MXPA05009336A - Compuestos de 2-propiliden-19-nor-vitamina d. - Google Patents
Compuestos de 2-propiliden-19-nor-vitamina d.Info
- Publication number
- MXPA05009336A MXPA05009336A MXPA05009336A MXPA05009336A MXPA05009336A MX PA05009336 A MXPA05009336 A MX PA05009336A MX PA05009336 A MXPA05009336 A MX PA05009336A MX PA05009336 A MXPA05009336 A MX PA05009336A MX PA05009336 A MXPA05009336 A MX PA05009336A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- activity
- diseases
- treatment
- bone
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 210000000988 bone and bone Anatomy 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000011540 hip replacement Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 238000013150 knee replacement Methods 0.000 abstract 1
- 206010025135 lupus erythematosus Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 230000027425 release of sequestered calcium ion into cytosol Effects 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
Se describen compuestos de 2-propiliden-19-nor-vitamina D, asi como usos farmaceuticos para estos compuestos y los metodos para sintetizar estos compuestos. Estos compuestos se caracterizan por alta actividad de movilizacion de calcio en huesos y alta actividad de transporte de calcio intestinal. Esto resulta en agentes terapeuticos novedosos para el tratamiento y profilaxis de enfermedades en donde se desea formacion de huesos, particularmente osteoporosis, asi como enfermedades autoinmunes tales como esclerosis multiple, diabetes mellitus y lupus. Estos compuestos tambien exhiben actividad pronunciada para frenar la proliferacion de celulas no diferenciadas e inducir su diferenciacion al monocito, evidenciando de esta manera el uso como un agente anti-cancer y para el tratamiento de enfermedades de la piel tales como psoriasis. Estos compuestos tambien incrementan tanto la resistencia a ruptura como al aplastamiento de huesos evidenciando el uso en conjunto con cirugia de reemplazo de huesos tales como reemplazos de cadera y rodilla.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46195803P | 2003-04-10 | 2003-04-10 | |
PCT/US2004/011059 WO2004092118A2 (en) | 2003-04-10 | 2004-04-09 | 2-propylidene-19-nor-vitamin d compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05009336A true MXPA05009336A (es) | 2005-11-04 |
Family
ID=33299883
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05009336A MXPA05009336A (es) | 2003-04-10 | 2004-04-09 | Compuestos de 2-propiliden-19-nor-vitamina d. |
Country Status (15)
Country | Link |
---|---|
US (3) | US7241747B2 (es) |
EP (1) | EP1613588B1 (es) |
JP (1) | JP5005340B2 (es) |
KR (1) | KR20050120787A (es) |
CN (2) | CN100534981C (es) |
AT (1) | ATE556999T1 (es) |
AU (1) | AU2004230948A1 (es) |
BR (1) | BRPI0409194A (es) |
CA (1) | CA2516233C (es) |
HK (1) | HK1086817A1 (es) |
MX (1) | MXPA05009336A (es) |
MY (1) | MY146504A (es) |
NZ (1) | NZ542674A (es) |
WO (1) | WO2004092118A2 (es) |
ZA (1) | ZA200506204B (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE556999T1 (de) * | 2003-04-10 | 2012-05-15 | Wisconsin Alumni Res Found | 2-propyliden-19-nor-vitamin d verbindungen |
US7713951B2 (en) * | 2004-04-09 | 2010-05-11 | Wisconsin Alumni Research Foundation | 2-alkylidene-18,19-dinor-vitamin D compounds |
MX2007009725A (es) * | 2005-02-11 | 2007-09-26 | Wisconsin Alumni Res Found | 2-metilen-19-nor-(20s-24epi)-1a, 25-dihidroxivitamina-d2. |
AU2006213727B2 (en) * | 2005-02-11 | 2011-08-18 | Wisconsin Alumni Research Foundation | 2-methylene-19-nor- (20S-24S) - 1alpha, 25-dihydroxyvitamin-D2 |
US8114393B2 (en) | 2005-09-14 | 2012-02-14 | Wisconsin Alumni Research Foundation | Methods and compositions for phosphate binding |
US20090281340A1 (en) * | 2006-04-05 | 2009-11-12 | Deluca Hector F | 1alpha-hydroxy-2-(3'-hydroxypropylidene)-19-nor-vitamin d compounds and methods of making and treatment thereof |
JP2009532482A (ja) | 2006-04-05 | 2009-09-10 | ウイスコンシン アラムニ リサーチ ファンデーション | 1α−ヒドロキシ−2−(3’−ヒドロキシプロピリデン)−19−ノル−ビタミンD化合物類及びそれらの製造及び使用方法 |
EP2001841B1 (en) * | 2006-04-06 | 2012-06-13 | Wisconsin Alumni Research Foundation | 2-methylene-1 alpha-hydroxy-18,19,21-trinorvitamin d3 analogs and uses thereof |
WO2008035207A2 (en) * | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha-hydroxy-19,21-dinorvitamin d3 analogs and uses thereof |
AU2007298673A1 (en) | 2006-04-06 | 2008-03-27 | Wisconsin Alumni Research Foundation | 2- substituted-1alpha, 25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof |
WO2007118198A2 (en) * | 2006-04-06 | 2007-10-18 | Wisconsin Alumni Research Foundation | 2-METHYLENE-1α,25-DIHYDROXY-19,21-DINORVITAMIN D3 ANALOGS AND USES THEREOF |
US7538098B2 (en) * | 2006-04-06 | 2009-05-26 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D analogs with 1,2 or 3,2 heterocyclic ring |
WO2008125901A2 (en) * | 2006-04-06 | 2008-10-23 | Wisconsin Alumni Research Foundation | 2-methylene-1alpha,25-dihydroxy-18,19,21-trinorvitamin d3 and uses thereof |
US7763598B2 (en) | 2006-04-10 | 2010-07-27 | Wisconsin Alumni Research Foundation | 1α-hydroxy-2-(3′-hydroxypropylidene)-19-nor-vitamin D compounds with a 1,1-dimethylpropyl side chain |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0078704B1 (en) | 1981-11-02 | 1987-04-29 | Research Institute For Medicine And Chemistry Inc. | Intermediates in the synthesis of vitamin d derivatives |
US4666634A (en) | 1984-12-05 | 1987-05-19 | Chugai Seiyaku Kabushiki Kaisha | vitamin D3 derivatives having a substituent at 2-position |
GB8904154D0 (en) | 1989-02-23 | 1989-04-05 | Leo Pharm Prod Ltd | Chemical compounds |
US5246925A (en) * | 1989-03-09 | 1993-09-21 | Wisconsin Alumni Research Foundation | 19-nor-vitamin D compounds for use in treating hyperparathyroidism |
CA1333616C (en) * | 1989-03-09 | 1994-12-20 | Hector F. Deluca | 19-nor-vitamin d compounds |
NZ232734A (en) | 1989-03-09 | 1991-11-26 | Wisconsin Alumni Res Found | 19-nor vitamin d derivatives and pharmaceutical compositions |
AU649057B2 (en) | 1990-08-24 | 1994-05-12 | Wisconsin Alumni Research Foundation | Methods and compositions containing vitamin D compounds for improvement of skin conditions |
DE69130497T2 (de) | 1990-09-07 | 1999-04-22 | Wisconsin Alumni Res Found | Neue Verwendung von 1-Alpha-hydroxylierten-19-nor-vitamin-D-Verbindungen zur Behandlung von Psoriasis |
AU650751B2 (en) | 1991-05-28 | 1994-06-30 | Wisconsin Alumni Research Foundation | Novel synthesis of 19-nor vitamin D compounds |
US5086191A (en) * | 1991-05-28 | 1992-02-04 | Wisconsin Alumni Research Foundation | Intermediates for the synthesis of 19-nor vitamin D compounds |
JP3213092B2 (ja) * | 1991-11-01 | 2001-09-25 | 中外製薬株式会社 | 2β位に置換基を有するビタミンD誘導体 |
DE69400495T2 (de) * | 1993-04-05 | 1997-04-30 | Wisconsin Alumni Res Found | 19-Nor-vitamin-D3-Verbindung mit einem Substituent an die 2. Stelle |
US5565589A (en) * | 1993-11-03 | 1996-10-15 | Wisconsin Alumni Research Foundation | 17-formyl-5,6-trans-vitamin D compounds |
US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
WO1996001811A1 (en) * | 1994-07-11 | 1996-01-25 | The Johns-Hopkins University | 2-substituted 1,25-dihydroxyvitamin d3 derivatives |
ATE176462T1 (de) * | 1994-11-21 | 1999-02-15 | Wisconsin Alumni Res Found | 18,19-dinor-vitamin-d-derivate |
US5877168A (en) * | 1995-02-10 | 1999-03-02 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivative with substituent at the 2β-position |
CA2175881A1 (en) * | 1995-05-09 | 1996-11-10 | Andrzej Kutner | Vitamin d compounds and methods of preparing these compounds |
US5945410A (en) * | 1997-03-17 | 1999-08-31 | Wisconsin Alumni Research Foundation | 2-alkyl-19-nor-vitamin D compounds |
US5843928A (en) | 1997-03-17 | 1998-12-01 | Wisconsin Alumni Research Foundation | 2-alkylidene-19-nor-vitamin D compounds |
US6392071B1 (en) * | 1997-03-17 | 2002-05-21 | Wisconsin Alumni: Research Foundation | 26,27-homologated-20-EPI-2-alkylidene-19-nor-vitamin D compounds |
GB9915839D0 (en) * | 1999-07-06 | 1999-09-08 | Textron Automotive U K | Valve assembly for vehicle washing system |
EP1524264A3 (en) * | 2000-05-31 | 2010-01-20 | Wisconsin Alumni Research Foundation | 2-ethylidene-19-nor-vitamin D compounds |
JP4022141B2 (ja) * | 2000-05-31 | 2007-12-12 | ウィスコンシン・アルムニ・リサーチ・ファウンデーション | 2−エチル及び2−エチリデン−19−ノル−ビタミンd化合物 |
US6846811B2 (en) * | 2002-04-22 | 2005-01-25 | Wisconsin Alumni Research Foundation | (20S) 1α-hydroxy-2α-methyl and 2β-methyl-19-nor-vitamin D3 and their uses |
ATE556999T1 (de) * | 2003-04-10 | 2012-05-15 | Wisconsin Alumni Res Found | 2-propyliden-19-nor-vitamin d verbindungen |
EP1694333A2 (en) * | 2003-11-25 | 2006-08-30 | Deltanoid Pharmaceuticals, Inc. | Methods for reducing body fat using vitamin d compounds |
-
2004
- 2004-04-09 AT AT04749961T patent/ATE556999T1/de active
- 2004-04-09 NZ NZ542674A patent/NZ542674A/en not_active IP Right Cessation
- 2004-04-09 CN CNB2004800096206A patent/CN100534981C/zh not_active Expired - Fee Related
- 2004-04-09 ZA ZA200506204A patent/ZA200506204B/en unknown
- 2004-04-09 EP EP04749961A patent/EP1613588B1/en not_active Expired - Lifetime
- 2004-04-09 US US10/821,479 patent/US7241747B2/en not_active Expired - Lifetime
- 2004-04-09 KR KR1020057019087A patent/KR20050120787A/ko active IP Right Grant
- 2004-04-09 AU AU2004230948A patent/AU2004230948A1/en not_active Abandoned
- 2004-04-09 WO PCT/US2004/011059 patent/WO2004092118A2/en active Application Filing
- 2004-04-09 MX MXPA05009336A patent/MXPA05009336A/es active IP Right Grant
- 2004-04-09 JP JP2006509883A patent/JP5005340B2/ja not_active Expired - Fee Related
- 2004-04-09 CA CA2516233A patent/CA2516233C/en not_active Expired - Fee Related
- 2004-04-09 CN CN2008101302056A patent/CN101293894B/zh not_active Expired - Fee Related
- 2004-04-09 BR BRPI0409194-9A patent/BRPI0409194A/pt not_active Application Discontinuation
- 2004-04-09 US US10/544,163 patent/US20060293291A1/en not_active Abandoned
- 2004-10-14 MY MYPI20044250A patent/MY146504A/en unknown
-
2006
- 2006-06-14 HK HK06106788.7A patent/HK1086817A1/xx not_active IP Right Cessation
-
2007
- 2007-05-17 US US11/750,172 patent/US7531527B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
MY146504A (en) | 2012-08-15 |
AU2004230948A1 (en) | 2004-10-28 |
US20070213546A1 (en) | 2007-09-13 |
JP2006523239A (ja) | 2006-10-12 |
CA2516233A1 (en) | 2004-10-28 |
US7241747B2 (en) | 2007-07-10 |
KR20050120787A (ko) | 2005-12-23 |
WO2004092118A2 (en) | 2004-10-28 |
CN100534981C (zh) | 2009-09-02 |
EP1613588A2 (en) | 2006-01-11 |
JP5005340B2 (ja) | 2012-08-22 |
HK1086817A1 (en) | 2006-09-29 |
ZA200506204B (en) | 2006-10-25 |
WO2004092118A3 (en) | 2005-01-27 |
ATE556999T1 (de) | 2012-05-15 |
US20040229851A1 (en) | 2004-11-18 |
BRPI0409194A (pt) | 2006-04-11 |
US20060293291A1 (en) | 2006-12-28 |
NZ542674A (en) | 2009-03-31 |
EP1613588B1 (en) | 2012-05-09 |
CN101293894B (zh) | 2011-04-06 |
US7531527B2 (en) | 2009-05-12 |
CN1771226A (zh) | 2006-05-10 |
CN101293894A (zh) | 2008-10-29 |
CA2516233C (en) | 2011-09-20 |
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