JP2008501036A5 - - Google Patents
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- Publication number
- JP2008501036A5 JP2008501036A5 JP2007515474A JP2007515474A JP2008501036A5 JP 2008501036 A5 JP2008501036 A5 JP 2008501036A5 JP 2007515474 A JP2007515474 A JP 2007515474A JP 2007515474 A JP2007515474 A JP 2007515474A JP 2008501036 A5 JP2008501036 A5 JP 2008501036A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- aralkyl
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 62
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000003710 aryl alkyl group Chemical group 0.000 claims 21
- 125000003118 aryl group Chemical group 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 150000001720 carbohydrates Chemical class 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 4
- 208000005374 Poisoning Diseases 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 3
- 231100000572 poisoning Toxicity 0.000 claims 3
- 230000000607 poisoning effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 230000000202 analgesic effect Effects 0.000 claims 2
- -1 azabicyclane Chemical compound 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- DKJCUVXSBOMWAV-PCWWUVHHSA-N naltrindole Chemical compound N1([C@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC2=C3[CH]C=CC=C3N=C25)O)CC1)O)CC1CC1 DKJCUVXSBOMWAV-PCWWUVHHSA-N 0.000 claims 2
- 229940127240 opiate Drugs 0.000 claims 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 1
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006709 (C5-C7) cycloalkenyl group Chemical group 0.000 claims 1
- LLSKXGRDUPMXLC-UHFFFAOYSA-N 1-phenylpiperidine Chemical compound C1CCCCN1C1=CC=CC=C1 LLSKXGRDUPMXLC-UHFFFAOYSA-N 0.000 claims 1
- CYNCTOZWFJADLD-UHFFFAOYSA-N 2-(N-phenylanilino)ethyl propanoate Chemical compound C1(=CC=CC=C1)N(C1=CC=CC=C1)CCOC(CC)=O CYNCTOZWFJADLD-UHFFFAOYSA-N 0.000 claims 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 1
- FGHNHZNKOHDKHY-UHFFFAOYSA-N 6-chloro-4-n-ethyl-2-n-propan-2-yl-1,3,5-triazine-2,4-diamine;3,4-dimethyl-2,6-dinitro-n-pentan-3-ylaniline Chemical compound CCNC1=NC(Cl)=NC(NC(C)C)=N1.CCC(CC)NC1=C([N+]([O-])=O)C=C(C)C(C)=C1[N+]([O-])=O FGHNHZNKOHDKHY-UHFFFAOYSA-N 0.000 claims 1
- 208000007848 Alcoholism Diseases 0.000 claims 1
- 208000001613 Gambling Diseases 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- 208000018526 Narcotic-Related disease Diseases 0.000 claims 1
- 206010057852 Nicotine dependence Diseases 0.000 claims 1
- 102000003840 Opioid Receptors Human genes 0.000 claims 1
- 108090000137 Opioid Receptors Proteins 0.000 claims 1
- 229940123257 Opioid receptor antagonist Drugs 0.000 claims 1
- 208000025569 Tobacco Use disease Diseases 0.000 claims 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 claims 1
- 229960004193 dextropropoxyphene Drugs 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- IFKPLJWIEQBPGG-UHFFFAOYSA-N isomethadone Chemical compound C=1C=CC=CC=1C(C(C)CN(C)C)(C(=O)CC)C1=CC=CC=C1 IFKPLJWIEQBPGG-UHFFFAOYSA-N 0.000 claims 1
- 229950009272 isomethadone Drugs 0.000 claims 1
- 229960001797 methadone Drugs 0.000 claims 1
- ZPAPCUKKKOSLPZ-UHFFFAOYSA-N morphan Chemical compound C1CNC2CCCC1C2 ZPAPCUKKKOSLPZ-UHFFFAOYSA-N 0.000 claims 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical compound C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 claims 1
- LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical compound ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 claims 1
- CMQADFZEKVVEKX-UHFFFAOYSA-N n-phenyl-2-piperidin-1-ylpropanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C)N1CCCCC1 CMQADFZEKVVEKX-UHFFFAOYSA-N 0.000 claims 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 1
- 229960003086 naltrexone Drugs 0.000 claims 1
- 239000003401 opiate antagonist Substances 0.000 claims 1
- 201000005040 opiate dependence Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 0 C[C@](Cc(cc1)c2[C@]34CCN*)[C@]3(*)C(*)=C(*)*=C(*)C4Oc2c1O Chemical compound C[C@](Cc(cc1)c2[C@]34CCN*)[C@]3(*)C(*)=C(*)*=C(*)C4Oc2c1O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57545104P | 2004-05-28 | 2004-05-28 | |
| US60/575,451 | 2004-05-28 | ||
| PCT/US2005/019000 WO2005117589A1 (en) | 2004-05-28 | 2005-05-31 | Synthesis of metabolically stable analgesics, pain medications and other agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012139959A Division JP2012254984A (ja) | 2004-05-28 | 2012-06-21 | 代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008501036A JP2008501036A (ja) | 2008-01-17 |
| JP2008501036A5 true JP2008501036A5 (enExample) | 2008-06-05 |
| JP5266492B2 JP5266492B2 (ja) | 2013-08-21 |
Family
ID=35462669
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515474A Expired - Fee Related JP5266492B2 (ja) | 2004-05-28 | 2005-05-31 | 代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成 |
| JP2012139959A Pending JP2012254984A (ja) | 2004-05-28 | 2012-06-21 | 代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012139959A Pending JP2012254984A (ja) | 2004-05-28 | 2012-06-21 | 代謝安定性鎮痛薬、疼痛薬物療法及び他の物質の合成 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8481501B2 (enExample) |
| EP (1) | EP1758452B1 (enExample) |
| JP (2) | JP5266492B2 (enExample) |
| AU (1) | AU2005249508A1 (enExample) |
| CA (1) | CA2568249C (enExample) |
| DK (1) | DK1758452T3 (enExample) |
| ES (1) | ES2623362T3 (enExample) |
| WO (1) | WO2005117589A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| EP2313400A4 (en) | 2008-07-10 | 2011-12-28 | Human Biomolecular Res Inst | SYNTHESIS OF METABOLIC STRENGTHS FOR ALCOHOL AND DRUG ABUSE |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| CN105152939A (zh) | 2008-11-10 | 2015-12-16 | 阿尔尼拉姆医药品有限公司 | 用于递送治疗剂的脂质和组合物 |
| FR2939437B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| FR2939796B1 (fr) * | 2008-12-11 | 2010-12-17 | Sanofi Aventis | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| US8772308B2 (en) | 2009-01-16 | 2014-07-08 | Virginia Commonwealth University | Non-peptidyl, potent, and selective mu opioid receptor antagonists |
| WO2011041470A2 (en) * | 2009-09-30 | 2011-04-07 | Mallinckrodt Inc. | Sustained-release opiate and opiate derivative compositions |
| BR112013009505B1 (pt) * | 2010-10-19 | 2022-06-21 | Memorial Sloan-Kettering Cancer Center | Composto, composição farmacêutica, métodos para ensaio quanto a um receptor, e, usos de um composto |
| WO2013119954A1 (en) * | 2012-02-08 | 2013-08-15 | Walter Reed Army Institute Of Research Department Of The Army | Induction of highly specific antibodies to a hapten but not to a carrier peptide by immunization |
| CN103450291A (zh) * | 2013-08-13 | 2013-12-18 | 张家港威胜生物医药有限公司 | 一种制备2，3，4，6-四-O-乙酰基-β-D-1-硫代吡喃葡萄糖的方法 |
| EP3291676B1 (en) | 2015-04-30 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | Mitragynine analogs and uses thereof |
| EP3432884A4 (en) | 2016-03-22 | 2019-11-20 | Regents of the University of Minnesota | COMBINATIONS FOR THE TREATMENT OF PAIN |
| US20180092839A1 (en) * | 2016-10-03 | 2018-04-05 | Lance L. Gooberman | Medicated spray for treatment of substance abuse, overdose, addiction and impulse control disorders |
| US20220117916A1 (en) * | 2020-10-19 | 2022-04-21 | SafeRx Pharmaceuticals, LLC | Combination Products to Mitigate the Risk of Non-Benzodiazepine Benzodiazepine Agonist Adverse Reaction and Overdose |
| EP4577667A2 (en) * | 2022-08-25 | 2025-07-02 | Biosynth GmbH | Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) * | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH03218379A (ja) * | 1989-11-13 | 1991-09-25 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| EP0846694A1 (en) * | 1992-01-23 | 1998-06-10 | Toray Industries, Inc. | Morphinan derivative and its pharmaceutical applications |
| EP0632041A1 (en) * | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| CA2220768A1 (en) * | 1996-03-13 | 1997-09-18 | Yale University | Smoking cessation treatments using naltrexone and related compounds |
| US5780479A (en) * | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
| PL344141A1 (en) * | 1998-05-13 | 2001-10-08 | Cenes Ltd | Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides |
| WO2002080918A1 (en) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Remedial or prophylactic agent for frequent urination or urinary incontinence |
-
2005
- 2005-05-31 JP JP2007515474A patent/JP5266492B2/ja not_active Expired - Fee Related
- 2005-05-31 CA CA2568249A patent/CA2568249C/en not_active Expired - Lifetime
- 2005-05-31 DK DK05754845.5T patent/DK1758452T3/en active
- 2005-05-31 WO PCT/US2005/019000 patent/WO2005117589A1/en not_active Ceased
- 2005-05-31 US US11/628,132 patent/US8481501B2/en not_active Expired - Fee Related
- 2005-05-31 AU AU2005249508A patent/AU2005249508A1/en not_active Abandoned
- 2005-05-31 EP EP05754845.5A patent/EP1758452B1/en not_active Expired - Lifetime
- 2005-05-31 ES ES05754845.5T patent/ES2623362T3/es not_active Expired - Lifetime
-
2012
- 2012-06-21 JP JP2012139959A patent/JP2012254984A/ja active Pending
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