JP2008007519A5 - - Google Patents

Info

Publication number

JP2008007519A5

JP2008007519A5 JP2007218474A JP2007218474A JP2008007519A5 JP 2008007519 A5 JP2008007519 A5 JP 2008007519A5 JP 2007218474 A JP2007218474 A JP 2007218474A JP 2007218474 A JP2007218474 A JP 2007218474A JP 2008007519 A5 JP2008007519 A5 JP 2008007519A5

Authority

JP

Japan

Prior art keywords

group

component

insulin

hyperglycemia

disease caused

Prior art date

2007-08-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims 11
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
• 125000000217 alkyl group Chemical group 0.000 claims 6
• 201000010099 disease Diseases 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 201000001421 hyperglycemia Diseases 0.000 claims 6
• 229940079593 drug Drugs 0.000 claims 5
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
• XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims 4
• 229940123208 Biguanide Drugs 0.000 claims 4
• 208000002249 Diabetes Complications Diseases 0.000 claims 4
• 102000004877 Insulin Human genes 0.000 claims 4
• 108090001061 Insulin Proteins 0.000 claims 4
• 206010022489 Insulin Resistance Diseases 0.000 claims 4
• 229940122199 Insulin secretagogue Drugs 0.000 claims 4
• 238000010521 absorption reaction Methods 0.000 claims 4
• 125000002252 acyl group Chemical group 0.000 claims 4
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
• 239000003623 enhancer Substances 0.000 claims 4
• 239000003112 inhibitor Substances 0.000 claims 4
• 229940125396 insulin Drugs 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 125000003545 alkoxy group Chemical group 0.000 claims 3
• 206010012655 Diabetic complications Diseases 0.000 claims 2
• 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 claims 2
• DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 2
• 101800000224 Glucagon-like peptide 1 Proteins 0.000 claims 2
• 208000008589 Obesity Diseases 0.000 claims 2
• 102100040918 Pro-glucagon Human genes 0.000 claims 2
• 239000003603 dipeptidyl peptidase IV inhibitor Substances 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• -1 insulin secretagogue Substances 0.000 claims 2
• 235000020824 obesity Nutrition 0.000 claims 2
• UAOCLDQAQNNEAX-ABMICEGHSA-N remogliflozin etabonate Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@@H](COC(=O)OCC)O[C@H]1OC1=NN(C(C)C)C(C)=C1CC1=CC=C(OC(C)C)C=C1 UAOCLDQAQNNEAX-ABMICEGHSA-N 0.000 claims 2
• 125000005042 acyloxymethyl group Chemical group 0.000 claims 1
• 125000005206 alkoxycarbonyloxymethyl group Chemical group 0.000 claims 1
• 125000004414 alkyl thio group Chemical group 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 0 *c1c(Cc2ccc(*)cc2)c(*)n[n]1* Chemical compound *c1c(Cc2ccc(*)cc2)c(*)n[n]1* 0.000 description 1
• HOVAGTYPODGVJG-XUUWZHRGSA-N CO[C@@H]([C@@H]([C@H]1O)O)O[C@H](CO)[C@H]1O Chemical compound CO[C@@H]([C@@H]([C@H]1O)O)O[C@H](CO)[C@H]1O HOVAGTYPODGVJG-XUUWZHRGSA-N 0.000 description 1