JP2007532540A5 - - Google Patents
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- Publication number
- JP2007532540A5 JP2007532540A5 JP2007507308A JP2007507308A JP2007532540A5 JP 2007532540 A5 JP2007532540 A5 JP 2007532540A5 JP 2007507308 A JP2007507308 A JP 2007507308A JP 2007507308 A JP2007507308 A JP 2007507308A JP 2007532540 A5 JP2007532540 A5 JP 2007532540A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutical composition
- compound
- composition according
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000011612 calcitriol Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 208000001132 Osteoporosis Diseases 0.000 claims 3
- 201000004681 Psoriasis Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 2
- 208000030136 Marchiafava-Bignami Disease Diseases 0.000 claims 2
- 208000029725 Metabolic bone disease Diseases 0.000 claims 2
- 230000037118 bone strength Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052805 deuterium Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000013725 Chronic Kidney Disease-Mineral and Bone disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010039984 Senile osteoporosis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 230000008416 bone turnover Effects 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 230000001054 cortical effect Effects 0.000 claims 1
- 125000005345 deuteroalkyl group Chemical group 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 206010025135 lupus erythematosus Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 claims 1
- 201000006409 renal osteodystrophy Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/821,828 | 2004-04-09 | ||
| US10/821,828 US7713951B2 (en) | 2004-04-09 | 2004-04-09 | 2-alkylidene-18,19-dinor-vitamin D compounds |
| PCT/US2005/003378 WO2005102995A1 (en) | 2004-04-09 | 2005-02-04 | 2-alkylidene-18,19-dinor-vitamin d compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007532540A JP2007532540A (ja) | 2007-11-15 |
| JP2007532540A5 true JP2007532540A5 (https=) | 2008-03-21 |
| JP4988551B2 JP4988551B2 (ja) | 2012-08-01 |
Family
ID=34960524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007507308A Expired - Fee Related JP4988551B2 (ja) | 2004-04-09 | 2005-02-04 | ２−アルキリデン１８，１９−ジノル−ビタミンｄ化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7713951B2 (https=) |
| EP (1) | EP1735277B1 (https=) |
| JP (1) | JP4988551B2 (https=) |
| AT (1) | ATE534623T1 (https=) |
| AU (1) | AU2005235957B2 (https=) |
| CA (1) | CA2562535C (https=) |
| MX (1) | MXPA06011499A (https=) |
| NZ (1) | NZ550234A (https=) |
| WO (1) | WO2005102995A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7834050B2 (en) | 2006-03-29 | 2010-11-16 | Duke University | Small molecule insulin mimetics absent quinones |
| JP2009533483A (ja) * | 2006-04-06 | 2009-09-17 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１α，２５−ジヒドロキシ−１８，１９，２１−トリノルビタミンＤ３およびその使用 |
| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| WO2010082837A1 (en) * | 2009-01-16 | 2010-07-22 | Jan Anne Lyftogt | Medicament for the treatment of pain and inflammation |
| ES2437921T3 (es) * | 2009-10-21 | 2014-01-15 | Wisconsin Alumni Research Foundation | Método para prevenir la diabetes tipo 1 |
| US8664206B2 (en) | 2010-03-23 | 2014-03-04 | Wisconsin Alumni Research Foundation | Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3 |
| AU2011232633B2 (en) * | 2010-03-23 | 2014-05-29 | Wisconsin Alumni Research Foundation | (20S)-2-methylene-19-nor-22-dimethyl-1alpha,25- dihydroxyvitamin D3 and (20R)-2-methylene-19-nor-22- dimethyl-1alpha,25-hydroxyvitamin D3 |
| JP5931845B2 (ja) * | 2010-03-23 | 2016-06-08 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１９−ノル−２２−メチル−１α，２５−ジヒドロキシビタミンＤ３のジアステレオマー |
| JP5930467B2 (ja) * | 2012-12-14 | 2016-06-08 | 花王株式会社 | ニトリル化合物 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0078704B1 (en) | 1981-11-02 | 1987-04-29 | Research Institute For Medicine And Chemistry Inc. | Intermediates in the synthesis of vitamin d derivatives |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| US5246925A (en) | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| DE69130497T2 (de) | 1990-09-07 | 1999-04-22 | Wisconsin Alumni Research Foundation, Madison, Wis. | Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| DE69400495T2 (de) | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| PT972762E (pt) * | 1993-07-09 | 2004-02-27 | Theramex | Novos analogos estruturais da vitamina d |
| WO1996001811A1 (en) | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| EP0793649B1 (en) | 1994-11-21 | 1999-02-03 | Wisconsin Alumni Research Foundation | 18,19-dinor-vitamin d compounds |
| US5661140A (en) * | 1994-11-21 | 1997-08-26 | Wisconsin Alumni Research Foundation | 18-nor-vitamin D compounds |
| US5877168A (en) | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| CA2175881A1 (en) | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6114317A (en) * | 1998-05-21 | 2000-09-05 | Wisconsin Alumni Research Foundation | Method of locking 1α-OH of vitamin D compounds in axial orientation |
| US5972917A (en) * | 1998-05-29 | 1999-10-26 | Bone Care Int Inc | 1 α-hydroxy-25-ene-vitamin D, analogs and uses thereof |
| TW396427B (en) * | 1998-12-16 | 2000-07-01 | United Microelectronics Corp | Method for fabricating double gates in semiconductor |
| US6806262B2 (en) * | 2000-05-31 | 2004-10-19 | Wisconsin Alumni Research Foundation | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds |
| WO2002005823A2 (en) * | 2000-07-14 | 2002-01-24 | Wisconsin Alumni Research Foundation | USE OF 2-METHYLENE-19-NOR-20(S)-1α,25-DIHYDROXYVITAMIN D3 TO INCREASE BONE STRENGTH |
| WO2002020021A1 (en) * | 2000-09-08 | 2002-03-14 | Wisconsin Alumni Research Foundation | 1alpha-hydroxy-2-methylene-19-nor-homopregnacalciferol and its therapeutic applications |
| BR0307896A (pt) * | 2002-03-29 | 2004-12-07 | Wisconsin Alumni Res Found | Método de produção de 1(alfa)-hidroxi-2-metileno-19-nor-homopregnacalcif erol |
| EP1559708A4 (en) * | 2002-10-10 | 2006-07-19 | Wisconsin Alumni Res Found | 2,2-DISUBSTITUTED 1A, 25-DIHYDROXY-19-NORVITAMINE D DERIVATIVE |
| BRPI0409194A (pt) * | 2003-04-10 | 2006-04-11 | Wisconsin Alumni Res Found | compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso |
| US6894037B2 (en) * | 2003-07-03 | 2005-05-17 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-20(S)-25-methyl-1α-hydroxycalciferol and its uses |
| AU2004266706B2 (en) * | 2003-08-20 | 2009-07-30 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor-vitamin D2 compounds |
| US7214670B2 (en) * | 2003-09-24 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 to increase the life expectancy of human beings |
| US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
| CA2544502A1 (en) * | 2003-11-25 | 2005-06-09 | Wisconsin Alumni Research Foundation | Vitamin d analogs for obesity prevention and treatment |
| ATE467614T1 (de) * | 2004-11-22 | 2010-05-15 | Wisconsin Alumni Res Found | 2-methylen-19,26,27-trinor-(20s)-1-alpha- hydroxyvitamin d3 and dessen verwendungen |
| US7238681B2 (en) * | 2004-11-22 | 2007-07-03 | Wisconsin Alumni Research Foundation | 2-Methylene-18,19-dinor-1α-hydroxy-homopregnacalciferol and its uses |
| NZ561076A (en) * | 2005-02-11 | 2010-01-29 | Wisconsin Alumni Res Found | 2-methylene-19-nor-(20S-24EPI)-1alpha,25-dihydroxyvitamin-D2 |
| CA2605727A1 (en) * | 2005-05-03 | 2006-11-09 | Wisconsin Alumni Research Foundation | 19,26,27-trinor-1.alpha.,25-dihydroxyvitamin d3 compounds |
-
2004
- 2004-04-09 US US10/821,828 patent/US7713951B2/en not_active Expired - Fee Related
-
2005
- 2005-02-04 JP JP2007507308A patent/JP4988551B2/ja not_active Expired - Fee Related
- 2005-02-04 WO PCT/US2005/003378 patent/WO2005102995A1/en not_active Ceased
- 2005-02-04 EP EP05722702A patent/EP1735277B1/en not_active Expired - Lifetime
- 2005-02-04 MX MXPA06011499A patent/MXPA06011499A/es active IP Right Grant
- 2005-02-04 AT AT05722702T patent/ATE534623T1/de active
- 2005-02-04 CA CA2562535A patent/CA2562535C/en not_active Expired - Fee Related
- 2005-02-04 NZ NZ550234A patent/NZ550234A/en not_active IP Right Cessation
- 2005-02-04 AU AU2005235957A patent/AU2005235957B2/en not_active Ceased
-
2010
- 2010-02-19 US US12/709,181 patent/US20100179344A1/en not_active Abandoned
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