JP2008069182A - ４’−ｃ−置換−２−ハロアデノシン誘導体 - Google Patents
４’−ｃ−置換−２−ハロアデノシン誘導体 Download PDFInfo
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- JP2008069182A JP2008069182A JP2007315315A JP2007315315A JP2008069182A JP 2008069182 A JP2008069182 A JP 2008069182A JP 2007315315 A JP2007315315 A JP 2007315315A JP 2007315315 A JP2007315315 A JP 2007315315A JP 2008069182 A JP2008069182 A JP 2008069182A
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- ethynyl
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- 125000005843 halogen group Chemical group 0.000 claims abstract description 23
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- 238000000034 method Methods 0.000 claims description 25
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- 229910052801 chlorine Chemical group 0.000 claims description 8
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- ZFRAIXAXTOMZET-QRPMWFLTSA-N (2r,3s,5r)-5-(6-amino-2-chloropurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@](CO)(C#C)O1 ZFRAIXAXTOMZET-QRPMWFLTSA-N 0.000 claims description 7
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- KLXASYNEJRYFMO-KRTXAFLBSA-N [(2r,5r)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyloxolan-2-yl]methanol Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@H]1CC[C@](CO)(C#C)O1 KLXASYNEJRYFMO-KRTXAFLBSA-N 0.000 claims description 6
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- CROLXOWGLQHCDS-KRTXAFLBSA-N [(2r,5r)-2-(6-amino-2-chloropurin-9-yl)-5-ethynyl-2h-furan-5-yl]methanol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@@](CO)(C#C)C=C1 CROLXOWGLQHCDS-KRTXAFLBSA-N 0.000 claims description 2
- GHCCTMGSDOFYPV-KRTXAFLBSA-N [(2r,5r)-5-(6-amino-2-chloropurin-9-yl)-2-ethynyloxolan-2-yl]methanol Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1CC[C@](CO)(C#C)O1 GHCCTMGSDOFYPV-KRTXAFLBSA-N 0.000 claims description 2
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- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 description 7
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| US9533938B2 (en) | 2007-01-31 | 2017-01-03 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters for the treatment of stroke |
| US9550722B2 (en) | 2012-01-18 | 2017-01-24 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbal esters for the treatment of stroke |
| US9603825B2 (en) | 2007-01-31 | 2017-03-28 | Biosuccess Biotech Company | Compositions and methods of use of phorbol esters |
| US9636317B2 (en) | 2007-01-31 | 2017-05-02 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
| US9974764B2 (en) | 2007-01-31 | 2018-05-22 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters in the treatment of neoplasms |
| US10099996B2 (en) | 2012-01-18 | 2018-10-16 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters in the treatment of neoplasms |
| US10369222B2 (en) | 2012-01-18 | 2019-08-06 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters for the treatment of stroke |
| US11564901B2 (en) | 2007-01-31 | 2023-01-31 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbol esters |
| US11696908B2 (en) | 2007-01-31 | 2023-07-11 | Biosuccess Biotech Co. Ltd. | Compositions and methods of use of phorbol esters |
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| US10772864B2 (en) | 2007-01-31 | 2020-09-15 | Biosuccess Biotech Co., Ltd. | Compositions and methods of use of phorbolesters |
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