JP2007532557A5 - - Google Patents
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- Publication number
- JP2007532557A5 JP2007532557A5 JP2007507478A JP2007507478A JP2007532557A5 JP 2007532557 A5 JP2007532557 A5 JP 2007532557A5 JP 2007507478 A JP2007507478 A JP 2007507478A JP 2007507478 A JP2007507478 A JP 2007507478A JP 2007532557 A5 JP2007532557 A5 JP 2007532557A5
- Authority
- JP
- Japan
- Prior art keywords
- solid dispersion
- dispersant
- pharmaceutical composition
- bazedoxifene acetate
- dispersion according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007962 solid dispersion Substances 0.000 claims 39
- 239000002270 dispersing agent Substances 0.000 claims 16
- OMZAMQFQZMUNTP-UHFFFAOYSA-N acetic acid;1-[[4-[2-(azepan-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methylindol-5-ol Chemical compound CC(O)=O.C=1C=C(OCCN2CCCCCC2)C=CC=1CN1C2=CC=C(O)C=C2C(C)=C1C1=CC=C(O)C=C1 OMZAMQFQZMUNTP-UHFFFAOYSA-N 0.000 claims 12
- 229960003713 bazedoxifene acetate Drugs 0.000 claims 12
- 239000000203 mixture Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 206010065687 Bone loss Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010030247 Oestrogen deficiency Diseases 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 230000002357 endometrial effect Effects 0.000 claims 2
- 201000006564 estrogen excess Diseases 0.000 claims 2
- -1 heteropolysaccharide Polymers 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 229920001983 poloxamer Polymers 0.000 claims 2
- 229960000502 poloxamer Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 230000001457 vasomotor Effects 0.000 claims 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 229920002307 Dextran Polymers 0.000 claims 1
- 206010016825 Flushing Diseases 0.000 claims 1
- 229920002534 Polyethylene Glycol 1450 Polymers 0.000 claims 1
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 239000005038 ethylene vinyl acetate Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229940014041 hyaluronate Drugs 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 229920001993 poloxamer 188 Polymers 0.000 claims 1
- 229940044519 poloxamer 188 Drugs 0.000 claims 1
- 229920001987 poloxamine Polymers 0.000 claims 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 239000004626 polylactic acid Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920002689 polyvinyl acetate Polymers 0.000 claims 1
- 239000011118 polyvinyl acetate Substances 0.000 claims 1
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
- 238000007711 solidification Methods 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56045204P | 2004-04-08 | 2004-04-08 | |
| PCT/US2005/011678 WO2005099677A1 (en) | 2004-04-08 | 2005-04-07 | Bazedoxifene acetate solid dispersion formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007532557A JP2007532557A (ja) | 2007-11-15 |
| JP2007532557A5 true JP2007532557A5 (https=) | 2008-05-22 |
Family
ID=34965020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507478A Pending JP2007532557A (ja) | 2004-04-08 | 2005-04-07 | バゼドキシフェンアセテート固体分散物製剤 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20050227966A1 (https=) |
| EP (1) | EP1732528A1 (https=) |
| JP (1) | JP2007532557A (https=) |
| CN (1) | CN1942177B (https=) |
| AR (1) | AR048534A1 (https=) |
| AU (1) | AU2005232640B2 (https=) |
| BR (1) | BRPI0509381A (https=) |
| CA (1) | CA2561124A1 (https=) |
| CR (1) | CR8617A (https=) |
| EC (1) | ECSP066912A (https=) |
| GT (1) | GT200500083A (https=) |
| IL (1) | IL178235A0 (https=) |
| MX (1) | MXPA06011685A (https=) |
| NO (1) | NO20065051L (https=) |
| PA (1) | PA8629301A1 (https=) |
| PE (1) | PE20060167A1 (https=) |
| RU (1) | RU2400227C2 (https=) |
| TW (1) | TW200605863A (https=) |
| UA (1) | UA86056C2 (https=) |
| WO (1) | WO2005099677A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007002823A2 (en) * | 2005-06-29 | 2007-01-04 | Wyeth | Formulations of conjugated estrogens and bazedoxifene |
| JP2009506053A (ja) * | 2005-08-24 | 2009-02-12 | ワイス | 酢酸バゼドキシフェン製剤 |
| AU2012275036B2 (en) * | 2005-08-24 | 2016-05-19 | Wyeth Llc | Bazedoxifene acetate formulations and manufacturing process thereof |
| CZ302358B6 (cs) * | 2007-07-25 | 2011-03-30 | Zentiva, A. S. | Nové soli bazedoxifenu |
| US20100016290A1 (en) * | 2008-02-11 | 2010-01-21 | Livius Cotarca | Amorphous polymorph of bazedoxifene acetate |
| AU2009223014A1 (en) * | 2008-03-11 | 2009-09-17 | Dr. Reddy's Laboratories Ltd. | Preparation of lenalidomide |
| ITMI20091109A1 (it) * | 2009-06-23 | 2010-12-24 | Wyeth Corp | Forma polimorfa d di bazedoxifene acetato e metodi per la sua preparazione |
| CN102552103B (zh) * | 2010-12-20 | 2013-11-20 | 西安力邦医药科技有限责任公司 | 拉米夫定固体分散体、其制备方法、药物组合物和用途 |
| WO2013056108A2 (en) * | 2011-10-14 | 2013-04-18 | Array Biopharma Inc. | Solid dispersion |
| WO2013182169A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Process of preparation of an antioxidant-free polymorphically and chemically stable formulation of bazedoxifene acetate |
| WO2013182170A1 (en) | 2012-06-07 | 2013-12-12 | Zentiva, K. S. | Enhancement of dissolution rate from pharmaceutical composition comprising bazedoxifene acetate |
| CN103845336B (zh) * | 2014-03-24 | 2016-03-09 | 江苏知原药业有限公司 | 一种性能优异的乙酸巴多昔芬组合物 |
| MX2017011469A (es) * | 2015-03-10 | 2018-01-23 | Shionogi Inc | Dispersiones sólidas. |
| CN113244240A (zh) * | 2021-05-26 | 2021-08-13 | 深圳市人民医院 | 醋酸巴多昔芬在治疗急性髓系白血病药物中的应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US5332727A (en) * | 1993-04-29 | 1994-07-26 | Birkmayer U.S.A. | Stable, ingestable and absorbable NADH and NADPH therapeutic compositions |
| US5478847A (en) * | 1994-03-02 | 1995-12-26 | Eli Lilly And Company | Methods of use for inhibiting bone loss and lowering serum cholesterol |
| US5811120A (en) * | 1994-03-02 | 1998-09-22 | Eli Lilly And Company | Solid orally administerable raloxifene hydrochloride pharmaceutical formulation |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| US5919800A (en) * | 1995-02-28 | 1999-07-06 | Eli Lilly And Company | Benzothiophene compounds, intermediates, compositions, and methods |
| TW487582B (en) * | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| US5780497A (en) * | 1996-04-19 | 1998-07-14 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| US5998402A (en) * | 1996-04-19 | 1999-12-07 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indoles as estrogenic agents |
| US5880137A (en) * | 1996-04-19 | 1999-03-09 | American Home Products Corporation | 2-phenyl-1- 4-(amino-1-yl-alk-1-ynyl)-benzyl!-1H-indol-5-ols as estrogenic agents |
| US6005102A (en) * | 1997-10-15 | 1999-12-21 | American Home Products Corporation | Aryloxy-alkyl-dialkylamines |
| US6479535B1 (en) * | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| AR029538A1 (es) * | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| EP1336602A1 (en) * | 2002-02-13 | 2003-08-20 | Giovanni Scaramuzzino | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases |
| SG162615A1 (en) * | 2002-06-13 | 2010-07-29 | Wyeth Corp | Bazedoxifene treatment regimens |
| DE602006010343D1 (de) * | 2005-03-31 | 2009-12-24 | Wyeth Corp | Kombinationsprodukt aus o-desmethylvenlafaxin und bazedoxifen und verwendungen davon |
| WO2007002823A2 (en) * | 2005-06-29 | 2007-01-04 | Wyeth | Formulations of conjugated estrogens and bazedoxifene |
| JP2009506053A (ja) * | 2005-08-24 | 2009-02-12 | ワイス | 酢酸バゼドキシフェン製剤 |
-
2005
- 2005-04-07 BR BRPI0509381-3A patent/BRPI0509381A/pt not_active IP Right Cessation
- 2005-04-07 TW TW094110997A patent/TW200605863A/zh unknown
- 2005-04-07 WO PCT/US2005/011678 patent/WO2005099677A1/en not_active Ceased
- 2005-04-07 AR ARP050101379A patent/AR048534A1/es unknown
- 2005-04-07 UA UAA200610673A patent/UA86056C2/ru unknown
- 2005-04-07 CA CA002561124A patent/CA2561124A1/en not_active Abandoned
- 2005-04-07 GT GT200500083A patent/GT200500083A/es unknown
- 2005-04-07 US US11/100,693 patent/US20050227966A1/en not_active Abandoned
- 2005-04-07 CN CN2005800120943A patent/CN1942177B/zh not_active Expired - Fee Related
- 2005-04-07 JP JP2007507478A patent/JP2007532557A/ja active Pending
- 2005-04-07 RU RU2006132179/15A patent/RU2400227C2/ru not_active IP Right Cessation
- 2005-04-07 EP EP05732942A patent/EP1732528A1/en not_active Withdrawn
- 2005-04-07 PA PA20058629301A patent/PA8629301A1/es unknown
- 2005-04-07 MX MXPA06011685A patent/MXPA06011685A/es active IP Right Grant
- 2005-04-07 PE PE2005000391A patent/PE20060167A1/es not_active Application Discontinuation
- 2005-04-07 AU AU2005232640A patent/AU2005232640B2/en not_active Expired - Fee Related
-
2006
- 2006-09-12 CR CR8617A patent/CR8617A/es not_active Application Discontinuation
- 2006-09-21 IL IL178235A patent/IL178235A0/en unknown
- 2006-10-06 EC EC2006006912A patent/ECSP066912A/es unknown
- 2006-11-02 NO NO20065051A patent/NO20065051L/no not_active Application Discontinuation
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