
EP1076715B1 (en) 1998-05-13 2007-07-18 Genetix Pharmaceuticals Inc. Lentiviral packaging cells
JP2003523721A (ja) * 1998-12-31 2003-08-12 カイロン コーポレイション 抗原性hivc型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用
WO2000072886A1 (en) * 1999-05-26 2000-12-07 Dana-Farber Cancer Institute, Inc. Episomally replicating lentiviral vectors
AU784910B2 (en) 1999-10-12 2006-07-27 Centre National De La Recherche Scientifique Lentiviral triplex DNA, and vectors and recombinant cells containing lentiviral triplex DNA
WO2002024897A2 (en) * 2000-09-22 2002-03-28 Virxsys Conditionally replicating viral vectors and their use
FR2825372B1 (fr) 2001-06-01 2004-06-18 Centre Nat Rech Scient Pseudotypage des vecteurs vih-1 par des enveloppes de rhabdovirus
US20070042494A1 (en) * 2005-05-31 2007-02-22 Tal Kafri Heterologous retroviral packaging system

Similar Documents

Publication Publication Date Title
JP2008503230A5 (OSRAM)
CY2015009I2 (el) Ινδολινονες υποκατεστημενες στη θεση 6, η παραγωγη αυτων και η χρηση αυτων ως φαρμακευτικα μεσα
JP2007507065A5 (OSRAM)
JP2011506530A5 (OSRAM)
JP2006213929A5 (OSRAM)
JP2008056926A5 (OSRAM)
JP2007520565A5 (OSRAM)
JP2007506705A5 (OSRAM)
JP2007510515A5 (OSRAM)
JP2007510403A5 (OSRAM)
JP2008542528A5 (OSRAM)
JP2008517002A5 (OSRAM)
JP2009532412A5 (OSRAM)
JP2007513894A5 (ja) Chp−ゲムシタビン複合剤および抗腫瘍剤、特に抗転移剤としてのその使用
JP2008514670A5 (OSRAM)
JP2006514072A5 (OSRAM)
DE602006003323D1 (de) Perfluoramidierte und hydrolysierte maleinsäureanhydridcopolymere
JP2012501322A5 (OSRAM)
CN300756698S (zh) 驾驶室(501)
TH85738B (th) ชิ้นส่วนสิ่งก่อสร้าง
JP2007505049A5 (OSRAM)
TH85366B (th) หน้าตัดโลหะ
TH85368B (th) หน้าตัดโลหะ
TH84514B (th) เก้าอี้
TH84515B (th) เก้าอี้