JP2007532576A - 心不整脈治療のための新化合物およびその使用方法 - Google Patents
心不整脈治療のための新化合物およびその使用方法 Download PDFInfo
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- JP2007532576A JP2007532576A JP2007507557A JP2007507557A JP2007532576A JP 2007532576 A JP2007532576 A JP 2007532576A JP 2007507557 A JP2007507557 A JP 2007507557A JP 2007507557 A JP2007507557 A JP 2007507557A JP 2007532576 A JP2007532576 A JP 2007532576A
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- Prior art keywords
- compounds
- compound
- benzoyl
- diiodo
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- REQCZEXYDRLIBE-UHFFFAOYSA-N procainamide Chemical compound CCN(CC)CCNC(=O)C1=CC=C(N)C=C1 REQCZEXYDRLIBE-UHFFFAOYSA-N 0.000 description 1
- 229960000244 procainamide Drugs 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000006410 propenylene group Chemical group 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229960003712 propranolol Drugs 0.000 description 1
- 125000001042 pteridinyl group Chemical group N1=C(N=CC2=NC=CN=C12)* 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000003226 pyrazolyl group Chemical group 0.000 description 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 125000005493 quinolyl group Chemical group 0.000 description 1
- 125000004621 quinuclidinyl group Chemical group N12C(CC(CC1)CC2)* 0.000 description 1
- 230000002336 repolarization Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 239000008137 solubility enhancer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical class OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 description 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000005302 thiazolylmethyl group Chemical group [H]C1=C([H])N=C(S1)C([H])([H])* 0.000 description 1
- 231100000440 toxicity profile Toxicity 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000000169 tricyclic heterocycle group Chemical group 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 1
- 229940072018 zofran Drugs 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56091704P | 2004-04-09 | 2004-04-09 | |
| PCT/US2005/012138 WO2005099684A1 (en) | 2004-04-09 | 2005-04-08 | Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532576A true JP2007532576A (ja) | 2007-11-15 |
| JP2007532576A5 JP2007532576A5 (https=) | 2008-05-15 |
Family
ID=34965215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507557A Abandoned JP2007532576A (ja) | 2004-04-09 | 2005-04-08 | 心不整脈治療のための新化合物およびその使用方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7105568B2 (https=) |
| EP (1) | EP1732537A1 (https=) |
| JP (1) | JP2007532576A (https=) |
| KR (1) | KR20070001259A (https=) |
| CN (1) | CN1950080A (https=) |
| AU (1) | AU2005232701A1 (https=) |
| BR (1) | BRPI0509740A (https=) |
| CA (1) | CA2560336A1 (https=) |
| IL (1) | IL178127A0 (https=) |
| MX (1) | MXPA06011647A (https=) |
| NO (1) | NO20065156L (https=) |
| RU (1) | RU2373199C2 (https=) |
| WO (1) | WO2005099684A1 (https=) |
| ZA (1) | ZA200607666B (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005099684A1 (en) * | 2004-04-09 | 2005-10-27 | Aryx Therapeutics | Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia |
| RU2446143C2 (ru) * | 2010-05-19 | 2012-03-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ЯГТУ) | Способ получения эфиров замещенных 5,6-дицианобензофуран-2-карбоновых кислот |
| CN108396016B (zh) * | 2018-02-05 | 2021-05-25 | 中国科学院南海海洋研究所 | 一种酯酶phe21及其编码基因和在手性乙酸仲丁酯制备中的应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2550091B1 (fr) * | 1983-08-02 | 1986-05-23 | Sanofi Sa | Composition pharmaceutique ou veterinaire destinee a combattre des troubles ischemiques cardiaques contenant un derive du benzofuranne |
| US5175187A (en) * | 1989-03-06 | 1992-12-29 | Soorianarain Baligadoo | Synergistic compositions for the treatment of coronary insufficiency and methods of use thereof |
| US5364880A (en) * | 1993-06-16 | 1994-11-15 | Advanced Therapies, Inc. | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use |
| US6309823B1 (en) * | 1993-10-26 | 2001-10-30 | Affymetrix, Inc. | Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same |
| US6121278A (en) * | 1997-09-03 | 2000-09-19 | Guilford Pharmaceuticals, Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| RU2138492C1 (ru) * | 1997-12-23 | 1999-09-27 | Пятигорская государственная фармацевтическая академия | Способ синтеза производных 3-(5-метилфур-2-ил)-бензофурана, обладающих гипотензивной, антиангинальной и антиаритмической активностями |
| AU774873B2 (en) * | 1999-10-15 | 2004-07-08 | Armetheon, Inc. | Novel enantiomeric compounds for treatment of cardiac arrhythmias and methods of use |
| WO2003050102A1 (en) * | 2001-12-10 | 2003-06-19 | Aryx Therapeutics | Novel compounds for the treatment of cardiac arrhythmia, synthesis, and methods of use |
| US7015568B2 (en) * | 2003-08-21 | 2006-03-21 | Texas Instruments Incorporated | System for ultraviolet atmospheric seed layer remediation |
| WO2005099684A1 (en) * | 2004-04-09 | 2005-10-27 | Aryx Therapeutics | Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia |
-
2005
- 2005-04-08 WO PCT/US2005/012138 patent/WO2005099684A1/en not_active Ceased
- 2005-04-08 JP JP2007507557A patent/JP2007532576A/ja not_active Abandoned
- 2005-04-08 RU RU2006139649/04A patent/RU2373199C2/ru not_active IP Right Cessation
- 2005-04-08 EP EP05735166A patent/EP1732537A1/en not_active Ceased
- 2005-04-08 MX MXPA06011647A patent/MXPA06011647A/es active IP Right Grant
- 2005-04-08 KR KR1020067022953A patent/KR20070001259A/ko not_active Ceased
- 2005-04-08 AU AU2005232701A patent/AU2005232701A1/en not_active Abandoned
- 2005-04-08 US US11/101,995 patent/US7105568B2/en not_active Expired - Lifetime
- 2005-04-08 CA CA002560336A patent/CA2560336A1/en not_active Abandoned
- 2005-04-08 CN CNA200580012140XA patent/CN1950080A/zh active Pending
- 2005-04-08 BR BRPI0509740-1A patent/BRPI0509740A/pt not_active IP Right Cessation
-
2006
- 2006-06-12 US US11/423,559 patent/US7351842B2/en not_active Expired - Fee Related
- 2006-09-13 ZA ZA200607666A patent/ZA200607666B/en unknown
- 2006-09-14 IL IL178127A patent/IL178127A0/en unknown
- 2006-11-09 NO NO20065156A patent/NO20065156L/no not_active Application Discontinuation
-
2007
- 2007-11-07 US US11/936,620 patent/US20080114059A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL178127A0 (en) | 2006-12-31 |
| EP1732537A1 (en) | 2006-12-20 |
| US7351842B2 (en) | 2008-04-01 |
| US20080114059A1 (en) | 2008-05-15 |
| WO2005099684A1 (en) | 2005-10-27 |
| CA2560336A1 (en) | 2005-10-27 |
| CN1950080A (zh) | 2007-04-18 |
| US20050228045A1 (en) | 2005-10-13 |
| NO20065156L (no) | 2006-11-09 |
| BRPI0509740A (pt) | 2007-09-25 |
| KR20070001259A (ko) | 2007-01-03 |
| RU2006139649A (ru) | 2008-05-20 |
| MXPA06011647A (es) | 2007-04-13 |
| US20060276535A1 (en) | 2006-12-07 |
| US7105568B2 (en) | 2006-09-12 |
| ZA200607666B (en) | 2008-03-26 |
| AU2005232701A1 (en) | 2005-10-27 |
| RU2373199C2 (ru) | 2009-11-20 |
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