AU2005249508A1 - Synthesis of metabolically stable analgesics, pain medications and other agents - Google Patents

Synthesis of metabolically stable analgesics, pain medications and other agents Download PDF

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Publication number
AU2005249508A1
AU2005249508A1 AU2005249508A AU2005249508A AU2005249508A1 AU 2005249508 A1 AU2005249508 A1 AU 2005249508A1 AU 2005249508 A AU2005249508 A AU 2005249508A AU 2005249508 A AU2005249508 A AU 2005249508A AU 2005249508 A1 AU2005249508 A1 AU 2005249508A1
Authority
AU
Australia
Prior art keywords
alkyl
group
compound
cio
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2005249508A
Other languages
English (en)
Inventor
John R. Cashman
James M. Macdougall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human BioMolecular Research Institute
Original Assignee
Human BioMolecular Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human BioMolecular Research Institute filed Critical Human BioMolecular Research Institute
Publication of AU2005249508A1 publication Critical patent/AU2005249508A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU2005249508A 2004-05-28 2005-05-31 Synthesis of metabolically stable analgesics, pain medications and other agents Abandoned AU2005249508A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57545104P 2004-05-28 2004-05-28
US60/575,451 2004-05-28
PCT/US2005/019000 WO2005117589A1 (en) 2004-05-28 2005-05-31 Synthesis of metabolically stable analgesics, pain medications and other agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011224079A Division AU2011224079A1 (en) 2004-05-28 2011-09-15 Synthesis of metabolically stable analgesics, pain medications and other agents

Publications (1)

Publication Number Publication Date
AU2005249508A1 true AU2005249508A1 (en) 2005-12-15

Family

ID=35462669

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005249508A Abandoned AU2005249508A1 (en) 2004-05-28 2005-05-31 Synthesis of metabolically stable analgesics, pain medications and other agents

Country Status (8)

Country Link
US (1) US8481501B2 (enExample)
EP (1) EP1758452B1 (enExample)
JP (2) JP5266492B2 (enExample)
AU (1) AU2005249508A1 (enExample)
CA (1) CA2568249C (enExample)
DK (1) DK1758452T3 (enExample)
ES (1) ES2623362T3 (enExample)
WO (1) WO2005117589A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006126529A1 (ja) 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
EP2313400A4 (en) * 2008-07-10 2011-12-28 Human Biomolecular Res Inst SYNTHESIS OF METABOLIC STRENGTHS FOR ALCOHOL AND DRUG ABUSE
WO2010006299A1 (en) * 2008-07-11 2010-01-14 Regents Of The University Of Minnesota Analgesic agents
EP3699172A3 (en) 2008-11-10 2020-11-18 Arbutus Biopharma Corporation Novel lipids and compositions for the delivery of therapeutics
FR2939437B1 (fr) * 2008-12-10 2010-12-17 Sanofi Aventis Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
FR2939796B1 (fr) * 2008-12-11 2010-12-17 Sanofi Aventis Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique
EP2387577A4 (en) * 2009-01-16 2012-10-17 Univ Virginia Commonwealth NON-PEPTIDE, POWERFUL AND SELECTIVE ANTAGONISTS OF MU OPIOID RECEPTORS
WO2011041470A2 (en) * 2009-09-30 2011-04-07 Mallinckrodt Inc. Sustained-release opiate and opiate derivative compositions
BR112013009505B1 (pt) * 2010-10-19 2022-06-21 Memorial Sloan-Kettering Cancer Center Composto, composição farmacêutica, métodos para ensaio quanto a um receptor, e, usos de um composto
WO2013119954A1 (en) * 2012-02-08 2013-08-15 Walter Reed Army Institute Of Research Department Of The Army Induction of highly specific antibodies to a hapten but not to a carrier peptide by immunization
CN103450291A (zh) * 2013-08-13 2013-12-18 张家港威胜生物医药有限公司 一种制备2，3，4，6-四-O-乙酰基-β-D-1-硫代吡喃葡萄糖的方法
EP4212532A3 (en) 2015-04-30 2023-09-27 Memorial Sloan Kettering Cancer Center Mitragynine analogs and uses thereof
WO2017165558A1 (en) 2016-03-22 2017-09-28 Regents Of The University Of Minnesota Combination for treating pain
US20180092839A1 (en) * 2016-10-03 2018-04-05 Lance L. Gooberman Medicated spray for treatment of substance abuse, overdose, addiction and impulse control disorders
US20220117916A1 (en) * 2020-10-19 2022-04-21 SafeRx Pharmaceuticals, LLC Combination Products to Mitigate the Risk of Non-Benzodiazepine Benzodiazepine Agonist Adverse Reaction and Overdose
EP4482840A4 (en) * 2022-02-22 2026-02-25 Univ Virginia Commonwealth Naltrexamine derivatives bearing 5-chain heterocyclic cyclic systems used as opioid receptor modulators
EP4577667A2 (en) * 2022-08-25 2025-07-02 Biosynth GmbH Procedure for production of opioid-antagonist-releasing compounds and their use as a medicine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
JPH03218379A (ja) * 1989-11-13 1991-09-25 Chugai Pharmaceut Co Ltd 新規なモルヒネ誘導体
JP2525552B2 (ja) * 1992-01-23 1996-08-21 東レ株式会社 モルヒナン誘導体および医薬用途
EP0632041A1 (en) * 1993-07-01 1995-01-04 Katholieke Universiteit Nijmegen New morphine derivatives having improved analgesic and narcotic properties
JPH11505547A (ja) * 1996-03-13 1999-05-21 エール ユニバーシティ ナルトレキソン及び関連化合物を用いる禁煙処置
US5780479A (en) * 1997-04-04 1998-07-14 Regents Of The University Of Minnesota Use of opioid antagonists to treat impulse-control disorders
WO1999058545A1 (en) * 1998-05-13 1999-11-18 Cenes Limited Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides
WO2002080918A1 (en) * 2001-04-02 2002-10-17 Toray Industries, Inc. Remedial or prophylactic agent for frequent urination or urinary incontinence

Also Published As

Publication number Publication date
EP1758452A4 (en) 2009-08-05
JP2008501036A (ja) 2008-01-17
JP2012254984A (ja) 2012-12-27
CA2568249A1 (en) 2005-12-15
EP1758452A1 (en) 2007-03-07
US8481501B2 (en) 2013-07-09
US20100190728A1 (en) 2010-07-29
CA2568249C (en) 2014-12-09
JP5266492B2 (ja) 2013-08-21
DK1758452T3 (en) 2017-05-01
EP1758452B1 (en) 2017-01-25
WO2005117589A1 (en) 2005-12-15
ES2623362T3 (es) 2017-07-11

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted