JP2008261842A - 光線を放射及び検出するための装置 - Google Patents

光線を放射及び検出するための装置 Download PDF

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Publication number
JP2008261842A
JP2008261842A JP2008037696A JP2008037696A JP2008261842A JP 2008261842 A JP2008261842 A JP 2008261842A JP 2008037696 A JP2008037696 A JP 2008037696A JP 2008037696 A JP2008037696 A JP 2008037696A JP 2008261842 A JP2008261842 A JP 2008261842A
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JP
Japan
Prior art keywords
light
excitation
reaction
light source
light guide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008037696A
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English (en)
Japanese (ja)
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JP2008261842A5 (cg-RX-API-DMAC10.html
Inventor
Roger Iten
アイテン ロゲル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2008261842A publication Critical patent/JP2008261842A/ja
Publication of JP2008261842A5 publication Critical patent/JP2008261842A5/ja
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0235—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using means for replacing an element by another, for replacing a filter or a grating
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/10—Arrangements of light sources specially adapted for spectrometry or colorimetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/32—Investigating bands of a spectrum in sequence by a single detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6471—Special filters, filter wheel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6484—Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0627—Use of several LED's for spectral resolution

Landscapes

  • Physics & Mathematics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2008037696A 2007-02-21 2008-02-19 光線を放射及び検出するための装置 Pending JP2008261842A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07102771A EP1962084A1 (en) 2007-02-21 2007-02-21 Apparatus for emitting and detecting beams of light

Publications (2)

Publication Number Publication Date
JP2008261842A true JP2008261842A (ja) 2008-10-30
JP2008261842A5 JP2008261842A5 (cg-RX-API-DMAC10.html) 2011-03-17

Family

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Family Applications (1)

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JP2008037696A Pending JP2008261842A (ja) 2007-02-21 2008-02-19 光線を放射及び検出するための装置

Country Status (7)

Country Link
US (1) US7947442B2 (cg-RX-API-DMAC10.html)
EP (2) EP1962084A1 (cg-RX-API-DMAC10.html)
JP (1) JP2008261842A (cg-RX-API-DMAC10.html)
CN (1) CN101251486A (cg-RX-API-DMAC10.html)
AU (1) AU2008200772A1 (cg-RX-API-DMAC10.html)
CA (1) CA2621877A1 (cg-RX-API-DMAC10.html)
RU (1) RU2008106636A (cg-RX-API-DMAC10.html)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016509A1 (ja) * 2009-08-06 2011-02-10 ユニバーサル・バイオ・リサーチ株式会社 光ファイバ測定装置およびその測定方法
JP2015503108A (ja) * 2011-12-22 2015-01-29 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 光学システムにおける光源寿命の延長
JP2016526670A (ja) * 2013-06-19 2016-09-05 エリューム・ピーティーワイ・リミテッド 蛍光標識を用いた分析装置
JP2017227642A (ja) * 2016-06-24 2017-12-28 タイゲン バイオサイエンス コーポレイション 多重チャンネル蛍光検出システムおよびそれを使用する方法
JP2018506039A (ja) * 2015-02-06 2018-03-01 ライフ テクノロジーズ コーポレーション 生体サンプルを評価するためのシステムおよび方法
KR20220061504A (ko) * 2020-11-06 2022-05-13 (주)바이오젠텍 형광 다중 유전자 등온증폭기
JP2023516354A (ja) * 2020-12-30 2023-04-19 北京中科生儀科技有限公司 Ｐｃｒ検出器及びその方法

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2525211B1 (en) 2011-05-16 2018-01-03 F. Hoffmann-La Roche AG Instrument and method for detecting analytes
GB201209738D0 (en) * 2012-05-31 2012-07-18 Ge Healthcare Bio Sciences Ab Methods and apparatus for measuring the concentration of a substance in a solution
JP6294823B2 (ja) 2012-07-17 2018-03-14 ユニバーサル・バイオ・リサーチ株式会社 反応容器用光測定装置およびその方法
US9932632B2 (en) 2012-08-10 2018-04-03 Streck, Inc. Real-time optical system for polymerase chain reaction
US10101274B2 (en) 2012-12-05 2018-10-16 Genepoc Inc. Optical interrogation device
AU2015275317A1 (en) * 2013-03-14 2016-01-21 Gen-Probe Incorporated Indexing signal detection module
AU2013202788B2 (en) 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
WO2014210593A1 (en) * 2013-06-28 2014-12-31 Streck, Inc. Devices for real-time polymerase chain reaction
KR102126032B1 (ko) * 2013-07-31 2020-07-08 삼성전자주식회사 다채널 형광 검출 모듈 및 이를 포함하는 핵산 분석 시스템
FI128285B (en) * 2014-06-27 2020-02-28 Metso Automation Oy Multichannel optical measurement unit, multichannel optical detector unit and related measurement method
CN104614351A (zh) * 2015-01-21 2015-05-13 南京中科神光科技有限公司 一种快速、多通道实时荧光定量检测装置
CN106680250B (zh) * 2015-11-10 2023-06-30 北京万泰生物药业股份有限公司 用于聚合酶链式反应的检测机构及聚合酶链式反应装置
GB201603380D0 (en) * 2016-02-26 2016-04-13 Ge Healthcare Bio Sciences Ab Apparatus and method for measuring the light absorbance of a substance in a solution
SE539770C2 (en) 2016-06-10 2017-11-21 Bomill Ab A detector system comprising a plurality of light guides and a spectrometer comprising the detector system
CN107101945A (zh) * 2017-05-26 2017-08-29 北京智云达科技股份有限公司 一种多通道多波长光谱检测装置
WO2019023294A1 (en) * 2017-07-26 2019-01-31 Gen-Probe Incorporated MODULES AND METHODS FOR OPTICAL SIGNAL DETECTION
CN107478629A (zh) * 2017-09-04 2017-12-15 中国科学院苏州生物医学工程技术研究所 一种大面积数字pcr微滴荧光高通量检测装置和方法
US12443028B2 (en) * 2019-02-27 2025-10-14 Seegene, Inc. Light module
US12571734B2 (en) 2019-05-31 2026-03-10 Seegene, Inc. Device and method for detecting light
US11178433B2 (en) * 2019-11-21 2021-11-16 Pluto Inc. Methods and systems for dynamic routing of content using a static playlist manifest
US12546720B2 (en) 2020-03-31 2026-02-10 Seegene, Inc. Optical signal detection device comprising sample holder divided into sample areas and light source units dedicated thereto
WO2023032256A1 (ja) * 2021-09-03 2023-03-09 ソニーセミコンダクタソリューションズ株式会社 分光感度測定装置及び分光感度測定方法
WO2023069651A1 (en) * 2021-10-20 2023-04-27 Bio-Rad Laboratories, Inc. Fluorescence detection system
CN117305086A (zh) * 2023-09-27 2023-12-29 上海邦先医疗科技有限公司 一种恒温扩增lamp检测仪的光学检测模块
EP4650753A1 (de) 2024-05-15 2025-11-19 Gerbion GmbH & Co. KG Vorrichtung zur lumineszenzdetektion für temperaturabhängige reaktionssysteme

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001255272A (ja) * 2000-01-14 2001-09-21 Becton Dickinson & Co 核酸アッセイ用自動光学リーダ
JP2004147706A (ja) * 2002-10-28 2004-05-27 Matsushita Electric Works Ltd 非侵襲型生体成分の定量装置及び定量方法
JP2004537053A (ja) * 2001-07-25 2004-12-09 アプレラ コーポレイション 電気泳動検出システムにおける時間遅延積分
JP2006215026A (ja) * 2005-02-03 2006-08-17 Samsung Electronics Co Ltd 多チャンネル蛍光測定用の光学系及びそれを採用した多チャンネル蛍光試料の分析装置

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477190A (en) * 1981-07-20 1984-10-16 American Hospital Supply Corporation Multichannel spectrophotometer
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DK171161B1 (da) 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
CA1339653C (en) 1986-02-25 1998-02-03 Larry J. Johnson Appartus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
DE4424961C2 (de) 1993-07-15 2002-05-08 Perkin Elmer Corp Wählvorrichtung für ein photometrisches Instrument mit Lichtleitfasern zur Analyse von entfernt befindlichen Proben
US6326605B1 (en) * 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6369893B1 (en) * 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
EP0953837A1 (en) 1998-05-01 1999-11-03 F. Hoffmann-La Roche Ag Fluorescence light measuring device and an apparatus wherein such a device is used
EP0953838A1 (en) * 1998-05-01 1999-11-03 F. Hoffmann-La Roche Ag Apparatus for simultaneously monitoring reactions taking place in a plurality of reaction vessels
DE10131687A1 (de) 2001-06-29 2003-01-16 Eppendorf Ag Vorrichtung zur Durchführung von Nukleinsäure-Amplifikationsreaktionen bei gleichzeitiger Verfolgung der Bildung von Amplifikationsprodukten
US7280207B2 (en) * 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
ATE537438T1 (de) 2002-05-17 2011-12-15 Life Technologies Corp Vorrichtung und verfahren zur unterscheidung mehrerer fluoreszenzsignale anhand ihrer anregungswellenlänge
WO2005121864A2 (en) * 2004-06-07 2005-12-22 Fluidigm Corporation Optical lens system and method for microfluidic devices
US7791728B2 (en) * 2005-08-11 2010-09-07 Hewlett-Packard Development Company, L.P. System for optically analyzing a substance with a selected single-wavelength
EP1991357B1 (en) * 2006-02-07 2016-09-14 Stokes Bio Limited A microfluidic analysis system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001255272A (ja) * 2000-01-14 2001-09-21 Becton Dickinson & Co 核酸アッセイ用自動光学リーダ
JP2004537053A (ja) * 2001-07-25 2004-12-09 アプレラ コーポレイション 電気泳動検出システムにおける時間遅延積分
JP2004147706A (ja) * 2002-10-28 2004-05-27 Matsushita Electric Works Ltd 非侵襲型生体成分の定量装置及び定量方法
JP2006215026A (ja) * 2005-02-03 2006-08-17 Samsung Electronics Co Ltd 多チャンネル蛍光測定用の光学系及びそれを採用した多チャンネル蛍光試料の分析装置

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011016509A1 (ja) * 2009-08-06 2011-02-10 ユニバーサル・バイオ・リサーチ株式会社 光ファイバ測定装置およびその測定方法
JPWO2011016509A1 (ja) * 2009-08-06 2013-01-10 ユニバーサル・バイオ・リサーチ株式会社 光ファイバ測定装置およびその測定方法
US8696992B2 (en) 2009-08-06 2014-04-15 Universal Bio Research Co., Ltd. Optical fiber measurement device and measurement method using same
JP2015503108A (ja) * 2011-12-22 2015-01-29 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト 光学システムにおける光源寿命の延長
US11442012B2 (en) 2013-06-19 2022-09-13 Ellume Limited Assay device employing fluorescent labels
US10578556B2 (en) 2013-06-19 2020-03-03 Ellume Limited Assay device employing fluorescent labels
JP2016526670A (ja) * 2013-06-19 2016-09-05 エリューム・ピーティーワイ・リミテッド 蛍光標識を用いた分析装置
JP2018506039A (ja) * 2015-02-06 2018-03-01 ライフ テクノロジーズ コーポレーション 生体サンプルを評価するためのシステムおよび方法
US11920191B2 (en) 2015-02-06 2024-03-05 Life Technologies Corporation Systems and methods for assessing biological samples
JP2017227642A (ja) * 2016-06-24 2017-12-28 タイゲン バイオサイエンス コーポレイション 多重チャンネル蛍光検出システムおよびそれを使用する方法
KR20220061504A (ko) * 2020-11-06 2022-05-13 (주)바이오젠텍 형광 다중 유전자 등온증폭기
KR102503418B1 (ko) * 2020-11-06 2023-02-27 (주)바이오젠텍 형광 다중 유전자 등온증폭기
JP2023516354A (ja) * 2020-12-30 2023-04-19 北京中科生儀科技有限公司 Ｐｃｒ検出器及びその方法
JP7438580B2 (ja) 2020-12-30 2024-02-27 北京中科生儀科技有限公司 Ｐｃｒ検出器及びその方法

Also Published As

Publication number Publication date
RU2008106636A (ru) 2009-08-27
EP1962084A1 (en) 2008-08-27
AU2008200772A1 (en) 2008-09-04
US20090068747A1 (en) 2009-03-12
EP1962085A3 (en) 2008-09-24
CA2621877A1 (en) 2008-08-21
CN101251486A (zh) 2008-08-27
EP1962085A2 (en) 2008-08-27
US7947442B2 (en) 2011-05-24

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