AU2005249508A1 - Synthesis of metabolically stable analgesics, pain medications and other agents - Google Patents
Synthesis of metabolically stable analgesics, pain medications and other agents Download PDFInfo
- Publication number
- AU2005249508A1 AU2005249508A1 AU2005249508A AU2005249508A AU2005249508A1 AU 2005249508 A1 AU2005249508 A1 AU 2005249508A1 AU 2005249508 A AU2005249508 A AU 2005249508A AU 2005249508 A AU2005249508 A AU 2005249508A AU 2005249508 A1 AU2005249508 A1 AU 2005249508A1
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- Prior art keywords
- alkyl
- group
- compound
- cio
- aryl
- Prior art date
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- 230000015572 biosynthetic process Effects 0.000 title description 13
- 238000003786 synthesis reaction Methods 0.000 title description 13
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- 239000000730 antalgic agent Substances 0.000 title description 11
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Classifications
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Addiction (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57545104P | 2004-05-28 | 2004-05-28 | |
| US60/575,451 | 2004-05-28 | ||
| PCT/US2005/019000 WO2005117589A1 (en) | 2004-05-28 | 2005-05-31 | Synthesis of metabolically stable analgesics, pain medications and other agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011224079A Division AU2011224079A1 (en) | 2004-05-28 | 2011-09-15 | Synthesis of metabolically stable analgesics, pain medications and other agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2005249508A1 true AU2005249508A1 (en) | 2005-12-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005249508A Abandoned AU2005249508A1 (en) | 2004-05-28 | 2005-05-31 | Synthesis of metabolically stable analgesics, pain medications and other agents |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8481501B2 (enExample) |
| EP (1) | EP1758452B1 (enExample) |
| JP (2) | JP5266492B2 (enExample) |
| AU (1) | AU2005249508A1 (enExample) |
| CA (1) | CA2568249C (enExample) |
| DK (1) | DK1758452T3 (enExample) |
| ES (1) | ES2623362T3 (enExample) |
| WO (1) | WO2005117589A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006126529A1 (ja) | 2005-05-25 | 2006-11-30 | Shionogi & Co., Ltd. | ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体 |
| EP2313400A4 (en) | 2008-07-10 | 2011-12-28 | Human Biomolecular Res Inst | SYNTHESIS OF METABOLIC STRENGTHS FOR ALCOHOL AND DRUG ABUSE |
| US8609682B2 (en) | 2008-07-11 | 2013-12-17 | Regents Of The University Of Minnesota | Analgesic agents |
| CN105152939A (zh) | 2008-11-10 | 2015-12-16 | 阿尔尼拉姆医药品有限公司 | 用于递送治疗剂的脂质和组合物 |
| FR2939437B1 (fr) * | 2008-12-10 | 2010-12-17 | Sanofi Aventis | Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| FR2939796B1 (fr) * | 2008-12-11 | 2010-12-17 | Sanofi Aventis | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
| US8772308B2 (en) | 2009-01-16 | 2014-07-08 | Virginia Commonwealth University | Non-peptidyl, potent, and selective mu opioid receptor antagonists |
| WO2011041470A2 (en) * | 2009-09-30 | 2011-04-07 | Mallinckrodt Inc. | Sustained-release opiate and opiate derivative compositions |
| BR112013009505B1 (pt) * | 2010-10-19 | 2022-06-21 | Memorial Sloan-Kettering Cancer Center | Composto, composição farmacêutica, métodos para ensaio quanto a um receptor, e, usos de um composto |
| WO2013119954A1 (en) * | 2012-02-08 | 2013-08-15 | Walter Reed Army Institute Of Research Department Of The Army | Induction of highly specific antibodies to a hapten but not to a carrier peptide by immunization |
| CN103450291A (zh) * | 2013-08-13 | 2013-12-18 | 张家港威胜生物医药有限公司 | 一种制备2，3，4，6-四-O-乙酰基-β-D-1-硫代吡喃葡萄糖的方法 |
| EP3291676B1 (en) | 2015-04-30 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | Mitragynine analogs and uses thereof |
| EP3432884A4 (en) | 2016-03-22 | 2019-11-20 | Regents of the University of Minnesota | COMBINATIONS FOR THE TREATMENT OF PAIN |
| US20180092839A1 (en) * | 2016-10-03 | 2018-04-05 | Lance L. Gooberman | Medicated spray for treatment of substance abuse, overdose, addiction and impulse control disorders |
| US20220117916A1 (en) * | 2020-10-19 | 2022-04-21 | SafeRx Pharmaceuticals, LLC | Combination Products to Mitigate the Risk of Non-Benzodiazepine Benzodiazepine Agonist Adverse Reaction and Overdose |
| EP4577667A2 (en) * | 2022-08-25 | 2025-07-02 | Biosynth GmbH | Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) * | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) * | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH03218379A (ja) * | 1989-11-13 | 1991-09-25 | Chugai Pharmaceut Co Ltd | 新規なモルヒネ誘導体 |
| EP0846694A1 (en) * | 1992-01-23 | 1998-06-10 | Toray Industries, Inc. | Morphinan derivative and its pharmaceutical applications |
| EP0632041A1 (en) * | 1993-07-01 | 1995-01-04 | Katholieke Universiteit Nijmegen | New morphine derivatives having improved analgesic and narcotic properties |
| CA2220768A1 (en) * | 1996-03-13 | 1997-09-18 | Yale University | Smoking cessation treatments using naltrexone and related compounds |
| US5780479A (en) * | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
| PL344141A1 (en) * | 1998-05-13 | 2001-10-08 | Cenes Ltd | Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides |
| WO2002080918A1 (en) * | 2001-04-02 | 2002-10-17 | Toray Industries, Inc. | Remedial or prophylactic agent for frequent urination or urinary incontinence |
-
2005
- 2005-05-31 JP JP2007515474A patent/JP5266492B2/ja not_active Expired - Fee Related
- 2005-05-31 CA CA2568249A patent/CA2568249C/en not_active Expired - Lifetime
- 2005-05-31 DK DK05754845.5T patent/DK1758452T3/en active
- 2005-05-31 WO PCT/US2005/019000 patent/WO2005117589A1/en not_active Ceased
- 2005-05-31 US US11/628,132 patent/US8481501B2/en not_active Expired - Fee Related
- 2005-05-31 AU AU2005249508A patent/AU2005249508A1/en not_active Abandoned
- 2005-05-31 EP EP05754845.5A patent/EP1758452B1/en not_active Expired - Lifetime
- 2005-05-31 ES ES05754845.5T patent/ES2623362T3/es not_active Expired - Lifetime
-
2012
- 2012-06-21 JP JP2012139959A patent/JP2012254984A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1758452A1 (en) | 2007-03-07 |
| WO2005117589A1 (en) | 2005-12-15 |
| CA2568249A1 (en) | 2005-12-15 |
| US8481501B2 (en) | 2013-07-09 |
| CA2568249C (en) | 2014-12-09 |
| DK1758452T3 (en) | 2017-05-01 |
| JP2012254984A (ja) | 2012-12-27 |
| JP2008501036A (ja) | 2008-01-17 |
| US20100190728A1 (en) | 2010-07-29 |
| JP5266492B2 (ja) | 2013-08-21 |
| ES2623362T3 (es) | 2017-07-11 |
| EP1758452A4 (en) | 2009-08-05 |
| EP1758452B1 (en) | 2017-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |