JP2008500373A5 - - Google Patents
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- Publication number
- JP2008500373A5 JP2008500373A5 JP2007515450A JP2007515450A JP2008500373A5 JP 2008500373 A5 JP2008500373 A5 JP 2008500373A5 JP 2007515450 A JP2007515450 A JP 2007515450A JP 2007515450 A JP2007515450 A JP 2007515450A JP 2008500373 A5 JP2008500373 A5 JP 2008500373A5
- Authority
- JP
- Japan
- Prior art keywords
- myostatin
- preparation
- protein
- amino acids
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims 19
- 108010056852 Myostatin Proteins 0.000 claims 19
- 238000002360 preparation method Methods 0.000 claims 14
- 239000005557 antagonist Substances 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 9
- 108090000623 proteins and genes Proteins 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 7
- 239000000825 pharmaceutical preparation Substances 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 102100034135 Activin receptor type-1C Human genes 0.000 claims 4
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims 4
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000001727 in vivo Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102100034134 Activin receptor type-1B Human genes 0.000 claims 2
- 102100025745 Cerberus Human genes 0.000 claims 2
- 101710010675 Cerberus Proteins 0.000 claims 2
- 108091026890 Coding region Proteins 0.000 claims 2
- 101001032872 Homo sapiens Gremlin-1 Proteins 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 230000012010 growth Effects 0.000 claims 2
- 208000030159 metabolic disease Diseases 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 108010049955 Bone Morphogenetic Protein 4 Proteins 0.000 claims 1
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims 1
- 241000202252 Cerberus Species 0.000 claims 1
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 claims 1
- 101000914195 Homo sapiens Cerberus Proteins 0.000 claims 1
- 101000912351 Homo sapiens DAN domain family member 5 Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 108010085220 Multiprotein Complexes Proteins 0.000 claims 1
- 102000007474 Multiprotein Complexes Human genes 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 108010023082 activin A Proteins 0.000 claims 1
- 230000009815 adipogenic differentiation Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000052506 human DAND5 Human genes 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000003473 lipid group Chemical group 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 230000037257 muscle growth Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000003571 reporter gene assay Methods 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57506204P | 2004-05-27 | 2004-05-27 | |
| PCT/US2005/018928 WO2005115439A2 (en) | 2004-05-27 | 2005-05-27 | Cerberus/coco derivatives and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008500373A JP2008500373A (ja) | 2008-01-10 |
| JP2008500373A5 true JP2008500373A5 (OSRAM) | 2008-07-17 |
Family
ID=35451405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007515450A Pending JP2008500373A (ja) | 2004-05-27 | 2005-05-27 | ケルベロス（Ｃｅｒｂｅｒｕｓ）／ココ（Ｃｏｃｏ）誘導体およびそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US20100183695A1 (OSRAM) |
| EP (1) | EP1755648A2 (OSRAM) |
| JP (1) | JP2008500373A (OSRAM) |
| KR (1) | KR20070026650A (OSRAM) |
| AU (1) | AU2005247508A1 (OSRAM) |
| CA (1) | CA2567810A1 (OSRAM) |
| IL (1) | IL179602A0 (OSRAM) |
| WO (1) | WO2005115439A2 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9045553B2 (en) * | 2004-05-27 | 2015-06-02 | Acceleron Pharma, Inc. | Cerberus/Coco derivatives and uses thereof |
| WO2007123391A1 (en) * | 2006-04-20 | 2007-11-01 | Academisch Ziekenhuis Leiden | Therapeutic intervention in a genetic disease in an individual by modifying expression of an aberrantly expressed gene. |
| PT2049664E (pt) | 2006-08-11 | 2012-01-03 | Prosensa Technologies Bv | Oligonucleotídeos de cadeia simples complementares dos elementos repetitivos para tratar perturbações genéticas associadas à instabilidade das repetições do adn |
| WO2008073351A2 (en) * | 2006-12-08 | 2008-06-19 | Acceleron Pharma Inc. | Uses of cerberus, coco and derivatives thereof |
| TWI606062B (zh) * | 2007-02-09 | 2017-11-21 | 艾瑟勒朗法瑪公司 | 包含ＡｃｔＲＩＩａ-Ｆｃ融合蛋白的醫藥組合物；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防與癌症相關的骨質流失之用途；ＡｃｔＲＩＩａ-Ｆｃ融合蛋白於治療或預防多發性骨髓瘤之用途 |
| US20100233137A1 (en) * | 2007-02-27 | 2010-09-16 | Lanx, Inc. | Compositions and Methods for Modification of Target Cells and to Their Uses Thereof |
| WO2008151119A2 (en) * | 2007-06-01 | 2008-12-11 | Lanx, Llc | Compositions and methods for use of scar tissue in repair of weight bearing surfaces |
| USRE48468E1 (en) | 2007-10-26 | 2021-03-16 | Biomarin Technologies B.V. | Means and methods for counteracting muscle disorders |
| PL2203173T3 (pl) | 2007-10-26 | 2016-06-30 | Academisch Ziekenhuis Leiden | Środki i sposoby przeciwdziałania zaburzeniom mięśni |
| WO2009105606A1 (en) * | 2008-02-21 | 2009-08-27 | Lanx, Llc | Compositions and methods for use of scar tissue in repair of weight bearing surfaces |
| EP2119783A1 (en) | 2008-05-14 | 2009-11-18 | Prosensa Technologies B.V. | Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means |
| US9149319B2 (en) * | 2008-09-23 | 2015-10-06 | Lanx, Llc | Methods and compositions for stabilization of a vertebra |
| WO2010123369A1 (en) | 2009-04-24 | 2010-10-28 | Prosensa Technologies B.V. | Oligonucleotide comprising an inosine for treating dmd |
| AU2010258931B2 (en) | 2009-06-08 | 2015-04-23 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
| JP6166041B2 (ja) * | 2009-06-15 | 2017-07-19 | バレリオン セラピューティクス， エルエルシー | ミオチューブラリン１（ｍｔｍ１）ポリペプチドを含むキメラポリペプチドを使用して筋細管ミオパシーを処置するための方法および組成物 |
| EP3260130B1 (en) | 2009-11-03 | 2021-03-10 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
| DE102010052941A1 (de) * | 2010-11-18 | 2012-05-24 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Therapeutisches Protein |
| JP2015509922A (ja) | 2012-01-27 | 2015-04-02 | プロセンサ テクノロジーズ ビー．ブイ．Ｐｒｏｓｅｎｓａ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． | デュシェンヌ型及びベッカー型筋ジストロフィーの治療のための改善された特徴を有するｒｎａ調節オリゴヌクレオチド |
| PL2981822T3 (pl) | 2013-05-06 | 2021-07-12 | Scholar Rock, Inc. | Kompozycje i sposoby modulacji czynnika wzrostu |
| WO2016008966A1 (en) * | 2014-07-17 | 2016-01-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating neuromuscular junction-related diseases |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| PL3350220T3 (pl) | 2015-09-15 | 2022-01-03 | Scholar Rock, Inc. | Przeciwciała przeciwko pro/latentnej miostatynie i ich zastosowania |
| AU2017206069A1 (en) | 2016-01-08 | 2018-07-19 | Scholar Rock, Inc. | Anti-pro/latent myostatin antibodies and methods of use thereof |
| US20170306027A1 (en) * | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
| PT3368069T (pt) * | 2016-06-13 | 2020-11-11 | Scholar Rock Inc | Uso de inibidores da miostatina e terapias de combinação |
| SI3565592T1 (sl) * | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| CN109758616B (zh) * | 2019-03-05 | 2021-11-19 | 中国医学科学院北京协和医院 | 一种新型促进骨再生材料及其制备方法 |
| KR20250122524A (ko) | 2022-12-22 | 2025-08-13 | 스칼러 락, 인크. | 미오스타틴 활성화의 선택적이고 강력한 억제 항체 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133232A (en) | 1996-06-20 | 2000-10-17 | The Regents Of The University Of California | Endoderm, cardiac and neural inducing factors |
| WO1998034951A1 (en) | 1997-02-11 | 1998-08-13 | Amrad Operations Pty. Ltd. | A new cytokine family and uses thereof |
| IL132443A0 (en) | 1997-04-29 | 2001-03-19 | Regeneron Pharma | Human cerberus protein |
| US5935852A (en) * | 1997-07-03 | 1999-08-10 | Genetics Institute, Inc. | DNA molecules encoding mammalian cerberus-like proteins |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| AU2586199A (en) | 1998-02-05 | 1999-08-23 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| WO2000055193A2 (en) * | 1999-03-12 | 2000-09-21 | Regeneron Pharmaceuticals, Inc. | Human dan/cerberus related protein 6 (dcr6) |
| WO2002032929A2 (en) * | 2000-10-19 | 2002-04-25 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the cer1 gene |
| EP1357828A2 (en) | 2001-01-12 | 2003-11-05 | University of Medicine and Dentistry of New Jersey | Bone morphogenetic protein-2 in the treatment and diagnosis of cancer |
| AU2002242842A1 (en) | 2001-03-23 | 2002-10-08 | Axordia Limited | Stem cell differentiation |
| WO2002078516A2 (en) | 2001-03-30 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of cancer |
| GB0111004D0 (en) | 2001-05-04 | 2001-06-27 | Univ Sheffield | Screening method |
| US6513196B2 (en) | 2001-06-22 | 2003-02-04 | Maytag Corporation | Top cover hinge and method for using same |
| CN1161875C (zh) | 2001-07-01 | 2004-08-11 | 周符明 | 开关稳功率电源 |
| GB0118223D0 (en) | 2001-07-26 | 2001-09-19 | Univ Sheffield | Stem loop RNA |
| KR100996226B1 (ko) | 2001-10-31 | 2010-11-24 | 유니버시티 오브 노스 텍사스 헬스 사이언스 센터 | 뼈 형태발생 단백질(ｂｍｐ), ｂｍｐ 수용체 및 ｂｍｐ결합 단백질 및 녹내장 진단 및 치료에서 그의 용도 |
| GB0130738D0 (en) | 2001-12-21 | 2002-02-06 | Serono Internat S A | Protein |
| US20030134790A1 (en) | 2002-01-11 | 2003-07-17 | University Of Medicine And Dentistry Of New Jersey | Bone Morphogenetic Protein-2 And Bone Morphogenetic Protein-4 In The Treatment And Diagnosis Of Cancer |
| EP1572934A4 (en) * | 2002-02-21 | 2007-12-19 | Wyeth Corp | FOLLISTATIN DOMAIN CONTAINING PROTEINS |
| US7193069B2 (en) | 2002-03-22 | 2007-03-20 | Research Association For Biotechnology | Full-length cDNA |
| US20030194704A1 (en) * | 2002-04-03 | 2003-10-16 | Penn Sharron Gaynor | Human genome-derived single exon nucleic acid probes useful for gene expression analysis two |
| WO2003106657A2 (en) | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
| CN101967490B (zh) | 2002-06-14 | 2014-07-16 | 先正达公司 | 木聚糖酶、编码木聚糖酶的核酸以及制备和应用它们的方法 |
| ES2359562T3 (es) * | 2002-12-20 | 2011-05-24 | Amgen, Inc. | Agentes de unión que inhiben miostatina. |
| WO2004074460A2 (en) * | 2003-02-19 | 2004-09-02 | The Rockefeller University | Nucleotide and protein sequences of coc genes and methods based thereon |
-
2005
- 2005-05-27 US US11/597,182 patent/US20100183695A1/en not_active Abandoned
- 2005-05-27 AU AU2005247508A patent/AU2005247508A1/en not_active Abandoned
- 2005-05-27 EP EP05780089A patent/EP1755648A2/en not_active Withdrawn
- 2005-05-27 KR KR1020067027257A patent/KR20070026650A/ko not_active Withdrawn
- 2005-05-27 US US11/140,024 patent/US7316998B2/en not_active Expired - Lifetime
- 2005-05-27 WO PCT/US2005/018928 patent/WO2005115439A2/en not_active Ceased
- 2005-05-27 JP JP2007515450A patent/JP2008500373A/ja active Pending
- 2005-05-27 CA CA002567810A patent/CA2567810A1/en not_active Abandoned
-
2006
- 2006-11-27 IL IL179602A patent/IL179602A0/en unknown
-
2007
- 2007-08-20 US US11/894,289 patent/US7981857B2/en active Active
-
2012
- 2012-06-26 US US13/533,733 patent/US20130029908A1/en not_active Abandoned
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