JP2008134253A - 液体サンプル用のサンプリングデバイス - Google Patents
液体サンプル用のサンプリングデバイス Download PDFInfo
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- JP2008134253A JP2008134253A JP2007315468A JP2007315468A JP2008134253A JP 2008134253 A JP2008134253 A JP 2008134253A JP 2007315468 A JP2007315468 A JP 2007315468A JP 2007315468 A JP2007315468 A JP 2007315468A JP 2008134253 A JP2008134253 A JP 2008134253A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54386—Analytical elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0636—Integrated biosensor, microarrays
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/069—Absorbents; Gels to retain a fluid
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0825—Test strips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
【解決手段】このデバイスでは、サンプルが、サンプリング箇所から測定箇所まで毛管活性チャネルで輸送され、毛管活性チャネルが、支持体と、カバーと、支持体とカバーとの間に位置する中間レイヤーと、から実質的に構成されている。支持体は、サンプリング箇所の近傍でカバーを越えて延在し、中間レイヤーは、後者の近傍でサンプリング箇所から後退している。このデバイスでは、サンプリング箇所の近傍の支持体の露出領域上へのサンプルの上方供給と該サンプルの側方供給の両方が可能である。
【選択図】図3
Description
EP-A 0 359 831; US 6,071,391; US 6,156,173; WO-A 00/20626; WO-A 99/29428; WO-A 99/29429; EP-A 0 170 375。
1. サンプル適用部位は、比較的大きな領域内にあり、試験ストリップの全幅にわたり自由に選択することができる。
図1は、本発明に係る分析試験エレメント(1)の上面図を示している。図1は、図2と組み合わせて、中間レイヤー(7)が両面接着テープの形態で接着されたキャリヤー(5)から分析試験エレメント(1)がいかに構成されるかを示している。中間レイヤー(7)は、毛管活性チャネル(2)用の切込みを有し、ここに示された実施形態では、切込みは、サンプリング部位(3)の領域で漏斗形に拡幅されている。場合により第2の毛管活性チャネル(2')(破線)を有しうる第2の中間レイヤー(7')もまた、キャリヤー(5)上に装着されている。中間レイヤー(7')もまた、図に示される実施形態では、両面接着テープであり、試験エレメント(1)の取扱いを単純化するために、その上にカバー(6')が接着されている。
2,2’ 毛管活性チャネル
3 サンプリング部位
4 測定部位
5 キャリヤー
6,6’ カバー
7,7’ 中間レイヤー
8 過剰サンプル取込み手段(排液ゾーン)
9 ベント開口
10 電極構造体
Claims (6)
- 液体サンプルをサンプリングするためのデバイス(1)であって、該サンプルが、サンプリング部位(3)から測定部位(4)まで毛管活性チャネル(2)で輸送され、該毛管活性チャネル(2)が、キャリヤー(5)と、カバー(6)と、該キャリヤー(5)と該カバー(6)との間に位置する中間レイヤー(7)と、により本質的に形成されており、該キャリヤー(5)が、該サンプリング部位(3)の領域で該カバー(6)を越えて突出しており、該キャリヤー(5)および該カバー(6)が該中間レイヤー(7)を越えて突出するように、該中間レイヤー(7)が、該サンプリング部位(3)の領域で該測定部位(4)の方向に後方に変位されていることを特徴とする、上記デバイス。
- 前記キャリヤーと前記中間レイヤー、または前記カバーと前記中間レイヤー、または前記キャリヤーと前記カバーと前記中間レイヤーが、1つの部片から作製されていることを特徴とする、請求項1に記載のデバイス。
- 前記毛管活性チャネルが、前記サンプリング部位の領域で拡幅されていることを特徴とする、請求項1または2に記載のデバイス。
- 前記毛管活性チャネルが、前記サンプリング部位の領域で前記デバイスの少なくとも一方の側縁まで拡幅されていることを特徴とする、請求項3に記載のデバイス。
- 前記毛管活性チャネルが、前記サンプリング部位の領域で前記デバイスの両方の側縁まで拡幅されていることを特徴とする、請求項4に記載のデバイス。
- 前記毛管活性チャネルが、本質的に、漏斗形に拡幅されていることを特徴とする、請求項3、4、または5に記載のデバイス。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10220296A DE10220296A1 (de) | 2002-05-07 | 2002-05-07 | Vorrichtung zur Probennahme von flüssigen Proben |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004503165A Division JP4117292B2 (ja) | 2002-05-07 | 2003-05-02 | 液体サンプル用のサンプリングデバイス |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008134253A true JP2008134253A (ja) | 2008-06-12 |
JP4627774B2 JP4627774B2 (ja) | 2011-02-09 |
Family
ID=29265113
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004503165A Expired - Lifetime JP4117292B2 (ja) | 2002-05-07 | 2003-05-02 | 液体サンプル用のサンプリングデバイス |
JP2007315468A Expired - Lifetime JP4627774B2 (ja) | 2002-05-07 | 2007-12-06 | 液体サンプル用のサンプリングデバイス |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004503165A Expired - Lifetime JP4117292B2 (ja) | 2002-05-07 | 2003-05-02 | 液体サンプル用のサンプリングデバイス |
Country Status (21)
Country | Link |
---|---|
US (1) | US8409413B2 (ja) |
EP (1) | EP1507589B1 (ja) |
JP (2) | JP4117292B2 (ja) |
KR (1) | KR100615871B1 (ja) |
CN (1) | CN1318141C (ja) |
AT (1) | ATE330704T1 (ja) |
AU (1) | AU2003227705B8 (ja) |
BR (1) | BR0309841B1 (ja) |
CA (1) | CA2493875C (ja) |
CY (1) | CY1107333T1 (ja) |
DE (2) | DE10220296A1 (ja) |
DK (1) | DK1507589T3 (ja) |
ES (1) | ES2266816T3 (ja) |
HK (1) | HK1081479A1 (ja) |
IL (2) | IL164776A0 (ja) |
MX (1) | MXPA04010941A (ja) |
NO (1) | NO331851B1 (ja) |
NZ (1) | NZ536345A (ja) |
RU (1) | RU2281165C2 (ja) |
WO (1) | WO2003095092A1 (ja) |
ZA (1) | ZA200408995B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008505330A (ja) * | 2004-07-09 | 2008-02-21 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 分析試験エレメント |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10346417A1 (de) | 2003-10-07 | 2005-06-02 | Roche Diagnostics Gmbh | Analytisches Testelement umfassend ein Netzwerk zur Bildung eines Kapillarkanals |
US7846311B2 (en) * | 2005-09-27 | 2010-12-07 | Abbott Diabetes Care Inc. | In vitro analyte sensor and methods of use |
US7429865B2 (en) | 2005-10-05 | 2008-09-30 | Roche Diagnostics Operations, Inc. | Method and system for error checking an electrochemical sensor |
US8178313B2 (en) * | 2008-06-24 | 2012-05-15 | Lifescan, Inc. | Method for determining an analyte in a bodily fluid |
US8187658B2 (en) * | 2008-06-24 | 2012-05-29 | Lifescan, Inc. | Method of manufacturing analyte test strip for accepting diverse sample volumes |
US7922985B2 (en) * | 2008-06-24 | 2011-04-12 | Lifescan, Inc. | Analyte test strip for accepting diverse sample volumes |
EP2269737B1 (en) * | 2009-07-02 | 2017-09-13 | Amic AB | Assay device comprising serial reaction zones |
US8877023B2 (en) * | 2012-06-21 | 2014-11-04 | Lifescan Scotland Limited | Electrochemical-based analytical test strip with intersecting sample-receiving chambers |
US20130341207A1 (en) * | 2012-06-21 | 2013-12-26 | Lifescan Scotland Limited | Analytical test strip with capillary sample-receiving chambers separated by stop junctions |
US9523653B2 (en) | 2013-05-09 | 2016-12-20 | Changsha Sinocare Inc. | Disposable test sensor with improved sampling entrance |
US9518951B2 (en) | 2013-12-06 | 2016-12-13 | Changsha Sinocare Inc. | Disposable test sensor with improved sampling entrance |
US9897566B2 (en) | 2014-01-13 | 2018-02-20 | Changsha Sinocare Inc. | Disposable test sensor |
US9939401B2 (en) | 2014-02-20 | 2018-04-10 | Changsha Sinocare Inc. | Test sensor with multiple sampling routes |
US9453812B2 (en) * | 2014-06-24 | 2016-09-27 | Lifescan Scotland Limited | End-fill electrochemical-based analytical test strip with perpendicular intersecting sample-receiving chambers |
BR112017011033B1 (pt) | 2014-12-19 | 2021-12-14 | F. Hoffmann-La Roche Ag | Sistema para determinar pelo menos uma propriedade de uma amostra e método para determinar pelo menos uma propriedade de uma amostra |
BR112018072459A2 (pt) | 2016-06-17 | 2019-03-12 | Hoffmann La Roche | sistema de teste para análise de amostras de fluidos corporais, método de controle de transporte de amostras de fluido corporal em fitas de teste e método de análise de amostras de fluido corporal |
JP6749721B1 (ja) * | 2020-05-27 | 2020-09-02 | 株式会社ファーストスクリーニング | 電気化学センサユニット |
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JPH11304748A (ja) * | 1998-04-23 | 1999-11-05 | Omron Corp | バイオセンサ |
JP2000035413A (ja) * | 1998-07-16 | 2000-02-02 | Sapporo Imuno Diagnostic Laboratory:Kk | 脱水素酵素と補酵素を用いたバイオセンサ |
JP2000162176A (ja) * | 1998-09-22 | 2000-06-16 | Omron Corp | バイオセンサを用いた測定方法及び測定装置 |
JP2001066274A (ja) * | 1999-08-27 | 2001-03-16 | Omron Corp | バイオセンサの評価方法 |
JP2001519032A (ja) * | 1997-03-25 | 2001-10-16 | ユーエスエフ・フィルトレイション・アンド・セパレイションズ・グループ・インコーポレイテッド | 改良された電気化学的なセル |
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2002
- 2002-05-07 DE DE10220296A patent/DE10220296A1/de not_active Withdrawn
-
2003
- 2003-05-02 RU RU2004135562/04A patent/RU2281165C2/ru not_active IP Right Cessation
- 2003-05-02 DK DK03725132T patent/DK1507589T3/da active
- 2003-05-02 KR KR1020047017917A patent/KR100615871B1/ko active IP Right Grant
- 2003-05-02 US US10/513,870 patent/US8409413B2/en active Active
- 2003-05-02 AU AU2003227705A patent/AU2003227705B8/en not_active Ceased
- 2003-05-02 NZ NZ536345A patent/NZ536345A/en not_active IP Right Cessation
- 2003-05-02 IL IL16477603A patent/IL164776A0/xx unknown
- 2003-05-02 AT AT03725132T patent/ATE330704T1/de active
- 2003-05-02 BR BRPI0309841-9A patent/BR0309841B1/pt not_active IP Right Cessation
- 2003-05-02 CN CNB038103311A patent/CN1318141C/zh not_active Expired - Lifetime
- 2003-05-02 ES ES03725132T patent/ES2266816T3/es not_active Expired - Lifetime
- 2003-05-02 MX MXPA04010941A patent/MXPA04010941A/es active IP Right Grant
- 2003-05-02 JP JP2004503165A patent/JP4117292B2/ja not_active Expired - Lifetime
- 2003-05-02 WO PCT/EP2003/004600 patent/WO2003095092A1/de active Search and Examination
- 2003-05-02 DE DE50303962T patent/DE50303962D1/de not_active Expired - Lifetime
- 2003-05-02 CA CA002493875A patent/CA2493875C/en not_active Expired - Fee Related
- 2003-05-02 EP EP03725132A patent/EP1507589B1/de not_active Expired - Lifetime
-
2004
- 2004-10-21 IL IL164776A patent/IL164776A/en unknown
- 2004-11-05 ZA ZA2004/08995A patent/ZA200408995B/en unknown
- 2004-12-06 NO NO20045332A patent/NO331851B1/no not_active IP Right Cessation
-
2006
- 2006-02-02 HK HK06101435A patent/HK1081479A1/xx not_active IP Right Cessation
- 2006-09-21 CY CY20061101364T patent/CY1107333T1/el unknown
-
2007
- 2007-12-06 JP JP2007315468A patent/JP4627774B2/ja not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2001519032A (ja) * | 1997-03-25 | 2001-10-16 | ユーエスエフ・フィルトレイション・アンド・セパレイションズ・グループ・インコーポレイテッド | 改良された電気化学的なセル |
JPH11304748A (ja) * | 1998-04-23 | 1999-11-05 | Omron Corp | バイオセンサ |
JP2000035413A (ja) * | 1998-07-16 | 2000-02-02 | Sapporo Imuno Diagnostic Laboratory:Kk | 脱水素酵素と補酵素を用いたバイオセンサ |
JP2000162176A (ja) * | 1998-09-22 | 2000-06-16 | Omron Corp | バイオセンサを用いた測定方法及び測定装置 |
JP2001066274A (ja) * | 1999-08-27 | 2001-03-16 | Omron Corp | バイオセンサの評価方法 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008505330A (ja) * | 2004-07-09 | 2008-02-21 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 分析試験エレメント |
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