PE20060291A1 - Composiciones farmaceuticas inyectables de posaconazol con particulas estabilizadas - Google Patents
Composiciones farmaceuticas inyectables de posaconazol con particulas estabilizadasInfo
- Publication number
- PE20060291A1 PE20060291A1 PE2005000599A PE2005000599A PE20060291A1 PE 20060291 A1 PE20060291 A1 PE 20060291A1 PE 2005000599 A PE2005000599 A PE 2005000599A PE 2005000599 A PE2005000599 A PE 2005000599A PE 20060291 A1 PE20060291 A1 PE 20060291A1
- Authority
- PE
- Peru
- Prior art keywords
- posaconazole
- microns
- particles
- infections
- moldes
- Prior art date
Links
- 239000002245 particle Substances 0.000 title abstract 3
- RAGOYPUPXAKGKH-XAKZXMRKSA-N posaconazole Chemical compound O=C1N([C@H]([C@H](C)O)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3C[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 RAGOYPUPXAKGKH-XAKZXMRKSA-N 0.000 title abstract 3
- 229960001589 posaconazole Drugs 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 208000015181 infectious disease Diseases 0.000 abstract 3
- 239000007853 buffer solution Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000001012 protector Effects 0.000 abstract 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 abstract 1
- DHMQDGOQFOQNFH-CNRUNOGKSA-N 2-amino-2-tritioacetic acid Chemical compound [3H]C(N)C(O)=O DHMQDGOQFOQNFH-CNRUNOGKSA-N 0.000 abstract 1
- 241000233866 Fungi Species 0.000 abstract 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 1
- 206010030154 Oesophageal candidiasis Diseases 0.000 abstract 1
- 206010050346 Oropharyngeal candidiasis Diseases 0.000 abstract 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 abstract 1
- 206010061418 Zygomycosis Diseases 0.000 abstract 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 201000005655 esophageal candidiasis Diseases 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 201000009085 invasive aspergillosis Diseases 0.000 abstract 1
- 201000007524 mucormycosis Diseases 0.000 abstract 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 abstract 1
- 150000003904 phospholipids Chemical class 0.000 abstract 1
- 239000001509 sodium citrate Substances 0.000 abstract 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57512604P | 2004-05-28 | 2004-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060291A1 true PE20060291A1 (es) | 2006-04-14 |
Family
ID=34971355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000599A PE20060291A1 (es) | 2004-05-28 | 2005-05-27 | Composiciones farmaceuticas inyectables de posaconazol con particulas estabilizadas |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1761247A1 (https=) |
| JP (1) | JP2008501034A (https=) |
| KR (1) | KR20070027564A (https=) |
| CN (1) | CN1988887A (https=) |
| AR (1) | AR049063A1 (https=) |
| AU (1) | AU2005249502A1 (https=) |
| CA (1) | CA2567803A1 (https=) |
| IL (1) | IL179627A0 (https=) |
| MX (1) | MXPA06013886A (https=) |
| NO (1) | NO20066005L (https=) |
| PE (1) | PE20060291A1 (https=) |
| RU (1) | RU2006146555A (https=) |
| TW (1) | TWI290051B (https=) |
| WO (1) | WO2005117831A1 (https=) |
| ZA (1) | ZA200609890B (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060009469A1 (en) * | 2004-05-28 | 2006-01-12 | Leonore Witchey-Lakshmanan | Particulate-stabilized injectable pharmacutical compositions of posaconazole |
| LT2018164T (lt) * | 2006-05-12 | 2017-07-10 | Christian Noe | Vaistų derinių, apimančių priešgrybelinius agentus, naudojimas |
| EP2130540A1 (en) * | 2008-06-02 | 2009-12-09 | Sandoz AG | Pharmaceutical compositions containing a crystalline form of posaconazole |
| EP2141159A1 (en) | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| EP2451805A1 (en) | 2009-07-09 | 2012-05-16 | Sandoz AG | A crystalline form of posaconazole |
| EP2571847B1 (en) | 2010-05-19 | 2016-09-21 | Sandoz AG | Process for the preparation of chiral hydrazides |
| US9040539B2 (en) | 2010-05-19 | 2015-05-26 | Sandoz Ag | Process for the preparation of chiral triazolones |
| RU2585683C2 (ru) | 2010-05-19 | 2016-06-10 | Сандоз Аг | Очистка позаконазола и промежуточных продуктов для синтеза позаконазола |
| CN102892762B (zh) | 2010-05-19 | 2016-04-20 | 桑多斯股份公司 | 制备泊沙康唑中间体 |
| MX338685B (es) * | 2010-06-29 | 2016-04-26 | Merck Sharp & Dohme | Formulaciones de solucion intravenosa de posaconacol estabilizadas mediante beta-ciclodextrina sustituida. |
| CN103635465A (zh) | 2011-06-16 | 2014-03-12 | 桑多斯股份公司 | 制备手性化合物的方法 |
| CN103284959B (zh) * | 2012-02-22 | 2015-06-03 | 重庆圣华曦药业股份有限公司 | 泊沙康唑冻干粉针剂及制备方法 |
| CN102755628B (zh) * | 2012-07-16 | 2013-10-23 | 中国科学院微生物研究所 | 一种抗真菌的药物组合物 |
| CN102805731B (zh) * | 2012-08-22 | 2014-04-30 | 北京莱瑞森医药科技有限公司 | 泊沙康唑干混悬剂及其制备方法 |
| CN105030668B (zh) * | 2015-06-26 | 2018-03-27 | 济川药业集团有限公司 | 泊沙康唑口服混悬剂及其制备方法 |
| CN106333925B (zh) * | 2015-07-10 | 2019-06-18 | 上海美悦生物科技发展有限公司 | 一种泊沙康唑液体混悬剂及其制备方法 |
| CN105997872B (zh) * | 2016-07-08 | 2019-02-19 | 河南省立眼科医院 | 一种含有泊沙康唑的眼用纳米胶束抗真菌溶液 |
| CA3056919A1 (en) * | 2017-03-26 | 2018-10-04 | Vivi Robyn Stafford | Method of treatment of skin conditions of eye lids |
| EP3609329A4 (en) * | 2017-04-12 | 2021-03-17 | Bhagwandin, Vikash J. | COMPOSITIONS, PACKAGED MEDICINAL PRODUCTS AND METHODS OF USE OF POSACONAZOLE FOR RESISTANT TUMORS Awareness |
| CN110507609B (zh) * | 2018-05-21 | 2021-09-17 | 上海医药工业研究院 | 泊沙康唑口服混悬剂的制备方法 |
| CN111514146A (zh) * | 2020-04-28 | 2020-08-11 | 山西振东泰盛制药有限公司 | 含有泊沙康唑的药物组合物 |
| CN113933131B (zh) * | 2021-09-24 | 2024-01-26 | 合肥天一生物技术研究所有限责任公司 | 一种阴道微生物荧光染色液 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5091188A (en) * | 1990-04-26 | 1992-02-25 | Haynes Duncan H | Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs |
| WO2002080678A1 (en) * | 2001-04-03 | 2002-10-17 | Schering Corporation | Antifungal composition with enhanced bioavailability |
-
2005
- 2005-05-27 CN CNA2005800248542A patent/CN1988887A/zh active Pending
- 2005-05-27 AR ARP050102203A patent/AR049063A1/es not_active Application Discontinuation
- 2005-05-27 CA CA002567803A patent/CA2567803A1/en not_active Abandoned
- 2005-05-27 MX MXPA06013886A patent/MXPA06013886A/es unknown
- 2005-05-27 AU AU2005249502A patent/AU2005249502A1/en not_active Abandoned
- 2005-05-27 RU RU2006146555/15A patent/RU2006146555A/ru not_active Application Discontinuation
- 2005-05-27 WO PCT/US2005/018945 patent/WO2005117831A1/en not_active Ceased
- 2005-05-27 JP JP2007515456A patent/JP2008501034A/ja not_active Withdrawn
- 2005-05-27 PE PE2005000599A patent/PE20060291A1/es not_active Application Discontinuation
- 2005-05-27 KR KR1020067024996A patent/KR20070027564A/ko not_active Withdrawn
- 2005-05-27 EP EP05755118A patent/EP1761247A1/en not_active Withdrawn
- 2005-05-27 TW TW094117524A patent/TWI290051B/zh not_active IP Right Cessation
-
2006
- 2006-11-27 IL IL179627A patent/IL179627A0/en unknown
- 2006-11-27 ZA ZA200609890A patent/ZA200609890B/xx unknown
- 2006-12-22 NO NO20066005A patent/NO20066005L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200609890B (en) | 2008-09-25 |
| TWI290051B (en) | 2007-11-21 |
| KR20070027564A (ko) | 2007-03-09 |
| IL179627A0 (en) | 2007-05-15 |
| AU2005249502A1 (en) | 2005-12-15 |
| TW200609001A (en) | 2006-03-16 |
| AR049063A1 (es) | 2006-06-21 |
| JP2008501034A (ja) | 2008-01-17 |
| RU2006146555A (ru) | 2008-07-20 |
| EP1761247A1 (en) | 2007-03-14 |
| MXPA06013886A (es) | 2007-01-26 |
| WO2005117831A1 (en) | 2005-12-15 |
| CA2567803A1 (en) | 2005-12-15 |
| CN1988887A (zh) | 2007-06-27 |
| NO20066005L (no) | 2007-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |