JP2006523239A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2006523239A5 JP2006523239A5 JP2006509883A JP2006509883A JP2006523239A5 JP 2006523239 A5 JP2006523239 A5 JP 2006523239A5 JP 2006509883 A JP2006509883 A JP 2006509883A JP 2006509883 A JP2006509883 A JP 2006509883A JP 2006523239 A5 JP2006523239 A5 JP 2006523239A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- following formula
- pharmaceutical composition
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46195803P | 2003-04-10 | 2003-04-10 | |
| US60/461,958 | 2003-04-10 | ||
| PCT/US2004/011059 WO2004092118A2 (en) | 2003-04-10 | 2004-04-09 | 2-propylidene-19-nor-vitamin d compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006523239A JP2006523239A (ja) | 2006-10-12 |
| JP2006523239A5 true JP2006523239A5 (https=) | 2007-04-19 |
| JP5005340B2 JP5005340B2 (ja) | 2012-08-22 |
Family
ID=33299883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006509883A Expired - Fee Related JP5005340B2 (ja) | 2003-04-10 | 2004-04-09 | ２−プロピリデン−１９−ノル−ビタミンｄ化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US20060293291A1 (https=) |
| EP (1) | EP1613588B1 (https=) |
| JP (1) | JP5005340B2 (https=) |
| KR (1) | KR20050120787A (https=) |
| CN (2) | CN101293894B (https=) |
| AT (1) | ATE556999T1 (https=) |
| AU (1) | AU2004230948A1 (https=) |
| BR (1) | BRPI0409194A (https=) |
| CA (1) | CA2516233C (https=) |
| MX (1) | MXPA05009336A (https=) |
| MY (1) | MY146504A (https=) |
| NZ (1) | NZ542674A (https=) |
| WO (1) | WO2004092118A2 (https=) |
| ZA (1) | ZA200506204B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0409194A (pt) * | 2003-04-10 | 2006-04-11 | Wisconsin Alumni Res Found | compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso |
| US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
| NZ561076A (en) * | 2005-02-11 | 2010-01-29 | Wisconsin Alumni Res Found | 2-methylene-19-nor-(20S-24EPI)-1alpha,25-dihydroxyvitamin-D2 |
| AU2006213727B2 (en) * | 2005-02-11 | 2011-08-18 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20S-24S) - 1alpha, 25-dihydroxyvitamin-D2 |
| US8114393B2 (en) | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
| EP2010483A2 (en) * | 2006-04-05 | 2009-01-07 | Wisconsin Alumni Research Foundation | 1.alpha.-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and use thereof |
| US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
| MX2008012671A (es) | 2006-04-06 | 2008-10-15 | Wisconsin Alumni Res Found | Analogos 1 a,25-dihidroxi- 19, 26,27-trinor vitamina d 2-sustituidos y sus usos. |
| WO2008026078A2 (en) * | 2006-04-06 | 2008-03-06 | Wisconsin Alumni Research Foundation | 19-nor-vitamin d analogs with 1,2,or 3,2 heterocyclic ring |
| JP2009533483A (ja) * | 2006-04-06 | 2009-09-17 | ウイスコンシン アラムニ リサーチ ファンデーション | ２−メチレン−１α，２５−ジヒドロキシ−１８，１９，２１−トリノルビタミンＤ３およびその使用 |
| US7648973B2 (en) * | 2006-04-06 | 2010-01-19 | Wisconsin Alumni Research Foundation | 2-methylene-1α,25-dihydroxy-19,21-dinorvitamin D3 analogs and uses thereof |
| CA2646909A1 (en) * | 2006-04-06 | 2008-03-27 | Hector F. Deluca | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
| AU2007298651A1 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin D3 analogs and uses thereof |
| DE602007012216D1 (de) | 2006-04-10 | 2011-03-10 | Wisconsin Alumni Res Found | 1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen mit einer 1,1-dimethylpropyl-seitenkette |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0078704B1 (en) | 1981-11-02 | 1987-04-29 | Research Institute For Medicine And Chemistry Inc. | Intermediates in the synthesis of vitamin d derivatives |
| US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
| GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
| CA1333616C (en) | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
| US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
| NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
| AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
| DE69130497T2 (de) | 1990-09-07 | 1999-04-22 | Wisconsin Alumni Research Foundation, Madison, Wis. | Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis |
| AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
| US5086191A (en) | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
| JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | ２β位に置換基を有するビタミンＤ誘導体 |
| DE69400495T2 (de) | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
| US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
| EP0793649B1 (en) | 1994-11-21 | 1999-02-03 | Wisconsin Alumni Research Foundation | 18,19-dinor-vitamin d compounds |
| US5877168A (en) * | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
| CA2175881A1 (en) * | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
| US5843928A (en) * | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
| US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
| US5945410A (en) | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
| GB9915839D0 (en) * | 1999-07-06 | 1999-09-08 | Textron Automotive U K | Valve assembly for vehicle washing system |
| US6806262B2 (en) * | 2000-05-31 | 2004-10-19 | Wisconsin Alumni Research Foundation | 2-ethyl and 2-ethylidene-19-nor-vitamin D compounds |
| EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
| US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
| BRPI0409194A (pt) * | 2003-04-10 | 2006-04-11 | Wisconsin Alumni Res Found | compostos, composição farmacêutica e método de tratamento de doença metabólica do osso, da psorìase, da leucemia, cáncer do cólon, cáncer da mama, cáncer da pele ou cáncer da próstata, de doença auto-imune, de doença inflamatória do intestino e de aumento da resistência do osso |
| US7053075B2 (en) * | 2003-11-25 | 2006-05-30 | Deluca Hector F | Methods for reducing body fat using vitamin D compounds |
-
2004
- 2004-04-09 BR BRPI0409194-9A patent/BRPI0409194A/pt not_active Application Discontinuation
- 2004-04-09 NZ NZ542674A patent/NZ542674A/en not_active IP Right Cessation
- 2004-04-09 US US10/544,163 patent/US20060293291A1/en not_active Abandoned
- 2004-04-09 KR KR1020057019087A patent/KR20050120787A/ko not_active Abandoned
- 2004-04-09 MX MXPA05009336A patent/MXPA05009336A/es active IP Right Grant
- 2004-04-09 CN CN2008101302056A patent/CN101293894B/zh not_active Expired - Fee Related
- 2004-04-09 AU AU2004230948A patent/AU2004230948A1/en not_active Abandoned
- 2004-04-09 JP JP2006509883A patent/JP5005340B2/ja not_active Expired - Fee Related
- 2004-04-09 AT AT04749961T patent/ATE556999T1/de active
- 2004-04-09 ZA ZA200506204A patent/ZA200506204B/en unknown
- 2004-04-09 EP EP04749961A patent/EP1613588B1/en not_active Expired - Lifetime
- 2004-04-09 CA CA2516233A patent/CA2516233C/en not_active Expired - Fee Related
- 2004-04-09 WO PCT/US2004/011059 patent/WO2004092118A2/en not_active Ceased
- 2004-04-09 CN CNB2004800096206A patent/CN100534981C/zh not_active Expired - Fee Related
- 2004-04-09 US US10/821,479 patent/US7241747B2/en not_active Expired - Lifetime
- 2004-10-14 MY MYPI20044250A patent/MY146504A/en unknown
-
2007
- 2007-05-17 US US11/750,172 patent/US7531527B2/en not_active Expired - Fee Related