JP2007533686A - 性的障害ｉｉ治療用の新規医薬組成物 - Google Patents

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Publication number

JP2007533686A

JP2007533686A JP2007508810A JP2007508810A JP2007533686A JP 2007533686 A JP2007533686 A JP 2007533686A JP 2007508810 A JP2007508810 A JP 2007508810A JP 2007508810 A JP2007508810 A JP 2007508810A JP 2007533686 A JP2007533686 A JP 2007533686A

Authority

JP

Japan

Prior art keywords

treatment

effective amount

pharmaceutically acceptable

therapeutically effective

acid addition

Prior art date

2004-04-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 75
• 208000012201 sexual and gender identity disease Diseases 0.000 title abstract description 8
• 208000015891 sexual disease Diseases 0.000 title abstract description 8
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• 229960002053 flibanserin Drugs 0.000 claims abstract description 53
• 239000004480 active ingredient Substances 0.000 claims abstract description 39
• 239000000203 mixture Substances 0.000 claims description 192
• 239000002253 acid Substances 0.000 claims description 182
• 150000003839 salts Chemical class 0.000 claims description 179
• 239000012453 solvate Substances 0.000 claims description 177
• 238000000034 method Methods 0.000 claims description 174
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 157
• 230000003287 optical effect Effects 0.000 claims description 152
• -1 NMI-775 Chemical compound 0.000 claims description 130
• 150000004677 hydrates Chemical class 0.000 claims description 122
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• 230000001568 sexual effect Effects 0.000 claims description 62
• 239000005557 antagonist Substances 0.000 claims description 44
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• 238000002560 therapeutic procedure Methods 0.000 claims description 33
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• 239000000556 agonist Substances 0.000 claims description 29
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• BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 8
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 8
• JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 8
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• 125000003118 aryl group Chemical group 0.000 claims description 8
• 229940079593 drug Drugs 0.000 claims description 8
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 8
• YPFZMBHKIVDSNR-UHFFFAOYSA-N 5-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylpyridin-3-yl]-3-ethyl-2-(2-methoxyethyl)-4h-pyrazolo[4,3-d]pyrimidin-7-one Chemical compound C1=C(C=2NC(=O)C3=NN(CCOC)C(CC)=C3N=2)C(OCC)=NC=C1S(=O)(=O)N1CCN(CC)CC1 YPFZMBHKIVDSNR-UHFFFAOYSA-N 0.000 claims description 7
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