JP2008501034A - ポサコナゾールを含む注射用薬学的懸濁液 - Google Patents

ポサコナゾールを含む注射用薬学的懸濁液 Download PDF

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Publication number
JP2008501034A
JP2008501034A JP2007515456A JP2007515456A JP2008501034A JP 2008501034 A JP2008501034 A JP 2008501034A JP 2007515456 A JP2007515456 A JP 2007515456A JP 2007515456 A JP2007515456 A JP 2007515456A JP 2008501034 A JP2008501034 A JP 2008501034A
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JP
Japan
Prior art keywords
formulation
posaconazole
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average
max
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JP2007515456A
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English (en)
Japanese (ja)
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JP2008501034A5 (https=
Inventor
レオノーレ ウィッチー−ラクシュマナン，
シドニー ウグウ，
バルダ サンドウェイス，
キャサリン ハルダロ，
ロベルタ エス． ヘア，
ゴパル クリシュナ，
ザイチー ワン，
マルコ タグレッティ，
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Merck Sharp and Dohme LLC
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Schering Corp
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Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2008501034A publication Critical patent/JP2008501034A/ja
Publication of JP2008501034A5 publication Critical patent/JP2008501034A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007515456A 2004-05-28 2005-05-27 ポサコナゾールを含む注射用薬学的懸濁液 Withdrawn JP2008501034A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57512604P 2004-05-28 2004-05-28
PCT/US2005/018945 WO2005117831A1 (en) 2004-05-28 2005-05-27 Injectable pharmaceutical suspension comprising posaconazole

Publications (2)

Publication Number Publication Date
JP2008501034A true JP2008501034A (ja) 2008-01-17
JP2008501034A5 JP2008501034A5 (https=) 2008-07-03

Family

ID=34971355

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007515456A Withdrawn JP2008501034A (ja) 2004-05-28 2005-05-27 ポサコナゾールを含む注射用薬学的懸濁液

Country Status (15)

Country Link
EP (1) EP1761247A1 (https=)
JP (1) JP2008501034A (https=)
KR (1) KR20070027564A (https=)
CN (1) CN1988887A (https=)
AR (1) AR049063A1 (https=)
AU (1) AU2005249502A1 (https=)
CA (1) CA2567803A1 (https=)
IL (1) IL179627A0 (https=)
MX (1) MXPA06013886A (https=)
NO (1) NO20066005L (https=)
PE (1) PE20060291A1 (https=)
RU (1) RU2006146555A (https=)
TW (1) TWI290051B (https=)
WO (1) WO2005117831A1 (https=)
ZA (1) ZA200609890B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013535422A (ja) * 2010-06-29 2013-09-12 メルク・シャープ・エンド・ドーム・コーポレイション 置換β−シクロデキストリンにより安定化されたポサコナゾール静脈注射用溶液製剤

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060009469A1 (en) * 2004-05-28 2006-01-12 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmacutical compositions of posaconazole
LT2018164T (lt) * 2006-05-12 2017-07-10 Christian Noe Vaistų derinių, apimančių priešgrybelinius agentus, naudojimas
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
EP2451805A1 (en) 2009-07-09 2012-05-16 Sandoz AG A crystalline form of posaconazole
EP2571847B1 (en) 2010-05-19 2016-09-21 Sandoz AG Process for the preparation of chiral hydrazides
US9040539B2 (en) 2010-05-19 2015-05-26 Sandoz Ag Process for the preparation of chiral triazolones
RU2585683C2 (ru) 2010-05-19 2016-06-10 Сандоз Аг Очистка позаконазола и промежуточных продуктов для синтеза позаконазола
CN102892762B (zh) 2010-05-19 2016-04-20 桑多斯股份公司 制备泊沙康唑中间体
CN103635465A (zh) 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
CN103284959B (zh) * 2012-02-22 2015-06-03 重庆圣华曦药业股份有限公司 泊沙康唑冻干粉针剂及制备方法
CN102755628B (zh) * 2012-07-16 2013-10-23 中国科学院微生物研究所 一种抗真菌的药物组合物
CN102805731B (zh) * 2012-08-22 2014-04-30 北京莱瑞森医药科技有限公司 泊沙康唑干混悬剂及其制备方法
CN105030668B (zh) * 2015-06-26 2018-03-27 济川药业集团有限公司 泊沙康唑口服混悬剂及其制备方法
CN106333925B (zh) * 2015-07-10 2019-06-18 上海美悦生物科技发展有限公司 一种泊沙康唑液体混悬剂及其制备方法
CN105997872B (zh) * 2016-07-08 2019-02-19 河南省立眼科医院 一种含有泊沙康唑的眼用纳米胶束抗真菌溶液
CA3056919A1 (en) * 2017-03-26 2018-10-04 Vivi Robyn Stafford Method of treatment of skin conditions of eye lids
EP3609329A4 (en) * 2017-04-12 2021-03-17 Bhagwandin, Vikash J. COMPOSITIONS, PACKAGED MEDICINAL PRODUCTS AND METHODS OF USE OF POSACONAZOLE FOR RESISTANT TUMORS Awareness
CN110507609B (zh) * 2018-05-21 2021-09-17 上海医药工业研究院 泊沙康唑口服混悬剂的制备方法
CN111514146A (zh) * 2020-04-28 2020-08-11 山西振东泰盛制药有限公司 含有泊沙康唑的药物组合物
CN113933131B (zh) * 2021-09-24 2024-01-26 合肥天一生物技术研究所有限责任公司 一种阴道微生物荧光染色液

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
WO2002080678A1 (en) * 2001-04-03 2002-10-17 Schering Corporation Antifungal composition with enhanced bioavailability

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013535422A (ja) * 2010-06-29 2013-09-12 メルク・シャープ・エンド・ドーム・コーポレイション 置換β−シクロデキストリンにより安定化されたポサコナゾール静脈注射用溶液製剤

Also Published As

Publication number Publication date
ZA200609890B (en) 2008-09-25
TWI290051B (en) 2007-11-21
KR20070027564A (ko) 2007-03-09
IL179627A0 (en) 2007-05-15
AU2005249502A1 (en) 2005-12-15
TW200609001A (en) 2006-03-16
AR049063A1 (es) 2006-06-21
PE20060291A1 (es) 2006-04-14
RU2006146555A (ru) 2008-07-20
EP1761247A1 (en) 2007-03-14
MXPA06013886A (es) 2007-01-26
WO2005117831A1 (en) 2005-12-15
CA2567803A1 (en) 2005-12-15
CN1988887A (zh) 2007-06-27
NO20066005L (no) 2007-02-27

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