JP2007536554A5 - - Google Patents
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- Publication number
- JP2007536554A5 JP2007536554A5 JP2007513078A JP2007513078A JP2007536554A5 JP 2007536554 A5 JP2007536554 A5 JP 2007536554A5 JP 2007513078 A JP2007513078 A JP 2007513078A JP 2007513078 A JP2007513078 A JP 2007513078A JP 2007536554 A5 JP2007536554 A5 JP 2007536554A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- epoxy group
- pna
- epoxy
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003700 epoxy group Chemical group 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
Description
本発明において、エポキシ基を有する重合体で、エポキシ基の含有量、すなわち、重合体で、エポキシ基を有するアクリレート単量体の占める重量％は、０．１−１００重量％まで可能であるが、望ましくは、１０重量％以上、さらに望ましくは、２０−３０重量％であることを特徴とする。エポキシ基が１０重量％より少ない場合には、低いエポキシ基の密度により、ＰＮＡを狭い領域に集積し難しくて蛍光信号が弱く示され、一方、４０重量％より多い場合には、ＰＮＡの固定化率がエポキシ基の密度上昇と共に増大しないということが分かった。これは、相対的に多くなったエポキシ基により、コーティング表面のエポキシ基が表面に突出できずに埋められる結果となり、ＰＮＡと効果的に反応できないためであると考えられる。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020040047677A KR100766752B1 (ko) | 2004-06-24 | 2004-06-24 | 에폭시기를 갖는 중합체가 코팅된 플라스틱 기판을 이용한ｐｎａ 칩 |
| PCT/KR2005/001920 WO2006001627A1 (en) | 2004-06-24 | 2005-06-21 | Pna chip using plastic substrate coated with epoxy group-containing polymer, method of manufacturing the pna chip, and method of detecting single nucleotide polymorphism using the pna chip |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007536554A JP2007536554A (ja) | 2007-12-13 |
| JP2007536554A5 true JP2007536554A5 (ja) | 2010-04-22 |
| JP4510080B2 JP4510080B2 (ja) | 2010-07-21 |
Family
ID=36640918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007513078A Expired - Fee Related JP4510080B2 (ja) | 2004-06-24 | 2005-06-21 | エポキシ基含有重合体がコーティングされたプラスチック基板を利用したｐｎａチップ、該ｐｎａチップの製造方法、及び該ｐｎａチップを利用した単一塩基遺伝子変異の検出方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7696130B2 (ja) |
| EP (1) | EP1759016A4 (ja) |
| JP (1) | JP4510080B2 (ja) |
| KR (1) | KR100766752B1 (ja) |
| CN (1) | CN1957093B (ja) |
| AU (1) | AU2005257596B2 (ja) |
| CA (1) | CA2563948A1 (ja) |
| TW (1) | TWI282371B (ja) |
| WO (1) | WO2006001627A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100653975B1 (ko) * | 2004-11-30 | 2006-12-05 | 한국과학기술원 | 집코드 방식을 이용한 ｐｎａ 칩 및 이의 제작방법 |
| KR100725579B1 (ko) * | 2005-02-16 | 2007-06-08 | 주식회사 엘지생명과학 | 에폭시기를 갖는 중합체가 코팅된 플라스틱 기판을 이용한마이코박테리아 유전자형 검출용 ｐｎａ 칩 및 그를 이용한마이코박테리아 유전자형 검출 방법 |
| US9051667B2 (en) * | 2007-10-26 | 2015-06-09 | Wisconsin Alumni Research Foundation | Substrate independent copolymers for biofunctionalization |
| KR100943421B1 (ko) * | 2007-12-24 | 2010-02-19 | 연세대학교 산학협력단 | 에폭시기와 불포화이중결합을 갖는 광중합성 단량체 및이를 함유한 광중합 조성물 |
| EP2311977A1 (en) | 2009-10-15 | 2011-04-20 | INSERM (Institut National de la Santé et de la Recherche Medicale) | Method for predicting responsiveness of a patient to a chemoradiation treatment |
| WO2012120129A1 (en) | 2011-03-10 | 2012-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of infectious diseases |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
| CA3009812A1 (en) * | 2015-12-28 | 2017-07-06 | Vibrant Holdings, Llc | Substrates, systems, and methods for nucleic acid array synthesis |
| WO2017170994A1 (ja) * | 2016-03-31 | 2017-10-05 | 古河電気工業株式会社 | 細胞収容チップ |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048953A (en) * | 1996-06-03 | 2000-04-11 | Toyo Ink Manufacturing Co., Ltd. | Curable liquid resin composition |
| JP4313861B2 (ja) * | 1997-08-01 | 2009-08-12 | キヤノン株式会社 | プローブアレイの製造方法 |
| DE60019512T2 (de) | 1999-06-07 | 2006-02-23 | Fuji Photo Film Co., Ltd., Minami-Ashigara | DNA Chip, PNA Chip, sowie Herstellungsverfahren |
| KR100359941B1 (ko) * | 2000-04-14 | 2002-11-07 | 엘지전자 주식회사 | 바이오칩 제조방법 |
| DE60033665T2 (de) * | 2000-10-31 | 2007-10-31 | Micronas Gmbh | Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung |
| WO2002056021A2 (en) * | 2001-01-10 | 2002-07-18 | Symyx Technologies Inc | Polymer brushes for immobilizing molecules to a surface |
| US20030109062A1 (en) * | 2001-06-05 | 2003-06-12 | Hiroko Inomata | Reactive solid support and DNA fragment detection tool |
| JP3824523B2 (ja) * | 2001-11-29 | 2006-09-20 | 住友ベークライト株式会社 | マイクロチップ用基板及びマイクロチップ |
-
2004
- 2004-06-24 KR KR1020040047677A patent/KR100766752B1/ko not_active IP Right Cessation
-
2005
- 2005-06-21 CN CN2005800161981A patent/CN1957093B/zh not_active Expired - Fee Related
- 2005-06-21 CA CA002563948A patent/CA2563948A1/en not_active Abandoned
- 2005-06-21 JP JP2007513078A patent/JP4510080B2/ja not_active Expired - Fee Related
- 2005-06-21 US US11/156,653 patent/US7696130B2/en not_active Expired - Fee Related
- 2005-06-21 TW TW094120545A patent/TWI282371B/zh not_active IP Right Cessation
- 2005-06-21 WO PCT/KR2005/001920 patent/WO2006001627A1/en not_active Application Discontinuation
- 2005-06-21 EP EP05765833A patent/EP1759016A4/en not_active Withdrawn
- 2005-06-21 AU AU2005257596A patent/AU2005257596B2/en not_active Ceased
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